JPH10316589A - Excipient - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an excipient capable of easily pulverizing the active ingredient extract solution of a mushroom or plant used as a medicine, etc. by pulverizing the dry product of the carpophore of Agaricus blazei Murill. SOLUTION: This excipient comprises a dry powder product having a particle diameter of <=40 meshes, is obtained by pulverizing the dry product of the carpophore of Agaricus blazei Murill, and has an antitumor activity and an appetite-stimulating activity. The powder of an extract of Agaricus blazei Murill is obtained by finely grinding the dry carpophore of the Agaricus blazei Murill, adding the ground product to hot pure water, stirring the mixture for 2 hr, heating the obtained extract to evaporate the water, and subsequently adding the above-mentioned excipient to the obtained soft extract to allow the dry powder to adsorb the water in the soft extract.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an excipient, and an object of the present invention is to provide an excipient capable of easily pulverizing an active ingredient extract solution of mushrooms and plants used as a drug. .

[0002]

2. Description of the Related Art Among excipients added to give a desired form to a drug, lactose and starch are the most common ones used for tablets and granules.

On the other hand, in recent years, studies have been made to adjust drugs using mushrooms and active ingredients of plants, and much research has been conducted on Kawariharatake (Agaricus blazei Murill) belonging to the genus Agaricus. Kawariharatake (Agar
icus blazei Murill) originates in the Piedate region of Brazil, a type of mushroom that has been eaten for a long time in this region. In recent years it has been cultivated in Japan,
At first, it was cultivated for raw food, but as a component it is extremely high in polysaccharide β-glucan, and it is rich in phosphoric acid, beneficial fat, etc. of nucleic acid diet that activates cells As it turned out, it was also used for medicinal purposes.

Agaricus blazei Muril
l) Pharmaceutical effects include improvement of liver, heart, gastrointestinal tract, etc., stabilization of blood pressure and blood sugar, recovery of back pain and stiff shoulders, prevention of aging, improvement of immunity, etc. Is an antitumor effect, and it is said that the overall cure rate of cancer is 90% or more and the inhibition rate is 99% or more. Incidentally, a technology for producing an orally-administered drug, a food and drink, etc. by utilizing the antitumor effect, the appetite-enhancing effect, the immunity-lowering improving effect of the polymer polysaccharide complex component of Kawariharatake (Agaricus blazei Murill) is disclosed in Japanese Unexamined Patent Publication No. It has already been clarified in JP-A-128164, JP-A-6-239761, JP-A-7-258107 and the like.

[0005]

As described above, oral administration agents, foods and drinks, etc. are produced using a high-molecular-weight polysaccharide complex component which is an active ingredient of Kawariharatake (Agaricus blazei Murill). (Agaricus b
Lazei Murill) contains a large amount of highly polar hemicellulose, which makes it difficult to concentrate after extraction compared to other mushrooms. There is a problem that it is difficult to do. Therefore, in order to efficiently use the polymer polysaccharide complex component by pulverizing the extract, a method of pulverizing the extract by freeze-drying has been used. However, using the freeze-drying method makes mass production difficult and cannot be produced at low cost, so that Kawariharatake (Agaricus blazei)
It has been desired to create an excipient capable of easily pulverizing the active ingredient of Murill) and using it efficiently.

[0006]

DISCLOSURE OF THE INVENTION The present invention has been made to solve the above-mentioned problems, and the invention according to claim 1 is based on the genus Agaricus blazei Mu.
The invention according to claim 2 relates to an excipient comprising a dry powder of rill), wherein the particle size of the dry powder is 40 mesh or less.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, a dry powder of Kawariharatake (Agaricus blazei Murill) is used as an excipient. The dried powder of Kawariharatake (Agaricus blazei Murill) can be used for the production of tablets and granules in the same manner as conventional excipients. In addition, this dried powder contains a large amount of high molecular weight polysaccharide complex components. Since the high molecular weight polysaccharide complex has excellent activities such as antitumor effect, appetite-enhancing effect, immunity-lowering improving effect, etc. An excipient having excellent activity can be obtained. The portion used for the dry powder is not particularly limited, but is preferably used because the fruiting body contains a large amount of active ingredients of Kawariharatake (Agaricus blazei Murill).

The particle size of the dry powder is not particularly limited.
Preferably, the mesh size is 0 mesh or less. If it exceeds 40 mesh, the resulting tablets and granules become large, making it difficult to drink, which is not preferable.

The drying method is not particularly limited, but the dry powder obtained by hot-air drying has a particularly high active ingredient concentration, and thus this method is preferably used.

[0010] The excipient according to the present invention is used for giving various drugs the required forms, similarly to the excipients conventionally used. Further, it is also possible to powder the extract by mixing it with a component extract solution obtained from medicinal plants, medicinal mushrooms and the like. Kawariharatake (Agar)
icus blazei Murill) can also be used, and in this case, the active ingredient of Kawariharatake (Agaricus blazei Murill) can be used more efficiently.

[0011] Kawariharatake (Agaricus blazei Muril)
The extract obtained by extracting the crushed product of l) contains about 60% of a high molecular weight polysaccharide complex component as an active ingredient.
Although water may be used for the extraction, hot water is more preferably used. The reason is that when extracted with hot water, a high molecular weight polysaccharide complex component containing an acidic polysaccharide, a neutral polysaccharide, a protein polysaccharide and the like is efficiently extracted.

Also, Kawariharatake (Agaricus blazei)
The fruiting body of Murill contains peculiar odor components and pigments, and these odor components emit an unpleasant odor. Therefore, before performing the above-mentioned extraction, extract with an organic solvent or a water-containing organic solvent. This is preferable because odor components and pigments are removed. Examples of the organic solvent used here include ethanol and ether.

As described above, the high molecular weight polysaccharide complex component contains a large amount of hemicellulose having a high polarity, which makes it difficult to concentrate. The concentrate obtained by evaporating water or concentrating under reduced pressure is a paste-like soft extract. Become. The active ingredient in this state is about 70%, and the remaining about 30% is water.

This soft extract contains about 30% of water and is difficult to concentrate. However, when the excipient according to the present invention is mixed, the water contained in the soft extract is a dry powder. It is adsorbed by the agent and has a shape that is easy to handle. Moreover, since the active ingredient of Kawariharatake (Agaricusblazei Murill) is contained in the soft extract and the excipient, the active ingredient as a whole is very high,
blazei Murill) can be used efficiently. The mixing ratio between the excipient and the soft extract is not particularly limited, but is preferably 0.1 to 1 when the dry powder is 1, and in this case, the water content is 5% to 6%.

The excipient according to the present invention is Kawariharatake (Ag
aricus blazei Murill) and Ganoderma lu
cidum), Choreimaitake (Grifora umbellata),
Kikubutake (Phellinus), Kaigaratake (Lenzite)
s), Matsutake (Armillaria matsutake), Shiitake (L
entinus edodes), Kawatake mushroom (Coriolus), Oyster mushroom (Pleurotus ostreatus), Kofukusaronokoshikatake (Elfvingia), Tsugasarunokoshaketake (Fomitops)
is), mushrooms such as Pholiota nameko, enokitake (Flammulina velutipes) and cordyceps (Cordyc
eps sinensis), mycelium, ginseng (Pana
x schinseng), seven carrots (Panax notoginseng)
It can also be used as a powdered excipient for an extract of medicinal plants such as. In particular, Ganoderma lucidu
m) has been known to have an antitumor effect, and tablets and granules obtained by pulverizing this extract with the excipient according to the present invention are used to produce Kawagaritake (Agaricus)
blazei Murill's active ingredient and litchi (Ganoderm)
a lucidum) can effectively exhibit the excellent effects of both due to the synergistic effect of the active ingredients.

[0016]

【Example】

(Example 1) Kawariharatake (Agaricus blazei Muril)
100 g of the dried fruit body of l) was pulverized by a pulverizer to obtain a dry powder. Also, Kawariharatake (Agaricus)
1000 g of the dried fruit body of Blazei Murill) was finely crushed to obtain a crushed product, and 5000 cc of purified water was added thereto and extracted with hot water for 2 hours while stirring. Next, the extract was heated to evaporate water until the water content reached 800 cc, thereby obtaining a soft extract. The powder was obtained by adding the dry powder as an excipient to the soft extract and allowing the moisture of the soft extract to adsorb to the dry powder.

(Example 2) Ganoderma lucidum
) Is finely crushed to obtain a crushed product,
After adding 5000 cc of purified water, the mixture was extracted with hot water for 3 hours while stirring. Next, the extract was concentrated under reduced pressure to obtain a component extract. To 70 g of this extract, 7 g of dry powder obtained by the same method as in Example 1 was added as an excipient to obtain a powder.

[0018]

As described in detail above, the invention according to claim 1 is related to the agaricus genus Kawarihara (Agaricus bla
zei Murill), which is an excipient consisting of a dry powder. In addition to the original excipient effect of giving the drug the required shape, it also has the effect of Kawariharatake (Agaricus blazei)
Murill) can efficiently exhibit excellent effects such as an antitumor effect and an appetite enhancing effect. In addition, substances that are difficult to pulverize, such as an extract obtained from an extract of Kawariharatake (Agaricus blazei Murill), can be easily pulverized, so that the action of the extract can be used more efficiently. In addition, this excipient is added to Reishi (Ganoderm
a lucidum) or other mushrooms or medicinal plant extracts to mix with Kawariharatake (Agaricus blaze)
i Murill) and the active ingredients of mushrooms and medicinal plants exhibit the effects of both more efficiently due to the synergistic effect of the active ingredients.

Further, the invention according to claim 2 relates to the excipient according to claim 1, wherein the particle size of the dry powder is 40 mesh or less. The extract liquid obtained from medicinal plants can be powdered, and the resulting tablets and granules can be easily drunk.

Claims (2)

[Claims] 1. Agaricus b. (Agaricus b)
excipient consisting of a dry powder of lazei Murill). 2. The excipient according to claim 1, wherein the particle size of the dry powder is 40 mesh or less.