JPS59222408A - Base for oral cavity composition - Google Patents

Abstract

PURPOSE:The titled base having high sweeping ability in spite of low abrasion action, capable of cleaning the teeth fully without damaging the enamelum, consisting of calcium hydrogenphosphate anhydride having specific average particle diameter and tap density. CONSTITUTION:A composition for oral cavity composition consisting of calcium hydrogenphosphate anhydride having 1-8mu, preferably 2-6mu average particle diameter measured by laser light scattering method, and 0.6-0.9g/cm<3>, preferably 0.65-0.85g/cm<3> calcium hydrogenphosphate. The base is used as an abrasive for oral cavity composition, e.g., dentifrice such as toothpaste, tooth powder, etc. or prophylaxis paste, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a base material for oral compositions used for toothpaste, glophyllakis paste, etc. More specifically, the present invention relates to a base material for oral compositions used for toothpaste, glophyllakis paste, etc. 6-0.99
The present invention relates to the use of water for a high-cleaning, low-abrasive oral composition made of calcium hydrogen phosphate anhydrate which is /lz'.

In general, base materials for oral compositions used in toothpastes, profilakis pastes, etc., are used as teeth cleaning bases to efficiently remove stains, plaque9, food particles, and other substances that adhere to or deposit on teeth by physical action. It is desirable to have an excellent cleaning ability, a mild abrasiveness that does not damage tooth enamel, and the ability to prevent the deposition of plaque and tartar.

In this case, the efficiency of physical removal of stains, dental plaque, food particles, etc. can be increased by increasing the abrasive power of the base material. However, increasing the polishing power and preventing damage to the tooth surface are generally contradictory, and the higher the polishing power, the more likely it is that the tooth surface will be scraped. If not, there is a risk of increasing the possibility of causing a maru-shaped defect, damaging the tooth surface, and further reducing the gloss of the tooth surface. For this reason, there has been a need for a base material for oral cavity compositions that does not damage tooth surfaces and has appropriate abrasive power and excellent cleaning effects.

The inventors of the present invention conducted extensive research to meet the above demands, and found that the average particle diameter is in the range of 1 to 8μ, and the tap density is in the range of 0.6 to 0.9 g/cm3. Calcium hydrogen phosphate anhydrate as shown in Figure 1 is obtained by dividing conventional calcium hydrogen phosphate anhydrate, which has an average particle size of about 10 to 30μ, into fine particles by classification, etc. Calcium chloride hydrate as shown in Figure 2 in diameter.
Phosphoric acid has physical properties suitable as an abrasive such that its cleaning power is poor even though its polishing power is about the same or lower than that of anhydrous product, and its average particle size and tag density are within the above range. We have discovered that when calcium hydrogen anhydrate is used as a base material for oral compositions, the cleaning power of the oral composition can be improved without increasing the abrasive power, and the teeth whitening effect is excellent. This is what led to the present invention.

In other words, in conventional polishing, the polishing power and cleaning power of the base material are almost proportional, so in order to increase the cleaning power, it is necessary to increase the polishing power. It was difficult to achieve. On the other hand, the average particle size is 1 to 8
μ and tag density 0.6 to Q, 9 g/an3
When calcium hydrogen phosphate anhydrate is used, the cleaning power is high despite its high abrasive power as shown in the examples below. It can sufficiently clean teeth without damaging tooth enamel just by using it, satisfies the characteristics of high cleaning power and [Boken] debit, and has a good tooth whitening effect. This is what we discovered.

It is conventionally known that calcium hydrogen phosphate anhydrate is used as an abrasive for polishing. However, the conventionally used calcium hydrogen phosphate anhydrate has a tap density larger than 0.9, which is within the normal particle size range (10 to 3
0 μ) has too high abrasive power, and when used alone as an abrasive, ADA (American
The RDA method (Radio Activation Act), which is set as an upper limit worldwide by
The abrasiveness value (Dentin Ablation method) exceeded 250, and there was a risk of causing a bruise-like defect if used for a long time. Conventionally, this polishing agent was used in combination with other abrasives. On the other hand, the calcium hydrogen phosphate anhydrate according to the present invention has an average particle size of 1 to 8μ,
It also has a tag density of 0.6 to 0.99/cm' and has significantly lower abrasive power than conventional products, so it can be used alone as an abrasive and has the same level of abrasive power. It has superior cleaning power (contamination removal power) compared to other abrasives, and it also exhibits an extremely favorable effect in terms of whitening teeth, which is a new finding of the present inventors. .

The present invention will be explained in detail below.

The base material for mouth and cavity compositions according to the present invention is a phosphorus material having an average particle diameter of 1 to 8 μm as measured by a laser light scattering method and a tap density of 0.6 to 0.9 fj/cm'. It is composed of calcium oxyhydrogen anhydrate, and as mentioned above, it has a moderate abrasive power and high cleaning power for teeth, and also has a good whitening effect on teeth. Note that the tap density value here is the result of measurement using a tap density measuring device, as shown in Examples described later.

In addition, calcium hydrogen phosphate used in the present invention
The anhydrate has an average particle size of 1 to 8 μm, but 2 to 6 μm is particularly preferable from the viewpoint of cleaning power, etc., and has a tap density of 06 to 0.9 and q/1yn5. However, those having a ratio of 0.65 to 0.85.9/- are particularly preferable from the viewpoint of cleaning power and the like. On the other hand, those with an average particle diameter smaller than 1μ and tap density smaller than 0.6VCIn' have low cleaning power, and those with an average particle diameter larger than 8μ and tap density smaller than 0.997cm'. For larger items, it is necessary to increase the polishing power to increase the cleaning power.
It cannot be used for the purpose of this invention.

As shown in FIG. 1, the calcium hydrogen phosphate anhydrate of the present invention has +1"q particles having a rice grain shape or an ellipse with a ratio of major axis to minor axis of approximately 4:1 to 3:2. The object of the present invention is achieved when the aggregate of these constituent particles has a spherical shape and a major axis of approximately 0.5 to 2 μ, and has an average particle diameter of 1 to 8 μ as measured by a laser light scattering method. It is preferable to do so.

In addition, the above-mentioned calcium hydrogen phosphate anhydrate includes:
Usual methods, e.g. Chemistry Handbook, Applied Edition, 2nd revised edition, 160
−('− Calcium hydrogen phosphate according to the method described in
A product obtained by producing a dihydrate, drying it, drying it, and dehydrating it can be used. In this case, in the above manufacturing process, among the reaction conditions, Pl-1, temperature, Jl
By adjusting the stirring speed, the mixing ratio of phosphoric acid and milk of lime, the reaction rate, the amount of stabilizer added, the drying time, the drying speed, etc. can be obtained.

The base material for oral compositions according to the present invention can be used for toothpaste, powder toothpaste, (
It can be used as an abrasive for oral compositions, such as tooth preparation and profilafsis paste.

In this case, as a component of the oral composition in which the base material of the present invention is blended, appropriate components can be used depending on the type of the oral composition.

For example, in the case of a dentifrice composition, the base material of the present invention may be used as an abrasive alone or together with other base materials, such as calcium hydrogen phosphate dihydrate and conventional calcium hydrogen phosphate anhydrate. , calcium carbonate, calcium birophosphate,
Insoluble sodium metaphosphate, amorphous silica, crystalline silica, precipitated silica, aluminosilicate, aluminum oxide.

Aluminum hydroxide, microcrystalline cellulose, resin.

One or more base materials such as tertiary magnesium phosphate and magnesium carbonate can be used in combination. In addition, when the calcium hydrogen phosphate/anhydrous product of the present invention is used in combination with other base materials, the amount of the calcium hydrogen phosphate/anhydrous product of the present invention to be used is determined based on the viewpoint of effectively demonstrating its effect. It is preferable that the total strength of the material is 5 to 100, particularly 10 to 100.

In addition, when preparing an oral composition using the base material for an oral composition of the present invention, furthermore, Cal-Z-ximedyl cellulose, hydroxyethyl cellulose, alginate, caradanan,
Arabic gum, binders such as polyvinyl alcohol, polyethylene glycol.

Thickening agents such as sorbitol, glycerin, globylene glycol, sodium lauryl sulfate, sodium dodecylbenzenesulfonate x Hydrogenated coconut fatty acid monoglyceride sodium monosulfate.

Foaming agents such as sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, lauroyl jetanolamide, sucrose fatty acid ester, and peppermint.

Essential oils such as spearmint, fragrance materials such as t-menthol, carvone, oidanol, anethole, etc., zasocalin sodium, stevioside.

Sweeteners and preservatives such as neohesberidyl dihydrochalcone, glycyryl, chin, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

Furthermore, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexizone or a salt thereof.

Sorbic acid, alexidine, hinokitiol, cetylbilisonium chloride, alkylglycine.

Alkyldiaminoethylglycine salt, allantoin, ε
- aminocaproic acid, tranexamic acid, azulene, vitamin E, sodium monofluorophosphate, sodium fluoride, stannous fluoride, water-soluble mono- or di-phosphates, quaternary ammonium compounds, sodium chloride, etc. Active ingredients etc. may be blended.

As mentioned above, the oral composition base material according to the present invention has an average particle diameter of 1 to 8 μm and a tap density of 0.6 to 0.0 μm.
Since it is composed of 99Arn3 calcium hydrogen phosphate anhydrate, it has moderate polishing power for teeth, high cleaning power, and excellent tooth whitening effect. In other words, calcium hydrogen phosphate anhydrate with an average particle size and tag density in the above ranges cannot be used with other polishers having similar polishing power, such as finer particles of conventional calcium hydrogen phosphate anhydrate. It has superior cleaning power compared to other cleaning agents, so it can remove stains, plaque, food particles, etc. that adhere to the teeth without damaging the tooth surface. ~8μ and tag density 0
．． Calcium hydrogen phosphate anhydrate with 6 to 0.9 fl/crn3 has significant abrasive power, so it does not necessarily need to be used in combination with other base materials like conventional calcium hydrogen phosphate anhydrate. , which can be used alone as an abrasive.

Next, examples and comparative examples will be shown to specifically explain the present invention.

[Example, comparative example]

f) The polishing power and cleaning power of each calcium hydrogen phosphate anhydrate having the average particle diameter and tag density shown in the table below were investigated by the following method, and the relationship between them was investigated.

Note that the average particle diameter is that of Leeds and North
Measurement was carried out using a Microtrac manufactured by RUP in a conventional manner.

In addition, the tap density was measured using a tap density measuring machine (Tap Danzer KYT 2000 model) manufactured by Seishin Enterprise Co., Ltd.
A cylindrical container with an inner diameter of 1.6 on and a volume of 20 marks is filled with calcium hydrogen phosphate anhydrate and operated at 3000 strokes at 120 strokes per minute and tapping space (high i) lcrn. and then the volume of sample M
The tag density was obtained by dividing f#, 'Fr:.

Furthermore, in the table, DCP-A indicates calcium hydrogen phosphate anhydrate, DCP-A■ to ■ are fine-grained conventional products, and I) CP-A■ is a conventional product.

Polishing force measurement method Using 5 g of powder (2.5 g of each calcium hydrogen phosphate anhydrate shown in the table and a suspension consisting of calcium hydrogen phosphate dihydrate), apply it to the load M2O og JIS H-
3361) A copper plate (112o hardness) was brushed 20,000 times in 92 hours using a horizontal polishing tester, and the wear amount of the copper plate was measured.

In addition, as a brushing brush, the number of hair strands is 44,
The thickness of the hair is 8 mil (approximately 0.2 mm) per bundle, the length of the hair is 12 m + n, and the quality is nylon (62 N), and the hardness of the abrasive material is M according to the Household Product Quality Indication Act. used.

Method for Measuring Cleaning Power Cigarette tar was collected in the usual manner, applied as a solution evenly on the tiles, dried at 7IrI temperature, set in a polishing container, and mixed with powder (aqueous solution of 15g
Brushing was carried out 1000 times at a load of 200p (the same brush was used as in the case of υFWf force m+] constant), and the removal rate of cigarette tar from the tile was visually observed after polishing. It was evaluated.

Evaluation base ((71 Rating 1: Cigarette tar removal rate O-1o 2:
11~20% 3: 21~30% 4: 31~40φ5,
41-50% 6 51-60 Chia: 61-70 Chi 8: 71-80%9,
81-90 attack 10: 91-100%.
The figure shows the relationship between the amount of copper plate wear and cleaning power for each sample.

Here, the reference numbers in the figure refer to sample j6 in the table, respectively.
, and the reference numbers in circles indicate the products of the present invention.

Moreover, FIGS. 1 and 2 are micrographs of calcium hydrogen phosphate anhydrate, A6 and AI in the table, respectively, magnified 10,000 times.

According to the results in the table and Figure 3, although the sample using calcium hydrogen phosphate anhydrate with an average particle size of 1 to 8μ and a tag density of O16 to 0.9jj/1yn5 has a low polishing power, It was confirmed that the calcium hydrogen phosphate anhydrate of the present invention has a high M lift force and satisfies low polishing power and high cleaning power at the same time.

In contrast, the conventional calcium hydrogen phosphate anhydrate has high polishing power even when the particle size is reduced through classification, and the polishing power of the calcium hydrogen phosphate anhydrate of the present invention is comparable to that of the present invention. The cleaning power was 1 degree lower than that of the old one.

Examples of formulations of oral compositions containing the base material of the present invention are shown below. In addition, in the compounding amounts of the following formulation examples, all
%.

[Formulation Example 1] Glycerin 35.0 Storium tisatukaphosphate o, 1 Sodium carboxymethylcellulose o, 6 Carrageenan
o, 6 Fragrance 1.
0 Sodium lauryl sulfate 1.5 Calcium hydrogen phosphate anhydrate 4.0.0 //
With trace amount of preservative
100.0% [Formulation Example 2] Propylene glycol 2.0% Sorbitol 30.0 Sodium tisatukaphosphate 0.2 Carpogysimethylcellulose sodium 1.2 Flavoring
1. OI Sodium lauryl sulfate 2.0I silicic anhydride 2.5N Sodium monofluorophosphate 0.76 // Calcium hydrogen phosphate anhydrate 45. O//preservative micro amount table autopsy
ioo, o [Formulation Example 3] Noropylene glycol 2.091S sorbitol IO, oI glycerin 10. C1# Sodium saccharinate Q, lj Sodium carboxymethyl cellulose 0.77 Carrageenan
0.3#Fragrance 1.0〃 Sodium lauryl sulfate 1.5〃Dextranase 2.0〃Calcium hydrogen phosphate anhydrous Q'/J 40.0#Preservative Trace amount Total
100.0 [Formulation Example 4] Propylene glycol 2.5 Thiquizanthan gum 1. OI glycerin
20.01 Polyethylene glycol
5.0 Sodium satsucarate
0.1! Stevioside Q,
lI Sodium lauryl sulfate 1.2I Fragrance 1.5〃 Sodium monofluorophosphate 0.767
'1) 79 hydrogen calcium anhydrate 50.07
[Formulation example 5] Propylene glycol 2.5 Glycerin 20.0# Sodium saccharinate 0.15# Glycyrrhizin
0. lI Sodium carboxymethyl cellulose 1.21 Fragrance 1. ON Sodium lauryl sulfate 1.0# Silicic anhydride 20 Calcium hydrogen phosphate dihydrate 20. OJ calcium hydrogen phosphate anhydrate 25. Ott lauroyl sarcosine) 0.5N preservative
Trace amount meter
100.0% [Formulation Example 6] Sorbitol 30.0q6 Glycerin 15.0# Xanthan Gum
0.51 carbo ball
o, 5 Polyvinylpyrrolidone
o, 1 Sodium satsucarate
0.11 Sodium lauryl sulfate
1,5# Silicic anhydride
3. o Calcium hydrogen phosphate anhydrate 35
．． 0°Fragrance 1. o.

[Brief explanation of the drawing]

Figure 1 is a photomicrograph of calcium hydrogen phosphate anhydrate used as the base material of the present invention, Figure 2 is a photomicrograph of conventional calcium hydrogen phosphate anhydrate, and Figure 3 is a photomicrograph of a conventional calcium hydrogen phosphate anhydrate. Sample (calcium hydrogen phosphate/anhydrous)
It is a graph showing the relationship between the amount of copper plate wear and cleaning power. Applicant Lion Co., Ltd. Agent Patent Attorney Takashi Kojima Figure 1 Figure 2 Figure 7゜Figure 3

Claims (1)

[Claims] 1. A base material for an oral composition, characterized in that it is made of calcium hydrogen phosphate anhydrate having an average particle diameter of 1 to 8 μm and a density a of 0.s to 0.97j10n3.