ZA954333B - 3'- (4'-) non-radioactively labelled nucleosides and nucleotides with aminocarboxylic acid peptide or carboxylic acid spacers - Google Patents

3'- (4'-) non-radioactively labelled nucleosides and nucleotides with aminocarboxylic acid peptide or carboxylic acid spacers

Info

Publication number
ZA954333B
ZA954333B ZA954333A ZA954333A ZA954333B ZA 954333 B ZA954333 B ZA 954333B ZA 954333 A ZA954333 A ZA 954333A ZA 954333 A ZA954333 A ZA 954333A ZA 954333 B ZA954333 B ZA 954333B
Authority
ZA
South Africa
Prior art keywords
nucleotides
carboxylic acid
radioactively labelled
spacers
labelled nucleosides
Prior art date
Application number
ZA954333A
Other languages
English (en)
Inventor
Konrad Faulstich
Siegfried Brandtner
Rainer Wechselberger
Joachim Engels
Christian Griesinger
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA954333B publication Critical patent/ZA954333B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
ZA954333A 1994-05-28 1995-05-26 3'- (4'-) non-radioactively labelled nucleosides and nucleotides with aminocarboxylic acid peptide or carboxylic acid spacers ZA954333B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4418691A DE4418691A1 (de) 1994-05-28 1994-05-28 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer

Publications (1)

Publication Number Publication Date
ZA954333B true ZA954333B (en) 1996-11-26

Family

ID=6519216

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA954333A ZA954333B (en) 1994-05-28 1995-05-26 3'- (4'-) non-radioactively labelled nucleosides and nucleotides with aminocarboxylic acid peptide or carboxylic acid spacers

Country Status (6)

Country Link
EP (1) EP0763051A1 (xx)
JP (1) JPH10500963A (xx)
CA (1) CA2190982A1 (xx)
DE (1) DE4418691A1 (xx)
WO (1) WO1995032985A1 (xx)
ZA (1) ZA954333B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
WO2011050938A1 (de) 2009-10-26 2011-05-05 Genovoxx Gmbh Konjugate von nukleotiden und methoden zu deren anwendung

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586704B1 (fr) * 1985-09-04 1987-12-18 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
FR2596761B1 (fr) * 1986-04-08 1988-05-20 Commissariat Energie Atomique Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
DE3788914T2 (de) * 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
WO1988004301A1 (fr) * 1986-12-02 1988-06-16 Centre National De La Recherche Scientifique (Cnrs OLIGONUCLEOTIDES alpha
US4962045A (en) * 1988-05-02 1990-10-09 The Perkin-Elmer Corporation Time-resolved fluorimetric detection of lanthanide labeled nucleotides
JPH0275957A (ja) * 1988-09-13 1990-03-15 Kao Corp Ｄｎａの蛍光色素標識方法
JPH0275958A (ja) * 1988-09-13 1990-03-15 Kao Corp Ｄｎａ検出法
DE3916595A1 (de) * 1989-05-22 1990-11-29 Boehringer Mannheim Gmbh Verfahren zur nichtradioaktiven messung der nucleinsaeuresynthese in eukaryontischen zellen
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
DK0497875T3 (da) * 1989-10-24 2000-07-03 Gilead Sciences Inc 2'-modificerede oligonukleotider
YU187991A (sh) * 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba
CA2084405A1 (en) * 1991-04-11 1992-10-12 Chao-Huei Jeffrey Wang Detection of dna/rna by fluorescence polarization
JP2562862B2 (ja) * 1991-08-28 1996-12-11 ベーリンガー・マンハイム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 鋳型依存性酵素的核酸合成用プライマーとしてのオリゴヌクレオチド同時合成および直接標識化のための機能性担体
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
FR2703052B1 (fr) * 1993-03-26 1995-06-02 Pasteur Institut Nouvelle méthode de séquençage d'acides nucléiques.

Also Published As

Publication number Publication date
CA2190982A1 (en) 1995-12-07
WO1995032985A1 (de) 1995-12-07
EP0763051A1 (de) 1997-03-19
JPH10500963A (ja) 1998-01-27
DE4418691A1 (de) 1996-02-22

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