JPH09510983A - 好酸球の顆粒球の病理学的な過剰反応性を減少するためのキサンチン誘導体の使用、新規なキサンチン化合物およびそれらの製法 - Google Patents

好酸球の顆粒球の病理学的な過剰反応性を減少するためのキサンチン誘導体の使用、新規なキサンチン化合物およびそれらの製法

Info

Publication number
JPH09510983A
JPH09510983A JP7525385A JP52538595A JPH09510983A JP H09510983 A JPH09510983 A JP H09510983A JP 7525385 A JP7525385 A JP 7525385A JP 52538595 A JP52538595 A JP 52538595A JP H09510983 A JPH09510983 A JP H09510983A
Authority
JP
Japan
Prior art keywords
formula
compound
methyl
group
xanthine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP7525385A
Other languages
English (en)
Japanese (ja)
Inventor
ゲーベルト，ウルリツヒ
アナグノストプロス，ヒリスト
クレーゲル，クラウス
カプ，アーレクサンダー
Original Assignee
ヘキスト・アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヘキスト・アクチエンゲゼルシヤフト filed Critical ヘキスト・アクチエンゲゼルシヤフト
Publication of JPH09510983A publication Critical patent/JPH09510983A/ja
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP7525385A 1994-04-05 1995-03-21 好酸球の顆粒球の病理学的な過剰反応性を減少するためのキサンチン誘導体の使用、新規なキサンチン化合物およびそれらの製法 Abandoned JPH09510983A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4411660.8 1994-04-05
DE4411660A DE4411660A1 (de) 1994-04-05 1994-04-05 Verwendung von Xanthinderivaten zur Reduktion der pathologischen Hyperreagibilität eosinophiler Granulozyten, neue Xanthinverbindungen und Verfahren zu deren Herstellung
PCT/EP1995/001060 WO1995026727A1 (de) 1994-04-05 1995-03-21 Verwendung von xanthinderivaten zur reduktion der pathologischen hyperreagibilität eosinophiler granulozyten, neue xanthinverbindungen und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
JPH09510983A true JPH09510983A (ja) 1997-11-04

Family

ID=6514636

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7525385A Abandoned JPH09510983A (ja) 1994-04-05 1995-03-21 好酸球の顆粒球の病理学的な過剰反応性を減少するためのキサンチン誘導体の使用、新規なキサンチン化合物およびそれらの製法

Country Status (11)

Country Link
EP (1) EP0758239A1 (de)
JP (1) JPH09510983A (de)
KR (1) KR100373948B1 (de)
CN (1) CN1098686C (de)
AU (1) AU695488B2 (de)
CA (1) CA2187081A1 (de)
DE (1) DE4411660A1 (de)
HU (1) HUT74732A (de)
RU (1) RU2159617C2 (de)
UA (1) UA39136C2 (de)
WO (1) WO1995026727A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005529934A (ja) * 2002-05-31 2005-10-06 シェーリング　コーポレイション キサンチンホスホジエステラーゼｖインヒビターおよびその前駆物質を調製するプロセス

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294350B1 (en) 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
US5985592A (en) * 1997-06-05 1999-11-16 Dalhousie University Uses for pentoxifylline or functional derivatives/metabolites thereof
AU3370099A (en) * 1998-03-31 1999-10-18 Mayo Foundation For Medical Education And Research Use of platelet activating factor (paf) inhibitors to inhibit il-5 induced eosinophil activation or degranulation
SI1509525T1 (sl) * 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8918297D0 (en) * 1989-08-10 1989-09-20 Beecham Group Plc Novel treatment
DD298051A5 (de) * 1989-08-16 1992-02-06 ��@���������@�������k�� Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten
GB9023783D0 (en) * 1990-11-01 1990-12-12 Celltech Ltd Pharmaceutical product
IL100195A0 (en) * 1990-11-30 1992-08-18 Hoechst Roussel Pharma Use of xanthines for the preparation of a medicament having immuno suppressing activity
WO1993003728A1 (en) * 1991-08-27 1993-03-04 Temple University Of The Commonwealth System Of Xanthine suppression of antigen activation of t- or b-cells
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005529934A (ja) * 2002-05-31 2005-10-06 シェーリング　コーポレイション キサンチンホスホジエステラーゼｖインヒビターおよびその前駆物質を調製するプロセス

Also Published As

Publication number Publication date
EP0758239A1 (de) 1997-02-19
UA39136C2 (uk) 2001-06-15
RU2159617C2 (ru) 2000-11-27
KR970702044A (ko) 1997-05-13
AU1951095A (en) 1995-10-23
WO1995026727A1 (de) 1995-10-12
KR100373948B1 (ko) 2003-06-09
DE4411660A1 (de) 1995-10-12
HU9602712D0 (en) 1996-11-28
AU695488B2 (en) 1998-08-13
CN1145029A (zh) 1997-03-12
CN1098686C (zh) 2003-01-15
CA2187081A1 (en) 1995-10-12
HUT74732A (en) 1997-02-28

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