JPH092927A - Dentifrice - Google Patents

Abstract

PURPOSE: To obtain a dentifrice which is enhanced in the ability to dissolve and remove bacterial plaque, excellent in refreshed feeling in mouth after brushing and in incorporation of fluorine into tooth surface. CONSTITUTION: This dentifrice contains 0.5-95wt.%, based on the total granules, of a water-insoluble alkali compound such as calcium carbonate/magnesium hydroxide and 1-50wt.% of granules which contains a water-insoluble inorganic binder (colloidal silica) and shows a pH of >=10 in aqueous slurry form. The granules are 75-500μm in sizes, preferable disintegrated on the load of 0.1-50 g/particle in strength and produced by the well-known spray-pelletizing process. When a fluorine compound such as sodium fluoride is formulated, a dentifrice excellent in tooth decay prevention can be obtained. In the water-insoluble alkali compound, the ratio of calcium carbonate/magnesium hydroxide is preferably 90/1-8/1.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice containing granules, and more specifically, the ability to dissolve and remove plaque is enhanced, the feeling of freshness in the mouth after use and the feeling of smoothness of teeth are improved, and the dentifrice on the tooth surface is improved. The present invention relates to a dentifrice having an improved fluorine uptake effect.

[0002]

2. Description of the Related Art Dentifrice containing granules or granular substances has been conventionally known. Such granules include those containing functional materials such as drugs, enzymes and abrasives, and those intended for the aesthetic effect thereof. As a binder for these granules, water-soluble binders such as methyl cellulose and carboxymethyl cellulose, and water-insoluble binders such as wax and ethyl cellulose have been used, but when the above-mentioned water-soluble binders are used, they are mixed at the time of manufacturing dentifrice. There is a problem that the granules may disintegrate in the process, and when the above water-insoluble binder is used, if the hardness and size of the granules are adjusted to a palpable level, the granules are perceived as a foreign body sensation in the mouth. There were problems such as being caught.

Therefore, the present applicant has proposed a dentifrice containing granules obtained by binding a water-insoluble powder material such as zeolite with a water-insoluble inorganic binder as a dentifrice for solving the above problems ( JP-A 1-299211).
This dentifrice is made by granulating a water-insoluble powder material with a water-insoluble binder and blending granules with a certain size and strength, so that the granules can be felt in the mouth and the effect feeling can be recognized. Despite this, the polishing power is enhanced with almost no feeling of foreign matter and without damaging the teeth.

[0004]

However, since this dentifrice removes dental plaque by the physical effect that the dull granules push out the dental plaque in the gaps between the teeth, it has the effect of removing dental plaque. It's not enough. That is, it is the adhesive polysaccharide that holds the bacterial cells in the dental plaque to the tooth surface, but it cannot be said that the adhesive structure of the dental plaque has a sufficient destructive effect.

[0005]

Under such circumstances, the present inventor has conducted diligent studies and as a result, when strong alkaline granules were blended with a dentifrice, a strong alkaline was locally applied to teeth. Therefore, it is excellent in the effect of chemically removing plaque by sufficiently destroying the adhesive structure of plaque, as well as the feeling of freshness in the mouth after use, the feeling of smoothness of teeth, and the effect of incorporating fluorine on the tooth surface. They have found that they are excellent and have completed the present invention.

That is, the present invention provides a dentifrice containing granules containing a water-insoluble alkaline compound and a water-insoluble inorganic binder and having a pH of 10 or more when made into a water slurry.

Examples of the water-insoluble alkaline compound used in the present invention include calcium carbonate, calcium hydroxide, calcium oxide, magnesium carbonate, magnesium hydroxide, magnesium oxide, calcium silicate, magnesium aluminum silicate, calcium hydrogen phosphate and phosphoric acid. Examples thereof include calcium dihydrogen, calcium phosphate, and calcium pyrophosphate, and these can be used alone or in combination of two or more. In the present invention, of these, calcium carbonate,
It is preferable to use calcium oxide, calcium hydrogen phosphate and calcium phosphate.

Of these water-insoluble alkaline compounds, magnesium hydroxide has a pH of 5% when made into a water slurry.
Since calcium hydroxide has a pH of 10.5, it can be used alone, but since calcium hydroxide has a pH of 12.7, the pH is too high, and it is not preferable to use it alone. Since all others have a pH of 9.8 or less, they are preferably used in combination with magnesium hydroxide and / or calcium hydroxide.

In the present invention, it is particularly preferable to use a mixture of calcium carbonate and magnesium hydroxide in terms of the effect of removing plaque and the effect of incorporating fluorine on the tooth surface. In this case, the content ratio of calcium carbonate and magnesium hydroxide in the granules is preferably calcium carbonate / magnesium hydroxide = 90/1 to 8/1.

The content of the water-insoluble alkaline compound is preferably 0.5 to 95% by weight (hereinafter simply referred to as%) of the whole granules, and particularly 50 to 90% by cost.
It is preferable in terms of easiness of granulation and granule strength.

Examples of the water-insoluble inorganic binder used in the present invention include colloidal silica, magnesium metasilicate aluminate, synthetic aluminum silicate, and alumina sol. These can be used alone or in combination of two or more. Of these, colloidal silica is preferably used in the present invention.

The size of the granules passes through a 30-mesh sieve (JIS standard) from the viewpoint that the granules are visually recognized, tactile in the oral cavity, and the roughness in the oral cavity is appropriate. The particle size (75 to 500 μm) that does not pass through a 200 mesh sieve (JIS standard) is preferable. In addition, the strength (hardness) of the granule is 0.1 to 50 g (more preferably 0.1 to 10 g) per granule from the viewpoint of recognizing the granule with the naked eye and softening the foreign body sensation in the oral cavity. Those that disintegrate when a load is applied are preferable.

The above granules can be produced by a known granulation method. Among them, the spray granulation method is suitable as a method for producing the granules of the present invention because the granules have almost spherical shapes and are easy to handle.

The granules used in the present invention are required to have a pH of 10 or more when made into a water slurry from the viewpoint of obtaining both a chemical plaque removing effect and a physical plaque removing effect. A more preferable pH is 10 to 10.5. In the present invention, it is necessary to make granules from the viewpoint of making the tooth topography alkaline. When an abrasive having a pH of 10 or more is blended without being made into granules, the entire oral cavity becomes strongly alkaline, which is not preferable.

The granules thus obtained can be mixed with various dentifrices such as toothpaste and powdered dentifrice, but it is particularly preferable to mix them with a toothpaste in order to express the aesthetics of the granules. The content of the granules in the dentifrice is preferably 1 to 50%, particularly preferably 3 to 30%.

Since the dentifrice of the present invention containing such granules is excellent in the effect of incorporating fluorine on the tooth surface, it is possible to obtain a dentifrice excellent in the prevention of tooth decay by incorporating a fluorine compound. Examples of the fluorine compound include sodium fluoride, tin fluoride and sodium monofluorophosphate. The blending amount of the fluorine compound is preferably 90 to 1000 ppm in the dentifrice as a fluorine concentration.

The preparation of the dentifrice of the present invention is carried out according to a conventional method, and it is possible to add other components which are usually added to the dentifrice. Examples of the binder include sodium carboxymethyl cellulose, sodium polyacrylate, hydroxyethyl cellulose, thickening silica, montmorillonite, carrageenan, sodium alginate, guar gum, pectin and the like. As a surfactant,
Examples thereof include salts of acylamino acids such as sodium acylglutamate and sodium acylsarcosine; salts of alkylphosphoric acid such as sodium lauryl phosphate; sucrose fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester and the like. Examples of the medicinal component include allantoin, tranexamic acid, vitamin E, vitamin C, sodium chloride, bittern, carbazochrome, propolis, glycyrrhetinic acid, cetylpyridinium chloride and the like. In addition, wetting agents, sweeteners, preservatives, flavors and the like can be added.

[0018]

EFFECTS OF THE INVENTION The dentifrice of the present invention has an enhanced ability to dissolve and remove plaque, improves the feeling of freshness in the mouth and the smoothness of teeth after use, and improves the effect of incorporating fluorine on the tooth surface. is there.

[0019]

Next, the present invention will be described with reference to examples, but the present invention is not limited to these examples.

Example 1 The components shown in Table 1 were spray dried by a conventional method to obtain granules having the composition shown in Table 2.

[0021]

Table 1 (Composition) (g) Calcium carbonate 42.584 Magnesium hydroxide 1.468 Colloidal silica M (manufactured by Nissan Chemical Industries, Ltd.) 33.656 Purified water 22.292 Total 100.000

[0022]

(Table 2) (Composition) (g) Calcium carbonate 87.00 Magnesium hydroxide 3.00 Silicic anhydride 10.00 Total 100.00

The resulting granules are white and tasteless and odorless. The pH of a 5% aqueous slurry is 10.5 and the particle size is 30 mesh sieve but not 200 mesh sieve. It had, and collapsed when a load of 5 g / piece was applied.

Test Example 1 Granules obtained in Example 1 and having the composition shown in Table 3 (a)
(PH 7.8 of 5% water slurry), granule (b) having the composition shown in Table 4 (pH 9.2 of 5% water slurry) and Example 1
The dentifrice having the composition shown in Table 5 in which the raw material powder of the granules of No. 1 was blended (inventive product, comparative product 1, comparative product 2 and comparative product 3 respectively)
Prepared) and tested by the following method,
The plaque removal rate on the interdental part and the smooth surface of the tooth was evaluated.
The results are shown in FIGS.

[0025]

Table 3 Granules (a) (Composition) (g) Aluminum hydroxide 90.00 Silicic anhydride 10.00 Total 100.00

[0026]

Table 4 Granules (b) (Composition) (g) Zeolite 60.00 Silicic anhydride 10.00 Magnesium metasilicate aluminate 30.00 Total 100.00

[0027]

[Table 5] Test dentifrice (composition) (g) Granules or granular raw material powder 15.00 Glycerin 10.00 Solbit solution 30.00 Iota carrageenan 2.00 Sodium lauryl sulfate 1.20 Saccharin sodium 0.10 Methylparaben 0.10 Fragrance 0.80 Sodium monofluorophosphate 0.68 Purified water Balance total 100.00

(Plaque Removal Rate Measuring Method) Using the above dentifrice,
Using the same toothbrush, the plaque removal rate was obtained by measuring the amount of plaque before and after using the dentifrice for 4 subjects. The method of Suzuki for measuring the amount of plaque (Journal of Oral Hygiene, 2
0 , 8, 1970). That is, as a test tooth,
After using the upper and lower jaws 6 teeth to stain the plaque with a plaque revealing agent, measure the height (mm) of the plaque from the gingival margin with a pocket probe, and there are 5 measurement sites on the labial side per tooth, A total of 10 sites, 5 sites on the side of the palate of the tongue, and the total of each site was defined as the amount of plaque. The plaque removal rate was calculated using the following formula.

[0029]

[Equation 1]

As shown in FIGS. 1 to 3, the dentifrice of the present invention showed a significantly higher (p <0.01) plaque removal rate than the comparative product.

Test Example 2 With respect to the test dentifrice, the effect of incorporating fluorine on the tooth surface was evaluated. 4 g of the dentifrices of the present invention product and the comparative product 2 were diluted to 20% with distilled water and allowed to stand. 1 g of hydroxyapatite powder, which is a tooth component, is added to 10 ml of the supernatant.
It was treated for 2 minutes, washed twice with 40 ml of distilled water, and after this treatment, apatite was dissolved by adding 3 ml of concentrated hydrochloric acid and appropriately diluted, and then taken in using a fluoride ion selective electrode (manufactured by Orion). The amount of fluorine was measured. The amount of fluorine taken in was 0.1 ppm for the product of the present invention and 0.06 ppm for Comparative product 2.

[Brief description of drawings]

FIG. 1 is a diagram showing the plaque removal rate of the entire tooth when using a dentifrice of the product of the present invention and a comparative product.

FIG. 2 is a graph showing a plaque removal rate in an interdental part when using dentifrices of the present invention product and a comparative product.

FIG. 3 is a diagram showing a plaque removal rate in a smooth part of a tooth when using a dentifrice of a product of the present invention and a comparative product.

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[Procedure amendment]

[Submission date] July 10, 1995

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0021

[Correction method] Change

[Correction contents]

[0021]

[Table 1]

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Koji Maeda 2606 Akabane Kai, Choi, Haga-gun, Tochigi Prefecture Kao Corporation Stock Research Institute (72) Inspector Yasuki Eguchi 2606 Akabane Kai, Haga-gun, Tochigi Research Institute Kao Stock Company

Claims (4)

[Claims] 1. A dentifrice containing granules containing a water-insoluble alkaline compound and a water-insoluble inorganic binder and having a pH of 10 or more when made into a water slurry. 2. The water-insoluble alkaline compound is calcium carbonate, calcium hydroxide, calcium oxide, magnesium carbonate, magnesium hydroxide, magnesium oxide, calcium silicate, magnesium aluminum silicate, calcium hydrogen phosphate, calcium dihydrogen phosphate, One or two selected from calcium phosphate and calcium pyrophosphate
The dentifrice according to claim 1, wherein the dentifrice is at least one species and the water-insoluble inorganic binder is one or more species selected from colloidal silica, magnesium aluminometasilicate, synthetic aluminum silicate and alumina sol. 3. The dentifrice according to claim 1 or 2, wherein the water-insoluble alkaline compound is a mixture of calcium carbonate and magnesium hydroxide. 4. The dentifrice according to claim 1, which further contains a fluorine compound.