JPH10182468A - Swelling improving agent and reducing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject improving agent excellent suppressing activity on a spontaneously generated swelling and weight reducing activity, and manifesting the effectiveness either by an oral use or by an external use on a skin, by making the agent containing α-glycosylated rutin as an active ingredient. SOLUTION: This swelling improving agent contain α-glycosylated rutin e.g. expressed by the formula (at least one of R<1> to R<6> is a monosaccharide or an oligo saccharide residue and the rests are H) as an active ingredient. Further, in order to obtain the above rutin, e.g. preferably a glycosyl residue transferease such as a glycosidase is effected on a composition obtained by adding a partially hydrolyzed starch as a saccharide donating material to the rutin, and in the case of oral administration, 0.01-10g as the α-glycosylated rutin for an adult daily and in the case of external agent of the skin, 0.01-10wt.% were preferably blended.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a swelling improving agent and a slimming agent.

[0002]

2. Description of the Related Art A naturally occurring lower body, especially a swelling of a foot caused by standing or sitting for a long time is not preferable in appearance, that is, cosmetically, in addition to physical obstacles such as inability to remove shoes. The main causes of such spontaneous swelling are an increase in hydrostatic pressure in the foot vascular system due to standing and sitting, and congestion caused by fluid leakage from the capillaries and imbalance in fluid collection by the vein and lymphatic system. Is considered to be a cause. Such swelling is considered to be closely related to the feeling of fatigue and swelling of the feet.

[0003]

However, cosmetics and foods capable of improving such spontaneous swelling have not been known, and these products have been desired from the viewpoint of beauty and health. . Accordingly, an object of the present invention is to provide cosmetics, foods, and the like that have a slimming effect by improving spontaneous swelling.

[0004]

Means for Solving the Problems Accordingly, the present inventors have:
Focusing on plant-derived components and chemically modified products thereof, various studies have been conducted with the effect on swelling as an index, and α-glycosylated rutin is excellent in the effect of suppressing spontaneous swelling and slimming, and However, they have found that the effect can be exerted even when applied externally to the skin, and have completed the present invention.

That is, the present invention provides a swelling improving agent containing α-glycosylated rutin as an active ingredient. The present invention also provides a slimming agent containing α-glycosylated rutin as an active ingredient.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS It is known that α-glycosylated rutin used in the present invention has a vitamin P enhancer, a yellow colorant, a melanin production inhibitory effect when applied to the skin (Japanese Unexamined Patent Publication No. -27293, JP-A-3-27
No. 5607) is not known to have a swelling inhibitory action or a slimming action.

[0007] α-glycosylated rutin can be prepared by adding a partially hydrolyzed starch as a sugar donor to rutin as described in, for example, JP-A-3-275607.
It can be produced by reacting a glycosyl transferase such as glycosidase or transglycosidase. The α-glycosylated rutin is represented, for example, by the following formula (1).

[0008]

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(Wherein at least one of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ represents a monosaccharide or oligosaccharide residue, and the remainder represents a hydrogen atom)

[0010] Of the above monosaccharide or oligosaccharide residues represented by R ^{1 to} R ⁶ , monosaccharide residues are preferred, and glucose residues are particularly preferred.

As the α-glycosylated rutin, the above-mentioned saccharification reaction mixture can be used as it is, but if necessary, purified by a known method may be used.

The swelling improving agent and the slimming agent of the present invention are effective in both external and oral administration forms. Examples of the form of the external preparation for skin include skin cosmetics, quasi-drugs for external use on skin and the like. Oral dosage forms include health foods,
Medical foods, pharmaceuticals and the like can be mentioned. The use of the swelling improving agent and the slimming agent of the present invention is usually 0.01 to 10 per day for adults as oral α-glycosylated rutin.
g is preferred. In the swelling improving agent and the slimming agent of the present invention, the amount of α-glycosylated rutin in the case of an external preparation for skin is preferably 0.01 to 10% by weight (hereinafter simply referred to as%), and 0.1 to 5%. Particularly preferred.

In the form of a skin external preparation, in addition to the above-mentioned components within a range not impairing the effects of the present invention, aqueous components, powders, oils, humectants, and the like, which are blended in ordinary cosmetics and medicines,
Alcohols, pH adjusters, preservatives, dyes, thickeners, fragrances, and the like can be appropriately blended. Specific examples of the form of the external preparation for skin include ointments, emulsions, gels, creams, and lotions. Such a skin external preparation can be produced according to a conventional method.

Examples of the form of oral administration include tablets (including chewable tablets), granules, powders, drinks, and processed foods such as cookies, biscuits, cakes, and breads.

[0015]

Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples.

Example 1 On four subjects, α-glucosylated rutin (αG rutin P, Toyo Seika Co., Ltd., dissolved in 60 ml of water on the first day and 60 ml of water on the second day, a rutin content of about 40% ) Was orally administered at the same time as the first day. The dose of αG rutin P was 1.25 g (0.5 g as rutin) per 60 kg of body weight. One hour after ingesting water or αG-rutin P, the subjects started sitting in an environment at room temperature of 27 ° C. and a humidity of 40%, and continued sitting for two hours. At the time of ingestion of water or αG rutin P, at the start of sitting,
It was measured at the end of the sitting position, and the increase or decrease during intake of water or αG-rutin P was examined. Table 1 shows the results. The numerical values shown in Table 1 are values obtained by correcting the measured values with water or αG rutin P being taken as 0.

[0017]

[Table 1]

From the mean value and SD at the end of the sitting position,
It can be seen that the swelling of the lower leg due to the sitting position is suppressed by 35% or more by oral administration of α-glucosylated rutin.

Embodiment 2

[0020]

(%) Α-glucosylated rutin (αG rutin P) 1.0 glycerin 4.0 1,3-butylene glycol 6.0 POE (20) sorbitan monolaurate 0.5 POE (15) lauryl alcohol Ether 0.5 Ethanol 10.0 Perfume Appropriate Colorant Appropriate Preservative Appropriate Antifading Agent Appropriate Buffer Buffer Appropriate Purified Water Balance

A cosmetic having the above composition is prepared according to a conventional method,
This was applied to the left calf of six subjects, and their perimeters were measured before application and after 8 hours of application. Application 8 to the perimeter of left and right calf before application
Table 3 shows the amount of increase in the perimeter of the left and right calves after the time.

[0022]

[Table 3]

From the results shown in Table 3, the increase in the perimeter of the left foot calf to which the above-mentioned lotion was applied was smaller than the increase in the perimeter of the right foot calf which was not applied, and the application of the lotion containing α-glucosylated rutin resulted in It can be seen that swelling was suppressed.

Example 3 The same cosmetics as in Example 2 were applied to the abdomen of six subjects once a day.
Times, applied for 14 days, before application and 14
The abdominal circumference after application for one day was measured. Table 4 shows the results
Shown in

[0025]

[Table 4]

From the results shown in Table 4, it can be seen that the abdominal circumference decreases after 14 days of application, and that α-glucosylated rutin is effective for slimming.

[0027]

Industrial Applicability The swelling improving agent and slimming agent of the present invention are effective for suppressing swelling of feet and the like and slimming abdomen and the like.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/00 A61K 7/00 W 7/48 7/48 (72) Inventor Kimihiko Hori 2606 Akabane, Kakaicho, Haga-gun, Tochigi Pref. Inside the company research laboratory

Claims (4)

[Claims] 1. A swelling improving agent comprising α-glycosylated rutin as an active ingredient. 2. The swelling improving agent according to claim 1, wherein the administration form is oral or topical. 3. A slimming agent comprising α-glycosylated rutin as an active ingredient. 4. The slimming agent according to claim 3, wherein the administration form is oral or topical.