JPH08505867A - 炎症治療用の可溶性補体レセプター１（ｓｃｒ−１）とアミジノフェニルまたはアミジノナフチルエステルの組み合わせ - Google Patents
炎症治療用の可溶性補体レセプター１（ｓｃｒ−１）とアミジノフェニルまたはアミジノナフチルエステルの組み合わせInfo
- Publication number
- JPH08505867A JPH08505867A JP6516809A JP51680994A JPH08505867A JP H08505867 A JPH08505867 A JP H08505867A JP 6516809 A JP6516809 A JP 6516809A JP 51680994 A JP51680994 A JP 51680994A JP H08505867 A JPH08505867 A JP H08505867A
- Authority
- JP
- Japan
- Prior art keywords
- apan
- amidinophenyl
- treatment
- soluble
- brl55730
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 210000002540 macrophage Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 206010028320 muscle necrosis Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000019254 respiratory burst Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939301289A GB9301289D0 (en) | 1993-01-22 | 1993-01-22 | Novel composition |
| GB9301289.6 | 1993-01-22 | ||
| PCT/GB1994/000122 WO1994016719A1 (en) | 1993-01-22 | 1994-01-21 | Combination of a soluble complement receptor -1(scr1) and an amidinophenyl or amidino naphthyl-ester for treating inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH08505867A true JPH08505867A (ja) | 1996-06-25 |
Family
ID=10729169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6516809A Pending JPH08505867A (ja) | 1993-01-22 | 1994-01-21 | 炎症治療用の可溶性補体レセプター１（ｓｃｒ−１）とアミジノフェニルまたはアミジノナフチルエステルの組み合わせ |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0680332A1 (enExample) |
| JP (1) | JPH08505867A (enExample) |
| CN (1) | CN1118141A (enExample) |
| AU (1) | AU5863694A (enExample) |
| CA (1) | CA2153797A1 (enExample) |
| GB (1) | GB9301289D0 (enExample) |
| NZ (1) | NZ259737A (enExample) |
| TW (1) | TW241203B (enExample) |
| WO (1) | WO1994016719A1 (enExample) |
| ZA (1) | ZA94398B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09504524A (ja) * | 1993-10-21 | 1997-05-06 | ジー．ディー．サール アンド カンパニー | 酸化窒素シンターゼ阻害剤として有用なアミジノ誘導体 |
| GB9604518D0 (en) * | 1996-03-02 | 1996-05-01 | Smithkline Beecham Plc | Novel compounds |
| US8088386B2 (en) * | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
| JP4897690B2 (ja) * | 2004-10-12 | 2012-03-14 | ジェネンテック， インコーポレイテッド | 補体関連障害の予防および処置のためのＣＲＩｇポリペプチド |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191320A (en) * | 1978-09-07 | 1982-09-14 | Beecham Group Ltd | In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions |
| FR2500825B1 (fr) * | 1981-02-27 | 1985-08-23 | Torii & Co Ltd | Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant |
| JPS57179147A (en) * | 1981-04-28 | 1982-11-04 | Torii Yakuhin Kk | Amidine derivative |
| US5256642A (en) * | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
| JPH06503344A (ja) * | 1990-12-06 | 1994-04-14 | ティーセル サイエンシズ，インコーポレーテッド | 可溶性の補体受容体と、補体を抑制しかつ／または免疫活性を抑制する化合物との相乗組成物 |
-
1993
- 1993-01-22 GB GB939301289A patent/GB9301289D0/en active Pending
-
1994
- 1994-01-20 ZA ZA94398A patent/ZA94398B/xx unknown
- 1994-01-21 EP EP94904705A patent/EP0680332A1/en not_active Withdrawn
- 1994-01-21 CN CN94191260A patent/CN1118141A/zh active Pending
- 1994-01-21 WO PCT/GB1994/000122 patent/WO1994016719A1/en not_active Ceased
- 1994-01-21 AU AU58636/94A patent/AU5863694A/en not_active Abandoned
- 1994-01-21 NZ NZ259737A patent/NZ259737A/en unknown
- 1994-01-21 JP JP6516809A patent/JPH08505867A/ja active Pending
- 1994-01-21 CA CA002153797A patent/CA2153797A1/en not_active Abandoned
- 1994-01-24 TW TW083100558A patent/TW241203B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA94398B (en) | 1994-11-15 |
| GB9301289D0 (en) | 1993-03-17 |
| AU5863694A (en) | 1994-08-15 |
| CN1118141A (zh) | 1996-03-06 |
| TW241203B (enExample) | 1995-02-21 |
| WO1994016719A1 (en) | 1994-08-04 |
| EP0680332A1 (en) | 1995-11-08 |
| CA2153797A1 (en) | 1994-08-04 |
| NZ259737A (en) | 1997-04-24 |
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