JPH10218777A - Swelling improver and slimming agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a swelling improver and a slimming agent capable of manifesting excellent suppressing actions on spontaneous swelling and excellent slimming actions and further effects thereof for external use for skin even by an oral route by including an α-glucosylated hesperidine as an active ingredient. SOLUTION: This swelling improver comprises (A) an α-glucosylated hesperidine represented by the formula (one or more of R<1> to R<6> are each a monosaccharide or an oligosaccharide residue and the others are H) as an active ingredient. The agent is formulated into a skin preparation for external use, e.g. an ointment, a milky lotion or a toilet lotion or further an oral administration form such as a tablet, a granule or a processed food, e.g. a biscuit, a cake or bread and administered in a daily dose of preferably 0.01-10g expressed in terms of the amount of the ingredient A for an adult in the case of oral administration.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a swelling improving agent and a slimming agent.

[0002]

2. Description of the Related Art A naturally occurring lower body, especially a swelling of a foot caused by standing or sitting for a long time is not preferable in appearance, that is, cosmetically, in addition to physical obstacles such as inability to remove shoes. The main causes of such spontaneous swelling are an increase in hydrostatic pressure in the foot vascular system due to standing and sitting, and congestion caused by fluid leakage from the capillaries and imbalance in fluid collection by the vein and lymphatic system. Is considered to be a cause. Such swelling is considered to be closely related to the feeling of fatigue and swelling of the feet.

[0003]

However, cosmetics and foods capable of improving such spontaneous swelling have not been known, and these products have been desired from the viewpoint of beauty and health. . Accordingly, an object of the present invention is to provide cosmetics, foods, and the like that have a slimming effect by improving spontaneous swelling.

[0004]

Means for Solving the Problems Accordingly, the present inventors have:
Focusing on plant-derived components and chemically modified products thereof, various studies have been conducted with the effect on swelling as an index, and α-glycosylated hesperidin is excellent in the action of suppressing spontaneous swelling and slimming, and However, they have found that the effect can be exerted even when applied externally to the skin, and have completed the present invention.

That is, the present invention provides a swelling improving agent containing α-glycosylated hesperidin as an active ingredient. The present invention also provides a slimming agent containing α-glycosylated hesperidin as an active ingredient.

[0006]

DETAILED DESCRIPTION OF THE INVENTION It is known that the α-glycosylated hesperidin used in the present invention can be used as a vitamin P enhancer, a yellow colorant, an anti-sensitive disease agent and the like (JP-A-3-7593). It has no known swelling inhibitory or slimming effect.

[0007] α-Glycosylated hesperidin may be obtained by any method as long as a sugar is α-glycosylated with the rutinose moiety of hesperidin. As a typical example, as described in JP-A-3-7593, it can be obtained by reacting hesperidin with a glycosyltransferase in the presence of an α-glycosyl saccharified compound. According to this method, α-glycosylated hesperidin in which the sugar moiety of hesperidin is α-glycosylated is obtained. The α-glycosylated hesperidin is represented, for example, by the following formula (1).

[0008]

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(Wherein at least one of R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ represents a monosaccharide or oligosaccharide residue, and the remainder represents a hydrogen atom)

[0010] Of the above monosaccharide or oligosaccharide residues represented by R ^{1 to} R ⁶ , monosaccharide residues are preferred, and glucose residues are particularly preferred.

As the α-glycosylated hesperidin, the above-mentioned saccharification reaction mixture can be used as it is, but if necessary, purified by a known method may be used.

The swelling improving agent and the slimming agent of the present invention are effective in both external and oral administration forms. Examples of the form of the external preparation for skin include skin cosmetics, quasi-drugs for external use on skin and the like. Oral dosage forms include health foods,
Medical foods, pharmaceuticals and the like can be mentioned. The use amount of the swelling improving agent and the slimming agent of the present invention is usually 0.01 g / day for an adult orally as α-glycosylated hesperidin.
-10 g are preferred. In the swelling improving agent and the slimming agent of the present invention, the amount of α-glycosylated hesperidin in the case of an external preparation for skin is preferably 0.01 to 10% by weight (hereinafter simply referred to as%), and 0.1 to 5%. Particularly preferred.

In the form of a skin external preparation, in addition to the above-mentioned components within a range not impairing the effects of the present invention, aqueous components, powders, oils, humectants, and the like, which are blended in ordinary cosmetics and medicines,
Alcohols, pH adjusters, preservatives, dyes, thickeners, fragrances, and the like can be appropriately blended. Specific examples of the form of the external preparation for skin include ointments, emulsions, gels, creams, and lotions. Such a skin external preparation can be produced according to a conventional method.

Examples of the form of oral administration include tablets (including chewable tablets), granules, powders, drinks, and processed foods such as cookies, biscuits, cakes, and breads.

[0015]

Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples.

Example 1 On four subjects, α-glucosylated hesperidin dissolved in 60 ml of water on the first day and 60 ml of water on the second day (αG hesperidin PS manufactured by Toyo Seika Co., Ltd., hesperidin content about 83%) ) Was orally administered at the same time as the first day. The dose of αG hesperidin PS is 0.6 g per 60 kg body weight
(0.5 g as hesperidin). One hour after ingestion of water or αG hesperidin PS, the subjects started sitting in an environment at room temperature of 27 ° C. and a humidity of 40%, and continued sitting for 2 hours. The sum of the three lower leg circumferences of the subject was calculated at the time of ingestion of water or αG hesperidin PS, at the start of sitting,
The measurement was performed at the end of the sitting position, and the increase or decrease during intake of water or αG hesperidin PS was examined. Table 1 shows the results. The numerical values shown in Table 1 are values obtained by correcting the measured values with water or αG hesperidin PS taken as 0.

[0017]

[Table 1]

From the mean value and SD at the end of the sitting position,
It can be seen that the swelling of the lower leg due to the sitting position is reduced by 35% or more by oral administration of α-glucosylated hesperidin.

Embodiment 2

[0020]

(%) Α-Glucosylated hesperidin (αG hesperidin PS) 1.0 glycerin 4.0 1,3-butylene glycol 6.0 POE (20) sorbitan monolaurate 0.5 POE (15) lauryl alcohol Ether 0.5 Ethanol 10.0 Perfume Appropriate Colorant Appropriate Preservative Appropriate Antifading Agent Appropriate Buffer Buffer Appropriate Purified Water Balance

A cosmetic having the above composition is prepared according to a conventional method,
This was applied to the left calf of six subjects, and their perimeters were measured before application and after 8 hours of application. Application 8 to the perimeter of left and right calf before application
Table 3 shows the amount of increase in the perimeter of the left and right calves after the time.

[0022]

[Table 3]

From the results in Table 3, the increase in the circumference of the left foot calf to which the above lotion was applied was smaller than the increase in the circumference of the right foot calf which was not applied, and the application of the lotion containing α-glucosylated hesperidin resulted in It can be seen that swelling was suppressed.

Example 3 The same cosmetics as in Example 2 were applied to the abdomen of six subjects once a day.
Times, applied for 14 days, before application and 14
The abdominal circumference after application for one day was measured. Table 4 shows the results
Shown in

[0025]

[Table 4]

The results in Table 4 show that the abdominal girth decreased after 14 days of application and that α-glucosylated hesperidin was effective for slimming.

[0027]

Industrial Applicability The swelling improving agent and slimming agent of the present invention are effective for suppressing swelling of feet and the like and slimming abdomen and the like.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/48 A61K 7/48 C07H 17/07 C07H 17/07 (72) Inventor Yuko Fukuda 2606 Akabane, Kakaicho, Haga-gun, Tochigi Prefecture Kao Inside the Research Laboratories of the Stock Company (72) Takashi Kitahara 2606, Kabane-cho, Akaga-cho, Haga-gun, Tochigi Prefecture Inside the Research Laboratories of Kao Corporation (72) Inventor Kimihiko Hori 2606, Akabane-Kai-cho, the city of Haga-gun, Tochigi Prefecture Within the Kao Research Institute (72) Inventor Noboru Matsuo 2606 Kabashi-cho, Akaga-cho, Haga-gun, Tochigi Pref. In Kao Co., Ltd. (72) Inventor Minoru Takizawa 2606 Kabachi-cho, Akabane-cho, Haga-gun, Tochigi pref.In Kao Co., Ltd. 1-33, Ishimacho (72) Inventor Takashi Yumoto 1-6-141, Iwasaki Nishi, Ichihara-shi, Chiba Prefecture Toyo Refinery Co., Ltd. Chiba Plant

Claims (4)

[Claims] 1. A swelling improving agent comprising α-glycosylated hesperidin as an active ingredient. 2. The swelling improving agent according to claim 1, wherein the administration form is oral or topical. 3. A slimming agent comprising α-glycosylated hesperidin as an active ingredient. 4. The slimming agent according to claim 3, wherein the administration form is oral or topical.