JPH09500380A - 組織保存及び無血手術のための溶液、ならびにそれを用いた方法 - Google Patents
組織保存及び無血手術のための溶液、ならびにそれを用いた方法Info
- Publication number
- JPH09500380A JPH09500380A JP7504696A JP50469695A JPH09500380A JP H09500380 A JPH09500380 A JP H09500380A JP 7504696 A JP7504696 A JP 7504696A JP 50469695 A JP50469695 A JP 50469695A JP H09500380 A JPH09500380 A JP H09500380A
- Authority
- JP
- Japan
- Prior art keywords
- solution
- blood
- effective
- ions
- concentration range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(1)35〜45mMの濃度範囲におけるカリウムイオン類、80〜12 0mMの濃度範囲におけるナトリウムイオン類、2〜10mMの濃度範囲におけ るマグネシウムイオン類及び0.01〜0.1mMの濃度範囲におけるカルシウ ムイオン類を含む電解質の水溶液、 (2)循環系からの脱出を制限するのに十分に大きい寸法を有し、血漿のそれに 等しい膠質浸透圧の維持に有効であり、ヒト血清アルブミン、多糖類及びコロイ ド澱粉から成る群より選ばれる巨大分子状腫脹剤、 (3)生理学的及び低体温条件下で有効な生物学的pH緩衝液、 (4)栄養的有効量の少なくとも1種の栄養単糖、 (5)不透過性及びヒドロキシル基掃去有効量のマンニトール、 (6)細胞膜に不透過性であり、低温暴露の間の細胞膨潤に対抗するために有効 であり、ラクトビオネート、グルコネート、シトレート及びグリセロホスフェー トから成る群より選ばれる少なくとも1つである不透過性アニオン、及び (7)アデノシン、フルクトース、リボース及びアデニンから成る群から選ばれ る少なくとも1つであるATPの再生のために有効な基質、ならびに場合により (8)グルタチオン を含む無−細胞低体温代用血液。 2.(1)電解質の該水溶液; (2)ヒト血清アルブミン、分子量が約30,000〜約70,000の範囲の 多糖及び人工コロイド性ワックス状澱粉から成る群より選ばれる、血漿のそれに 等しい膠質浸透圧の維持に有効な量の該コロイド状巨 大分子状腫脹剤; (3)該生物学的pH緩衝液; (4)約1mM〜約1Mの該栄養糖; (5)約10mM〜約20mMのマンニトール; (6)低温暴露の間の細胞膨潤に対抗するために有効な量の該不透過性アニオン ; (7)約0.5mM〜約2mMの該ATP基質; 及び (8)最高約5mMのグルタチオン を含む請求の範囲第1項に記載の代用血液。 3.(1)電解質の該水溶液; (2)正常なヒト血清のそれに近いコロイド圧を与えるのに十分な量の、分子量 が約30,000〜約70,000の範囲の不透過性多糖; (3)該生物学的pH緩衝液; (4)約1mM〜約10mMのグルコース; (5)約10mM〜約20mMのマンニトール; (6)約80mM〜約120mMのラクトビオネート; (7)約0.5mM〜約2mMのアデノシン;及び (8)約1mM〜約5mMのグルタチオン を含み、該組成物が約300〜370ミリオスモルの範囲のオスモル濃度を有す る請求の範囲第1項に記載の代用血液。 4.電解質の該水溶液におけるカルシウムイオン類の濃度が約0.01〜0. 07mMであり、マグネシウムイオン類の濃度が約2.5〜7.5mMであり、 電解質の該水溶液がさらに約2.5〜7.0mMの範囲 の濃度におけるクロリドイオン類を含む請求の範囲第3項に記載の代用血液。 5.該溶液がさらに少なくとも1種の高速チャンネル阻害剤を含む請求の範囲 第1項に記載の代用血液。 6.該溶液がさらに緩衝量のH2PO4 -及びHCO3 -を含む請求の範囲第1項 に記載の代用血液。 7.(1)大体生理学的濃度の電解質の第1水溶液、(2)巨大分子状腫脹剤、 (3)生理学的温度及び低体温条件において有効な生物学的pH緩衝液、(4) 栄養単糖、及び(5)ATPの再生のための基質を含む(A)浄化溶液、ならび に、 (1)35〜45mMの濃度範囲におけるカリウムイオン類、80〜120mM の濃度範囲におけるナトリウムイオン類、2〜10mMの濃度範囲におけるマグ ネシウムイオン類、15〜20mMのクロリドイオン類、及び0.01〜0.1 mMの濃度範囲におけるカルシウムイオン類を含む電解質の第2水溶液、 (2)細胞膜に不透過性であり、低温暴露の間の細胞膨潤に対抗するために有効 であり、ラクトビオネート、グルコネート、シトレート及びグリセロホスフェー トから成る群より選ばれる不透過性アニオン、 (3)不透過性及びヒドロキシル基掃去有効量のマンニトール、 (4)循環からの脱出を制限するのに十分に大きい寸法を有し、血漿のそれに等 しい膠質浸透圧の維持に有効であり、ヒト血清アルブミン、多糖及びコロイド澱 粉から成る群より選ばれる巨大分子状腫脹剤、 (5)栄養的有効量の少なくとも1種の栄養単糖 (6)アデノシン、フルクトース、リボース及びアデニンから成る群か ら選ばれるATPの再生のために有効な基質、及び (7)生理学的及び低体温条件下で有効な生物学的pH緩衝液、ならびに場合に より (8)グルタチオン を含む(B)維持溶液を含む、20℃より低い温度において患者又はその器官を 維持することができる代用血液。 8.該浄化溶液がさらに(6)1.0〜3mMの濃度のH2PO4 -及び(7) 20〜30mMの濃度のHCO3 -を含み、該維持溶液がさらに(9)5〜15m Mの濃度のH2PO4 -及び(10)3〜7mMの濃度のHCO3 -を含む請求の範 囲第7項に記載の代用血液。 9.該浄化及び該維持溶液の巨大分子状腫脹剤が、分子量が30,000〜7 0,000の範囲の多糖である請求の範囲第7項に記載の代用血液。 10.該浄化溶液及び該維持溶液がそれぞれさらに少なくとも1種の高速チャ ンネル阻害剤又はカルシウムチャンネル阻害剤、あるいはそれらの混合物を含む 請求の範囲第7項に記載の代用血液。 11.該維持溶液の該不透過性アニオンがラクトビオネートである請求の範囲 第8項に記載の代用血液。 12.移植されるべき器官を、 (1)35〜45mMの濃度範囲におけるカリウムイオン類、80〜120mM の濃度範囲におけるナトリウムイオン類、2〜10mMの濃度範囲におけるマグ ネシウムイオン類及び0.01〜0.1mMの濃度範囲におけるカルシウムイオ ン類を含む電解質の水溶液、 (2)循環系からの脱出を制限するのに十分に大きい寸法を有し、血漿 のそれに等しい膠質浸透圧の維持に有効であり、ヒト血清アルブミン、多糖類及 びコロイド澱粉から成る群より選ばれる巨大分子状腫脹剤、 (3)生理学的及び低体温条件下で有効な生物学的pH緩衝液、 (4)栄養的有効量の少なくとも1種の栄養単糖、 (5)不透過性及びヒドロキシル基掃去有効量のマンニトール、 (6)細胞膜に不透過性であり、低温暴露の間の細胞膨潤に対抗するために有効 であり、ラクトビオネート、グルコネート、シトレート及びグリセロホスフェー トから成る群より選ばれる少なくとも1つである不透過性アニオン、及び (7)アデノシン、フルクトース、リボース及びアデニンから成る群から選ばれ る少なくとも1つであるATPの再生のために有効な基質、ならびに場合により (8)グルタチオン を含む保存的有効量の細胞内維持溶液を用いて輸液することを含む、移植用の器 官の保存の方法。 13.(a)患者の核心体温を、氷点より高く、心臓細動を引き起こすには不 十分な温度に下げ; (b)本質的に患者の循環血のすべてを除去するのに十分な量の、大体生理学的 濃度の電解質の第1水溶液、巨大分子状腫脹剤、生理学的温度及び低体温におい て有効な生物学的pH緩衝液、栄養単糖、ATPの再生のための基質及びグルタ チオンを含む第1潅流液で患者を潅流し、第2潅流液で置換するまで潅流を続け 、 (c)該循環している第1潅流液の本質的にすべてを、心臓収縮活動を急激に停 止させるのに十分な35〜45mMの濃度範囲におけるカリウ ムイオン類、80〜120mMの濃度範囲におけるナトリウムイオン類、2〜1 0mMの濃度範囲におけるマグネシウムイオン類及び0.01〜0.07mMの 濃度範囲におけるカルシウムイオン類を含む電解質の第2水溶液、循環系から脱 出するのを制限するのに十分に大きい寸法を有し、血漿のそれと等しい膠質浸透 圧の維持に有効であり、ヒト血清アルブミン、多糖及びコロイド澱粉から成る群 より選ばれる巨大分子状腫脹剤、生理学的温度及び低体温条件下において有効な 生物学的pH緩衝液、栄養的有効量の少なくとも1種の栄養単糖、不透過性及び ヒドロキシル基掃去有効量のマンニトール、細胞膜に不透過性であり、低温暴露 の間の細胞膨潤に対抗するために有効であり、ラクトビオネート、グルコネート 、シトレート及びグリセロホスフェートから成る群より選ばれる1つである不透 過性アニオン、ATPの再生のために有効であり、アデノシン、フルクトース、 リボース及びアデニンから成る群より選ばれる少なくとも1つである基質、なら びに場合によりグルタチオンを含む第2潅流液で置換し; (d)患者に低体温処置を行い; (e)循環している第2潅流液の本質的にすべてを第1潅流液で置換し; (f)患者に血液を再導入する 段階を含む無血低体温処置を、それが必要な適温患者に行う方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US092,456 | 1993-07-16 | ||
US08/092,456 US5405742A (en) | 1993-07-16 | 1993-07-16 | Solutions for tissue preservation and bloodless surgery and methods using same |
PCT/US1994/007872 WO1995002326A1 (en) | 1993-07-16 | 1994-07-14 | Solutions for tissue preservation and bloodless surgery and methods using same |
Publications (1)
Publication Number | Publication Date |
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JPH09500380A true JPH09500380A (ja) | 1997-01-14 |
Family
ID=22233307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7504696A Ceased JPH09500380A (ja) | 1993-07-16 | 1994-07-14 | 組織保存及び無血手術のための溶液、ならびにそれを用いた方法 |
Country Status (6)
Country | Link |
---|---|
US (2) | US5405742A (ja) |
EP (1) | EP0708595A4 (ja) |
JP (1) | JPH09500380A (ja) |
AU (1) | AU680928B2 (ja) |
CA (1) | CA2167409A1 (ja) |
WO (1) | WO1995002326A1 (ja) |
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Also Published As
Publication number | Publication date |
---|---|
CA2167409A1 (en) | 1995-01-26 |
US5514536A (en) | 1996-05-07 |
US5405742A (en) | 1995-04-11 |
EP0708595A4 (en) | 1997-11-19 |
AU680928B2 (en) | 1997-08-14 |
WO1995002326A1 (en) | 1995-01-26 |
EP0708595A1 (en) | 1996-05-01 |
AU7332094A (en) | 1995-02-13 |
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