JP2934436B1 - Oral composition - Google Patents

Abstract

The present invention provides an oral composition having a soft feeling of use and capable of effectively removing plaque. SOLUTION: Cellulose powder is 99 to 10 parts by weight and a water-soluble substance (eg, lactose, xylitol, etc.) is 1 to 90 parts.
An oral composition comprising 0.2 to 20% by weight of spherical granules consisting of parts by weight and having an average particle size of 50 μm to 2000 μm.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for oral cavity which can impart soft feeling of use and effectively remove plaque by blending spherical granules comprising cellulose powder and a water-soluble substance.

[0002]

2. Description of the Related Art Conventionally, it is known that dental plaque is the main cause of dental caries and periodontal diseases, which are two major diseases in the oral cavity. In addition, plaque tends to accumulate between teeth, causing most of the caries to develop from such gaps and periodontal disease from the periodontal pockets, which are the gaps between teeth and gums. Is also known. For the purpose of removing plaque or suppressing plaque formation, dentifrices containing various bactericides, plaque-decomposing enzymes, and the like, various toothbrushes, dental floss, and the like have been developed and marketed.

[0003] However, it is difficult to remove plaque in a portion where the bristle tip of the toothbrush does not reach, such as a gap between teeth and a fissure, only by brushing using a toothpaste and a toothbrush together. Further, dental floss is effective in removing plaque between teeth, but has a drawback that fissures and plaque between teeth and gingiva can hardly be removed.

[0004] On the other hand, it has been generally practiced to mix granules with oral compositions, and oral compositions containing various granules have been proposed. For example, as a proposal of an oral composition for the purpose of removing plaque by an abrasive effect, there are JP-A-55-98111, JP-A-1-299211, JP-A-4-243816, and the like. In the above method, the degree of plaque removal in the oral cavity was not sufficiently satisfactory.

In Japanese Patent Application Laid-Open No. 9-40537,
Although there is a proposal for an oral composition containing granulated cellulose obtained by granulating cellulose powder, when this is used, the granulated cellulose is hard, and it hurts when it hits the gums or is caught in the gap between the denture and soft. There is a problem of lack of usability, and improvement of usability has been desired.

[0006]

The object of the present invention is to provide a composition for oral cavity which gives a soft feeling of use and can effectively remove plaque which causes dental caries and periodontal disease. Aim.

[0007]

Means for Solving the Problems As a result of intensive studies to achieve the above object, the present inventor has found that by blending spherical granules comprising a cellulose powder and a water-soluble substance with an oral composition, The present inventors have found that a soft feeling of use can be imparted and plaque can be effectively removed, and the present invention has been accomplished.

That is, according to the present invention, the cellulose powder has a viscosity of 99 to
Spherical granules comprising 10 parts by weight and 1 to 90 parts by weight of a water-soluble substance and having an average particle size of
The present invention relates to an oral composition characterized by being blended at a ratio of about 20% by weight.

The oral composition of the present invention is suitably used as a toothpaste, a liquid toothpaste, a liquid toothpaste, a gingival massage cream, a paste-like topical application, and the like, as when granulated cellulose is used. The plaque which causes dental caries, periodontal disease, etc. can be effectively removed without any pain inside.

Examples of the cellulose powder used in the present invention include mechanically treated pulp, acid-hydrolyzed or alkali-oxidized pulp, and pulp before or after acid-hydrolyzed or alkali-decomposed pulp. Treated, insoluble powdered cellulose, and powdered α-cellulose,
Other insoluble cellulose powders and the like are mentioned, and one or more of these are preferably used.

The water-soluble substance used in the present invention includes:
For example, sugars such as sucrose, lactose, glucose, trehalose and various oligosaccharides, processed starch products such as dextrin, pregelatinized starch, sugar alcohols such as xylitol, sorbitol, mannitol, synthetic polymers such as polyvinylpyrrolidone, polyethylene glycol, chlorides Water-soluble substances that can be used as oral compositions, such as water-soluble metal salts such as sodium and potassium chloride, polysaccharides such as gum arabic, carrageenan, xanthan gum, pullulan, and cellulose derivatives such as hydroxyethyl cellulose, carboxymethyl cellulose, and hydroxypropyl cellulose. Or a combination of two or more.

The ratio of the cellulose powder to the water-soluble substance in the spherical granules is preferably 1 to 90 parts by weight of the water-soluble substance with respect to 99 to 10 parts by weight of the cellulose powder, preferably 90 to 15 parts by weight of the cellulose powder. 85 parts by weight,
More preferably, the water-soluble substance is 15 to 80 parts by weight based on 85 to 20 parts by weight of the cellulose powder. Water-soluble substance is 1
When the amount is less than the weight part, the spherical granules are hard, and when used, they may feel pain when they hit the gums or are caught in the gaps between the dentures, and there is a problem in usability. If it exceeds 90 parts by weight, the spherical granules become brittle in the oral composition, and the plaque removing effect is poor.

The average particle size of the spherical granules is 50 μm in a dry state.
m to 2000 μm, preferably 70 μm to 1700 μ
m, more preferably 100 μm to 1500 μm.
If the average particle size of the spherical granules is smaller than 50 μm, the effect of removing plaque is inferior.

The mixing ratio of the spherical granules is 0.2 to 20% by weight, preferably 0.1 to 20% by weight, based on the total amount of the oral composition of the present invention.
5 to 15% by weight, more preferably 0.8 to 10% by weight
It is. If the compounding ratio is less than 0.2% by weight, the effects of the present invention cannot be sufficiently exhibited, and if it exceeds 20% by weight, the feeling of use may be adversely affected.

The spherical granules are prepared by using the above-mentioned raw materials and an appropriate amount of water by a general granulation method using a general-purpose granulator such as a stirring granulator, a tumbling granulator, a fluidized bed granulator or the like. The granules can be obtained by drying. Granulators can be used alone or in combination of two or more.

The oral composition of the present invention is produced according to a conventional method, and the spherical granules comprising the cellulose powder and the water-soluble substance of the present invention and the binders and thickeners used in ordinary oral compositions are used. Components such as a surfactant, a sweetener, a flavor, a medicinal component, and water can be added as necessary.

In the oral composition of the present invention, various medicinal ingredients, fragrances and the like can be blended into the spherical granules or dyed with a pigment.

[0018]

Next, the present invention will be described in more detail by way of examples. The average particle size of the spherical granules was measured by the following method.

Average particle diameter of spherical granules (μm) JIS standard sieve (Z8801-198) using a low tap sieve shaker (Hireko Seisakusho, sieve shaker A type).
Using 5), a sample of 50 g was sieved for 5 minutes, and the particle size of 50% by weight was defined as the average particle size of the spherical granules.

[0020]

EXAMPLE 1 18% by weight of spherical granules having an average particle size of 100 μm, consisting of 95 parts by weight of crystalline cellulose and 5 parts by weight of lactose, 20% by weight of silicic anhydride, 10% by weight of glycerin,
Toothpaste having a composition of 20% by weight of sorbitol solution, 2% by weight of iota carrageenan, 1.2% by weight of sodium lauryl sulfate, 0.1% by weight of sodium saccharin, 0.1% by weight of methylparaben, 1% by weight of fragrance and 27.6% by weight of water The preparation was adjusted, and the feeling of use and the effect of removing plaque were determined. Table 1 shows the determination results.

[0021]

Example 2 5% by weight of spherical granules having an average particle diameter of 1000 μm, comprising 60 parts by weight of crystalline cellulose and 40 parts by weight of purified salt, 20% by weight of silicic anhydride, 10% by weight of calcium hydrogen phosphate, and 15% by weight of glycerin %, Sorbit liquid 2
5% by weight, iota carrageenan 2% by weight, sodium lauryl sulfate 1.2% by weight, sodium saccharin 0.1
A dentifrice having a composition of 1% by weight, 0.1% by weight of methylparaben and 20.6% by weight of water was prepared, and the feeling of use and the effect of removing plaque were determined. Table 1 shows the determination results.

[0022]

Example 3 0.5% by weight of spherical granules having an average particle size of 1800 μm, comprising 25 parts by weight of crystalline cellulose and 75 parts by weight of gum arabic, 20% by weight of silicic anhydride, 10% by weight of calcium hydrogen phosphate, glycerin Toothpaste having a composition of 15% by weight, 30% by weight of sorbitol solution, 2% by weight of iota carrageenan, 1.2% by weight of sodium lauryl sulfate, 0.1% by weight of sodium saccharin, 0.1% by weight of methyl paraben, and 20.1% by weight of water Was adjusted to determine the feeling of use and the plaque removing effect. Table 1 shows the determination results.

[0023]

Example 4 18% by weight of spherical granules consisting of 90 parts by weight of crystalline cellulose and 10 parts by weight of xylitol and having an average particle size of 1000 μm, 20% by weight of silicic anhydride, 10% by weight of glycerin, 20% by weight of sorbitol solution, iota Carrageenan 2% by weight, sodium lauryl sulfate 1.2% by weight,
A dentifrice having a composition of 0.1% by weight of sodium saccharin, 0.1% by weight of methylparaben, 1% by weight of flavor, and 27.6% by weight of water was prepared, and the feeling of use and the effect of removing plaque were determined. Table 1 shows the determination results.

[0024]

[Comparative Example 1] Average particle size of only crystalline cellulose 6
A dentifrice was prepared in the same manner as in Example 2 except that the spherical granules were changed to 00 μm, and the feeling of use and the effect of removing plaque were determined. Table 1 shows the determination results.

[0025]

Comparative Example 2 A dentifrice was prepared in the same manner as in Example 2 except that the spherical granules were changed to 0.1% by weight and the water was changed to 25.5% by weight, and the feeling of use and the effect of removing plaque were determined. . Table 1 shows the determination results.

[0026]

Comparative Example 3 A dentifrice was prepared in the same manner as in Example 1 except that the spherical granules were changed to 25% by weight and the water was changed to 20.6% by weight, and the feeling of use and the plaque removing effect were judged. Table 1 shows the determination results.

[0027]

Comparative Example 4 A dentifrice was prepared in the same manner as in Example 2 except that the average particle size of the spherical granules was changed to 2500 μm, and the feeling of use and the effect of removing plaque were determined. Table 1 shows the determination results.

[0028]

Comparative Example 5 A dentifrice was prepared in the same manner as in Example 1 except that the average particle size of the spherical granules was changed to 40 μm, and the feeling of use and the effect of removing plaque were evaluated. Table 1 shows the evaluation results.

[0029]

Comparative Example 6 A dentifrice was prepared in the same manner as in Example 2 except that spherical granules consisting of 5 parts by weight of crystalline cellulose and 95 parts by weight of sucrose and having an average particle size of 1000 μm were used. The removal effect was determined. Table 1 shows the determination results.

[0030]

[Table 1]

The determination method in Table 1 is as follows.

(1) Feeling of use: Twenty panelists brushed their teeth with each toothpaste, and the number of persons who answered that the feeling of use was good and soft was judged as follows.

：: 15 or more, Δ: 10 to 14 and X: 9 or less (2) Plaque removal effect: Plaque before tooth brushing, which was stained with plaque revealing liquid on the upper and lower anterior teeth. The area and the plaque area after tooth brushing were measured by an image analyzer, and the plaque removal rate was calculated from the following equation, and determined as follows.

Plaque removal rate (%) = [1- (area after brushing) / (area before brushing) × 100 ○: plaque removal rate of 70% or more, Δ: plaque removal rate 40 to 69
%, ×: plaque removal rate 39% or less

[0035]

The oral composition of the present invention imparts a soft feeling of use and effectively removes plaque by blending spherical granules comprising a specific ratio of cellulose powder and a water-soluble substance. be able to.

Claims (1)

(57) [Claims] 1. A cellulose powder comprising 99 to 10 parts by weight and a water-soluble substance of 1 to 90 parts by weight, having an average particle size of 50 μm.
An oral composition comprising 0.2 to 20% by weight of spherical granules having a size of 2000 μm.