JPH09503752A - 酵母及び胞子微生物を殺傷するための殺菌方法並びに組成物 - Google Patents
酵母及び胞子微生物を殺傷するための殺菌方法並びに組成物Info
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- JPH09503752A JPH09503752A JP7506009A JP50600995A JPH09503752A JP H09503752 A JPH09503752 A JP H09503752A JP 7506009 A JP7506009 A JP 7506009A JP 50600995 A JP50600995 A JP 50600995A JP H09503752 A JPH09503752 A JP H09503752A
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- C12Y111/02—Oxidoreductases acting on a peroxide as acceptor (1.11) with H2O2 as acceptor, one oxygen atom of which is incorporated into the product (1.11.2)
- C12Y111/02002—Myeloperoxidase (1.11.2.2)
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.酵母若しくは胞子性微生物を殺し、又はその成長を阻害する方法であって 、パーオキサイド及びクロライド若しくはブロマイドの存在下で、該微生物を、 ハロペルオキシダーゼ及び少なくとも1つの下式の抗菌活性増強剤と接触させる ことを具備した方法。 但し、R1は水素、無置換であるか、或いはヒドロキシ若しくはアミノ置 換された1から6の炭素原子を有する直鎖若しくは分岐鎖アルキル基、又は無置 換であるか、或いはヒドロキシ若しくはアミノ置換された7から12の炭素原子 を有するアリールアルキル基であり、R2は、水素、又は1から6の炭素原子を 有する直鎖若しくは分岐鎖アルキル基である。 2.ハロペルオキシダーゼが、ミエロペルオキシダーゼ、エオシノフィルペル オキシダーゼ及びこれらの組合せから選択される請求の範囲第1項に記載の方法 。 3.抗菌活性増強剤が、グリシン並びにアラニン、バリン、ロイシン、イソロ イシン、セリン、スレオニン、リジン、フェニルアラニン、チロシン及びこれら のアルキルエステルのl−若しくはd−エナンチオマーよりなる群から選択され るα−アミノ酸である請求の範囲第1項に記載の方法。 4.ハロペルオキシダーゼがミエロペルオキシダーゼであり、ハライドがクロ ライド若しくはブロマイドである請求の範囲第2項に記載の方法。 5.ハロペルオキシダーゼがエオシノフィルオキシダーゼであり、ハライドが ブロマイドである請求の範囲第2項に記載の方法。 6.微生物が、少なくとも0.01pmol/mlのハロペルオキシダーゼ及び少なく とも0.005μmol/mlの抗菌活性増強剤を含有する液体溶液と接触される請求 の範囲第1項に記載の方法。 7.該液体溶液が、0.1pmol/mlから500pmol/mlのハロペルオキシダーゼ 及び0.05μmol/mlから50μmol/mlの抗菌活性増強剤を含有する請求の範囲 第6項に記載の方法。 8.該溶液が、1mlの該溶液あたり0.5pmolから50pmolのハロペルオキシダ ーゼを含有する請求の範囲第6項に記載の方法。 9.該液体溶液が、パーオキサイド又はパーオキサイドを生成することができ る試薬を更に含有する請求の範囲第6項に記載の方法。 10.酵母若しくは胞子性微生物を殺し、又はその成長を阻害する組成物であ って、ハロペルオキシダーゼ及び少なくとも1つの下式の抗菌活性増強剤を具備 した組成物。 但し、R1は水素、無置換であるか、或いはヒドロキシ若しくはアミノ置 換された1から6の炭素原子を有する直鎖若しくは分岐鎖アルキル基、又は無置 換であるか、或いはヒドロキシ若しくはアミノ置換された7から12の炭素原子 を有するアリールアルキル基であり、R2は、水素、又は1から6の炭素原子を 有する直鎖若しくは分岐鎖アルキル基である。 11.ハロペルオキシダーゼが、ミエロペルオキシダーゼ又はエオシノフィル ペルオキシダーゼである請求の範囲第10項に記載の組成物。 12.抗菌活性増強剤が、グリシン並びにアラニン、バリン、ロイシン、イソ ロイシン、セリン、スレオニン、リジン、フェニルアラニン、チロシン及びこれ らのアルキルエステルのl−若しくはd−エナンチオマーよりなる群から選択さ れるα−アミノ酸である請求の範囲第10項に記載の組成物。 13.ハロペルオキシダーゼがミエロペルオキシダーゼである請求の範囲第1 1項に記載の組成物。 14.液体担体中に少なくとも0.01pmol/mlのミエロペルオキシダーゼを含 有する請求の範囲第13項に記載の組成物。 15.液体担体中に0.1pmol/mlから500pmol/mlのミエロペルオキシダー ゼを含有する請求の範囲第14項に記載の組成物。 16.液体担体中に0.5pmol/mlから50pmol/mlのミエロペルオキシダーゼ を含有する請求の範囲第14項に記載の 組成物。 17.液体担体中に少なくとも0.005μmol/mlの抗菌活性増強剤を含有す る請求の範囲第12項に記載の組成物。 18.液体担体中に0.05μmol/mlから50μmol/mlの抗菌活性増強剤を含 有する請求の範囲第17項に記載の組成物。 19.ハロペルオキシダーゼがエオシノフィルペルオキシダーゼであり、ハラ イドがブロマイドである請求の範囲第11項に記載の組成物。 20.液体担体中に少なくとも0.01pmolのエオシノフィルオキシダーゼを 含有する請求の範囲第19項に記載の組成物。 21.液体担体の1mlあたり0.1pmolから500pmolのエオシノフィルペル オキシダーゼを含有する請求の範囲第19項に記載の組成物。 22.0.5pmol/mlから50pmol/mlのエオシノフィルオキシダーゼを含有す る請求の範囲第20項に記載の組成物。 23.10nmol/mlから10μmol/mlのブロマイドを更に含有する請求の範囲 第20項に記載の組成物。 24.過酸化水素又はオキシダーゼに対する基質の存在下でパーオキサイドを 産生することができるオキシダーゼを更に含有する請求の範囲第10項に記載の 組成物。 25.オキシダーゼに対する基質の存在下で、1分につき、1mlあたり100 pmolから50μmolのパーオキサイドをを生成するのに効果的なパーオキサイド 産生オキシダーゼを 含有する請求の範囲第24項に記載の組成物。 26.請求の範囲第10項に記載の組成物を含有する殺菌−滅菌溶液。 27.請求の範囲第26項に記載の殺菌−滅菌溶液であって、0.1pmol/ml から500pmol/mlのミエロペルオキシダーゼ、エオシノフィルペルオキシダー ゼ又はこれらの組合せ、並びに0.005μmol/mlから50μmol/mlの、グリシ ン並びにアラニン、バリン、ロイシン、イソロイシン、セリン、スレオニン、リ ジン、フェニルアラニン、チロシン及びこれらのアルキルエステルのl−若しく はd−エナンチオマーよりなる群から選択されるα−アミノ酸を液体担体中に含 有するもの。 28.請求の範囲第10項に記載の組成物を含有する眼用溶液。 29.請求の範囲第8項に記載の眼用溶液であって、0.1pmol/mlから500 pmol/mlのミエロペルオキシダーゼ、エオシノフィルペルオキシダーゼ又はこれ らの組合せ、並びに0.005μmol/mlから50μmol/mlの、グリシン並びにア ラニン、バリン、ロイシン、イソロイシン、セリン、スレオニン、リジン、フェ ニルアラニン、チロシン及びこれらのアルキルエステルのl−若しくはd−エナ ンチオマーよりなる群から選択されるα−アミノ酸を液体担体中に含有するもの 。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/100,780 | 1993-08-02 | ||
US08/100,780 US5389369A (en) | 1991-02-21 | 1993-08-02 | Halo peroxidase containing compositions for killing yeast and sporular microorganisms |
PCT/US1994/008608 WO1995004135A1 (en) | 1993-08-02 | 1994-08-01 | Fungicidal methods and compositions for killing yeast and sporular microorganisms |
Publications (2)
Publication Number | Publication Date |
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JPH09503752A true JPH09503752A (ja) | 1997-04-15 |
JP3723209B2 JP3723209B2 (ja) | 2005-12-07 |
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Application Number | Title | Priority Date | Filing Date |
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JP50600995A Expired - Lifetime JP3723209B2 (ja) | 1993-08-02 | 1994-08-01 | 酵母及び胞子微生物を殺傷するための殺菌方法並びに組成物 |
Country Status (11)
Country | Link |
---|---|
US (3) | US5389369A (ja) |
EP (1) | EP0713527B1 (ja) |
JP (1) | JP3723209B2 (ja) |
KR (1) | KR100325901B1 (ja) |
CN (1) | CN1081672C (ja) |
AT (1) | ATE208563T1 (ja) |
AU (1) | AU679777B2 (ja) |
CA (1) | CA2167525C (ja) |
DE (1) | DE69429094T2 (ja) |
DK (1) | DK0713527T3 (ja) |
WO (1) | WO1995004135A1 (ja) |
Cited By (4)
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JP2011500761A (ja) * | 2007-10-23 | 2011-01-06 | ノボザイムス アクティーゼルスカブ | 胞子を死滅させるための、及び機器を消毒又は滅菌するための方法 |
JP2011519954A (ja) * | 2008-05-09 | 2011-07-14 | エクソゼミス,インコーポレイテッド | ミエロペルオキシダーゼの抗菌活性を増強するための組成物、およびそれらの使用方法 |
JP2014520853A (ja) * | 2011-07-11 | 2014-08-25 | エクソゼミス,インコーポレイテッド | 好酸球ペルオキシダーゼ組成物およびその使用方法 |
JP2018115147A (ja) * | 2017-01-16 | 2018-07-26 | 御木本製薬株式会社 | 抗菌性組成物並びに該抗菌性組成物を配合した皮膚外用剤 |
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1993
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- 1994-08-01 KR KR1019960700557A patent/KR100325901B1/ko not_active IP Right Cessation
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011500761A (ja) * | 2007-10-23 | 2011-01-06 | ノボザイムス アクティーゼルスカブ | 胞子を死滅させるための、及び機器を消毒又は滅菌するための方法 |
JP2011519954A (ja) * | 2008-05-09 | 2011-07-14 | エクソゼミス,インコーポレイテッド | ミエロペルオキシダーゼの抗菌活性を増強するための組成物、およびそれらの使用方法 |
JP2014520853A (ja) * | 2011-07-11 | 2014-08-25 | エクソゼミス,インコーポレイテッド | 好酸球ペルオキシダーゼ組成物およびその使用方法 |
JP2018115147A (ja) * | 2017-01-16 | 2018-07-26 | 御木本製薬株式会社 | 抗菌性組成物並びに該抗菌性組成物を配合した皮膚外用剤 |
JP2022118037A (ja) * | 2017-01-16 | 2022-08-12 | 御木本製薬株式会社 | 抗菌用皮膚外用剤 |
Also Published As
Publication number | Publication date |
---|---|
JP3723209B2 (ja) | 2005-12-07 |
DE69429094D1 (de) | 2001-12-20 |
EP0713527A1 (en) | 1996-05-29 |
AU7477294A (en) | 1995-02-28 |
KR100325901B1 (ko) | 2002-06-29 |
CA2167525C (en) | 2006-11-28 |
CN1128044A (zh) | 1996-07-31 |
WO1995004135A1 (en) | 1995-02-09 |
DE69429094T2 (de) | 2002-03-21 |
CA2167525A1 (en) | 1995-02-09 |
US5451402A (en) | 1995-09-19 |
ATE208563T1 (de) | 2001-11-15 |
US5389369A (en) | 1995-02-14 |
EP0713527A4 (en) | 1998-01-07 |
CN1081672C (zh) | 2002-03-27 |
AU679777B2 (en) | 1997-07-10 |
EP0713527B1 (en) | 2001-11-14 |
US5510104A (en) | 1996-04-23 |
DK0713527T3 (da) | 2001-12-10 |
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