JPS6040404B2 - Toothpaste with excellent cleaning and polishing properties - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a relatively abrasive oral cleansing agent, i.e., having a particle size of about 1 to 15 microns in diameter, and having a particle size of greater than about 450 microns for tooth brushing.
a hydrated siliceous abrasive and a calcined alumina abrasive in an amount to provide a enamel polishing value (REA) compliant with In addition, siliceous abrasives are used in toothpastes with at least 10%
% by weight); and small amounts of calcium, magnesium or sodium salts to reduce the abrasive power of the toothpaste on enamel. The polishing power may be further reduced by increasing its pH).

It has heretofore been difficult to provide a toothpaste for daily toothpaste cleaning that has the desired balance of cleaning and polishing action. This is primarily due to the difficulty in selecting a suitable abrasive that can remove the maximum amount of dirt and food particles without damaging the tooth enamel surface. The function of abrasive substances in oral formulations is to remove various deposits from tooth surfaces, including thin films.

This thin film is a strongly adherent film that often contains brown to yellow pigments and gives teeth an unsightly appearance. Advantageous abrasive materials included in dental formulations are those that provide maximum removal of film without overly abrasive hard tooth tissue. While typical soft abrasives used in dental compositions (e.g., dicalcium phosphate and calcium pyrophosphate) do not overly abrade tooth tissue, hard abrasives are necessary to remove these undesirable deposits from teeth. Not as effective as abrasives. but,
Due to their pronounced abrasive properties, hard abrasives tend to over-abrasive the hard tissues of the mouth (enamel, teeth, cementum) and can cause serious problems when present in dental preparations. be. Now about 0.1 to 5% by weight, preferably 1 to 5% by weight, of calcium, magnesium or sodium salts are added to the dentifrice abrasive system consisting of the hydrated siliceous abrasive and the calcined alumina hard abrasive. Well, the pH of toothpaste
It has been discovered that the enamel polishing power of the radioactive method is significantly reduced either with or without raising the ratio above about 7.

This is a desirable feature when applied to polishing systems containing calcined alumina, which is a hard abrasive. Toothpaste formulations now include hard abrasives (which until now were relatively undesirable because they are too enamel abrasive) to provide superior polishing and cleaning without the problem of excessively abrasive enamel. It is possible to give In addition to a lower RED (Radioactive Enamel Polishing Value), other beneficial changes are observed in these highly polished human enamel surfaces. In other words, the reduction in tooth scars can be seen under a microscope. Thus, a small amount of a calcium, magnesium or sodium compound and an amount of hydrated silica having a particle size of about 1 to 15 microns in diameter and giving a radioactive enamel polishing value (REA) of greater than about 450. Polishing system consisting of abrasive and calcined alumina:
It is possible to prescribe a toothpaste that has excellent cleaning and polishing effects, but does not have increased abrasive power on enamel.

It has also been discovered that the enamel abrasive power exhibited by REA is also reduced by increasing the pH of the toothpaste as shown in the following table.

In the table, the pH of the composition containing 24% quartz abrasive and 10% alumina abrasive was adjusted by addition of HCI or NaOH. Table 1 *Tooth polishing value using radioactive method The table above shows that the enamel polishing power is sensitive to pH in the pH range of 5 to 10, and becomes stronger as the pH increases, while the tooth polishing power is It clearly shows that within the pH range from 6 to 10, the values remain virtually the same.

Contains a siliceous abrasive, calcined alumina, and further contains 5% C.
The effectiveness of reducing the abrasive power on enamel by changing the pH of toothpaste with or without aC12 is clearly shown in the following table (abrasives include 10% alumina and 24% alumina).
siliceous abrasive).

Table □ The table above also shows that the combination of salt addition and pH adjustment affects the polishing power on enamel.

It is noted that the polishing force against tooth structure was not substantially affected. The following table further shows the 5% enamel abrasive power of a toothpaste containing 24% hydrated siliceous abrasive and 10% calcined alumina.
This figure shows the effect of adding a certain amount of salt, and the effect of combining salt addition and pH adjustment.

The pH of the toothpaste was not adjusted. Table m Therefore, in order to further reduce the abrasive power of toothpaste on enamel, it is desirable to adjust its pH.

This can be achieved by the addition of suitable alkaline buffers, ie the presence of the calcium, magnesium or sodium salts mentioned above. This pH adjustment can be achieved by adding appropriate amounts of sodium hydroxide, sodium hydrogen phosphate, trisodium phosphate, sodium bicarbonate, and the like. A particularly useful buffer system is a phosphate buffer system consisting of sodium carbonate monobicarbonate; tetrasodium pyrate; Na2HP04 and Na3P04, with appropriate ratios of the compounds selected to provide the desired barrier. A group of salts that have been found to be particularly effective in reducing radioactive versus enamel polishing values of abrasives include about 0.1 to 5%, preferably 1 to 5% by weight of the total formulation. of calcium, magnesium or sodium salts selected from the group consisting of carbonates, bicarbonates, chlorides, phosphates, silicates, nitrates.

Calcium salts are generally more effective than magnesium salts, which are better than sodium salts. Similarly, as shown in the following table (evaluating a pH 8 toothpaste consisting of 24% hydrated siliceous abrasive, 10% calcined alumina, and 5% sodium salts), some anions may interfere with other anions. more effective. Table W Magnesium Silicates Found to be Particularly Useful (Denoted herein as Mg-Si04)
has a Mg0:Si02 ratio of 1:2.5.

It has been discovered that even less than 1% added salt reduces the polishing power of a polishing system consisting of a hydrated siliceous abrasive and calcined alumina.

For example, calcium chloride was added in an amount of 0.1 to 5.0% to a composition consisting of 20% siliceous abrasive and 10% calcined alumina, and the following results regarding enamel polishing power were obtained. Table V Added salt in amounts greater than 5% had no significant effect in reducing the polishing power of the composition below that obtained with 5% of the salt, as shown in the following table.

The table shows the results when sodium bicarbonate is added to a composition consisting of 10% calcined alumina and hydrated lotus acid abrasive. Table W These results clearly show that additive concentrations above 6% do not beneficially affect enamel polishing power.

Hard, inorganic, mineral-like substances, well known for their abrasive properties, are generally unsuitable as dentifrice cleaners because they are too abrasive.

However, the hardness of certain groups of particulate mineral-like materials can provide effective cleaning and polishing power, and their enamel polishing power is minimized by the addition of small amounts of calcium and magnesium salts. Addition of an alkaline buffer further reduces the abrasive power of the toothpaste on enamel. This inorganic mineral-like substance, when present in an amount of at least about 7.5% by weight, is present in toothpastes containing about 45% by weight.
■It is possible to give a REA larger than the unit, and also about 1 to
The particles must have an average particle diameter within the range of 15 microns. The preferred particle size is 1-10 microns. The hard abrasive material for dentifrices is calcined alumina and can impart a REA of greater than about 450 to the dentifrice. Most of the toothpastes currently on the market are up to about 300 or 5
It has a low REA of 0. Calcined alumina is the preferred abrasive in this invention.

Exfoliated calcined alumina is defined as a flat flake of Q-alumina crystals in the shape of a disk or plate having a (weighted) average particle diameter of less than about 7 microns (eg, 2-7 microns). When viewed under a scanning electron microscope, the flat alumina particles have sharp edges indicating that they are fractured perpendicular to their parallel planes. Generally, the thickness of the flat flake is less than about 1/3 of its diameter (e.g., about 1/3 to 1'1
0) and in the range of about 1/2 micron (or less) to about 2 microns (eg, about 1 micron).
The flat Q-alumina crystals and their method of preparation are described in US Pat. No. 3,121,623. Another type of calcined alumina abrasive useful in the present invention is disclosed in U.S. Patent Application Ser. It is defined as a Q-alumina crystal with a particle size.

The calcined alumina product sold as RC-152DBM is very dense and highly stable.

It has an average particle size of about 1-2 microns, typically about 1.6 microns. Its typical size distribution is as follows. Particle diameter〃 Percentage of particles with a diameter smaller than the corresponding diameter Under a hanging microscope, large particles appeared to have sharp flat sides, while small particles were irregularly rounded into a ring or oval shape.

Crystalline alumina RC-152DBM is obtained by grinding crude alumina commercially available as RC-152. R
C-152 has a crystal grain size where 98% of the particles pass through a 200 mesh screen and 25% pass through a 100 mesh screen. This crystalline Q-alumina was chemically analyzed as follows.

The proportion of calcined alumina (flat alumina particles) and other hard abrasives in the toothpaste may be, for example, 7.5% or more, about 7.5% or more.
It is in the range of 5-20%, preferably about 7.5-10%.

In addition to the calcined alumina abrasive, it is preferred to include a sufficient amount of a siliceous abrasive as an additional dentifrice abrasive.

Therefore, this siliceous abrasive is a relatively soft abrasive,
Commonly used in toothpastes. Siliceous abrasives particularly useful in the present invention have a refractive index of about 1.44 to 1.47;
Contains at least 70% siliceous abrasive by weight, up to about 10% alumina, up to about 20% moisture, up to about 10% sodium oxide, with a moisture content of about 10 to 2 as measured by weight loss. is preferably an amorphous alkali metal or alkali metal aluminosilicate with a typical content of sodium oxide of about 5 to 1% by weight.

However, when very little alumina is present in the aluminum/silicate (eg, less than about 1%), the material may be alumina-bound silica. Silicate abrasive for toothpaste is about 2~
It has a particle size of 40 microns and is present in the form of relatively large (hard particles) agglomerates that are visible to the naked eye but easily ground to finer particle sizes that are not palpable by tooth brushing in the mouth. You can also do it.

Such agglomerates may be agglomerated with or without a binder, which may be hydrophilic or water-insoluble. For most purposes, siliceous abrasives for toothpaste have two
It has a particle size of 0 microns to avoid grittiness. The proportion of such additional dentifrice abrasives in the toothpaste is usually in the range of about 10-70%, preferably 10-50%, and when Q-alumina is not included in the toothpaste, RDA (radioactive abrasive) Measured tooth polishing value) is approximately 10
0-600, preferably about 100-200-450
It is preferable that it is within the range of .

In order to manufacture toothpaste and digital cream, Q.
- flat flakes of alumina, hard abrasives such as silicic abrasives or other dentifrice abrasives in a dentifrice vehicle (a liquid such as water and/or a liquid such as glycerin, sorbitol, xyrite, propylene glycol, polyethylene glycol 400); (preferably containing appropriate mixtures thereof).

It is usually advantageous to use a mixture of both water and one or two heat retaining agents, and polyethylene glycols of reasonable molecular weight, such as polyethylene glycol 60, may also be present. The total liquid content is generally much greater than 20% by weight of the vehicle (sorbitol, which is generally present mixed with water, is considered a liquid here).
. Preferred humectants are glycerin and sorbitol. Typically, the vehicle contains, by weight, about 0-80% glycerin, up to about 80% sorbitol, and about 5-80% water. Calcium, magnesium or sodium salts selected from the group consisting of carbonates, bicarbonates, chlorides, phosphates, silicates and nitrates may be added directly to the dentifrice vehicle containing the abrasive; The abrasive may be pretreated with an aqueous solution of the salt and the pretreated abrasive added to a suitable dentifrice vehicle.

Because of their insolubility, insoluble salts are preferably added directly to the vehicle with the abrasive. Water-soluble salts dissolve in aqueous solution and together with abrasives (both hard and soft abrasives)
You can admire it for minutes. The solid is then isolated and washed with water. The salt-treated abrasive is then incorporated into a dentifrice vehicle. The vehicle is also a good thickening agent.

Gelling agents such as natural and synthetic gums, gummy substances (eg Irish moss, gum tragacanth), alkali metals (eg Li, K, Na), carboxymethyl cellulose, hyde. oxymethylcarboxyethylcellulose,
polyvinylpyrrolidone, starch, xyrite, hydrophilic colloidal carboxyvinyl polymers (e.g. those sold under the trademark Carbopol 934, 940), hydroxyethyl cellulose,
Indian gum, acacia gum, agar, locust bean gum, Laponite CP or SP
[Each of these is Laportin Industries Limited, L. ), and inorganic thickening agents such as pectin or colloidal silica, such as trade names Cab-○-S; IM5, Syloid 244, Syloid 260. Also included are synthetic finely divided silicas, including those sold under Zeosil 200 and Aerosil D200.

The solid portion of the vehicle is typically present in an amount up to about 1% by weight of the toothpaste, preferably about 0.5 to 8% by weight. Fine particles of thermoplastic resin, such as molecular weight of 1000 or more (preferably 10,000 or more, e.g. about 10,000-100,000 or more) and less than about 50 microns (preferably about 0.5-50 microns, e.g. about 10-30 microns) Particles of a solid polymer having an average diameter (within the range of 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000s000 type0 type type type type type type type type type form type form type form type form to form a solid polymer may also be present are particles of a solid polymer having an average diameter (within the range of)

The polymer particles can be prepared by emulsion or suspension polymerization or directly by grinding the polymer mass and can be present in amounts up to about 60% or more of the toothpaste, e.g.
about 20-60%, such as 0-50% (e.g. about 30-50%)
%). Examples of thermoplastic resins include polymerized ethylenically unsaturated compounds, such as polyolefins (e.g. polyethylene, polypropylene) or vinyl resins or vinylidene resins (e.g. polyvinyl chloride, polystyrene, vinyl chloride/pinyl acetate copolymers,
styrene/butadiene copolymers, polyvinylidene chloride); polyamides such as nylon (e.g. Nylon 6);
It is a cellulose like cellulose acetate. The bran toothpaste of the present invention also contains a surfactant, for example, to enhance the preventive effect,
It can help complete dispersion of the composition of the present invention in the oral cavity, making the composition of the present invention even more preferable.

The organic surfactant may be anionic, nonionic, amphoteric or cationic, and it is preferred to use a detergent that imparts cleaning and foaming properties to the composition. Suitable types of such detergents include water-soluble salts of higher fatty acid monoglyceride monosulfates, such as monosulfated monoglycerides or sodium salts of hydrogenated coconut oil and higher alkyl sulfates (e.g. sodium uryl sulfate).
, alkylaryl sulfonates (e.g. sodium dodecylbenzenesulfonate), higher alkyl sulfoacetates, 1,2-hydroxypropanesulfonate higher fatty acid esters, substantially saturated higher fatty acylamides of lower fatty acid aminocarboxylic acid compounds (e.g. fatty acid alkyl or having 12 to 16 carbon atoms in the acyl group). Examples of the last mentioned amides are N-lauroylsarcosine and N-lauroylsarcosinate,
Sodium salts, potassium salts and ethanolamine acid of N-myristylsarcosinate or N-palmitylsarcosinate, which are substantially free of soap or similar higher fatty acid substances which tend to substantially reduce their effectiveness. No. The use of these sarcosinate compounds in the dentifrice compositions of the present invention shows that in addition to making tooth enamel slightly less soluble in acid solutions, the use of these sarcosinate compounds in the oral cavity due to carbohydrates It is particularly advantageous because it shows a long-term and significant effect in preventing the occurrence of the disease. Other suitable surfactants are nonionic agents such as a condensate of sorbitan monostearate and about 60 moles of ethylene oxide, a condensate of ethylene oxide and a propylene oxide condensate of propylene glycol (Pluronics); , di-isoptylphenoxyethyldimethyl benzyl ammonium chloride, benzyl dimethyl stearyl ammonium chloride, one aliphatic alkyl group (
C, 2-, 8) and two (poly)oxyethylene groups attached to the nitrogen atom (typically containing a total of about 2 to 5 N groups per molecule of aethenoxy groups). It is a cationic surfactant bactericidal, antimicrobial agent, and salts of these acids, and has the formula: (wherein R is an aliphatic alkyl containing about 12 to 18 carbon atoms, and the sum of x, y, and z is 3 or more), and these inorganic acids,
Salts with organic acids can also be used.

It is preferred that the total amount of surfactant is about 0.05% by weight of the toothpaste, preferably about 1-3%. Various other substances may also be incorporated into the oral preparations of the present invention.

Examples are coloring agents such as titanium dioxide, whitening agents, preservatives, silicones, chlorophyll compounds, ammonia compounds (eg urea, diammonium phosphate and mixtures thereof) and others. Each of these ajebandes can be incorporated into the toothpaste of the present invention, typically in amounts up to about 5%.
The bran dentifrice of the present invention may also contain an antimicrobial agent in an amount of about 0.01-5%.

Typical examples of such drugs are guanidines, picanidines,
Amines, such as N-(4-chlorobenzyl)-N5-
2.4-(dichlorobenzyl)biguanide; p-chlorphenylbiguanide; 4-chlorobenzhydrylbiagnide; 4-chlorobenzhydrylguaniurea; N'-3-lauroxybropyl-NP-p- Chlorbesodyl biguanide; 1,6-di p-chlorphenyl biguanide hexaso; 1-(lauryldimethylammonium)-(p-chlorobenzylmethylammonium) octane dichloride; 5,6-dichloro-2-guanidinobenzimidazole; N'-p-chlorophenyl W-
lauryl biagnide; 5-amino-1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine; and nontoxic acid addition salts thereof; penzetonium chloride; and cetylpyridium chloride.

Suitable hydration enhancers can be used to formulate the fragrance of the compositions of the invention. Examples of suitable breath-soothing ingredients are perfumed oils such as spearmint, peppermint, wintergreen,
Oils of Satsandra, Clove, Sage, Eucalyptus, Majorana, Cinnamon, Lemon, Orange, and Methyl Salicylate. Suitable flavoring agents are sucrose, lacrose, maltose, sorpito, sodium cyclamate, saccharin. Suitably, the total flavoring agent and flavoring agent constitute from about 0.01 to 5% or more of the composition of the present invention. The toothpaste of the present invention can be manufactured by appropriately mixing its components.

For example, in the manufacture of toothpaste, a gelling agent such as sodium carboxymethylcellulose, Rubopol 934, and a preservative such as sodium benzoate (if used) are dispersed with a heat insulating agent such as glycerin. let Water may also be present. The dispersion is then mixed with another heat insulating agent, such as a 70% sorbitol solution, and water to form a paste.
A gel or cream is formed. Then add the dentifrice abrasive, surfactant, and flavoring agent. The toothpaste is then completely degassed (eg, in a vacuum) and placed in a tube. It is preferable that the amount of water-insoluble aromatic essential oil is 0.5% or more and 2% or less.

Strongly odorized toothpaste contains 1% or more, e.g. about 1.2~
Contains 1.5% perfumed oil. It has been found that the formulations of the present invention are useful as prophylactic dentifrice pastes applied exclusively, as well as for use in dentures and as preparations for daily use on teeth.

The following examples illustrate the invention.

In the examples, all measurements are by weight unless otherwise specified. Example 1 A toothpaste was manufactured according to the following formulation.

Glycerin 25%; Carboxymethyl cellulose sodium 1.4%; Sodium benzoate 0.50%; Soluble saccharin 0.20%: Sodium aluminosilicate (silicic abrasive) 24.0%: Titanium dioxide 0.4%; Calcined alumina RC-152DBMIO. 0%: sodium lauryl sulfate 1.5%: perfumed oil 1.00%, appropriate amount of deionized water.

This toothpaste had a pH of 7.1 and an REA of 751.
The pH of this toothpaste was changed by adding an appropriate acid or base and the following results were obtained.

It is clear that the pH of the toothpaste has a considerable influence on its abrasive power, with lower abrasive power being obtained at alkaline pH.

REA represents the enamel polishing value obtained according to the radioactive method, which is a method described in known literature.

The method for measuring the enamel polishing value is as follows.

The molars are exposed to neutron radiation, which converts a predetermined amount of phosphoric acid into 戊2.

Each enamel specimen is placed in a hardening polymer such as methyl methacrylate. The specimen is then placed in a specially designed apparatus whose essential elements include means for immobilizing the specimen, a tube containing diluted toothpaste, and a toothbrush under tension of 150 min. Then, the toothbrush coated with the test toothpaste was applied to the enamel sample at 450°C. 2. Toothpaste used.
0' in a planner, dry at room temperature, and measure radioactivity (戊2) using a conventional Geiger-Mueller detector. The radioactivity of the experimental paste was determined by comparing the radioactivity of the slurry of the test toothpaste with the radioactivity obtained for each enamel specimen using a reference standard of calcium pyrophosphate (with an arbitrarily determined enamel polishing value of 500). The relative polishing force can be determined. RDA can be suitably measured by subjecting a tooth isolated from a human canine tooth to 1000 brush strokes.

This radioactive method is described in the literature, Sbokey. C. K
．． and Muhler. J. C. Co-authored with “J.Denta
lReseareh''47, pp. 527-538 (19
1968) is described in more detail. In order to prevent or minimize damage to the hard tissues in the mouth, the abrasive force on teeth should not be too high, similar to REA. Examples 2, 3,
4 Example 1 was repeated with the content of the siliceous abrasive reduced by 20%, carbonate or lesium added in an amount of 1%, 3% or 5% and the pH maintained at 8, and the following results were obtained.

The above results clearly show that even when the addition of calcium carbonate is as small as 1%, the REA is significantly reduced (i.e. 437 compared to 751 for the control) when the pH is maintained at 8. There is.

If the amount of CaC03 is increased from 1% to 5%, the polishing force on enamel will further decrease. Example 5 The abrasive toothpaste of Example 4 was prepared with 89-91% silica, 0.
The 10% calcined alumina of Example 4 was replaced with "Microgrit" by replacing the sodium aluminosilicate containing 8-1.2% alumina, 0.3-0.9% sodium oxide, and about 10% water. It was replaced with 8% of calcined alumina sold under the name.

The Q-alumina flakes of this "Microgrid Alumina" have an average particle diameter of about 4 microns, all particles have a diameter of less than 10 microns, and about 85-95% (by weight) of 6.
Approximately 30-35% have a diameter of less than 3.5 microns
with a diameter of less than a micron. The pH of the generated toothpaste is 7. &
REA was 294 and RDA was 451. Example 6 Example 5 was repeated with the content of siliceous abrasive reduced to 20%.

The REA of the generated toothpaste was 285 and the RDA was 420. 5
The REA of the toothpaste obtained without including % CaC03 is 8
48 and RDA was 367.

Example Example 1 was repeated except that 75% NaHC03 was added to the toothpaste.

The pH of the generated toothpaste is 8.4, the REA is 373, and the RDA is 4.
It was 09. Example 8 The content of the silicic abrasive was reduced to 20%, and the calcined alumina of Example 5, sold as "Microgrit", was subjected to RC.
-Used in place of 152 brand product, 5% Mg-S
Example 1 was repeated with the addition of i04.

The pH of the produced toothpaste is 8. REA is 377, RDA is 4
It was 53. REA for formulations where M did not include j04
was 665 and RDA was 394. Example 9 Example 8 was repeated using RC-152 brand calcined alumina in place of "microgrit."

The generated toothpaste had an REA of 318 and an RDA of 464.
Example 10 Example 8 was repeated using 5% CaC03 instead of 5% Mg-Si04.

The REA of the synthetic toothpaste was 349 and the RDA was 519. Example 11 Example 8 was repeated using 5% NaHC03 instead of 5% Mg-SiQ.

REA=311, RDA=490 Example 12 Example 10 was repeated using 1 piece'aI RC-152 calcined alumina in place of the "microgrit" enamel.

REA! 307, RDA=498'b} Calcined alumina (sold as Diamex) with an average particle diameter of 5 microns was used in place of "microgrit".

The pH of the product composition is 8, the REA is 451, and the RDA is 44.
It's 3. Ivy. Example 13 Example 1 was repeated using "Microgrit" alumina in place of the RC-152 brand product and adding sodium hydroxide until a pH of 9.6 was obtained.

REA=367 Example 14, 1f16 Example 1 was repeated by lowering the content of the acid abrasive to 20%, adding calcium chloride in an amount of 1%, 3% or 5%, and maintaining the pH at 8. repeated.

I got the following results. The above results show that the addition of calcium chloride reduces the polishing power, and the degree of polishing power decreases as the amount of calcium chloride increases from 1% to 5% (REA of the control material without calcium chloride is 751). ) is clearly shown.

This reduction in REA is similar to the reduction obtained by simply increasing the pH (as shown in Example 1, the REA at pH 8
is larger than 603). Compared to infusible CaC03, soluble CaC12 has a higher REA when used at the same concentration.
significantly decreases. Examples 17, 18 Example 1 was repeated with the addition of either 1% or 3% Mg-Si04.

Although the REA was not reduced to the same extent as when calcium salts were used, the polishing power was significantly reduced (the REA of the control was 751).

Example 19 Example 10 was repeated with the content of siliceous abrasive increased to 24%.

REA was 312 and RDA was 356. 5% CaC
When 03 was not included, 723 REA and 430 RDA were obtained.

The pH of the resulting composition was 8.0. Example 20 Example 7 was repeated using 5% CaC03 instead of 5% NaHC03.

REA=37f RDA=353 Example 21 Example 11 was repeated using RC-152 calcined alumina.

The pH of the produced toothpaste is 8. Since then, REA has been 367. Example 22 20% sodium aluminosilicate of Example 5 was mixed with 10% "microgrit" alumina and 5% calcium carbonate.

The pH of the generated toothpaste is 8, REA is 367, and RDA is 442.
It was. It is within the scope of this invention to include other Q-aluminas in admixture with the siliceous abrasive.

An example of another calcined alumina is irregularly shaped and approximately 3 to 4
It is powdered Q-alumina with an average particle size of microns (all of the irregular particles are about 7 microns in largest dimension). Sodium hydroxide, sodium hydrogen phosphate,
Trisodium phosphate, sodium carbonate, sodium monobicarbonate, tetrasodium pyrophosphate, Na2HP04-Na3
The above embodiments can be further modified by adding a suitable alkaline agent such as P04 or alkaline buffer.

The use of siliceous abrasives and calcined alumina abrasives, together with the calcium, magnesium or sodium salts mentioned above, has also proven most useful in toothpastes, but they do not reduce the strength of the pourable steel. It can be similarly incorporated into toothpaste or dental cream. The particle diameters shown in the examples were measured by conventional methods.

Claims (1)

[Claims] 1. A toothpaste with excellent cleaning and polishing properties, having a particle size of about 1 to 15 microns in diameter,
silicic abrasives and calcined alumina abrasives in amounts to provide a radioactive enamel polishing value of greater than 50; and carbonates, bicarbonates, chlorides, phosphates, silicates and nitrates. a small amount of calcium for reducing the enamel polishing value of a toothpaste, selected from the group
Toothpaste consisting of magnesium or sodium salt. 2. The toothpaste of claim 1, comprising calcined alumina in an amount of at least about 7.5% by weight of the total toothpaste. 3. The toothpaste according to claim 1, wherein the pH of the toothpaste is increased by adding an alkaline agent to further reduce the polishing power on enamel. 4. The toothpaste of claim 3, having a pH greater than about 7. 5. The toothpaste of claim 3, which includes an alkaline buffer to maintain the pH above about 7. 6. The toothpaste of claim 2, wherein the calcined alumina is in the form of alpha-alumina flakes having an average particle diameter within the range of 1 to 15 microns. 7. The dentifrice of claim 1, wherein the silicate abrasive is an amorphous aluminosilicate having a particle size of about 2 to 40 microns. 8. A toothpaste according to claim 1, wherein the proportion of the siliceous abrasive is in the range of about 10-50% by weight and the proportion of the alumina abrasive is about 7.5-2% by weight. 9 The siliceous abrasive is a sodium aluminosilicate comprising at least about 70% by weight silica, up to 10% by weight alumina, about 10-20% by weight water, and up to 10% by weight sodium oxide. The toothpaste according to item 7. 10. The toothpaste according to claim 1, wherein the calcium, magnesium or sodium salt accounts for 1 to 5% by weight.