JPH08509487A - シクロオキシゲナーゼ及び5−リポキシゲナーゼを阻害するヒドロキサム酸誘導体 - Google Patents
シクロオキシゲナーゼ及び5−リポキシゲナーゼを阻害するヒドロキサム酸誘導体Info
- Publication number
- JPH08509487A JPH08509487A JP6524018A JP52401894A JPH08509487A JP H08509487 A JPH08509487 A JP H08509487A JP 6524018 A JP6524018 A JP 6524018A JP 52401894 A JP52401894 A JP 52401894A JP H08509487 A JPH08509487 A JP H08509487A
- Authority
- JP
- Japan
- Prior art keywords
- biphenylyl
- formula
- methyl
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939308652A GB9308652D0 (en) | 1993-04-27 | 1993-04-27 | Anti-inflammatory compounds |
GB9308652-8 | 1993-04-27 | ||
PCT/GB1994/000885 WO1994025430A1 (fr) | 1993-04-27 | 1994-04-26 | Derives de l'acide hydroxamique inhibiteurs de la cyclooxygenase et de la 5-lipoxygenase |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH08509487A true JPH08509487A (ja) | 1996-10-08 |
Family
ID=10734525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6524018A Pending JPH08509487A (ja) | 1993-04-27 | 1994-04-26 | シクロオキシゲナーゼ及び5−リポキシゲナーゼを阻害するヒドロキサム酸誘導体 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0696271A1 (fr) |
JP (1) | JPH08509487A (fr) |
AU (1) | AU6574994A (fr) |
GB (1) | GB9308652D0 (fr) |
WO (1) | WO1994025430A1 (fr) |
ZA (1) | ZA942911B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0807626A4 (fr) * | 1995-02-02 | 1998-05-06 | Nikken Chemicals Co Ltd | Derives de n-hydroxyuree |
JPH11507670A (ja) * | 1995-06-12 | 1999-07-06 | ジー.ディー.サール アンド カンパニー | シクロオキシゲナーゼ−2インヒビターと5−リポキシゲナーゼインヒビターの組合せによる炎症と炎症関連疾患の治療 |
WO2005061448A1 (fr) * | 2003-12-24 | 2005-07-07 | Monash University | Compositions et methodes de traitement d'affections vasculaires |
CN103450077B (zh) | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK117986A (da) * | 1985-03-16 | 1986-09-17 | Wellcome Found | Arylderivater, fremgangsmaader til deres fremstilling og deres anvendelse |
PL154186B1 (en) * | 1987-07-15 | 1991-07-31 | Wellcome Found | Method for manufacturing arylic derivatives of the hydroxamic acid |
FI900536A0 (fi) * | 1989-02-03 | 1990-02-02 | Wellcome Found | Anti-inflammatoriska arylkompositioner. |
JPH06256285A (ja) * | 1990-12-11 | 1994-09-13 | Pfizer Pharmaceut Co Ltd | ヒドロキサム酸誘導体およびその用途 |
US5169854A (en) * | 1992-02-26 | 1992-12-08 | Abbott Laboratories | N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity |
-
1993
- 1993-04-27 GB GB939308652A patent/GB9308652D0/en active Pending
-
1994
- 1994-04-26 ZA ZA942911A patent/ZA942911B/xx unknown
- 1994-04-26 WO PCT/GB1994/000885 patent/WO1994025430A1/fr not_active Application Discontinuation
- 1994-04-26 EP EP94913699A patent/EP0696271A1/fr not_active Ceased
- 1994-04-26 AU AU65749/94A patent/AU6574994A/en not_active Abandoned
- 1994-04-26 JP JP6524018A patent/JPH08509487A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA942911B (en) | 1995-10-26 |
EP0696271A1 (fr) | 1996-02-14 |
GB9308652D0 (en) | 1993-06-09 |
AU6574994A (en) | 1994-11-21 |
WO1994025430A1 (fr) | 1994-11-10 |
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