JPH08510716A - 安定化されたランチオニンバクテリオシン組成物 - Google Patents
安定化されたランチオニンバクテリオシン組成物Info
- Publication number
- JPH08510716A JPH08510716A JP6514346A JP51434694A JPH08510716A JP H08510716 A JPH08510716 A JP H08510716A JP 6514346 A JP6514346 A JP 6514346A JP 51434694 A JP51434694 A JP 51434694A JP H08510716 A JPH08510716 A JP H08510716A
- Authority
- JP
- Japan
- Prior art keywords
- nisin
- composition
- bacteriocin
- lanthionine
- methionine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ランチオニン含有バクテリオシン及びチオエーテル安定剤を含んで成る分解 に対して安定化されたランチオニン含有バクテリオシン組成物。 2.バクテリオシンがナイシンである請求の範囲第1項記載の組成物。 3.ランチオニン含有バクテリオシンと式(I): R1-S-R2 (I) [式中R1は、1〜6個の炭素原子を有するアルキル (式中、nは、0〜5であり;R3は、水素原子、アミノ基、又はヒドロキシル基 であり;そしてR4は、水素原子、カルボキシル基、エステル基又はアミド基であ り、アミノ官能性はアミノ酸残基の寄与による)を有するか、あるいは、R1及び R2は一緒に結合して、硫黄とともに、チアゾリジン環を形成する]で表される化 合物を含んで成る分解に対して安定化されたランチオニン含有バクテリオシン組 成物。 4.前記組成物は、界面活性剤も含んで成る請求の範囲第3項記載の組成物。 5.前記組成物は、キレート化剤も含んで成る請求の 範囲第3項記載の組成物。 6.前記バクテリオシンがナイシンである請求の範囲第3項記載の組成物。 7.前記界面活性剤がポリソルベートである請求の範囲第4項記載の組成物。 8.前記キレート化剤が、EDTA又はクエン酸塩である請求の範囲第5項記載 の組成物。 9.前記式(I)の化合物は、メチオニン又はメチオニンヒドロキシ類似体であ る請求の範囲第3項記載の組成物。 10.メチオニンの濃度が1〜50mMの範囲にある請求の範囲第9項記載の組 成物。 11.メチオニンの濃度が1〜10mMの範囲にある請求の範囲第10項記載の 組成物。 12.濃度範囲0.1〜1000μg/mlのバクテリオシン、濃度範囲0.1 〜10%の界面活性剤、濃度範囲0.1〜20mMのキレート化剤、及び1mM 〜50mMの濃度範囲のチオエーテル安定剤を含んで成る分解に対して安定化さ れたランチオニン含有バクテリオシン組成物。 13.前記バクテリオシンがナイシンであり、安定化剤がメチオニンである請求 の範囲第12項記載の組成物。 14.組成物のランチオニンバクテリオシン成分を分解に対して安定化する請求 の範囲第3項の式(I)に係る化合物の利用法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98667192A | 1992-12-08 | 1992-12-08 | |
US07/986,671 | 1992-12-08 | ||
PCT/US1993/011884 WO1994013143A1 (en) | 1992-12-08 | 1993-12-08 | Stabilized lanthionine bacteriocin compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08510716A true JPH08510716A (ja) | 1996-11-12 |
JP3692389B2 JP3692389B2 (ja) | 2005-09-07 |
Family
ID=25532645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51434694A Expired - Lifetime JP3692389B2 (ja) | 1992-12-08 | 1993-12-08 | 安定化されたランチオニンバクテリオシン組成物 |
Country Status (12)
Country | Link |
---|---|
US (1) | US5763395A (ja) |
EP (1) | EP0673199B1 (ja) |
JP (1) | JP3692389B2 (ja) |
AT (1) | ATE177904T1 (ja) |
AU (1) | AU5743094A (ja) |
DE (1) | DE69324159T2 (ja) |
DK (1) | DK0673199T3 (ja) |
ES (1) | ES2130401T3 (ja) |
GR (1) | GR3029943T3 (ja) |
IL (1) | IL107887A (ja) |
WO (1) | WO1994013143A1 (ja) |
ZA (1) | ZA939170B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018203726A (ja) * | 2017-06-01 | 2018-12-27 | 学校法人日本大学 | 除菌剤、除菌方法及び除菌キット |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5912228A (en) * | 1995-01-13 | 1999-06-15 | Xoma Corporation | Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products |
GB9510719D0 (en) * | 1995-05-26 | 1995-07-19 | Smithkline Beecham Plc | Novel compositions |
US5762948A (en) * | 1995-06-07 | 1998-06-09 | Ambi Inc. | Moist bacteriocin disinfectant wipes and methods of using the same |
AU7365596A (en) * | 1995-09-20 | 1997-04-09 | Ambi Inc. | Nisin compositions to prevent the promotion of tooth decay bysuppressing formation of acid from foods by oral bacteria |
US6759050B1 (en) * | 1998-12-03 | 2004-07-06 | Avigen, Inc. | Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith |
JP2000247903A (ja) * | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
BR0014486A (pt) * | 1999-10-04 | 2002-09-17 | Chiron Corp | Composições farmacêuticas contendo polipeptìdeo lìquido estabilizado |
AU2004204720B2 (en) | 2003-01-08 | 2009-08-06 | Novartis Vaccines And Diagnostics, Inc. | Stabilized aqueous compositions comprising tissue factor pathway inhibitor (TFPI) or tissue factor pathway inhibitor variant |
ATE433746T1 (de) * | 2004-03-12 | 2009-07-15 | Biodel Inc | Insulinzusammensetzungen mit verbesserter wirkstoffabsorption |
GB0410038D0 (en) * | 2004-05-05 | 2004-06-09 | Danisco | Composition |
WO2007044700A2 (en) * | 2005-10-07 | 2007-04-19 | Board Of Trustees Of Southern Illinois University | Protectant combinations for reducing toxicities |
GB0600928D0 (en) * | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
US8617568B2 (en) | 2007-07-10 | 2013-12-31 | Medy-Tox, Inc. | Pharmaceutical liquid composition of botulinum toxin with improved stability |
EP2182798B1 (en) | 2007-07-16 | 2020-11-18 | Allvivo Vascular, Inc. | Antimicrobial constructs |
GB0714030D0 (en) * | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
GB0714029D0 (en) * | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
AR073014A1 (es) * | 2008-08-12 | 2010-10-06 | Dsm Ip Assets Bv | Composiciones liquidas de nisina |
US9120861B2 (en) * | 2008-10-17 | 2015-09-01 | Mississippi State University | Functional enhancement of antimicrobials |
CA2749278A1 (en) * | 2009-01-14 | 2010-07-22 | Novacta Biosystems Limited | Deoxyactagardine derivatives |
CN102388060B (zh) | 2009-02-04 | 2014-09-10 | 诺瓦克塔生物系统有限公司 | 阿肽加定衍生物 |
GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
GB201013513D0 (en) | 2010-08-11 | 2010-09-22 | Novacta Biosystems Ltd | Formulations |
US9200251B1 (en) | 2011-03-31 | 2015-12-01 | David Gordon Bermudes | Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith |
US11110063B2 (en) | 2017-08-25 | 2021-09-07 | MAIA Pharmaceuticals, Inc. | Storage stable sincalide formulations |
US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135910A (en) * | 1988-06-22 | 1992-08-04 | The Public Health Research Institute Of The City Of New York | Nisin compositions for use as enhanced, broad range bactericides |
DE68913189T2 (de) * | 1988-06-22 | 1994-05-19 | Applied Microbiology Inc | Nisin-zusammensetzungen zur anwendung als erhöhte breit-spektrum-bakterizide. |
US4980163A (en) * | 1989-03-01 | 1990-12-25 | Public Health Research Institute Of The City Of New York | Novel bacteriocin compositions for use as enhanced broad range bactericides and methods of preventing and treating microbial infection |
DK0431663T3 (da) * | 1989-12-06 | 1994-03-07 | Akzo Nobel Nv | Stabiliserende opløsninger af psykotrope midler |
US5272135A (en) * | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
-
1993
- 1993-12-06 IL IL10788793A patent/IL107887A/xx not_active IP Right Cessation
- 1993-12-07 ZA ZA939170A patent/ZA939170B/xx unknown
- 1993-12-08 AU AU57430/94A patent/AU5743094A/en not_active Abandoned
- 1993-12-08 JP JP51434694A patent/JP3692389B2/ja not_active Expired - Lifetime
- 1993-12-08 WO PCT/US1993/011884 patent/WO1994013143A1/en active IP Right Grant
- 1993-12-08 DK DK94903513T patent/DK0673199T3/da active
- 1993-12-08 AT AT94903513T patent/ATE177904T1/de not_active IP Right Cessation
- 1993-12-08 ES ES94903513T patent/ES2130401T3/es not_active Expired - Lifetime
- 1993-12-08 DE DE69324159T patent/DE69324159T2/de not_active Expired - Lifetime
- 1993-12-08 EP EP94903513A patent/EP0673199B1/en not_active Expired - Lifetime
-
1995
- 1995-02-09 US US08/386,122 patent/US5763395A/en not_active Expired - Lifetime
-
1999
- 1999-04-13 GR GR990401033T patent/GR3029943T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018203726A (ja) * | 2017-06-01 | 2018-12-27 | 学校法人日本大学 | 除菌剤、除菌方法及び除菌キット |
Also Published As
Publication number | Publication date |
---|---|
AU5743094A (en) | 1994-07-04 |
ZA939170B (en) | 1994-08-08 |
DE69324159D1 (de) | 1999-04-29 |
DK0673199T3 (da) | 1999-05-25 |
US5763395A (en) | 1998-06-09 |
ATE177904T1 (de) | 1999-04-15 |
JP3692389B2 (ja) | 2005-09-07 |
DE69324159T2 (de) | 2009-09-10 |
ES2130401T3 (es) | 1999-07-01 |
EP0673199B1 (en) | 1999-03-24 |
EP0673199A1 (en) | 1995-09-27 |
GR3029943T3 (en) | 1999-07-30 |
WO1994013143A1 (en) | 1994-06-23 |
IL107887A (en) | 2003-07-06 |
IL107887A0 (en) | 1994-04-12 |
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