JPH09241116A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition free from offensive odor and capable of significantly remitting muscular swelling and myalgia through promoting blood circulation at sites applied to. SOLUTION: This cosmetic composition in the form of lotion, gel, spray etc., contains at least one kind of eugenol derivative selected from acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl eugenol, ethyl isoeugenol and eugenol salicylate, and 0.05-0.7wt.% eugenol based on the above eugenol derivatives.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic composition which increases blood flow without irritating the skin, effectively improves swelling and myalgia, and has no odor.

[0002]

2. Description of the Related Art At present, vascular smooth muscle dilators, α-antagonists and β-antagonists are used as blood circulation promoters. In addition, in the field of Kampo, anti-congestive agents such as button pie, senkyu, touki, kouka, and tounin have been used. However, both drugs are used internally, and are rarely used externally from the viewpoints of percutaneous absorption and effects. Other than pharmaceuticals, drugs such as dl-α-tocopherol acetate, glycerin, and ethanol are used as peripheral blood flow improving agents in the fields of cosmetics and quasi-drugs, but their effects cannot be said to be sufficient. .

It has been known for a long time to give a warm feeling to the skin by applying a skin stimulant such as capsicum extract, capsicum powder, and capsaicin to the skin. These are used as external preparations for the purpose of anti-inflammatory and analgesia for stiff shoulders, low back pain, etc. However, the concentration generally applied at present has low thermal sensation and high skin irritation. For example, when applied as a poultice, pain rather than thermal sensation or redness of the skin is often observed. Attempts have also been made to give a warm feeling to the skin by using spicy crude drugs such as ginger and salamander, but the actual effects and feelings cannot be expected.

On the other hand, as a drug for improving swelling, an antihypertensive diuretic such as thiazide has been devised for internal use and a part for external use, such as a massage agent. In any case, the effect or usability is satisfactory. It can not be said. In addition, salicylic acid compounds such as methyl salicylate, indomethacin, ketoprofen, etc. are used as drugs for treating muscle pain, but they are highly irritating to delicate skin and are not particularly preferable for children and women. Among the eugenol derivatives contained in Clove extract, etc.,
Such substances as eugenol, isoeugenol, acetylisoeugenol, dihydroeugenol, benzyl eugenol and the like, which have high skin sensitization, are included and have been a problem.

Therefore, the applicant of the present invention has previously proposed a skin external preparation composition containing a specific eugenol derivative (JP-A-6-287135). This external preparation for skin has an effect of increasing peripheral blood flow and improving swelling, but is not completely satisfactory.
Moreover, a specific eugenol derivative which is a component of this external preparation for skin, such as acetyleugenol, can be obtained from clove extract, etc., but is usually produced by reacting eugenol as a raw material, and is commercially available. However, these commercially available eugenol derivatives also have a problem of having an odor.

[0006]

DISCLOSURE OF THE INVENTION The present invention promotes an increase in peripheral blood flow without feeling skin pain or skin redness, thereby further improving local swelling / muscle pain, and odor. The present invention provides a cosmetic composition free from the above.

[0007]

Means for Solving the Problems As a result of intensive research to solve the above problems, the inventors of the present invention found that eugenol, which causes a mixed odor, is the cause.
Further, in order to solve the odor problem of these eugenol derivatives, it has been found that highly pure ones, that is, those not containing eugenol or those having a very small eugenol content are preferable. As a result of further study, when using a eugenol derivative having a purity of 100% or extremely high purity, although the odor can be solved, the swelling improving effect is rather inferior, and surprisingly a small amount of eugenol, That is, the odor improving effect can be exhibited by containing eugenol in the range of 0.05 to 0.7% by weight with respect to the content of the specific eugenol derivative,
Moreover, they have found that the peripheral blood flow volume can be significantly increased without causing skin pain and redness, whereby swelling / muscle pain can be further improved, and the present invention has been completed.

That is, according to the present invention, at least one eugenol derivative selected from acetyleugenol, methyleugenol, methylisoeugenol, ethyleugenol, ethylisoeugenol, and eugenol salicylate is contained, and the content of the eugenol derivative is Provided is a cosmetic composition comprising 0.05 to 0.7% by weight of eugenol.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The eugenol derivatives acetyleugenol, methyleugenol, methylisoeugenol, ethyleugenol, ethylisoeugenol, and eugenol salicylate, which are eugenol derivatives used in the present invention, are synthesized from natural products such as clove extract. Goods may be used. In order that the cosmetic composition of the present invention has no odor and has an excellent swelling improving effect, the eugenol content is in the range of 0.05 to 0.7% by weight based on the eugenol derivative. is important. If the content of eugenol is less than 0.05% by weight with respect to the content of the eugenol derivative, the swelling improving effect is not improved so much, and if it exceeds 0.7% by weight, odor becomes strong, which is not preferable.
In addition, isoeugenol is also included in the eugenol in the present invention.

The above-mentioned eugenol derivative is commercially available, and when this is used as the eugenol raw material, the commercially available product has a purity of about 99% and contains about 1% of eugenol. It is necessary to perform purification treatment until the content of the eugenol derivative becomes 0.05 to 0.7% by weight. Also, when the eugenol derivative raw material synthesized from eugenol is used, it is necessary to carry out a purification treatment until the eugenol content falls within the above range. Furthermore, as the eugenol derivative raw material, the purity is 100%.
In the case of using those of eugenol or those of extremely high purity, it is necessary to add and adjust eugenol so that the content of eugenol falls within the above range. The method for purifying the eugenol derivative is not particularly limited, but it can be carried out by a treatment means such as fractional distillation, ion-exchange resin-treated activated carbon, gas chromatography treatment, carbon dioxide extraction and the like.

The amount of the eugenol derivative used in the present invention is preferably 0.5 to 20.0% by weight, more preferably 2.5 to 8.0% by weight, based on the entire composition.

Further, when a large amount of water is present in the cosmetic composition of the present invention, hydrolysis of the eugenol derivative occurs, eugenol causing odor is generated, and the content of eugenol increases, which is not preferable. . Therefore, in the present invention, it is preferable to reduce the amount of water present in the cosmetic composition as much as possible, specifically 5000 ppm or less, preferably 100 ppm, based on the total cosmetic composition.
It is desirable that the content be 0 ppm or less. Such a cosmetic composition having a low water content can be prepared, for example, by using high-purity ethanol as a solvent. Since such a cosmetic composition having a low water content suppresses the hydrolysis reaction of the eugenol derivative, which is the main component in the composition, it has no odor even after long-term use and has a long swelling improving effect. It has a long shelf life and excellent long-term storage stability.

Further, the cosmetic composition of the present invention may contain various components usually contained in cosmetics.
Examples of such components include surfactants, higher alcohols, fatty acids, oils such as silicones, crude drugs such as peony and ginger roots, and fragrances.

The composition of the present invention may be in any form such as lotion, gel and spray.

The present invention will be specifically described below based on examples. Examples 1 to 5 and Comparative Examples 1 to 2 Cosmetic compositions having the formulations shown in Table 1 were prepared, and the odor and swelling improving effects were evaluated by the following measuring methods and evaluation criteria, and the results are shown in Table 1. . 1) Odor evaluation method Sensory evaluation by 10 professional panelists (5-level evaluation) 5 No odor 4 Almost no odor 3 Slight offensive odor 2 Clear odor 1 Very offensive odor 2) Evaluation method of swelling improvement effect Sensory evaluation by 10 people who were standing all day (5-level evaluation) A certain amount of the product of the present invention (aerosol) was sprayed in the evening, and evaluated 30 minutes later. 5 Very improved 4 Slightly improved 3 Unchanged 2 Slightly puffed 1 Instead, puffed

[0016]

[Table 1]

Example 2 Aerosol Acetyl Eugenol 2.0 wt% Eugenol 0.007 Isononyl isononanoate 1.5 Decamethylpentasiloxane 2.0 Peony extract 0.02 Shobu extract 0.02 Perfume Fine amount Ethanol balance (stock solution / LPG = 1/1)

Example 3 Aerosol Acetyl Eugenol 2.5 wt% Eugenol 0.005 Methylphenylpolysiloxane 1.5 Squalane 0.5 Birch extract 0.02 Peony extract 0.02 Perfume Fine amount Ethanol balance (stock solution / LPG = 1/1)

Example 4 Gel Acetyl Eugenol 4.0 wt% Eugenol 0.01 Hydroxypropyl cellulose 3.0 β-Glylyrrhetinic acid 0.2 Squalane 1.0 Perfume Micro amount Ethanol balance

[0020]

EFFECTS OF THE INVENTION The cosmetic composition of the present invention has no odor, and when applied topically, it does not cause redness, pain, etc., promotes blood flow at the application site, and significantly causes swelling / muscle pain. Can be improved.

Continuation of the front page (51) Int.Cl. ⁶ Identification number Reference number in the agency FI Technical display location A61K 31/60 ADA A61K 31/60 ADA (72) Inventor Gen Takenaka 1-3-7, Honjo, Sumida-ku, Tokyo No. Lion Co., Ltd. (72) Inventor Sadanori Yoshimune 1-3-7, Honjo, Sumida-ku, Tokyo Within Lion Co., Ltd.

Claims (1)

[Claims] 1. Acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl eugenol,
A cosmetic composition comprising at least one eugenol derivative selected from ethyl isoeugenol and eugenol salicylate, and 0.05 to 0.7% by weight of eugenol relative to the content of the eugenol derivative. .