JPH0912433A - Composition for head - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for head, effective for preventing and improving dandruff, itch, fallen hair, etc. SOLUTION: This composition for head contains an extract originated from the seeds of an Annonaceae plant in an amount of 0.005-20wt.%, preferably 0.01-10wt.%, as an active ingredient. The extract is preferably extracted with a lower alkanol (e.g. methanol) so as to contain fat-soluble ingredients in an amount of >=60wt.% per the whole weight of the extract. The Annonaceae plant includes Annona L., Anomianthus Zoll., Ellipeiopsis R. E. Fries, Artabotrys R. Br., Melodram Hook. f., Goniothamus. Hook. f., Asimina Adans., Rollinia A. St. Hil, and Uvaira. L. The active ingredient is used at a dose of 0.01-100mg, preferably 0.1-10mg/kg/adult/once a day on the percutaneous administration to the head. The composition is prepared in the form of hair tonics, hair creams, shampoos, scalp treatments, rises, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair growth composition containing an extract from a plant as an active ingredient. More specifically, the extract is the Anemoneaceae ( Annonacea).
e ) A composition for hair growth which is a specific extract from the seed of a plant belonging to e ).

[0002]

2. Description of the Related Art Various compositions have been proposed for the purpose of preventing hair loss and promoting hair growth. Of these, as an interesting one, it is disclosed that an extract from each plant part of a plant belonging to the family Annaceaceae exhibits an excellent hair-growing effect in experimental animals and the like.
No. 0861 can be mentioned. According to this publication,
It has been suggested that the organic solvent extract such as dried bark powder of Anemone sinensis exhibits excellent effects, but the methanol extract of the seeds hardly shows the desired effect.

[0003] On the other hand, old, Sweetsop (Anona s
quamosa L .; : " Anona " is " Ann
( seems to be used interchangeably with " ona ") suggests that a composition in which the crushed product of itself is dispersed in sesame oil or the like has a hair growth promoting effect (West German Patent No. 3614448). However, since the seed itself shows toxicity, it has not been put to practical use yet.

The inventors of the present invention have described the above-mentioned Japanese Patent Laid-Open No. 6-40861
Connection with the invention disclosed in JP, Annonaceous (Ann
onaceae ), the utilization of the seeds was also reexamined in order to make effective use of each plant part of the plant.

As a result, it was revealed that the extraction efficiency of the hair-growth active ingredient from Anemone sinensis varies depending on each plant part. In particular, the active ingredient derived from the seeds of plants belonging to the Anemoneaceae family can be obtained in a sufficient amount by dipping extraction using several times as much methanol as the seed weight as described in JP-A-6-40861. It was confirmed that the substance could not be produced and was highly lipophilic. Thus, the extract sufficiently containing a substance highly lipophilic in the seeds of plants belonging to the family Annonaceae not only exhibits an excellent hair-growing effect, but also significantly reduces the toxic effect on the application site, such as the scalp. It was discovered.

[0006]

According to the present invention, therefore, an extract derived from seeds of at least one plant belonging to the family Annonaceae is contained as an active ingredient, and the extract is mainly composed of a fat-soluble ingredient. A head composition is provided which is characterized by the fact that it is water-soluble.

Typical examples of plants belonging to the Anemoneaceae family are genus Annona ( Annona L.) and genus Anomianthus ( Anomianthus Zol).
l. ), Elipeiopsis
s R. E. FIG. Fries), Artabotris ( Art
abotrys R.A. Br. ), Melodrum ( Mel
odorum Hook. f. ), Goniotaramusu genus (Goniothamus Hook.f.), Asimina genus (Asimina Adans.), May be mentioned those belonging to Rorinia genus (Rollinia A.St.Hil.) And Ubaria genus (Uvaria L.).

Specific examples of these plants include annua ( Annona squamosa L.),
Chierimoya ( Annona cherimola Mi
ller), Hoshiban Reishi ( Annona mont
ana Macfad. ), Togeban Reishi ( Anno
na muricata L. ) And Giusinri ( An
nona reticulata L. ), Annona
Bratta ( Annonabullata A. Ric
h. ) And Annona Denshikoma ( Annonaden)
sicoma Mart. ) Etc. ( Ann
ona L. ), A plant belonging to Anomianthus dulucis J.
Sincl. ) Anomi Anthus Auritus ( Anom
ianthus auritus Backer ex
K. Heyne), Anomiansasu Al Jenchi mouse (Anomianthus argenteus B
ackre), and Anomianthus heterocarpus Z
ol. ) Etc. ( Anomianth
us Sincl. ) To which plants belong, as well as Elipeiopsis c
herrevensis R. E. FIG. Fries) and other genus Ellipeopsis R.
E. FIG. A plant belonging to Fries, Artabotrys odoratisis
simus R. Br. ), Artabotrys harmandii F
inet & Gagnep. ) Etc. belonging to the genus Artabotrys R. Br.
Barren wig ( Melodorum aberrans)
J. Sincl. ) Etc. Melodyrum genus ( Melodo
rum Hook. f. ), A plant belonging to ( Goniothalamus tapis)
Miq. ), Gonio Talamus giganteus ( Gon
iothalamus giganteus Hook
f. & Thoms. ) Etc. ( Gon
iothalamus Hook. f. ), A plant belonging to), Asimina trilo
ba Dun. ) Etc. ( Asimina A)
Dans. ), A plant belonging to the category: Rollinia membranacea Pla
nch. & Triana), Rolinia Mukosa ( Ro
llinia mucosa Bail . ), Rorinia-Papirionera (Rollinia papilio
nella Diels), Rolinia Silvatika ( R
ollinia sylvatica Warm. ),
Rorinia-Ulei (Rollinia ulei Di
els) and the like ( Rollinia A. St.
Hill. ), A plant belonging to Ubaria acminata ( U
varia acuminata Oliver, Uvaria narum Wal
l. ) And other plants belonging to the genus Uvalia ( Uvaria L.).

For the sake of brevity, the present invention will be described below by taking the seeds of Annona squamosa L. as an example. However, seeds of other plants belonging to the Anemone spp. Behaves differently.

The term "mainly composed of fat-soluble components" as used in the present invention means that at least a certain amount of components soluble in ethyl acetate are contained. Therefore, for example, when a methanol extract of dried crushed anemone seeds is taken as an example, when the extract is liquid-liquid partitioned with ethyl acetate-water (2/1), the components distributed in the ethyl acetate layer (the present (Meaning the "fat-soluble component" in the present invention) accounts for 60% by weight or more, preferably 75% by weight or more, more preferably 80% by weight or more of the total weight of the methanol extract. Therefore, in various organic solvent extracts including methanol extract, at least 60% by weight of the components distributed in the ethyl acetate layer based on the total weight of the extract in the ethyl acetate-water distribution system as described above. If included, it can be used as the extract "mainly composed of fat-soluble components" of the present invention.

Such an extract is obtained by treating a dried crushed product of Anemone sinensis seeds with a lower alkanol such as methanol, ethanol, n-propanol, iso-propanol, tert-butanol, iso-butanol or, if necessary, water thereof. Mixtures, esters such as ethyl acetate or butyl acetate, acetone, methyl ethyl ketone, iso-
Ketones such as butyl methyl ketone, glycols such as ethylene glycol or propylene glycol, n-
Hydrocarbons such as hexane, n-heptane, n-pentane and cyclohexane, dioxane, tetrahydrofuran,
It can be prepared by dipping or reflux extraction using ethers such as diethyl ether and di-iso-propyl ether, petroleum ether, benzene, chloroform, dichloromethane, acetonitrile alone or a mixture thereof. The use ratio of the seed and the extraction solvent varies depending on the type of the solvent and the extraction method, but in any case, in the ethyl acetate-water distribution system as described above, the component distributed to the ethyl acetate layer is 60% by weight. It suffices to select the extraction conditions so as to become the above.

In the methanol extraction method described in JP-A-5-40861, an extract which meets the object of the present invention has not been obtained, but the amount of methanol used is 20 times that of the dried crushed product of Anchovy seeds. By subjecting the crushed product to 60 times and subjecting it to immersion or reflux extraction, the “extract mainly composed of fat-soluble components” according to the present invention can be obtained. The extraction time cannot be specified because it depends on the amount of processing solvent and the temperature. For example, when methanol is used in an amount 30 times as much as that of Anemone sinensis seeds and subjected to immersion extraction at room temperature for 3 days, an extract usually containing about 70 to 80% by weight of the fat-soluble component is obtained.

The term "composition for the head" as used in the present invention is a concept including all compositions which act to contribute to the prevention of hair loss, the promotion of hair growth, and the prevention of dandruff on the scalp. I'm using it. Therefore, the head composition of the present invention,
It exhibits at least one action of preventing hair loss, promoting hair growth and preventing dandruff. Although the amount of the active ingredient used in the composition of the present invention varies depending on the intended effect, the condition of the subject, etc., in the case of transdermal administration to the head, the weight-equivalent dose of the extract is In addition, the body weight is 1 kg and the daily dose is 0.01 to 100 mg, preferably 0.1 to 100 mg.
It is 10 mg. This amount can be administered once or several times a day.

For the extract of the present invention mainly composed of fat-soluble components, the extract may be used as it is, as a concentrated concentrate, or may be concentrated and dried, depending on the dosage form of the head composition containing them. It can be used as a solidified and pulverized powder.

The content of the above extract in the head composition of the present invention is not limited because the optimum amount varies depending on the dosage form, but the content per formulation is generally 0.005. % To 20% by weight, preferably 0.01 to 1
Adjust to 0% by weight. If it is less than 0.005% by weight, the effect of the present invention will not be sufficiently exhibited, and if it exceeds 20% by weight, it is disadvantageous in terms of formulation, which is not preferable.

The head composition of the present invention comprises the above extract,
Salicylic acid, vitamin E acetate, menthol, hinokitiol, benzyl nicotinate, nicotinamide,
1 selected from the group consisting of pantothenyl ethyl ether
One or more components can be further included as active ingredients. By including these components in combination with the above extract, the effect in the present invention is synergistically enhanced, and even if the content of the above extract in the composition is reduced, the same level of effect can be obtained.

The head composition of the present invention contains, in addition to the above-mentioned essential components, various components generally used in cosmetics, quasi drugs, pharmaceuticals, etc., if necessary, within a range that does not impair the effects of the present invention. , For example, glyceryl monooleate, oils such as funnel oil, blood flow promoters such as cembly extract, testosterone-5α-reductase inhibitors such as glycyrrhetinic acid, hormones such as ethinyl estradiol, hair root activators such as vitamin H , Polyoxyethylene (8 mol) oleyl alcohol ether, sorbitan monolaurate, sorbitan monopalmitate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyethylene glycol monooleate , Polio Non-ionic surfactants such as cyethylene alkyl ether, polyglycol diester, lauryl diethanol amide, fatty acid isopropanol amide, polyoxyethylene hydrogenated castor oil, stearyl trimethyl ammonium chloride, cationic surfactants such as benzalkonium chloride, sodium palmitate , Sodium laurate, sodium lauryl sulfate,
Anionic surfactants such as potassium lauryl sulfate, triethanolamine alkylsulfate, linear dodecylbenzenesulfate, polyoxyethylene hydrogenated castor oil maleic acid, semipolar surfactants such as lauryldimethylamine oxide and oleindimethylamine oxide, amphoteric surfactant Agents, heat retaining agents, thickening agents, preservatives, antioxidants, fragrances, coloring agents and the like can be added. The hair-growing composition of the present invention is not limited in its dosage form, and can be in any dosage form such as tonics, hair creams, shampoos, scrub treatments, rinses, etc. Can follow methods known per se.

The hair-growing composition of the present invention exhibits excellent effects of preventing hair loss, promoting hair growth and preventing dandruff, especially when administered to the human scalp.

[0019]

EXAMPLES The present invention will be described in more detail below.
The technical scope of the present invention is not limited by these. The blending amount in the following description is% by weight based on the total weight of the formulation, unless otherwise specified.

The effects of the hair-growing composition of the present invention can be confirmed by the following test methods.

Hair Growth Test Male C3H mice (60 days old) were used and the method of Ogawa et al. (Normal and Abnormal Epid) was used.
ERM. Se
iji and I. A. The experiment is conducted according to Berstein's edition, The University of Tokyo Press. Approximately 2 x 4 on the back hair of a mouse
After shaving to a size of cm, the test sample is applied once a day every day from the next day, the change in the area of the part where hair regeneration starts is determined, and the speed of hair regeneration is compared. For each sample, 10 mice are used, and the average value of the area is calculated.
The effect is expressed by the number of days required to achieve 50% hair growth rate by each sample, or the result of the area of hair regrowth after 25 days is expressed as a percentage and evaluated.

Trichogram test The hair roots of the removed hair before and after the use of the hair-growing composition are observed under a microscope, and the number of resting hair roots is counted from the morphology of the hair roots.
The hair-feeding effect of the composition is compared by increasing or decreasing the ratio. Resting hair roots are hair roots that have stopped growing, and it has been recognized that people who complain of hair loss have a higher proportion of resting hair roots than normal people.

The test sample was applied to the scalp of 20 or 10 male subjects twice a day, 2 ml each, continuously for 6 months. Immediately before application and immediately before the end of application for 6 months, 100 The effect is evaluated by removing the hair one by one and examining the roots of each hair.

Examples 1-18 Preparation of Extract Preparation of Extract Example 1 Bannaishi ( Annona squamosa L.)
1000 g of dried crushed seeds was extracted with 50 liters of methanol. After that, the solvent methanol was distilled off. The extract yield was 210 g and the yield was 21%. The extract thus obtained was subjected to liquid-liquid partition with ethyl acetate (2 liters of about 10 times the yield of the extract, 2 liters twice, total 4 liters) -water (about 2 liters of the extract yield of about 10 times), and acetic acid was added. The ethyl layer (81% by weight) was collected, concentrated under reduced pressure and dried. Extract yield 170g, 17% yield.

Example 2 Bannaishi ( Annona squamosa L.)
Soxhlet extraction was performed on 100 g of dried crushed seeds with 2 liters of petroleum ether. After that, petroleum ether was distilled off,
It was concentrated under reduced pressure. Extract yield 24g, yield 24
%.

Example 3 Bannaishi ( Annona squamosa L.)
500 g of dried crushed seeds was subjected to reflux extraction with 20 liters of 70% ethanol. Then, 70% ethanol of the solvent was distilled off. The extract yield was 75 g and the yield was 15%.
Ethyl acetate thus obtained (1 liter x 2)
-Liquid-liquid partition with water (1 liter), ethyl acetate layer (9
(0% by weight) was collected and concentrated under reduced pressure to dryness. Extract yield 67.5 g, yield 13.5%.

Example 4 Bannaishi ( Annona squamosa L.)
500 g of dried crushed seeds was extracted with 15 liters of ethyl acetate. The seed residue was extracted again with 5 l of ethyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 80g, 16% yield.

Example 5 Bannaishi ( Annona squamosa L.)
300 g of dried crushed seeds was extracted with 8 liters of acetone. The seed residue was extracted again with 5 liters of acetone. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 45 g, yield 15%.

Example 6 Thinerimoya ( Annona cherimola Mi
ll. ) 500 g of dried crushed seeds was defatted with 1 liter of hexane. After that, the seed residue is replaced with 10 kg of ethyl acetate.
It was extracted with and concentrated under reduced pressure to dryness. Extract yield 60 g, yield 12%.

Example 7 Thornbill ( Annona muricata)
L. ) 1000 g of dried seeds were extracted with 20 l of butyl acetate. The seed residue was extracted again with 5 liters of butyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 180g, yield 18%.

Example 8 Annona montana Ma
cfad. ) 750 g of dried crushed seeds was added to acetone 20
Extracted in liters. The residue was extracted again with 2 liters of acetone, both extracts were combined and concentrated under reduced pressure to give a dry solid. The extract yield was 150 g and the yield was 20%. The extract thus obtained was treated with ethyl acetate (1.5 liters x 2)-
Liquid-liquid partition was performed with water (1.5 liter), the ethyl acetate layer was recovered, and concentrated under reduced pressure to dryness. Extract yield 142.5
g, yield 19%.

Example 9 Annona reticulata
L. ) 800 g of dry crushed seeds were extracted with 20 l of acetone. The seed residue was extracted again with acetone, and both extracts were combined and concentrated under reduced pressure to give a dry solid. Extract yield 140
The yield was 17.5%. The extract thus obtained was mixed with ethyl acetate (1.5 liters x 2) -water (1.5
Liquid-liquid partition was performed, and the ethyl acetate layer was collected and concentrated under reduced pressure to dryness. Extract yield 123.2 g, yield 15.
4%.

Example 10 Anomianthus Dulcis
dulucis J. Sincl. ) 500 g of dried seeds were extracted with 6 l of ethyl acetate. The seed residue was extracted again with 1 liter of ethyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 100 g, yield 20%.

EXAMPLE 11 Ellipeiopsis
psis cherrevensis R .; E. FIG. Fri
es. ) 100 g of dried crushed seeds was subjected to reflux extraction with 2 liters of ethanol and concentrated under reduced pressure to dryness. Extract yield 7
The yield was 7%. The extract thus obtained was liquid-liquid partitioned with ethyl acetate (100 ml × 2) -water (100 ml), and the ethyl acetate layer was recovered and concentrated to dryness. Extract yield 5.95 g, yield 6.0%.

Example 12 Anomianthus auritus
auritus Backre ex K. Heyn
e) 300 g of dried crushed seeds was extracted with 4 liters of ethyl acetate. The seed residue was extracted again with 1 liter of ethyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 54g, yield 18%.

Example 13 Anomianthus argentius ( Anomiant
200 g of a dried crushed product of Hus argenteus Backer) was Soxhlet extracted with 4 liters of petroleum ether. Then, petroleum ether was concentrated under reduced pressure to dryness. Extract yield 50 g, yield 25%.

Example 14 Anomianthus Heteroarbs
us hetrocarps Zoll. ) 500 g of dried crushed seeds is refluxed and extracted with 5 liters of ethanol,
When dried under reduced pressure, the extract yield was 50 g and the yield was 10%. The extract thus obtained was liquid-liquid partitioned with ethyl acetate (500 ml × 2) -water (500 ml), and the ethyl acetate layer was recovered and concentrated to dryness. Extract yield 39 g, yield 7.8%.

Example 15 Artabotry odratissima
s odoratissimus R. Br. ) 200 g of dried crushed seeds was reflux-extracted with 4 liters of 70% ethanol. Then, 70% ethanol of the solvent was distilled off. The extract yield was 32 g and the yield was 16%. The extract thus obtained was added to ethyl acetate (500 ml × 2)
-Liquid-liquid partition was performed with water (500 ml), the ethyl acetate layer was recovered, and concentrated under reduced pressure to dryness. Extract yield 25.6 g, yield 12.8%.

Example 16 Artabotrys Harmandi
harmandii Finet & Gagne
p. ) 800 g of dried seeds were extracted with 40 liters of methanol. Then, the solvent methanol was distilled off. The extract yield was 192 g and the yield was 24%. The extract thus obtained was treated with ethyl acetate (2 liters x
2) Liquid-liquid partition was performed with water (2 liters), the ethyl acetate layer was recovered, and concentrated under reduced pressure to dryness. Extract yield 145g,
Yield 18%.

Example 17 Melodorum aberrans
J. Sincl. ) 300 g of dried seeds were extracted with 7 liters of acetone. Seed residue again with acetone 1
Extracted in liters. Both extracts were combined and concentrated under reduced pressure to dryness. The extract yield was 60 g and the yield was 20%. The extract thus obtained was mixed with ethyl acetate (800 ml
X2) -Water (800 ml) was used for liquid-liquid partition, the ethyl acetate layer was collected, and concentrated under reduced pressure to dryness. Extract yield 48g,
Yield 16%.

Example 18 Goniothalamus
tapis Miq. 1 kg of dried seed crushed product was extracted with 30 liters of butyl acetate. The seed residue was extracted again with 5 liters of butyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 180
g, 18% yield.

Example 19 Annona bullata
R. Rich. ) 400 g of dried seeds were extracted with 5 l of ethyl acetate. Seed residue again with ethyl acetate 1
Extracted in liters. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 72g, yield 18%.

Example 20 Cherimoya ( Annona cherimola Mi
(1ler) 1 kg of dried crushed seeds was extracted with 30 liters of butyl acetate and concentrated to dryness under reduced pressure. Extract yield 200 g, yield 20%.

Example 21 Annona densico
ma Mart. ) 100 g of dried crushed seeds was subjected to reflux extraction with 2 liters of ethanol and concentrated under reduced pressure to dryness. Extract yield 10 g, yield 10%. The extract thus obtained was added to ethyl acetate (120 ml × 2) -water (100 m).
Liquid-liquid partition was carried out in l), and the ethyl acetate layer was recovered and concentrated to dryness. Extract yield 8.1g, 81% yield.

Example 22 Hoshiban Reishi ( Annona montana Ma
cfad. ) 300 g of dried seeds were Soxhlet extracted with 5 liters of petroleum ether. Then, petroleum ether was concentrated under reduced pressure to dryness. Extract yield 51 g, yield 17%.

Example 23 Asimina triloba
Dun. ) 500 g of dry seed crushed material was Soxhlet extracted with 8 liters of petroleum ether. Then, petroleum ether was concentrated under reduced pressure to dryness. Extract yield 90 g, yield 18%.

Example 24 Goniothala
mus giganteus Hook. f. & Th
oms. ) 500 g of dried crushed seeds was extracted with 15 liters of butyl acetate and concentrated under reduced pressure to dryness. Extract yield 80g, 16% yield.

Example 25 Rollinia mem
branacea Planch. & Triana)
800 g of dried seeds were extracted with 20 liters of acetone. The residue was extracted again with 3 liters of acetone, and both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 150
g, yield 18.8%. The extract thus obtained was liquid-liquid partitioned with ethyl acetate (1.5 l × 2) -water (1.5 l), and the ethyl acetate layer was recovered and concentrated under reduced pressure to dryness. Extract yield 125g, yield 15.6%.

Example 26 Rollinia mucosa
Bail. ) 100 g of dried seed crushed with hexane 2
Degreased in liters. Then, the seed residue is washed with ethyl acetate 2
It was extracted with kg and concentrated under reduced pressure to dryness. Extract yield 20
g, 20% yield.

Example 27 Rollinia papi
lionella Diels. ) Dried crushed seeds 5
00 g was extracted with 6 liters of ethyl acetate and concentrated under reduced pressure to dryness. Extract yield 75 g, yield 15%.

Example 28 Rollinia sylvica
atica Warm. ) 200 g of dried seeds were extracted with 8 liters of acetone. The seed residue was extracted again with 5 liters of acetone. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 34 g, yield 17%.

Example 29 Rollinia ulei Di
els. ) 100 g of dried seeds crushed with hexane 2.5
Soxhlet extraction in liters. Then, hexane was distilled off, and the mixture was concentrated under reduced pressure to dryness. Extract yield 22g, 22% yield.

Example 30 Uvaria acumina
(Ta Oliver) dry crushed product (500 g) was extracted with 20 liters of butyl acetate and concentrated under reduced pressure to dryness. Extract yield 95g, yield 19%.

Example 31 Uvaria narum Wal
l. ) 200 g of dried crushed seeds were mixed with 70% ethanol 4
Extracted under reflux with liter. Then, the yield of the extract obtained by distilling off 70% of the solvent ethanol was 36 g (yield 18%). The extract thus obtained was added to ethyl acetate (500 ml x
2) -Water (500 ml) was used for liquid-liquid partition, the ethyl acetate layer was collected, and concentrated under reduced pressure to dryness. Extract yield 30 g, 15% yield.

Example 32 Anomianthus argentius ( Anomiant
Dried crushed product of Hus argenteus Backer) (500 g) was extracted with 15 liters of ethyl acetate. The seed residue was extracted again with 5 l of ethyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 90 g, yield 18%.

Example 33 Annona reticulata
L. ) 1 kg of dried crushed seeds was mixed with butyl acetate 2
Extracted with 0 liters. The seed residue was extracted again with 5 liters of butyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 150 g, yield 15%.

Example 34 Annona montana Ma
cfad. ) 500 g of dried crushed seeds was reflux-extracted with 20 L of 70% ethanol. Then, the solvent 70
% Ethanol was distilled off. Extract yield 85g, 17
%. The extract thus obtained was liquid-liquid partitioned with ethyl acetate (1 liter x 2) -water (1 liter), the ethyl acetate layer was recovered, and concentrated under reduced pressure to dryness. Extract yield 7
0 g, 14% yield.

Example 35 Thornbill ( Annona muricata)
L. ) 300 g of dried seeds were extracted with 8 liters of acetone. The seed residue was extracted again with 5 liters of acetone. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 51 g, yield 17%.

Example 36 Cherimoya ( Annona cherimola Mi
ller. ) Ethanol 2 with 100 g of dried crushed seeds
It was subjected to reflux extraction with liter and concentrated under reduced pressure to dryness. Extract yield 13 g, yield 13%. The extract thus obtained was liquid-liquid partitioned with ethyl acetate (100 ml × 2) -water (100 ml), and the ethyl acetate layer was recovered and concentrated to dryness. Extract yield 10 g, yield 10%.

Example 37 Thornbill ( Annona muricata)
L. ) 100 g of dried crushed seeds was subjected to reflux extraction with 2 liters of ethanol and concentrated under reduced pressure to dryness. Extract yield 17
g, 17% yield. The extract thus obtained was liquid-liquid partitioned with ethyl acetate (100 ml × 2) -water (100 ml), and the ethyl acetate layer was recovered and concentrated to dryness. Extract yield 13 g, yield 13%.

Example 38 Annona reticulata
L. ) 200 g of dried seeds were extracted with 5 l of ethyl acetate. The seed residue was extracted again with 1 liter of ethyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 32g, 16% yield.

Example 39 Cherimoya ( Annona cherimola Mi
ller. ) 500 g of dried crushed seeds was mixed with ethyl acetate 6
Extracted in liters. The seed residue was extracted again with 1 liter of ethyl acetate. Both extracts were combined and concentrated under reduced pressure to dryness. Extract yield 65 g, yield 13%.

Example 40 Annona montana Ma
cfad. ) 500 g of dried crushed seeds was added to ethanol 5
It was subjected to reflux extraction with liter and concentrated under reduced pressure to dryness. Extract yield 105 g, 21% yield. The extract thus obtained was added to ethyl acetate (500 ml × 2) -water (500 ml).
The liquid-liquid partition was carried out with and the ethyl acetate layer was collected and concentrated to dryness. Extract yield 85 g, 17% yield.

Formulation examples using the above extract are given (the amount of the extract used in the formulation represents% by weight).

Formulation Example 1 (1) 70% ethanol extract (dry product) in Extraction Example 2.0 2.0 (2) 75% ethanol Residual Formulation Example 2 (1) Extract of Extraction Example 6 (dry product) 5 (2) 75% ethanol Residual formulation example 3 (1) Ethyl acetate re-extract (dry product) extracted with methanol in extraction example 1 0.01 (2) Ethanol residual formulation example 4 (1) Acetone extraction in extraction example 8 Dry matter 0.3 (2) Acetone extract in Extraction Example 9 (dry matter) 0.5 (3) 75% ethanol Residual formulation example 5 (1) Extraction Example 7 extract (dry matter) 1 (2) Acetone extract of Extraction example 9 (dry product) 0.9 (3) 75% ethanol Residual formulation example 6 (1) Extract of extract example 10 (dry product) 0.2 (2) Extraction example 11 Extract (dried product) in 0.3 (3) 75% ethanol Residual formulation example 7 (1) Extraction example 2 Source (dry matter) 0.1 (3) 75% ethanol Residual formulation example 8 1) Extract (dry matter) 0.5 of extraction example 12 2) 75% Ethanol formulation example 9 1) Extract of extraction example 13 (Dry matter) 1.0 2) 75% ethanol formulation example 10 1) Ethyl acetate re-extract of ethanol extraction of Extraction example 14 (dry matter) 0.01 2) 75% ethanol formulation example 11 1) Extraction example 15 70% ethanol extract (dry matter) 0.5 2) 75% ethanol 0.01 Formulation Example 12 1) Methanol extract of Extraction Example 16 0.3 2) Ethyl acetate re-extract of acetone extraction of Extraction Example 17 ( Dry matter) 0.3 3) Extract of Extraction Example 18 (dry matter) 0.4 4) 75% ethanol 0.4 Formulation Example 13 1) 70% ethanol extract according to Extraction Example 3 (extraction before solvent evaporation) things) 0.1 2) 75% ethanol balance formulation example 14 1) extraction example 3 Cormorant 70% ethanol extract (dry matter) 0.005 2) Menthol 0.1 3) 75% ethanol balance Formulation Example 15 1) 70% ethanol extract according to extraction example 3 (dry matter) 0.005 2) nicotinic acid Benzyl 0.5 3) 75% ethanol residual formulation example 16 1) 70% ethanol extract (dry matter) according to extraction example 3 0.005 2) Nicotinamide 0.8 3) 75% ethanol residual formulation example 17 1) 70% ethanol extract according to Extraction Example 3 (dry matter) 0.005 2) Pantothenyl ethyl ether 0.1 3) 75% ethanol Residual formulation example 18 1) 70% Ethanol extract according to Extraction Example 3 (dry matter) 0 .005 2) salicylic acid 0.5 3) vitamin E acetate 0.2 4) hinokitiol 0.1 5) 75% ethanol balance formulation example 19 1) extraction example 4 extract Dry matter) 1.0 2) 75% ethanol balance Formulation Example 20 1) extract (dried product of Extract Example 5) 0.2 2) 75% ethanol balance Formulation Example 21 1) Extraction Example 19 extract (dry matter ) 0.5 2) 75% ethanol residual formulation example 22 1) Extraction example 20 extract (dry matter) 0.3 2) Extraction example 21 extract (dry matter) 0.3 3) 75% ethanol residual formulation Example 23 1) Extract of Example 22 (dry matter) 0.2 2) Extract of Example 23 (dry matter) 0.2 3) Extract of Example 24 (dry matter) 0.2 4) 75 % Ethanol Residual formulation example 24 1) Extract of Extraction example 25 (dry matter) 1.0 2) 75% Ethanol Residual formulation example 25 1) Extract of Extraction example 26 (dry matter) 0.3 2) Extraction example 27 Extract (dry product) 0.3 3) Extract of Example 28 (dry product) 0.3 4) 75% ethanol residue Formulation Example 26 1) Extraction Example 29 extract (dry matter) 0.2 2) 75% ethanol balance Formulation Example 27 1) Extraction Example 30 extract (dry matter) 0.5 2) extract of Extract Example 31 (Dry product) 0.5 3) 75% ethanol Residual hair growth effect The results of the above hair growth test for each preparation are shown below (the control example is a 75% ethanol solution).

[0066] KoTsuta the trichogram tested using the formulation prepared in trichogram test above Formulation Examples 1 to 6. The results are shown in the table below.

[0067]

[Table 1]

From the above results, it is understood that the composition of the present invention has an action of significantly reducing the number of resting hair roots. Such an effect was similarly observed in the other compositions of the present invention.

Throughout the present test, it was confirmed that the composition of the present invention did not exert any adverse effect on the scalp as in the case of the control.

For prevention of dandruff and hair loss and promotion of hair growth
Actual use test against the same For the purpose of performing the title test on the hair nut, a hair nut having the following composition was prepared.

[0071] The above hair nicks are applied to 15 men (ages 25 to 55 years old) having symptoms such as dandruff, hair growth and hair loss 1-2 times a day.
Administered 1 to 3 ml each for 4 months, and Table 1 below.
Was obtained. As is clear from Table 1, excellent results are achieved for promoting hair nick hair growth and preventing dandruff and hair loss.

(1) Antidandruff Effect Test “Ineffective” means that no improvement is observed despite treatment.

"Effective" means that the occurrence of dandruff is reduced.

“Remarkably effective” means that the occurrence of dandruff has stopped.

(2) Hair growth result test [Ineffective] means that no improvement is observed despite treatment.

[Effective] means that ⅔ or more of new hair is recognized in the hair loss part.

"Remarkably effective" The hair is grown on the hair loss part.

(3) Hair loss effect test "Ineffective" means that no improvement is observed despite treatment.

“Effective” means that the progression of the hair loss part is reduced.

“Remarkably effective” means that hair loss has stopped.

[0081] Other formulation examples are shown below. In addition, all compounding amounts are weight%.

Formulation Example 28 Heart Nick (1) Extract of Extraction Example 3 1.3 (2) Extract of Extraction Example 20 (dried product) 0.05 (3) Polyoxyethylene (60) hydrogenated castor oil 0.5 (4) Sodium hyaluronate 0.01 (5) 75% ethanol Residual formulation example 29 Heart nick (1) Extraction example 6 extract 3.0 (2) Extraction example 32 extract (dry product) 1.0 (3) ) Polyoxyethylene (60) Hydrogenated castor oil 0.3 (4) Propylene glycol 5.0 (5) Sodium hyaluronate 0.01 (6) 75% ethanol Residue Hair growth and hair growth in both formulations 28 and 29. It was shown to be effective in preventing hair loss.

Further, the following preparation was produced by a conventional method. In addition, all compounding amounts are weight%.

Formulation Example 30 Heart nick (1) Hinokitiol 0.1 (2) Assembly extract 1.0 (3) Vitamin B ₆ 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic acid 0.1 (7) Acetic acid ethyl ester extract of Extraction Example 0.5 (8) Pantothenyl ethyl ether 0.5 (9) Polyoxyethylene (60) Hydrogenated castor oil 0.1 (10) Propylene glycol 2. 0 (11) 75% ethanol Residual formulation example 31 Heart nick (1) Hinokitiol 0.1 (2) Assembly extract 1.0 (3) Vitamin B ₆ 0.2 (4) Vitamin E 0.01 (5) Menthol 0.0 2 (6) Salicylic acid 0.1 (7) Acetone extract of Extraction Example 1.0 (8) Polyoxyethylene (60) Hydrogenated castor oil 0.1 (9) Propylene glycol 2.0 (10) 75 % Ethanol Residual formulation example 32 Heart nick (1) Hinokitiol 0.1 (2) Assembly extract 1.0 (3) Vitamin B ₆ 0.2 (4) Vitamin E acetate 0.01 (5) Menthol 0.2 (6) Salicylic acid 0.1 (7) Extract of Example 33 0.1 (8) Polyoxyethylene (60) Hydrogenated castor oil 0.1 (9) Propylene glycol 2.0 Formulation 33 Heart art (1) Hinokitiol 0.1 (2) Assembly extract 1.0 (3) Vitamin B ₆ 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic acid 0.1 (7) Extraction of acetic acid butyl ester of Example 7 things 0.5 (8) polyoxyethylene (60) hardened castor oil 0.1 (9) propylene glycol 2.0 (10) nicotinic acid amide 0.5 (11) 75% ethanol balance formulation example 34 Art Nitsuku (1) Hinokitiol 0.1 (2) assembly extract 1.0 (3) Vitamin B ₆ 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic acid 0.1 (7 ) Extraction Example 70 70% ethanol extract 1.0 (8) Polyoxyethylene (5) Polyoxypropylene (15) Block copolymer 0.1 (9) Propylene glycol 2.0 (10) 75% ethanol Residual Formulation Example 35 Heart art (1) Hinokitiol 0.1 (2) Assembly extract 1.0 (3) Vitamin B ₆ 0.2 (4) Vitamin E 0.01 (5) Menthol 0.2 (6) Salicylic acid 0.1 (7) Acetone extract of Extraction Example 1.0 (8) Polyoxyethylene (60) Hydrogenated castor oil 0.1 (9) Propylene glycol 2.0 (10) 75% ethanol Residue (11) Nicochi Benzyl 0.3 Formulation Example 36 Shampoo (1) cocoyl methyl taurate sodium 2.0 (2) Polyoxyethylene (8 moles) oleyl alcohol ether 2.0 (3) Lauric acid diethanolamide 4.0 (4) Ethylene glycol Fatty acid ester 1.0 (5) Glycerin 2.0 (6) Menthol 0.1 (7) Extract of Example 35 2.0 (8) Disodium edetate 0.1 (9) Perfume proper amount (10) Purification Water balance Formulation Example 37 Shampoo (1) Cocoyl methyl taurine sodium 2.0 (2) Polyoxyethylene (8 mol) oleyl alcohol ether 2.0 (3) Lauric acid diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1 .0 (5) Glycerin 2.0 (6) Menthol 0.1 (7) Extract of Example 35 1.0 (8) D Preparative 2 Sodium 0.1 (9) Perfume Appropriate amount (10) Purified water balance Formulation Example 38 Shampoo (1) cocoyl methyl taurate sodium 2.0 (2) Polyoxyethylene (8 moles) oleyl alcohol ether 2.0 (3 ) Lauric acid diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1.0 (5) Glycerin 0.2 (6) Menthol 0.1 (7) Extract of Extraction Example 36 0.5 (8) Editoic acid Sodium 0.1 (9) Perfume proper amount (10) Purified water Balance Preparation Example 39 Shampoo (1) Sodium cocoyl methyl taurine 2.0 (2) Polyoxyethylene (8 mol) oleyl alcohol ether 2.0 (3) Lauric acid Diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1.0 (5) Glycerin 0.2 (6) Menthol 0.1 (7) Extract of Extraction Example 0.5 (8) Sodium edetiodate 0.1 (9) Perfume proper amount (10) Purified water Balance of rest Example 40 Shampoo (1) Sodium cocoylmethyl taurine 2.0 (2) Polyoxyethylene (8 mol) oleyl alcohol ether 2.0 (3) lauric acid diethanolamide 4.0 (4) ethylene glycol fatty acid ester 1.0 (5) glycerin 0.2 (6) menthol 0.1 (7) Acetone extract of Extraction Example 1.0 (8) Sodium edetodiate 0.1 (9) Aroma (appropriate amount) (10) Purified water Residual formulation example 41 Shampoo (1) Sodium cocoylmethyl taurine 2.0 (2) Polyoxy Ethylene (8 mol) oleyl alcohol ether 2.0 (3) Lauric acid diethanolamide 4.0 (4) Ethylene glycol fatty acid ester 1.0 5) Glycerin 0.2 (6) Menthol 0.1 (7) ethanol extract 2.0 (8) edetate 2 Sodium 0.1 (9) Perfume Appropriate amount (10 Extraction Example 37) Purified water balance Formulation Example 42 Rinse (1) Stearyl trimethyl ammonium chloride 1.5 (2) Dimethyl polysiloxane (20 cs) 3.0 (3) Polyoxyethylene (10 mol) oleyl alcohol ether 1.0 (4) Glycerin 5.0 (5) Extraction Extract of Example 38 0.2 (6) Preservative Suitable amount (7) Ultraviolet absorber Suitable amount (8) Purified water Balance Preparation Example 43 Rinse (1) Stearyltrimethylammonium chloride 1.5 (2) Dimethylpolysiloxane (20cs) 3.0 (3) Polyoxyethylene (10 mol) oleyl alcohol ether 1.0 (4) Glycerin 5.0 (5) Acetate of Extraction Example 8 Extract 1.0 (6) Preservative qs (7) Ultraviolet absorber qs (8) Purified water Balance Formulation Example 44 Rinse (1) Stearyl trimethyl ammonium chloride 1.5 (2) Dimethyl polysiloxane (20 cs) 3.0 (3) Polyoxyethylene (10 mol) oleyl alcohol ether 1.0 (4) Glycerin 5.0 (5) Extract of Example 39 0.1 (6) Preservative proper amount (7) UV absorber proper amount (8) ) Purified water Residual formulation example 45 Rinse (1) Stearyl trimethyl ammonium chloride 1.5 (2) Dimethyl polysiloxane (20 cs) 3.0 (3) Polyoxyethylene (10 mol) oleyl alcohol ether 1.0 (4) Glycerin 5.0 (5) extract 1.0 extract example 5 (6) preservative qs (7) ultraviolet absorber qs (8) purified water balance formulation example 46 Li Su (1) Stearyl trimethyl ammonium chloride 1.5 (2) Dimethyl polysiloxane (20 cs) 3.0 (3) Polyoxyethylene (10 mol) oleyl alcohol ether 1.0 (4) Glycerin 5.0 (5) Extraction Extract of Example 4 0.5 (6) Preservative Appropriate amount (7) Ultraviolet absorber Adequate amount (8) Purified water Balance Preparation Example 47 Rinse (1) Stearyltrimethylammonium chloride 1.5 (2) Dimethylpolysiloxane (20cs) 3.0 (3) Polyoxyethylene (10 mol) oleyl alcohol ether 1.0 (4) Glycerin 5.0 (5) Extract of Extraction Example 35 1.0 (6) Preservative proper amount (7) UV absorber qs (8) purified water balance formulation example 48 Skull Bed treatment (1) flow Parafun 27.0 (2) stearic acid 5.0 (3) Setano 5.0 (4) Sorbitan monooleate 2.0 (5) Polyoxyethylene sorbitan monooleate 3.0 (6) Ethyl acetate extract of Extraction Example 0.5 0.5 (7) 1.3-Butylene glycol 5.0 (8) Preservative Appropriate amount (9) Purified water Remainder Components (5) to (6) are dissolved in components (1) to (4),
After being heated to 0 ° C. to be uniformly dissolved, it is cooled to 30 ° C., and this is mixed with components (7) to (9) adjusted to 30 ° C. and stirred to produce.

The following formulation examples were also produced in the same manner.

Formulation Example 49 Scarb Treatment (1) Liquid Parafun 27.0 (2) Stearic Acid 5.0 (3) Cetanol 5.0 (4) Sorbitan Monooleate 2.0 (5) Extraction Example 35 Extraction Product 1.0 (6) 1.3-Butylene glycol 5.0 (8) Preservative proper amount (9) Purified water Balance formulation example 50 Scalb treatment (1) Liquid parafun 27.0 (2) Stearic acid 5.0 (3) Cetanol 5.0 (4) Sorbitan monooleate 2.0 (5) Polyoxyethylene sorbitan monooleate 3.0 (6) Extraction Example 36 ethanol extract 0.5 (7) 1.3- butylene glycol 5.0 (8) preservative qs (9) purified water balance formulation example 51 Skull Bed treatment (1) flow Parafun 27.0 (2) stearic acid 5.0 (3) cetanol 5.0 ( ) Sorbitan monooleate 2.0 (5) Extraction Example 6 ethyl acetate extract 1.0 (6) 1.3 butylene glycol 5.0 (8) Preservative qs (9) Purified water Balance Formulation Example 52 Skull Butreatment (1) Liquid parafun 27.0 (2) Stearic acid 5.0 (3) Cetanol 5.0 (4) Sorbitan monooleate 2.0 (5) Ethyl acetate partition of Extraction Example 9 0.1 (6) ) 1.3-Butylene glycol 5.0 (8) Preservative proper amount (9) Purified water Remainder formulation example 53 Scalb treatment (1) Liquid parafun 27.0 (2) Stearic acid 5.0 (3) Cetanol 5. 0 (4) Sorbitan monooleate 2.0 (5) Extract of Extraction Example 22 1.0 (6) 1.3-Butylene glycol 5.0 (8) Preservative proper amount (9) Purified water Residual formulation example 54 Skull Treatment (1 ) Liquid parafun 27.0 (2) Stearic acid 5.0 (3) Cetanol 5.0 (4) Sorbitan monooleate 2.0 (5) Extract of Extraction Example 4 0.5 (6) Extraction Example 4 Acetone extract 0.3 (7) 1.3-Butylene glycol 5.0 (8) Preservative proper amount (9) Purified water balance

[0087]

INDUSTRIAL APPLICABILITY The present invention provides a head composition which is particularly effective in preventing and improving dandruff, itchiness, hair loss and the like, which is superior to conventional head compositions. Such an effect can be obtained by using a fat-soluble component derived from the seeds of a plant belonging to the Anopheles family as one component of the head composition.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Hisayuki Komazaki 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Inside Shiseido Daiichi Research Center, Inc. (72) Inventor Koji Kobayashi 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Stock company Shiseido Daiichi Research Center (72) Inventor Hirohiko Sakamoto 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Stock Company Shiseido Daiichi Research Center (72) Inventor Chika Harusawa, Kohoku-ku, Yokohama-shi, Kanagawa Shibaido Daiichi Research Center, Inc. 1050, Nippa-cho (72) Inventor Yoshiharu Tsuji, Shibaido Daiichi Research Center, 1050 Niba-cho, Kohoku-ku, Yokohama, Kanagawa Prefecture (72) Inventor Shin Tsunao, Kanagawa Yokohama, Kanagawa Shiseido Daiichi Research Center Co., Ltd. 1050 Shinba-cho, Kohoku Ward (72) Toshiyuki Nishi, 14th Nishinoshomonguchi-cho, Kichijoin, Minami-ku, Kyoto-shi, Kyoto Prefecture Nippon Shinyaku Co., Ltd.

Claims (16)

[Claims] 1. Anemoneaceae ( Annonaceae )
A head composition comprising an extract derived from the seeds of at least one plant belonging to the formula (1) as an active ingredient, wherein the extract is mainly composed of a fat-soluble ingredient. 2. The extract has at least 6 parts by weight based on its total weight.
2. 1% by weight of fat-soluble components.
A composition as described. 3. The plant is of the genus Annona ( Annona).
L. ), Anomianthus
Zoll. ), Ellipio
psi R. E. FIG. Fries), Artabotrys R. Br., Melodrum Hook.f., and Goniothalamus Hook.
f. ) Asimina genus ( Asimina Adans.),
Rorinia genus (Rollinia A.St.Hil.)
And the composition according to claim 1, which belongs to the genus Uvaria ( Uvaria L.). 4. The plant is Anemone ( Annona s)
quamosa L .; ), Chierimoya ( Annona
cherimola Miller), Hoshiban Reishi ( Annona montana Macfad.),
Togeban Reishi ( Annona muricata)
L. ), Giuna Shinri ( Annona reticula
ta L. ), An'nona Brata (Annona bu
Llata A. Rich. ) And Annona densicoma Mar
t. ) Is the composition of claim 1 or 2. 5. The plant is Anomianthus dulucis J. Si.
ncl. ), Anomianthus Auritus ( Anomi
anthus auritus Backer ex
K. Heyne), Anomiansasu Al Jenchi mouse (Anomianthus argenteus Ba
cker), Anomianthus Heterocarps ( Ano
mianthus hetrocarpus Zol
l. ) Is the composition of claim 1 or 2. 6. The plant is Artabotrys odoratissimu.
s R. Br. ), Artabotris Harmandi ( A
rtabotrys harmandii Finet
& Gagnep. ) Is the composition of claim 1 or 2. 7. The plant is a vine ( Merodor).
um aberrans J. Sincl. ) Is the composition of claim 1 or 2. 8. The plant is Goniotarums tapis ( Go
niothalamus tapis Miq. ), Goniotalamus Giganthaus
us giganteus Hook f. & Tho
ms. ) Is the composition of claim 1 or 2. 9. The plant is Asimina trilobus ( Asimi).
na triloba Dun. ) Is the composition of claim 1 or 2. 10. The plant is Rolinia membracea ( Ro).
llinia membranasea Planc
h. & Triana), Rolinia Mukosa ( Roll)
inia mucosa Bail . ), Rolinia
Papirionera (Rollinia papilione
lla Diels), Rolinia Silvačka ( Rol
linia sylvatica Warm. ), Rollinia ulei Diel
The composition according to claim 1 or 2, which is s). 11. The extract is Uvalia acluminata ( Uv).
aria acuminata Oliver, Uvaria narum Wall.
The composition according to claim 1 or 2, which is 12. The plant is an anemone ( Annona).
squamosa L .; ) Is the composition of claim 1 or 2. 13. The plant is Anomianthus dulucis J. Si.
ncl. ) Is the composition of claim 1 or 2. 14. The plant is Ellipeiopsis cherreve.
nsis R. E. FIG. Fries).
A composition as described. 15. The composition according to claim 1, wherein the extract is a hydrous ethanol extract. 16. Salicylic acid, vitamin E acetate,
The composition according to any one of claims 1 to 15, further comprising, as an active ingredient, one or more components selected from the group consisting of menthol, hinokitiol, benzyl nicotinate, nicotinamide and pantothenyl ethyl ether.