JPH09511140A - スタンニウスの小体の蛋白、スタンニオカルシン - Google Patents
スタンニウスの小体の蛋白、スタンニオカルシンInfo
- Publication number
- JPH09511140A JPH09511140A JP7523421A JP52342195A JPH09511140A JP H09511140 A JPH09511140 A JP H09511140A JP 7523421 A JP7523421 A JP 7523421A JP 52342195 A JP52342195 A JP 52342195A JP H09511140 A JPH09511140 A JP H09511140A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polynucleotide
- stannius
- dna
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.スタンニウスの小体のポリペプチドをコードしている単離ポリヌクレオチ ドであって、 (a)図1の推定アミノ酸配列を有するスタンニウスの小体のポリペプチドま たは該ポリペプチドのフラグメント、アナログもしくは誘導体をコードしている ポリヌクレオチド (b)ATCC寄託物75652中に含まれるcDNAによりコードされるア ミノ酸配列を有するスタンニウスの小体のポリペプチドまたは該ポリペプチドの フラグメント、アナログもしくは誘導体をコードしているポリヌクレオチド からなる群より選択されるポリヌクレオチド。 2.DNAである請求項1のポリヌクレオチド。 3.RNAである請求項1のポリヌクレオチド。 4.ゲノムDNAである請求項1のポリヌクレオチド。 5.図1の推定アミノ酸配列を有するスタンニウスの小体のポリペプチドをコ ードしている請求項2のポリヌクレオチド。 6.ATCC寄託物75652のcDNAによりコードされるスタンニウスの 小体のポリペプチドをコードしている請求項2のポリヌクレオチド。 7.図1に示すスタンニウスの小体のポリペプチドに関するコーディング配列 を有する請求項1のポリヌクレオチド。 8.ATCC寄託物75652として寄託されたスタンニウスの小体のポリペ プチドに関するコーディング配列を有する請求項2のポリヌクレオチド。 9.請求項2のDNAを含むベクター。 10.請求項9のベクターで遺伝学的に処理された宿主細胞。 11.請求項10の宿主細胞から上記DNAによりコードされるポリペプチド を発現させることを特徴とするポリペプチドの製造方法。 12.請求項9のベクターで細胞を遺伝学的に処理することを特徴とする、ポ リペプチドを発現しうる細胞の製造方法。 13.請求項2のDNAにハイブリダイズ可能で、スタンニウスの小体のポリ ペプチド活性を有するポリペプチドをコードしている単離DNA。 14.(i)図1の推定アミノ酸配列を有するスタンニウスの小体のポリペプ チドおよびそのフラグメント、アナログならびに誘導体 および(ii)ATCC寄託物75652のcDNAによりコードされるスタンニ ウスの小体のポリペプチドおよび該ポリペプチドのフラグメント、アナログなら びに誘導体 からなる群より選択されるポリペプチド。 15.図1の推定アミノ酸配列を有するスタンニウスの小体のポリペプチドで ある請求項14のポリペプチド。 16.請求項14のポリペプチドに対する抗体。 17.請求項14のポリペプチドに対するアンタゴニスト/阻害剤。 18.治療上有効量の請求項14のポリペプチドを患者に投与することを特徴 とする、スタンニウスの小体のポリペプチドに対する必要性のある患者の治療方 法。 19.請求項14のポリペプチドに対する治療上有効量のアンタゴニスト/阻 害剤を患者に投与することを特徴とする、スタンニウスの小体のポリペプチドを 阻害する必要性のある患者の治療方法。 20.請求項14のポリペプチドおよび医薬上許容される担体からなる医薬組 成物。 21.ポリペプチドをコードしているDNAを患者に提供し、次いで、該ポリ ペプチドをインビボで発現させることにより該治療上有効量のポリペプチドが投 与される請求項18の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/208,005 US5837498A (en) | 1994-03-08 | 1994-03-08 | Corpuscles of stannius protein, stanniocalcin |
US08/208,005 | 1994-03-08 | ||
PCT/US1994/005136 WO1995024411A1 (en) | 1994-03-08 | 1994-05-09 | Corpuscles of stannius protein, stanniocalcin |
Publications (2)
Publication Number | Publication Date |
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JPH09511140A true JPH09511140A (ja) | 1997-11-11 |
JP3687974B2 JP3687974B2 (ja) | 2005-08-24 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP52342195A Expired - Fee Related JP3687974B2 (ja) | 1994-03-08 | 1994-05-09 | スタンニウスの小体の蛋白、スタンニオカルシン |
Country Status (15)
Country | Link |
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US (5) | US5837498A (ja) |
EP (1) | EP0750626B1 (ja) |
JP (1) | JP3687974B2 (ja) |
KR (1) | KR100338583B1 (ja) |
CN (2) | CN1560080A (ja) |
AT (1) | ATE197155T1 (ja) |
AU (1) | AU684297B2 (ja) |
CA (1) | CA2184905A1 (ja) |
DE (1) | DE69426209T2 (ja) |
DK (1) | DK0750626T3 (ja) |
ES (1) | ES2151557T3 (ja) |
GR (1) | GR3035099T3 (ja) |
PT (1) | PT750626E (ja) |
WO (1) | WO1995024411A1 (ja) |
ZA (1) | ZA943702B (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US5837498A (en) * | 1994-03-08 | 1998-11-17 | Human Genome Scienes, Inc. | Corpuscles of stannius protein, stanniocalcin |
JPH10509036A (ja) * | 1994-11-10 | 1998-09-08 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | ヒトスタニオカルシン−α |
US6008322A (en) * | 1996-04-02 | 1999-12-28 | Zymogenetics, Inc. | Stanniocalcin-2 |
WO1999033864A1 (fr) * | 1997-12-26 | 1999-07-08 | Daiichi Pharmaceutical Co., Ltd. | Derives peptidiques |
WO2000016795A1 (fr) * | 1998-09-17 | 2000-03-30 | Snow Brand Milk Products Co., Ltd. | Agents pour la prevention et/ou le traitement de l'obesite |
CA2387685A1 (en) * | 1999-10-27 | 2001-05-03 | Human Genome Sciences, Inc. | Stanniocalcin proteins and nucleic acids and methods based thereon |
US6902890B1 (en) * | 1999-11-04 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing monitoring, staging, imaging and treating cancer |
US20040254102A1 (en) * | 2000-07-11 | 2004-12-16 | Yuji Yoshiko | Remedies for bone diseases |
US20040009171A1 (en) * | 2001-10-18 | 2004-01-15 | Genentech, Inc. | Methods for the treatment of carcinoma |
EP1442062A4 (en) * | 2001-10-18 | 2005-11-09 | Genentech Inc | METHOD FOR TREATING CARCINOMA |
US7056685B1 (en) | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
US8759298B2 (en) | 2010-05-03 | 2014-06-24 | Scott & White Healthcare | Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration |
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US5447841A (en) * | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
WO1988003949A1 (en) * | 1986-11-21 | 1988-06-02 | Howard Florey Institute Of Experimental Physiology | The cs protein of the corpuscles of stannius |
US5491224A (en) * | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
US5538869A (en) * | 1990-12-13 | 1996-07-23 | Board Of Regents, The University Of Texas System | In-situ hybridization probes for identification and banding of specific human chromosomes and regions |
US5866344A (en) * | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
US5545524A (en) * | 1991-12-04 | 1996-08-13 | The Regents Of The University Of Michigan | Compositions and methods for chromosome region-specific probes |
US5837498A (en) * | 1994-03-08 | 1998-11-17 | Human Genome Scienes, Inc. | Corpuscles of stannius protein, stanniocalcin |
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1994
- 1994-03-08 US US08/208,005 patent/US5837498A/en not_active Expired - Lifetime
- 1994-05-09 CN CNA2004100027180A patent/CN1560080A/zh active Pending
- 1994-05-09 AT AT94923154T patent/ATE197155T1/de not_active IP Right Cessation
- 1994-05-09 CN CNB941950522A patent/CN1178950C/zh not_active Expired - Fee Related
- 1994-05-09 PT PT94923154T patent/PT750626E/pt unknown
- 1994-05-09 KR KR1019960704922A patent/KR100338583B1/ko not_active IP Right Cessation
- 1994-05-09 DK DK94923154T patent/DK0750626T3/da active
- 1994-05-09 ES ES94923154T patent/ES2151557T3/es not_active Expired - Lifetime
- 1994-05-09 AU AU73109/94A patent/AU684297B2/en not_active Ceased
- 1994-05-09 JP JP52342195A patent/JP3687974B2/ja not_active Expired - Fee Related
- 1994-05-09 WO PCT/US1994/005136 patent/WO1995024411A1/en active IP Right Grant
- 1994-05-09 EP EP94923154A patent/EP0750626B1/en not_active Expired - Lifetime
- 1994-05-09 CA CA002184905A patent/CA2184905A1/en not_active Abandoned
- 1994-05-09 DE DE69426209T patent/DE69426209T2/de not_active Expired - Fee Related
- 1994-05-26 ZA ZA943702A patent/ZA943702B/xx unknown
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1995
- 1995-04-28 US US08/431,117 patent/US5994301A/en not_active Expired - Fee Related
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1998
- 1998-03-11 US US09/038,597 patent/US5877290A/en not_active Expired - Lifetime
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2000
- 2000-12-18 GR GR20000402787T patent/GR3035099T3/el not_active IP Right Cessation
-
2002
- 2002-04-05 US US10/116,051 patent/US20020146791A1/en not_active Abandoned
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2005
- 2005-03-10 US US11/076,158 patent/US7326537B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1995024411A1 (en) | 1995-09-14 |
CN1560080A (zh) | 2005-01-05 |
AU684297B2 (en) | 1997-12-11 |
US5877290A (en) | 1999-03-02 |
ZA943702B (en) | 1995-11-27 |
CN1143371A (zh) | 1997-02-19 |
US5837498A (en) | 1998-11-17 |
CN1178950C (zh) | 2004-12-08 |
GR3035099T3 (en) | 2001-03-30 |
ES2151557T3 (es) | 2001-01-01 |
US5994301A (en) | 1999-11-30 |
US7326537B2 (en) | 2008-02-05 |
EP0750626B1 (en) | 2000-10-25 |
DE69426209D1 (de) | 2000-11-30 |
US20050208552A1 (en) | 2005-09-22 |
CA2184905A1 (en) | 1995-09-14 |
ATE197155T1 (de) | 2000-11-15 |
PT750626E (pt) | 2001-03-30 |
KR970701724A (ko) | 1997-04-12 |
JP3687974B2 (ja) | 2005-08-24 |
US20020146791A1 (en) | 2002-10-10 |
EP0750626A1 (en) | 1997-01-02 |
AU7310994A (en) | 1995-09-25 |
KR100338583B1 (ko) | 2002-11-14 |
DK0750626T3 (da) | 2000-11-20 |
EP0750626A4 (en) | 1997-06-11 |
DE69426209T2 (de) | 2001-06-07 |
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