JPH09506904A - プロポフォルの精製 - Google Patents
プロポフォルの精製Info
- Publication number
- JPH09506904A JPH09506904A JP8503661A JP50366196A JPH09506904A JP H09506904 A JPH09506904 A JP H09506904A JP 8503661 A JP8503661 A JP 8503661A JP 50366196 A JP50366196 A JP 50366196A JP H09506904 A JPH09506904 A JP H09506904A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- propofol
- solvent
- alkyl group
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
- C07C37/86—Purification; separation; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式 (RO)n−R′ ここで、Rは、水素あるいは直鎖または分鎖アルキル基、好ましくは1から 4個の炭素原子の低アルキル基、R′は、アルカリまたはアルカリ土類金属そし てnは、前記金属R′に依存して、1または2、 で表される塩基で、原料生成物を処理し、得られた塩を分離し、それを、有機ま たは無機の酸、好ましくは鉱酸で中和して純粋のプロポフォルに転化する、こと からなる2,6−ジイソプロピルフェノールの精製方法。 2.前記用いられる塩基が、式 (RO)n−R′ ここで、Rは、ナトリウムまたはカリウム、R′は、1から4個の炭素原子 からなる低アルキル基、そしてnは1、 を有することを特徴とする請求項1に記載の方法。 3.ナトリウムメチラートが塩基として使用され、前記塩化がメタノール中で行 われることを特徴とする請求項1に記載の方法。 4.前記中和が、鉱酸または有機酸により、行われることを特徴とする請求項1 に記載の方法。 5.前記鉱酸が塩酸水溶液であることを特徴とする請求項4に記載の方法。 6.前記有機酸がメタンスルホン酸、ギ酸および酢酸からなる群から選ばれるこ とを特徴とする請求項4に記載の方法。 7.前記得られるアルカリまたはアルカリ土類金属2,6−ジイソプロピルフェ ナートが、該塩が不溶の溶媒により、洗浄されることを特徴とする請求項1に記 載の方法。 8.前記溶媒がトルエンであることを特徴とする請求項7に記載の方法。 9.前記純粋な2,6−ジイソプロピルフェノールの分離が、98〜100℃、 1.7・103パスカルの圧力で、蒸留されることにより、行われることを特徴 とする請求項1に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT94A001377 | 1994-07-01 | ||
ITMI941377A IT1269977B (it) | 1994-07-01 | 1994-07-01 | Purificazione del propofol |
PCT/EP1995/002520 WO1996001243A1 (en) | 1994-07-01 | 1995-06-28 | Propofol purification |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09506904A true JPH09506904A (ja) | 1997-07-08 |
JP3751022B2 JP3751022B2 (ja) | 2006-03-01 |
Family
ID=11369202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50366196A Expired - Lifetime JP3751022B2 (ja) | 1994-07-01 | 1995-06-28 | プロポフォルの精製 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5696300A (ja) |
EP (1) | EP0716645B1 (ja) |
JP (1) | JP3751022B2 (ja) |
AU (1) | AU2978595A (ja) |
DE (1) | DE69508894T2 (ja) |
DK (1) | DK0716645T3 (ja) |
ES (1) | ES2129835T3 (ja) |
IT (1) | IT1269977B (ja) |
WO (1) | WO1996001243A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014043561A (ja) * | 2012-07-30 | 2014-03-13 | Jnc Corp | 液晶組成物、酸化防止剤および液晶表示素子 |
JP2015535009A (ja) * | 2012-11-20 | 2015-12-07 | シェブロン・オロナイト・カンパニー・エルエルシー | 硫化アルキル置換ヒドロキシ芳香族化合物塩を含む組成物を調製するための方法 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7991448B2 (en) | 1998-10-15 | 2011-08-02 | Philips Electronics North America Corporation | Method, apparatus, and system for removing motion artifacts from measurements of bodily parameters |
KR20000047871A (ko) * | 1998-12-04 | 2000-07-25 | 강재헌 | 고순도 2,6-디이소프로필페놀의 정제방법 |
WO2000034218A1 (en) * | 1998-12-04 | 2000-06-15 | Dong Kook Pharmaceutical Co., Ltd. | Process for purification of 2,6-diisopropyl phenol |
US8664452B2 (en) | 2010-06-23 | 2014-03-04 | Harman Finochem Limited | Process for preparing extra pure 2, 6-diisopropyl phenol |
CN103360219B (zh) * | 2012-04-06 | 2015-08-19 | 辽宁诺康生物制药有限责任公司 | 一种高纯度丙泊酚的合成方法 |
WO2021156776A1 (en) * | 2020-02-06 | 2021-08-12 | Nandkumar Chodankar | Simple manufacturing and purification technology for high purity propofol |
CN114133318B (zh) * | 2021-12-09 | 2023-08-29 | 广东嘉博制药有限公司 | 一种降除丙泊酚产品中丙泊酚杂质o的方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2831898A (en) | 1954-04-29 | 1958-04-22 | Ethyl Corp | Phenol alkylation process |
GB855489A (en) * | 1959-04-23 | 1960-11-30 | Yorkshire Tar Distillers Ltd | Isolation of dimethyl phenol |
US3517072A (en) * | 1963-10-28 | 1970-06-23 | Consolidation Coal Co | High purity 2,6-xylenol |
GB1316276A (en) * | 1969-12-12 | 1973-05-09 | Coalite Chemical Products Ltd | Separation of chlorophenols |
US3630855A (en) * | 1970-05-04 | 1971-12-28 | Dow Chemical Co | Process for removing naphthalene from phenol by extractive distillation |
SU443019A1 (ru) | 1973-01-05 | 1974-09-15 | Предприятие П/Я Г-4740 | Способ получени 2,6-диизопропилфенола |
GB1472793A (en) | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
US4103096A (en) | 1977-10-13 | 1978-07-25 | Stauffer Chemical Company | Preparation of meta-alkylphenols |
US4208537A (en) | 1977-10-27 | 1980-06-17 | Mitsui Toatsu Chemicals Incorporated | Process for the selective ortho-alkylation of phenolic compounds |
US4275248A (en) | 1979-06-25 | 1981-06-23 | Uop Inc. | Preparation of 2,4,6-triisopropylphenol |
FR2530877A1 (fr) | 1982-07-22 | 1984-01-27 | Marchal Equip Auto | Porte-balais et moteur electrique muni d'un tel porte-balais |
US4447657A (en) | 1982-11-10 | 1984-05-08 | Uop Inc. | Preparation of ortho-alkylated phenols |
DE3314372A1 (de) | 1983-04-20 | 1984-10-25 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von substituierten phenolen |
JPS62209034A (ja) | 1986-03-08 | 1987-09-14 | Maruzen Petrochem Co Ltd | 2,6−ジ−t−ブチルフエノ−ルの製造法 |
FI912102A (fi) * | 1991-04-30 | 1992-10-31 | Leiras Oy | Foerfarande foer rening av 2,6-diisopropylfenol |
FR2686293B1 (fr) | 1992-01-17 | 1995-03-24 | Oce Graphics France | Machine a dessiner a outils d'ecriture interchangeables a partir d'une reserve d'outils, avec possiblite de definition de groupes d'outils stockes, reserve d'outils et procede de definition de groupes d'outils pour une telle machine. |
-
1994
- 1994-07-01 IT ITMI941377A patent/IT1269977B/it active IP Right Grant
-
1995
- 1995-06-28 AU AU29785/95A patent/AU2978595A/en not_active Abandoned
- 1995-06-28 ES ES95925780T patent/ES2129835T3/es not_active Expired - Lifetime
- 1995-06-28 EP EP95925780A patent/EP0716645B1/en not_active Expired - Lifetime
- 1995-06-28 WO PCT/EP1995/002520 patent/WO1996001243A1/en active IP Right Grant
- 1995-06-28 JP JP50366196A patent/JP3751022B2/ja not_active Expired - Lifetime
- 1995-06-28 DK DK95925780T patent/DK0716645T3/da active
- 1995-06-28 DE DE69508894T patent/DE69508894T2/de not_active Expired - Lifetime
- 1995-06-28 US US08/591,600 patent/US5696300A/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014043561A (ja) * | 2012-07-30 | 2014-03-13 | Jnc Corp | 液晶組成物、酸化防止剤および液晶表示素子 |
JP2015535009A (ja) * | 2012-11-20 | 2015-12-07 | シェブロン・オロナイト・カンパニー・エルエルシー | 硫化アルキル置換ヒドロキシ芳香族化合物塩を含む組成物を調製するための方法 |
Also Published As
Publication number | Publication date |
---|---|
EP0716645A1 (en) | 1996-06-19 |
US5696300A (en) | 1997-12-09 |
DK0716645T3 (da) | 1999-10-18 |
AU2978595A (en) | 1996-01-25 |
IT1269977B (it) | 1997-04-16 |
ITMI941377A1 (it) | 1996-01-01 |
EP0716645B1 (en) | 1999-04-07 |
ES2129835T3 (es) | 1999-06-16 |
WO1996001243A1 (en) | 1996-01-18 |
ITMI941377A0 (it) | 1994-07-01 |
JP3751022B2 (ja) | 2006-03-01 |
DE69508894T2 (de) | 1999-08-12 |
DE69508894D1 (de) | 1999-05-12 |
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