JPS62167723A - Dentifrice with high cleaning and brushing characteristics - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a relatively abrasive oral cleanser, i.e., a particle size of about 1 to 15 microns in diameter, and a radioactive method (deαdioac
a calcined alumina abrasive in an amount to provide an enamel polishing value (REA) compliant with the dentifrice; and a small amount of a calcium, magnesium or sodium salt to reduce the enamel abrasiveness of the dentifrice. ; and a toothpaste with excellent cleaning and cleaning properties (the abrasive power of this toothpaste may be further reduced by increasing its pH).

It has heretofore been difficult to provide a toothpaste for use in daily tR cleaning that has the desired balanced cleaning and polishing action. This is primarily due to the difficulty in selecting a suitable abrasive that will maximize the removal of dirt and food particles without damaging the tooth enamel surface.

The function of abrasive substances in oral formulations is to remove various deposits from tooth surfaces, including thin films.

This thin film is a decorative adhesive film that often contains brown to yellow pigments and gives the teeth an unsightly appearance. Advantageous abrasive materials included in dual-use formulations are those that provide maximum removal of film without overly abrasive hard tooth tissue. Typical soft abrasives used in dental compositions (e.g., dicalcium phosphate and calcium birophosphate>FiI21m) are not overly abrasive, but are effective in removing these undesirable deposits from the teeth. It is not as effective as hard ωF polishes.However, hard abrasives tend to over-abrasive the hard tissues (enamel, tooth, cementum) due to their pronounced abrasive nature. can cause serious problems when present in pharmaceutical preparations.

Now about 0.1-5'M servings%, preferably 1-5% by weight
Calcium salt, magnesium salt or sodium salt of
Composed of water-use silicic acid abrasive and calcined alumina hard abrasive
It has been discovered that when added to a Calendar polishing system, the enamel polishing power of the radioactive method is significantly reduced, whether or not the pH of the toothpaste is raised by a certain amount above that of Leopard 7. This is a desirable feature when applied to polishing systems containing calcined alumina, which is a hard abrasive. It is now possible to include hard abrasives (which until now have been relatively undesirable because they are too enamel abrasive) in toothpaste formulations to remove tooth decay without the problem of excessively abrasive enamel.・OT ability is to give m-purity.

In addition to a lower RED (Radioactive vs. Enamel Polish), there are other beneficial changes observed in the highly polished human enamel surface. You can see the decrease in the negative part of the tooth by looking at the button sharpening.

Fecal material contains small amounts of calcium, magnesium or sodium compounds; with a particle size of approximately 1 to 15 microns in diameter, an amount of 1 to 100 ml gives a radioactive enamel polishing value (REA) of greater than 450. With synthetic alumina:
It is possible to prescribe a toothpaste that has excellent cleaning and polishing effects, but does not have an increased polishing power on enamel.

It has also been discovered that the enamel abrasive power exhibited by REA is also reduced by increasing the pH of the toothpaste as shown in the following table. In Table 2, the pH of the composition containing 24% quartz abrasive and 10% alumina abrasive is HC
l or by addition of NaOH.

Table 1 4 HCl 4855 7145
HCl 2563 4326
HCl 1200 3386°6 No adjustment 891 3537 NaOH792
342 8NaOH656348 9NaOH488349 10NaOH434346 The above table shows tooth polishing values by radioactive method.
The enamel abrasive force is sensitive to pH within the pH range of 5 to 10 and becomes stronger as the pH increases, whereas the enamel abrasive force remains at virtually the same value within the pH range of 6 to 10. clearly shows.

Contains siliceous abrasive and calcined alumina, and further contains 57oC
a The effectiveness of reducing the abrasive power on enamel by changing the pH of toothpastes containing or not enriched with Ct2 is clearly shown in the following table (abrasives include 10% alumina and 24% alumina).
% of silicate abrasive).

Table ■ The table above also shows that the addition of salt in combination with pH adjustment affects enamel 1υ1.

It is noted that the polishing force against tooth structure was not substantially affected.

The following table further shows the effect of adding 5% salt on the enamel polishing power of VLJ polishing with 24% water-based silica polishing agent and 10% calcined alumina, and the relationship between salt addition and pH adjustment. This shows the effect of combined use. The pHFi of toothpaste was not adjusted.

Kinugawa CaC0,2843777,9 CaHPO6・ 316 291 6
．． 92H, Q Cabin, 234-- 7.8Ca
CL2 406 271 5.9C
α(No,), 589 267 5
．． 7Mg-5i04 288 -
-8. IMgCL, 648
325 5.7NaHC0,3423098,
3. Therefore, in order to further reduce the ωf polishing force of toothpaste on enamel, it is desirable to adjust its pH. this is,
This can be achieved by the presence of a suitable alkaline buffer, ie the calcium, magnesium or sodium salts mentioned above. This pHfA adjustment can be achieved by adding hydroxide, sodium hydrogen phosphate, trisodium phosphorus, and sodium bicarbonate. Particularly useful (the receiving system is sodium carbonate-sodium bicarbonate:tetrasodium virolin alpha: Nα, a phosphorus salt-retaining system consisting of HPO4 and Nα, PO4, and an appropriate ratio of compounds) can be selected as desired. Set to pH.

Radioactive methods of abrasives versus salts that have been found to be particularly effective in reducing enamel abrasive values are 1
．． flO, 1-5% of the total formulation, preferably 1
Calcium, magnesium or sodium salts selected from the group consisting of carbonates, bicarbonates, chlorides, phosphates, silicates, nitrates with a concentration of ~5%. Calcium salts are generally more effective than magnesium salts, which are better than sodium salts. Similarly, as shown in the following table (we evaluated a pH 8 I upper layer consisting of 24% siliceous abrasive, 10% calcined alumina, and 5% sodium salts), some anions are different from others. More effective than anion.

Clothing Iv Control 520 34O Nano, 490 343NaC1453
333 NaliC0,436336 Nα, HPO4395339 Magnesium silicate (denoted as Mg-8i04 in Unknown Honors) has been found to be particularly useful: 1:
It has a MgO:5i02 ratio of 2.5.

It has been discovered that even 1% Dennozoe 7JO salt reduces the polishing power of a polishing system consisting of a water-based silicic acid polishing agent and calcined alumina. For example, in a composition consisting of 20% siliceous abrasive and 10% calcined alumina, 0.1-5.
With the addition of 0% normal calcium chloride, the following results regarding enamel polishing power were obtained.

Table V REA [Control (not added) 763 0, I CaC1,600 0,3CaCL, 51 (JO,5Ca
CL, 4991, OCaCL,
4755, OCaCL snow 39
Added salt in amounts greater than 45% had no significant effect in reducing the polishing power of the composition below that obtained with 5% of the salt, as shown in the arrow table. The table shows the results when sodium bicarbonate is added to an acid composition consisting of 10% calcined alumina and aqueous siliceous abrasive.

Table ■ Irrigation of sodium bicarbonate with 10% calcined alumina (control) 24 0 917 7.024
15 466 8.220 1
5 469 8.624 15 465
8.324 5 443 8.82
4 2 434 8.4 These results clearly show that stock additive concentrations above 5% do not beneficially affect enamel polishing power.

Hard, inorganic, mineral-like substances, well known for their abrasive properties, are generally too abrasive and are therefore generally unsuitable as dentifrice cleaners. However, the hardness of certain groups of particulate mineral-like materials can provide effective cleaning and polishing power, and their enamel polishing power is minimized by the addition of rat calcium and magnesium salts. Addition of alkaline buffer further reduces the polishing power of Fi@polishing on enamel. The inorganic mineral-like material can provide the toothpaste with an REA of greater than about 450 units when present in an amount of at least about 7.5% by weight and has an average particle diameter within the range of about 1 to 15 microns. It must be a particle body. The preferred particle size range is 1-10 microns. The hard abrasive material for dentifrices is calcined alumina and can provide dentifrices with an REA of greater than about 450. Most of the toothpastes currently on the market have an R of about 3001 or as low as 50.
I have an EA.

Sakai formed alumina is the preferred abrasive in the present invention.

Exfoliated calcined alumina is defined as flat flakes of α-alumina crystals in the shape of disks or plates, which flakes have an average particle diameter (by weight) of less than about 7 microns (e.g. FJ2-7 microns). When viewed under a scanning electron microscope, the flat alumina particles have sharp edges indicating that they are fractured perpendicular to their parallel planes. Generally, the thickness of the flat flake is less than about (eg, about z-tail) its diameter and is in the range of about 1 micron (or less) to about 2 microns (eg, about 1 micron). flat α
-Alumina crystal and its manufacturing method are U.S. Patent Nos. 3 and 12.
No. 1,623.

Another type of calcined alumina abrasive useful in the present invention is 19
U.S. Patent Application No. 675,09 filed April 9, 1976
No. 8 specification, crushed to its ultimate particle form at 1, about 1-
It is defined as an alpha-alumina crystal with an average ultimate particle size of 2 microns.

The calcined alumina product sold as ItC-152DBM is very dense and highly stable. It expects an average particle size of FJ 1-2 microns, typically about 1.6 microns. Its typical size distribution is as follows.

Particle diameter μ % of particles with a diameter smaller than the corresponding diameter 1
0 Approximately 100 5 Approximately 95 3 F+ 85 2 Approximately 75 1 Approximately 25 0.5 Approximately 5 The large particles appeared to have sharp flat sides on the electron mirror, and the small particles were irregularly rounded into annular or oval shapes.

Crystalline alumina ItC-152DBM is found by grinding crude alumina commercially available as RC-152.

RC-152 has a grain size where 98% of the grains pass through a 200 mesh screen and 25% pass through a 100 mesh screen.

This crystalline α-alumina was chemically analyzed as follows.

Weight% ppm At snow 0. 99.7 Na*0 0.04 S i 0. 0.065F alO,0
,024 T i 0. 0.0016Mn0
O,0012Ca OO,045 Cde, Q, 0.00036B,
0.0.001 F, 200 α-phase alumina 90 The proportion of calcined alumina (flat alumina particles) and other hard abrasives in toothpaste may be, for example, 7.5% or more, about 7.5% or more.
It is in the range of 5-20%, preferably about 7.5-10%.

In addition to the calcined alumina abrasive, it is preferred to include a sufficient amount of a siliceous abrasive as an additional dentifrice abrasive. This siliceous abrasive is therefore relatively soft abrasive and is commonly used in toothpastes.

Siliceous abrasives that are particularly useful in this invention are about 1.44 to 16
47 refractive index, at least 70% by weight siliceous abrasive, up to IO% alumina, up to 20% water;
Contains the highest lO% of sodium oxide and has a water content of 100%.
Amorphous alkali metal or alkaline earth metal aluminosilicates, preferably from about 10 to 201% by weight, as measured by 0°C loss, with typical terms for sodium oxide being about 5 to 10''@% by weight. However, most often when no alumina is present in the aluminosilicate (e.g. less than about 1%)
In other embodiments, the material may be silica bonded with alumina.

Silicate abrasives for toothpaste have a particle size of approximately 2 to 40 microns, and are relatively large particles that can be easily ground into fine particle sizes that are visible to the naked eye but cannot be touched by brushing teeth in O. ) can also exist in the form of agglomerates. The agglomerate to be bent may be agglomerated with a binder, which may be water-soluble or water-insoluble, or may be without a pedestal.

For most purposes, the silicic acid polish is 20%
Avoid grid texture by having sub-micron particle size.

The proportion of such additional dentifrice abrasive in the toothpaste is usually in the range of about lθ to 70%, preferably 10 to 50%, and when alpha-alumina is not included in the toothpaste, RDA
(Flesh quality polishing value measured by radioactivity utilization measurement) is approximately 100 to 6
00, preferably within the range of about 100 to 200-450.

To produce toothpaste or dental cream, α-
Flat flakes of alumina, hard materials such as silicic abrasives, and other dentifrice abrasives can be used in toothpaste vehicles (liquids such as water and/or glycerin, fulvit, xylit, etc.).
Propylene glycol, polyethylene glycol 400
(preferably containing a suitable mixture thereof) such as a humectant, such as a moisturizing agent, etc. It is usually advantageous to use a mixture of both water and one or two humectants; a polyethylene glycol of a suitable molecular weight, such as polyethylene glycol 600, may also be present.

The total liquid content is generally much greater than 20% of the vehicle (sorbitol, which is generally present mixed with water, is considered the enemy here). Preferred humectants are glycerin and sorbitol. Typically, the vehicle will contain, by weight, about 0 to 80% glycerin, up to about 80% norbit, and about 5 to 80% water.

Calcium, magnesium or sodium salts selected from the group consisting of reconstituted salts, bicarbonates, chlorides, phosphates, silicates and nitrates may be added directly to the RA polishing vehicle containing the abrasive. Alternatively, the abrasive may be pretreated with an aqueous solution of the salt and the pretreated (θf polishing agent) added to a suitable dentifrice vehicle.

Because of its water insolubility, the nonresident salt is preferably added directly to the vehicle with the abrasive. The swamp salts dissolve due to the water bath and can be stirred with the abrasives (both hard JR abrasives and soft abrasives) for 5 minutes.

The solid is then isolated and washed with water. The salt-treated abrasive is then incorporated into a dentifrice vehicle.

The vehicle may also include thickening or gelling agents, such as natural or synthetic gums, gum-like substances (e.g., iris moss, gum tragacanth), alkali metals (e.g., Li% to %Nα).
) carboxymethylcellulose, hydroxymethylcarboxyethylcellulose, polyvinylpyrrolidone, starch, xylit, water-soluble hydrophilic colloidal carboxyvinyl polymers [e.g.
opol) 9) 4.940], hydroxyethyl cellulose, Indian gum, acacia gum, agar, locust bean gum, rabonai) (L
aponite) CP or SP [These are Taniya Laboratories Limited (LaporteIndustries Limited)
a synthetic inorganic composite silicate clay sold under the trade name Laponite by P. Industries, Ltd.], and non-corrosive thickening agents such as ictin or colloidal silica, such as trade names Cab-0-8iLM5, Siloid 244,
Cyloid 266, Zeosil 200,7 Erosil D200
Also includes synthetic fine silica, including those sold in The solid part of the vehicle is typically the most important part of the story.
It is present in an amount of about 0.5-8% by weight, preferably about 0.5-8% by weight.

The molecular weight of the thermoplastic resin, for example, 1000 or more (preferably 10,000 or more, for example about 10,000 to 100,
000 or more) and less than about 50 microns (preferably about 0.5 to 50 microns, e.g.
Particles of solid polymer having a flat y-J diameter (in the range of 30 microns) may also be present. The polymer particles can be hardened by emulsion or suspension polymerization or by grinding the polymer mass, and can also be used to improve the quality of toothpaste.
A, 'J 60% or more than 1, for example, about 20-60%, such as about 20-50% of the width of Streptomyces (for example:!
J30-50%). Examples of thermoplastic oils include polymerized ethylene-type compounds such as polyolefins (e.g. polyethylene, polymer Robile/) or vinyl ItL or vinylidene (the first row is polyvinyl chloride, polysulfate). death/
, vinyl chloride/vinegar rfl vinyl copolymers, styrene/phtadiene copolymers, vinylidene borinamide); polyamides such as nylon (eg nylon 6); cellulosic materials such as cellulose acetate.

The paste of the present invention (1) may also contain a surfactant, for example, to enhance the preventive effect, to help the complete dispersion of the composition of the present invention in the oral cavity, and to make the composition of the present invention even more preferable. can. The organic surfactant may be anionic, nonionic, amphoteric, or cationic, and it is preferable to use a detergent that imparts cleaning and foaming properties to the composition as the surfactant. Suitable types of such detergents include water-soluble salts of higher fatty acid monoglyceride monosulfates, such as monosulfated monoglycerides or hydrogenated coconut fats, Nα salts of acid series alkyl sulfates (<y++ sodium lauryl sulfate), alkylaryl sulfone) (
(for example, sodium dodecylbenzenesulfonate), higher alkyl sulfoacetates, higher fatty acid esters of 1,2-hydroxypropanesulfonate, substantially saturated light aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds (e.g. fatty acid alkyl or 1 in the acyl group
2 to 16 carbon atoms). Examples of the amides mentioned are N-lauroylsarcosine, N-lauroylsarcosinate, N-myristylsarcosinate or N''''valmitylsarcosine ferment thorium salt, potash salt and ethanolamine salt, which are known for their effects. The use of these sarcosinate compounds in the dentifrice compositions of the present invention means that they are free of soap or similar higher fatty acid substances which tend to substantially reduce tooth enamel. It is particularly advantageous because, in addition to being slightly less soluble in carbohydrates, it also has a long-term and significant effect on inhibiting the development of oral cavities due to carbohydrates.

Other suitable surfactants are a condensate of sorbitan monostearate and about 60 moles of ethylene oxide, a condensate of ethylene oxide and a ff-7'robilene condensate of propylene glycol (Plwronics).
Nonionic agents such as diinbunalphenoxyethyldimethyl benzyl ammonium chloride, benzyl dimethyl stearyl ammonium chloride, 1
tertiary amines with 1 aliphatic alkyl groups (CI2-11) and 2 hepoly)oxyethylene groups attached to the nitrogen atom (typically containing a total of about 2-50 ethenoxy groups/molecule) ) are active bactericidal, antibacterial agents, and salts of these acids; , 111 g is 3 or more) and their salts with non-fiff, organic acids can also be used. The total amount of surfactant in toothpaste is about o,
The amount of osi is preferably about 1 to 3%.

Various other substances may also be incorporated into the oral preparations of the present invention. Examples are coloring or whitening agents such as titanium dioxide, preservatives, silicones, chlorophyll compounds, ammoniated compounds (eg urea, ammonium phosphate and mixtures thereof), and others.

Each of these adjuvants can be incorporated into the toothpastes of the present invention, typically in amounts of about 10%.

The toothpaste of the present invention may also contain an antimicrobial agent in an amount of about 0.01-5%. Representative examples of such agents are guanidines, biguayudines, amines such as N'-(4-chlorobenzyl)-N-2, 4-(dichlorobenzyl) biguanide: p-chlorphenylvidanide: 4-chlor Benzhydryl biguanito: 4-Florobenzhydrylphanyl urea; N'-3-ciwaloxyprobyl-7yS-p-chlorobenzyl biguanide; -dichloro-2-guanidinobenzimidazole; N'-p-chlorphenyl-N5-9lylbiguanide; 5-amino-1,3-bis(2-ethylhexyk)-5
-methyl hexahydropyrimidine; and non-toxic addition salts thereof; benzethoniwam chloride; cetylpyridinium chloride;

In order to formulate the fragrance of the composition of the present invention, appropriate odor and flavor masking saliva promotion7! rl+",!' can be used.

Examples of suitable odorants include fragrant oils, such as sulfur mint,
These are peppermint, wintergreen, satin grass, clove, sage, eucalyptus, majorana, cinnamon, lemon, orange oil, and salicylic l-methyl. Appropriate flavor correction
are sucrose, lactose, maltose, sorbitol, sodium cyclamate, and saccharin. For the combination of flavoring agent and flavoring 1A11, 4v is about 0% of the composition of the present invention.
．． It is important to account for 0.1 to 5% or more.

The toothpaste of the present invention can be manufactured by appropriately mixing its components. For example, toothpaste! In 1q production, carboxymethylcellulose sodium, carbopol9)4
A gelatinization process such as this will disperse a preservative (if used), such as sodium benzoate, along with a humectant, such as glycerin. Water may also be present. A yeast, gel or cream is then formed by mixing the dispersion with water and another humectant such as Sorvit 70% Water Bath. Then add the tooth abrasive, surfactant, and flavoring agent. The Streptomyces ia are then completely degassed (e.g., under vacuum) and placed in a tube.

It is preferable that the amount of water-insoluble aromatic essential oil is 0.5% or more and 2% or less. Strongly odorized toothpaste contains 1% or more,
1311 contains about 1.2-1.5% perfumed oil.

The formulations of the present invention have been found to be useful as professionally applied prophylactic dentifrices, as well as for use in dentures and as preparations for daily use on teeth.

The following examples illustrate the invention.

In the examples, all proportions are based on the amount of M unless otherwise specified.

A toothpaste was manufactured according to the following formulation.

Glycerin 25%: Sodium carboxymethyl cellulose 1.4%; Sodium benzoate 0.50%; Saccharin deuterium 0.20%; Sodium aluminogylene (
Silicic acid abrasive) 24.0%: 2Th! (Hititan 0.4
%: Calcined alumina RC-152Dj? M10.0%; lauryl Ut [sodium 1.5%; perfumed oil 1.00%;
Deionized water in moderation. This toothpaste has a pH of 57.1 and has a RE
A was 751.

The pH of this toothpaste was changed to 6 to 71a using an appropriate acid or base to obtain the results shown in the arrow.

■ pHREA Control material 7.1 751 4.5 2975 ts, 0 1141 8.1 603 9.3 506 In other words, the pH of toothpaste affects its polishing power by 1, and low polishing power is obtained at alkaline pH. It is clear that it will happen.

REA represents one-stage enamel polishing obtained in accordance with the radioactive method, which is a method described in known literature.

The method for measuring the enamel polishing value is as follows.

The molars are exposed to neutron radiation, which exposes them to a predetermined amount of phosphoric acid p32. Each enamel specimen is placed in a self-hardening polymer such as methyl methacrylate. Then means for fixing the specimen, a tube containing diluted toothpaste, 1
It is placed in a specially designed device whose essential element is a toothbrush head under a tension of 50 g. Then, the pointed surface of the enamel specimen was brushed 4,500 times with a toothbrush coated with the test toothpaste. Use N! Place 2.0M of J polishing powder in a blanket, let it dry at room temperature, and use a regular Geiger-Mueller detector to determine the radioactivity (P"). Radioactivity of the slurry of the test toothpaste is determined. , the reference standard calcium birophosphate (
The relative polishing power of the experimental paste can be determined by comparing it with the radioactivity obtained in the valley enamel shell specimen using the enamel polishing value (arbitrarily defined as 500).

RDA uses 1000 dentin parts isolated from human canine teeth.
Appropriate measurements can be made by applying the brush back and forth twice.

This radioactive method is described in the literature, Stookg5. C,
Co-authored with Mshler, J.C.-J.

Dental Re5aareh'''47,524~5
More details are given on page 38 (1968). To prevent or minimize damage to the intraoral hard tragus, REA
Similarly, the polishing power for teeth should not be too high.

Example 1 was repeated by lowering the content of silicate polishing agent 49 to 20%, adding calcium carbonate in an amount of 1%, 3% or 5%, and maintaining pH 8, to obtain the following results.

Example 2 1.0 8 437 359
Example 3 3.0 8 395 342
Example 4 5. Os 375 371 The above results demonstrate that even a small amount of 1% calcium carbonate addition significantly reduces the REA if the pH is maintained at 8 (i.e. 437 compared to 751 for the control). It is shown in

When the amount of CaCO3 is increased from 1% to 5%, the M-abrasive force on enamel further decreases.

Example 5 The siliceous abrasive of Example 4 was mixed with 89-91% silica, 0
．． In place of the sodium aluminosilicate containing 8-1.2% alumina, 0.3-0.9% sodium overnight, and about 10% water, 10% calcined alumina of Example 4 was used as a "microgrit". The α-alumina flakes of this 1 micro grit alumina had an average particle diameter of approximately 4 microns, and all particles were less than 10 microns. about 85-95% (by weight) have a diameter of less than tio, o microns, and about 30-35% have a diameter of less than 3.5 microns. 294, RDA was 461.

Example 6 Example 5 was repeated except that the amount of siliceous abrasive was reduced to 20%. The REA of the generated toothpaste was 285 and the RDA was 420. RE of toothpaste obtained without 5% CaCO2
A was 848 and RDA was 367.

Example 7 Example 1 was repeated except that 5% NaHCO3 was added to the toothpaste. The pH of the generated toothpaste is 8.4, and the REA is 373.
, RDA was 409.

Example 8 The 11 content of the silicate abrasive was reduced to 20%, and the calcined alumina of Example 5, sold as ``Microgrit'', was RC
-152 used in place of branded product, 5% Mg-8
Example 1 was repeated with the addition of i04. Generated toothpaste p
H was 8.5, REA was 377, and RDA was 453.

REAFi665 formulation without MgSiO4
, RDA was 394.

Example 8 was repeated using RC-152 brand calcined alumina in place of 1 micro grit. The resulting toothpaste had an REA of 318 and an RDA of 464.

Example 10. Example 8 was repeated using 51% CaCO8 instead of 5% Mg-8i04. REA of generated toothpaste
was 349 and RDA was 519.

EXAMPLE 11 Example 8 was repeated using 5% NaHCO3 in place of 5% Mg-8i04.

RgA-311, RDA=490 Example 12α, 12b α) Example 10 was repeated using RC-152 calcined alumina in place of 1 microgrit 1 alumina.

REA-307, RDA-498 b) Calcined alumina (sold as Diamez) with an average particle diameter of 5 microns was conveniently substituted for "microgrit".The pH of the product composition was 8, RgA was 451, and RDA was 443.

EXAMPLE 13 Example 1 was repeated using 1 Microgrit "Alumina 4RC-152 brand product in place of the product and adding sodium hydroxide until a pH of 9.6 was obtained.

REA 367 Example 1 was repeated with the amount of siliceous abrasive reduced to 20%, calcium chloride added at 1%, 3% or 5%, and the pH maintained at 8. I got a strange result.

%CaCL2 pHREA RDA Example 14
5.0 8 319 288 Example 1
5 3.0 8 349 294 Example 1
6 1.0 8 391 303 The above results show that the 1g grinding force of calcium chloride decreases due to Σ addition, and the degree of grinding force decreases as the amount of calcium chloride increases from 1% to 5% (calcium chloride The REA of the control sample that does not carry out the test is 751). This decrease in REA is similar to the decrease obtained by simply increasing the pH (as shown in Example 1, the RE at pH 8
A is larger than 603). Compared to insoluble CaCO3, soluble Ca CL has a higher R when used at the same concentration.
Significantly lowers EA.

Example 1 was repeated with the addition of 1% or 3% Mσ-3iO.

Example 17 1.0 588 Example 18
3.0 The REA did not decrease to the same extent as when using 526 calcium salt, but the polishing force decreased significantly (the REA of the control substance was 751).

Example 19° Example 1° was repeated with the content of siliceous abrasive increased to 24%. REAu312. It was RDAu356. 5%
CaC0,'z: 723 R if not reduced
An EA and an RDA of 430 were obtained. The pH of the resulting composition was 8.0.

Example 7 was repeated using 5% CaCO,f instead of 5% NaHCO.

REA 375, RDA-353 Example 21 Example 11 was repeated using 1° RC-152 calcined alumina. The pH of the product mill was 8.9 and the REA was 367.

EXAMPLE 22 20% of the sodium aluminosilicate of Example 5 was mixed with 10% of 1 mitalogrite alumina and 5% of calcium carbonate. The pH of the resulting toothpaste was 8, the REA was 367, and the eDA was 442.

It is within the scope of this invention to include other alpha aluminas in admixture with the siliceous abrasive. Another example of calcined alumina is powdered alpha-alumina, which is irregularly shaped and has an average particle size of about 3 to 4 microns (all of the irregular particles have a maximum dimension of less than about 7 microns). be.

Water [sodium hydroxide, trisodium phosphate, sodium carbonate-sodium bicarbonate, tetrasodium birophosphate, Nα, HPO-Nα, PO
, etc. (The above embodiments can be further modified by adding appropriate alkaline agents and alkaline buffers.

The use of siliceous abrasives and calcined alumina abrasives together with the calcium, magnesium or sodium salts described above has proven most useful in toothpastes, but they are It can be similarly incorporated into toothpaste or dental cream.

The particle diameter shown in the experimental probe was measured by a conventional method.

That is, the heavy liquid sedimentation method was used. Calculation of parishioner diameter based on sedimentation data is carried out as usual, and the individual shapes of particles are calculated using W! !
(I was prompted to do this based on Stokes' law.

The above detailed notes and descriptions are for illustrative purposes only, and changes and modifications may be made without departing from the original cycle. The above excerpt is merely for the convenience of researchers.
This is not related to the scope of the present invention.

Patent applicant: Colgate-Palmolive Company Representative: Patent attorney: Kyozo Yuasa (full name)

Claims (10)

[Claims] (1) In a toothpaste with excellent cleaning and polishing properties, wait for a particle size of about 1 to 15 microns in diameter, and polish with an amount of calcined alumina that gives the toothpaste a radioactive enamel polishing value of greater than about 450. siliceous abrasives and small amounts selected from the group consisting of carbonates, bicarbonates, chlorides, phosphates, silicates and nitrates to reduce the enamel abrasive value of the toothpaste. Toothpaste containing calcium, magnesium or sodium salts. (2) The dentifrice of claim 1, comprising calcined alumina in an amount of at least about 7.5% by weight of the total dentifrice. (3) The toothpaste according to claim 1, wherein the pH of the toothpaste is increased by adding an alkaline agent to further reduce the polishing power on enamel. (4) The toothpaste according to claim 3, having a pH higher than about 7. (5) The toothpaste of claim 3, which includes an alkaline buffer to maintain the pH above about 7. 6. The toothpaste of claim 2, wherein said calcined alumina is in the form of alpha-alumina flakes having an average particle diameter within the range of 1 to 15 microns. (7) The toothpaste of claim 1, wherein the silicate abrasive is an amorphous aluminosilicate having a particle size of about 2 to 40 microns. (8) The proportion of the siliceous abrasive is within the range of about 10 to 50% by weight, and the proportion of the alumina abrasive is about 7.5 to 20% by weight.
The toothpaste according to claim 1, which is % by weight. (9) the siliceous abrasive is a sodium aluminosilicate comprising at least about 70% by weight silica, up to 10% by weight alumina, about 10-20% by weight water, and up to 10% by weight sodium oxide; The toothpaste according to claim 7. (10) The toothpaste according to claim 1, wherein the calcium, magnesium or sodium salt accounts for 1 to 5% by weight.