JPH10500963A - アミノカルボン酸、ペプチドまたはカルボン酸スペーサーを有する3’−(4’−)非放射性標識ヌクレオシドおよびヌクレオチド - Google Patents
アミノカルボン酸、ペプチドまたはカルボン酸スペーサーを有する3’−(4’−)非放射性標識ヌクレオシドおよびヌクレオチドInfo
- Publication number
- JPH10500963A JPH10500963A JP8500261A JP50026195A JPH10500963A JP H10500963 A JPH10500963 A JP H10500963A JP 8500261 A JP8500261 A JP 8500261A JP 50026195 A JP50026195 A JP 50026195A JP H10500963 A JPH10500963 A JP H10500963A
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- amino
- minutes
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4418691A DE4418691A1 (de) | 1994-05-28 | 1994-05-28 | 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer |
DE4418691.6 | 1994-05-28 | ||
PCT/EP1995/001950 WO1995032985A1 (de) | 1994-05-28 | 1995-05-23 | 3'-(4'-)nicht-radioaktiv markierte nukleoside und nukleotide mit aminocarbonsäure-, peptid- oder carbonsäure-spacer |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10500963A true JPH10500963A (ja) | 1998-01-27 |
Family
ID=6519216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8500261A Pending JPH10500963A (ja) | 1994-05-28 | 1995-05-23 | アミノカルボン酸、ペプチドまたはカルボン酸スペーサーを有する3’−(4’−)非放射性標識ヌクレオシドおよびヌクレオチド |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0763051A1 (de) |
JP (1) | JPH10500963A (de) |
CA (1) | CA2190982A1 (de) |
DE (1) | DE4418691A1 (de) |
WO (1) | WO1995032985A1 (de) |
ZA (1) | ZA954333B (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8637650B2 (en) | 2003-11-05 | 2014-01-28 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
WO2011050938A1 (de) | 2009-10-26 | 2011-05-05 | Genovoxx Gmbh | Konjugate von nukleotiden und methoden zu deren anwendung |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2586704B1 (fr) * | 1985-09-04 | 1987-12-18 | Centre Nat Rech Scient | Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs) |
FR2596761B1 (fr) * | 1986-04-08 | 1988-05-20 | Commissariat Energie Atomique | Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides |
DE3788914T2 (de) * | 1986-09-08 | 1994-08-25 | Ajinomoto Kk | Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere. |
WO1988004301A1 (fr) * | 1986-12-02 | 1988-06-16 | Centre National De La Recherche Scientifique (Cnrs | OLIGONUCLEOTIDES alpha |
US4962045A (en) * | 1988-05-02 | 1990-10-09 | The Perkin-Elmer Corporation | Time-resolved fluorimetric detection of lanthanide labeled nucleotides |
JPH0275957A (ja) * | 1988-09-13 | 1990-03-15 | Kao Corp | Dnaの蛍光色素標識方法 |
JPH0275958A (ja) * | 1988-09-13 | 1990-03-15 | Kao Corp | Dna検出法 |
DE3916595A1 (de) * | 1989-05-22 | 1990-11-29 | Boehringer Mannheim Gmbh | Verfahren zur nichtradioaktiven messung der nucleinsaeuresynthese in eukaryontischen zellen |
DE3916871A1 (de) * | 1989-05-24 | 1990-11-29 | Boehringer Mannheim Gmbh | Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren |
DK0497875T3 (da) * | 1989-10-24 | 2000-07-03 | Gilead Sciences Inc | 2'-modificerede oligonukleotider |
YU187991A (sh) * | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
CA2084405A1 (en) * | 1991-04-11 | 1992-10-12 | Chao-Huei Jeffrey Wang | Detection of dna/rna by fluorescence polarization |
JP2562862B2 (ja) * | 1991-08-28 | 1996-12-11 | ベーリンガー・マンハイム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 鋳型依存性酵素的核酸合成用プライマーとしてのオリゴヌクレオチド同時合成および直接標識化のための機能性担体 |
US5646261A (en) * | 1992-01-22 | 1997-07-08 | Hoechst Aktiengesellschaft | 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use |
FR2703052B1 (fr) * | 1993-03-26 | 1995-06-02 | Pasteur Institut | Nouvelle méthode de séquençage d'acides nucléiques. |
-
1994
- 1994-05-28 DE DE4418691A patent/DE4418691A1/de not_active Withdrawn
-
1995
- 1995-05-23 JP JP8500261A patent/JPH10500963A/ja active Pending
- 1995-05-23 CA CA002190982A patent/CA2190982A1/en not_active Abandoned
- 1995-05-23 WO PCT/EP1995/001950 patent/WO1995032985A1/de not_active Application Discontinuation
- 1995-05-23 EP EP95920863A patent/EP0763051A1/de not_active Ceased
- 1995-05-26 ZA ZA954333A patent/ZA954333B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2190982A1 (en) | 1995-12-07 |
WO1995032985A1 (de) | 1995-12-07 |
EP0763051A1 (de) | 1997-03-19 |
ZA954333B (en) | 1996-11-26 |
DE4418691A1 (de) | 1996-02-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6605611B2 (en) | Base analogues | |
US4948882A (en) | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis | |
JP3119171B2 (ja) | オリゴヌクレオチド−ポリアミド コンジュゲート | |
RU2073682C1 (ru) | 3' и/или 2'-амино- или тиолмодифицированные нуклеозиды, нуклеотиды или олигонуклеотиды, способ получения соединений | |
Wojczewski et al. | Fluorescent oligonucleotides-Versatile tools as probes and primers for DNA and RNA analysis | |
CN101605743A (zh) | 用于产生报告分子的点击化学 | |
WO2002002817A2 (en) | Multipartite high-affinity nucleic acid probes | |
CN112218640A (zh) | 核苷酸类似物及其在核酸测序和分析中的用途 | |
JP4908714B2 (ja) | ポリアミド核酸誘導体および薬剤、ならびにその調製方法 | |
FR2632955A1 (fr) | Derives de nucleosides utilisables pour la synthese d'oligonucleotides marques, oligonucleotides obtenus a partir de ces derives et leur synthese | |
US7345163B2 (en) | Process for separating and deprotecting oligonucleotides | |
JP2002525288A (ja) | 2重末端選択を用いるオリゴマーの精製 | |
US6013434A (en) | Oligonucleotide-polyamide conjugates | |
WO2008075718A1 (ja) | 蛍光発生分子 | |
JPH10500963A (ja) | アミノカルボン酸、ペプチドまたはカルボン酸スペーサーを有する3’−(4’−)非放射性標識ヌクレオシドおよびヌクレオチド | |
WO2002074950A1 (fr) | Procede d'analyse d'interaction intermoleculaire | |
Capasso et al. | Solid phase synthesis of DNA-3′-PNA chimeras by using Bhoc/Fmoc PNA monomers | |
WO1993024511A1 (en) | Oligonucleotide-polyamide conjugates | |
US5859259A (en) | Activated esters of 1-phenylpyrazolin-5-one for labeling amine-functionalized molecules | |
JP3379774B2 (ja) | 塩基配列決定方法 | |
JP2723360B2 (ja) | オリゴヌクレオチド−ポリアミドコンジュゲート | |
JPH03500169A (ja) | 標識オリゴヌクレオチドの化学的製造方法及び生物学的使用 | |
Dubey et al. | Synthesis of 3'-and 3', 5'-modified oligonucleotides on functionalized silica Silochrom-2 | |
JP2002107364A (ja) | ノンラベル検出用生物試薬アレイ及びその作製方法 | |
AU4054693A (en) | Oligonucleotide-polyamide conjugates |