JPH0940537A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavities, good in the use feeling and capable of effectively removing bacterial plaques causing dental caries, periodontal diseases, etc. SOLUTION: This composition for oral cavities contains granulate cellulose having an average particle diameter of 50-1,000μm, preferably 70-700μm, in a dry state and obtained by granulating water-insoluble cellulose powder having an average particle diameter of 1-50μm in an amount of 0.2-20wt.%, preferably 0.5-10wt.%. The composition further contains conventional abrasive agent, binder, surfactant, medicinally active ingredient, perfume, pigment, etc., and may be prepared into a tooth paste, a liquid dentifrice, a gingival massage cream, a paste local coating agent, etc. Pulp powder, insoluble powder cellulose, powder α-cellulose, fine crystalline cellulose, pulp, chemically treated insoluble cellulose or other insoluble cellulose substances are used as a raw material for water- insoluble particulate cellulose, and can be granulated by a conventional method.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an oral cavity which has a good feeling in use and can effectively remove dental plaque which causes caries, periodontal disease, etc. by blending granulated cellulose insoluble in water. Composition.

[0002]

2. Description of the Related Art It has been known that dental plaque is the cause of dental caries and periodontal disease, which are the two major diseases in the oral cavity. Therefore, various dentifrices containing bactericides, plaque degrading enzymes and the like have been developed and introduced to the market for the purpose of removing plaque or suppressing the formation of plaque.

However, it is difficult to sufficiently remove plaque in a tooth gap, a fissure, and a periodontal / gingival pocket only by brushing with a toothbrush, which is used as a basis for plaque removal in combination with a dentifrice. It was In addition to toothbrushes, there are dental plaque removers such as dental floss and water pick, but all have problems in usability and removal effect.

On the other hand, various proposals have been made for oral compositions in which granules and capsules are added to oral compositions to impart various functions. For example, a pigment is blended with the granules to reveal the pigments during brushing and to serve as an indicator at the end of tooth brushing (JP-A-60-16913), granular taste components and granules coated with a coating substance. A mixture of a toothpaste base for the purpose of changing the taste during toothbrushing (JP-A-62-116505) and a granule containing a medicinal component to stabilize the drug (JP-A-48). -19738, 49-132249, 55
No. 153709, JP-A-3-271215),
Further, those for the purpose of removing plaque (Japanese Patent Laid-Open No. 1-299 / 1990).
No. 211, No. 4-243816) and the like.

However, the degree of plaque removal in the oral cavity is not sufficiently satisfactory in any of the above methods, and depending on the granules to be mixed, during the use of dentifrice,
There may be a feeling of discomfort such as powderyness and roughness after use, and development of an oral composition having a higher plaque removing effect and a good feeling of use is desired.

The present invention has been made in view of the above circumstances, and provides an oral composition which has a good feeling in use and can effectively remove dental plaque which causes caries, periodontal disease and the like. To aim.

[0007]

Means for Solving the Problems and Modes for Carrying Out the Invention As a result of extensive studies to achieve the above object, the present inventor has granulated a water-insoluble cellulose powder in an oral composition. It was found that by adding the granulated cellulose, the plaque can be effectively removed by the cleaning power, and the feeling of use becomes good.

That is, the water-insoluble cellulose particles having an average particle size of 1 to 50 μm have an average particle size in a dry state of 50 to 1
Granulation to 000 μm and blending the granulated cellulose in a proportion of 0.2 to 20% by weight based on the total weight of the composition allows the cleaning power of the granulated cellulose to prevent caries, periodontal disease and the like. The causative agent, plaque, can be effectively removed, and the discomfort due to graininess and graininess that occurs when using an amorphous cellulose powder that has not been granulated can be eliminated, and the cellulose powder has a large diameter. Suppresses unpleasant feeling of use such as foreign body feeling when it is too much, feels good in the mouth during use and after use, and granulated cellulose also has an effect of adsorbing and removing dirt and bad breath in the oral cavity, The inventors have found that they are also excellent in safety and have completed the present invention.

The present applicant has also proposed to reduce the wear of teeth by blending a water-insoluble cellulose powder having an average particle diameter of 5 to 1000 μm with the composition for oral cavity (JP-A-55-55). No. 98111), the plaque removal performance is not sufficient even when non-granulated cellulose powder is used, as is clear from the results of experiments described later, and as described above, it is used when the particle size of cellulose powder becomes large. The feeling is reduced. On the other hand, the granulated cellulose powder according to the present invention has an excellent ability to remove plaque and gives a good feeling of use even if the diameter is increased.

Therefore, according to the present invention, a water-insoluble average particle size of 1
Provided is a composition for oral cavity, which comprises 0.2 to 20% by weight of granulated cellulose having an average particle size of 50 to 1000 μm obtained by granulating a cellulose powder having a particle size of ˜50 μm.

The present invention will be described in more detail below. The composition for oral cavity of the present invention comprises water-insoluble granulated cellulose, and contains toothpaste, liquid toothpaste, liquid toothpaste, gingival massage cream, It can be suitably used as a paste-like topical coating agent and the like.

Here, as the raw material of the water-insoluble granulated cellulose, pulp powder, insoluble powdered cellulose, powdered α-cellulose, microcrystalline cellulose, pulp and celluloses which have been chemically insolubilized, and other insoluble celluloses are used. One kind or two or more kinds of substances are preferably used, and the average particle size thereof is 1 to 50 μm, preferably 3 to 45.
It is necessary to use those having a thickness of μm, more preferably 10 to 40 μm.

The water-insoluble granulated cellulose of the present invention is
The above raw materials can be produced using a known granulation method, for example, a stirring granulator, a fluidized bed granulator, a stirring fluidized bed granulator, etc., and one kind or a combination of two or more kinds of these granules can be used. . That is, the above cellulose raw material is required to be granulated to a certain particle size in order to exert the excellent effect of the present invention, and is a granular cellulose raw material such as pulp powder, insoluble powder cellulose, powder α cellulose, and microcrystalline cellulose. When used as an oral composition as it is as an amorphous powder without granulating a material obtained by chemically treating pulp and cellulose to make them insoluble,
Poor plaque removal effect and a feeling of powderiness and the like cause a problem in use.

Regarding the particle size of the above granulated cellulose, the average particle size in the dry state is 50 to 1000 μm, and particularly 70 to 700 μm.
m is preferable. If the average particle size is smaller than 50 μm, the effect of removing plaque is poor, while if it is larger than 1000 μm, a foreign substance feeling occurs when compounded in the oral composition and the gums are damaged.

Further, the blending ratio of the granulated cellulose is 0.2 to 20% by weight, particularly preferably 0.
5 to 10% by weight. If the blending ratio is less than 0.2% by weight, the effect of the present invention cannot be sufficiently exerted, and if it exceeds 20% by weight, the feeling of roughness is increased and the use feeling may be adversely affected.

In the oral composition of the present invention, it is possible to use the components other than the above-mentioned components which are usually used in oral compositions, and the addition amount of these components hinders the effect of the present invention. It can be a normal amount within the range not present.

For example, as the abrasive for toothpaste, only the above-mentioned water-insoluble granulated cellulose may be used, but if necessary, dibasic calcium phosphate dihydrate and anhydrate, monobasic calcium phosphate, Tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic acid anhydride, aluminum silicate, insoluble sodium metaphosphate, third magnesium phosphate,
One or more of magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, polymethylmethacrylate, and other synthetic resins may be used in an amount of 5 to 60% of the total composition.
%, Especially 10 to 50%.

In the case of a paste composition such as toothpaste, as a binder, a cellulose derivative such as carrageenan, sodium carboxymethyl cellulose, methyl cellulose and hydroxyethyl cellulose, gums such as xanthan gum, tragacanth gum, karaya gum and gum arabic, One or more kinds of synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, bee gum and laponite may be blended.

Further, in the production of paste-like or liquid dentifrice such as dentifrice, sorbit, glycerin,
Ethylene glycol, propylene glycol, 1,3-
One or more of butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol and the like may be blended.

The oral composition of the present invention includes menthol,
Anethole, carvone, eugenol, limonene, n-
Decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, piment oil, cinnamon leaf oil,
Perfumes such as perilla oil, wintergreen oil, clove oil, and eucalyptus oil may be blended alone or in combination, and saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanine methyl ester, p. -A sweetener such as methoxycinnamic aldehyde may be added.

Further, enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, etc., alkali metal monofluorophosphates such as sodium monofluorophosphate, potassium monofluorophosphate and sodium fluoride. , Fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, dihydrocholestanol, glycyrrhizinic acid, glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerophosphate, chlorophyll, copper gluconate, chloride 1 of active ingredients such as sodium, water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride Or it may be incorporated two or more.

As the surface active agent, an anionic surface active agent, a nonionic surface active agent and a zwitterionic surface active agent are used.

Specifically, as the anionic surfactant, sodium lauryl sulfate, sodium alkylsulfate such as sodium myristate sulfate, sodium N-lauroyl sarcosinate, sodium N-acyl sarcosinate such as sodium N-myristoyl sarcosinate, N-acylglutamates such as sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, N-methyl-N-
Acyl taurine sodium, sodium N-methyl-N-acyl alanine, sodium α-olefin sulfonate and the like are used.

Examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid ester such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan monolaurate. Polyoxyethylene sorbitan monostearate and other polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and other polyoxyethylene fatty acid esters, lauric acid mono- or diethanolamide, myristic acid mono- or diethanolamide fatty acid diethanolamide, Sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene Such as oxypropylene fatty esters are used.

As the zwitterionic surfactant, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, 2-alkyl-1- Hydroxyethyl imidazoline betaine sodium and the like are used.

In this case, the surfactant is preferably an anionic surfactant, and specifically, sodium alkyl sulfate such as sodium lauryl sulfate is suitable. These surfactants may be used alone or in combination of two or more, and the compounding amount thereof is usually 0.01 to 5% by weight, more preferably 0. It is from 05 to 3% by weight.

In the oral composition of the present invention, the above-mentioned granulated cellulose may be blended with various kinds of the above-mentioned medicinal components, fragrances or the like or dyed with a dye. In this case, various legal dyes are used as the dye, for example, Red No. 2,
Red No. 3, Red No. 226, Yellow No. 4, Yellow No. 5, Blue 1
No. 2, Blue No. 2, Blue No. 201, Blue No. 204, etc. are preferably used.

The oral composition of the present invention includes
Pulp powder, insoluble powdered cellulose, powdered α-cellulose, microcrystalline cellulose and the like can be used in combination with the above-mentioned granulated cellulose as water-insoluble powdered cellulose.

[0029]

EFFECTS OF THE INVENTION The oral composition of the present invention has a good feeling in use and is effective in treating dental plaque causing caries, periodontal disease, etc. by blending water-insoluble granulated cellulose. Can be removed.

[0030]

EXAMPLES The present invention will be described below in detail with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

[Experimental Example] A toothpaste having the following composition was prepared, and the feeling of use and the effect of removing plaque were evaluated according to the following methods. The results are shown in Table 1. Granulated Cellulose or Microcrystalline Cellulose Amount shown in Table 1 Dicalcium phosphate dihydrate 30% Dicalcium phosphate dihydrate 5 Glycerin 19 Carboxymethyl cellulose 1.2 Sodium saccharin 0.2 Sodium lauryl sulfate 1.3 Perfume 1 Water Balance 100%

Evaluation method (1) Feeling of use: Five panelists actually brushed with a toothbrush using each of the above dentifrices, and the feel during and after use was judged according to the following criteria. Evaluation criteria for feeling during use ○: Good △: Normal ×: Poor mouth feel after use ○: Sluggishness decreased △: Some slimyness remained ×: Sluggishness did not decrease (2) Plaque removal effect: For the upper and lower anterior teeth, the plaque area before the start of brushing and the plaque area after the completion of brushing are stained with a plaque revealing solution, and the plaque area is measured with an image analyzer, and the plaque is calculated from the following formula. The removal rate was calculated. The result was judged according to the following criteria.

[0033]

[Equation 1] Evaluation criteria ○: Plaque removal rate 70% or more △: Plaque removal rate 40 to 69% ×: Plaque removal rate 39% or less

[0034]

[Table 1]

[Example 1] Granulated cellulose (average particle size 200 µm) [70 µm] 5% silicic acid anhydride 15 propylene glycol 3 sorbit solution 25 carboxymethyl cellulose 1 sodium saccharin 0.1 sodium lauryl sulfate 1.0 perfume 1.0 water Balance 100%

[Example 2] Granulated cellulose (average particle size 250 µm) [80 µm] 3% Aluminum hydroxide 35 Propylene glycol 2 Glycerin 20 Carboxymethyl cellulose 1 Tranexamic acid 0.01 Sodium saccharin 0.1 Sodium lauryl sulfate 0.5 Perfume 0.5 water balance 100%

Example 3 Granulated cellulose (average particle size 150 μm) [50 μm] 1% Microcrystalline cellulose 1 Dicalcium phosphate dihydrate 40 Glycerin 18 Xanthan gum 0.5 Sodium polyacrylate 0.8 Sodium saccharin 0 .2 Sodium lauryl sulfate 1.0 Fragrance 0.8 Water Balance 100%

[Example 4] Granulated cellulose (average particle size 300 µm) [90 µm] 2% Dicalcium phosphate dihydrate 30 Dicalcium phosphate dihydrate 5 Glycerin 19 Carboxymethyl cellulose 1.2 Sodium saccharin 0.2 Sodium lauryl sulfate 1.3 Perfume 1 Water balance 100%

[Example 5] Granulated cellulose (average particle size 100 µm) [30 µm] 1% silicic acid anhydride 16 propylene glycol 3 glycerin 24 sorbit 50 xanthan gum 0.2 sodium polyacrylate 0.2 saccharin sodium 0.2 lauryl sulfate Sodium 1.5 Perfume 0.9 Water 100% balance

Example 6 Granulated cellulose (average particle size 300 μm) [50 μm] 3% sorbit 10 ethanol 5 polyoxyethylene (60 mol) hydrogenated castor oil 0.1 sucrose monopalmitate 0.2 saccharin sodium 0.1. 2 fragrance 0.6 water 100% balance

With respect to the compositions of the above Examples, the feeling during use, the feeling in the mouth after use, and the plaque removal rate were evaluated in the same manner as in the Experimental Examples, and the results were all ◯.

Claims (1)

[Claims] 1. An average particle size of 5 obtained by granulating a cellulose powder having an average particle size of 1 to 50 μm insoluble in water.
An oral composition comprising 0.2 to 20% by weight of granulated cellulose of 0 to 1000 μm.