JPH08191873A - Transfusion container - Google Patents

Abstract

PURPOSE: To enable mixing of an amino acid, a grape sugar liquid, a fatty emulsion or the like in use by sectioning a transfusion container into a first chamber for housing the grape sugar and an electrolyte and a second chamber for fatty emulsion and the amino acid. CONSTITUTION: A partition zone part 3 is a band-shaped body formed from a right side wall of a transfusion container to a left side wall thereof to section the transfusion container into a first chamber 1 and a second chamber 2. A transfusion-injecting port 4 is provided on an upper wall of the transfusion container being allowed to communicate with a second chamber 2. A transfusion pouring-in/out port 5 is provided on the bottom wall of the first chamber 1 and plays both roles of a transfusion injecting port to pour a transfusion into the first chamber 1 and a transfusion pouring-out port to pour out a mixture of transfusions in chambers 1 and 2. Here, a grape sugar liquid and an electrolyte are housed in the chamber 1 and a fatty emulsion and an amino acid liquid in the second chamber 2.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an infusion container separated into two chambers, and more particularly to an infusion container prepared by mixing glucose, amino acid, fat emulsion and electrolyte infusions in two chambers. .

[0002]

2. Description of the Related Art Conventionally, when an amino acid solution and a glucose solution are mixed and stored in advance, the mixed solution is deteriorated. Therefore, the amino acid solution and the glucose solution are stored in separate bottles and mixed before use. . In addition, when the respective infusion solutions are taken out of the bottle and mixed thoroughly before use, glucose, which is a hypertonic solution, is infused after the amino acid first, resulting in poor absorption of the drug solution into the body. As an infusion container which solves such a problem, in JP-B-63-20550, an infusion liquid containing amino acid solution and glucose solution as main components is separated into two infusion container chambers and the partition between the two chambers is removed at the time of use. An infusion container that allows two infusions to communicate with each other has been introduced.

Since the infusion container consisting of these two chambers can mix two infusions in a sealed state at the time of use, it is easy to operate and hygienic, and thus has been widely spread in the market in recent years. Such infusion preparations are separated into two chambers, each containing an amino acid solution and a glucose solution as main components, and stored. Infusion solutions such as electrolytes, fat emulsions and vitamins are added to each chamber and stored, and they are mixed before use. ing. Japanese Unexamined Patent Publication No. 6-209979 discloses an infusion container which is divided into a chamber containing glucose, a fat emulsion and various vitamins and a chamber containing amino acids, electrolytes and vitamins.

[0004]

However, the stability of the fat emulsion mixed with the glucose solution varies depending on the conditions of storage in the infusion container, the emulsified state is broken, and the fat and oil particles become coarse and phase-separated, resulting in instability. is there. Further, the electrolyte infusion has a problem that the pH is increased by the amino acid and calcium phosphate is precipitated. The present invention has been made to solve such problems, and an object of the present invention is to provide an amino acid solution,
It is intended to provide an infusion container capable of distributing a glucose solution, an electrolyte solution, a fat emulsion solution, and a vitamins solution in two chambers and mixing them at the time of use.

[0005]

That is, according to the present invention, an infusion container is defined in a first chamber and a second chamber, butto sugar and an electrolyte are provided in the first chamber, and a fat emulsion is provided in the second chamber. And an amino acid are contained in the infusion container. Further, the present invention is the infusion container, wherein the first chamber contains a water-soluble vitamin and the second chamber contains a fat-soluble vitamin.

[0006]

[Function] In the first chamber, a glucose solution and an electrolyte solution, and in the second chamber, a mixed infusion solution of a fat emulsion solution and an amino acid solution is injected into each chamber through an infusion solution injection port provided on the wall of the infusion container. save. When the second chamber is pressed during use, the seals of the partition strips of the first chamber and the second chamber are opened, and the mixed infusion of the fat emulsion solution and the amino acid solution in the second chamber becomes the first. The glucose solution in the chamber and the electrolytic chamber solution flow into the mixed infusion solution, and the respective solutions are mixed. After sufficiently mixed, the mixed infusion solution is poured out from an infusion solution inlet / outlet portion corresponding to an infusion solution inlet portion of the first chamber provided on the bottom wall of the first chamber of the infusion container.

[0007]

The present invention will be described in the following examples. FIG. 1 is an explanatory diagram of an infusion solution container showing an embodiment of the present invention, in which 1 is a first chamber, 2 is a second chamber, 3 is a partition band, and 4 is an infusion port of the second chamber. Reference numeral 5 denotes the infusion solution inlet / outlet portion of the first chamber.

FIG. 1 is an explanatory view of an infusion solution container according to an embodiment of the present invention, in which a partition band portion 3 is a strip-shaped member formed from the right side wall of the infusion solution container to the left side wall of the infusion solution container, The first chamber and the second chamber are defined. On the upper wall of the infusion solution container, a first infusion solution injection port portion 4 that can communicate with the second chamber 2 is provided. Then, an infusion solution injection port for injecting an infusion solution into the first chamber, and an infusion solution for injecting a mixed infusion solution obtained by mixing the infusion solution in the first chamber and the infusion solution in the second chamber are provided on the bottom wall of the first chamber. An infusion solution inlet / outlet portion 5 which also serves as an outlet portion is provided. The infusion solution inlet / outlet portion 5 is connected to a drip set (not shown), and the mixed infusion solution is injected into the human body through the drip set. The infusion solution inlet port 4 and the infusion solution inlet / outlet port portion 5 are sealed with rubber stoppers or sheets so that each chamber is isolated from the outside air.
The infusion solution inlet port 4 and the infusion solution inlet / outlet portion 5 inject the infusion solution into the respective chambers with the injection needle of the syringe. Also, the infusion solution outlet part 5
Is connected to the drip set, and a double-ended needle is provided at the proximal end of the drip set, and the puncture needle punctures the rubber stopper to allow the mixed infusion contained in the first chamber 1 to flow out to the drip set. Inject it into the human body.

The partition strip portion 3 is provided with a bent rod at the partition strip portion so that the partition rod portion can be folded and connected at the time of communication, or a ball ball can be provided at the partition strip portion to shut off the infusion solution. It is also possible to drop the leu ball from the partition strip into the first chamber 1 to make it communicate with each other, but the inner layers are weakly adhered to each other without heat welding, and the weak adhesion is peeled off by the external pressure to open the seal. A partition strip part is preferred. The outer layer of the partition strip is a laminated sheet made of a thermoplastic resin sheet. Examples of the thermoplastic resin include polyvinyl chloride, polyethylene, polypropylene, polyester, polyamide and acrylic resin. The partition strip is manufactured by sandwiching the infusion container at the partition strip with a sandwiching body having the shape of the partition strip, and the inner layer is weakly adhered without heat welding, and the weak adhesive is peeled off by external pressure. It can be molded by storing the infusion container therein. The outer edge of the infusion container is heat-sealed by a mold at a temperature higher than that at the time of manufacturing the partition strip so that the inner layer side of the two laminated sheets is the inner side, and the infusion container is formed.

The infusion solution container having two chambers of the present invention contains infusion solutions of glucose, amino acid, fat emulsion and electrolyte. In particular, an infusion container in which the butto sugar solution and the electrolyte solution are contained in the first chamber and the fat emulsion solution and the amino acid solution are contained in the second chamber is preferable. Examples of the amino acid include various amino acids that have been conventionally used, and examples thereof include L-leucine, L-isoleucine, L-lysine acetate, L-methionine, L-phenylalanine, L-threonine and L.
-Tryptophan, L-valine, L-tyrosine, L-arginine, L-histidine, L-alanine, L-aspartic acid, L-glutamic acid, aminoacetic acid, L-proline, L-serine, L-cysteine, L-lysine, Glycine and the like.

Examples of electrolytes include L-sodium lactate, calcium gluconate, sodium chloride, potassium acetate, potassium monohydrogen phosphate, potassium dihydrogen phosphate,
Magnesium chloride, potassium chloride, zinc sulfate, copper sulfate,
Examples thereof include manganese chloride, chromium chloride, magnesium sulfate, potassium glycerophosphate and the like. The fat emulsion is prepared, for example, by emulsifying oils and fats such as soybean oil, egg yolk lecithin, egg yolk phospholipids and soybean phospholipids with water and an emulsifier. If necessary, vitamins may be added to these various infusion solutions. The second chamber 2 containing the fat emulsion solution and the amino acid solution preferably contains a fat-soluble vitamin, and the first chamber containing the mixed infusion solution of glucose solution and electrolyte solution is water-soluble. Preferably, sex vitamins are included. Examples of fat-soluble vitamins include vitamin A, vitamin D, vitamin E, and vitamin K, and examples of water-soluble vitamins include vitamin B and vitamin C.
As the vitamins, these derivatives may be used, and retinol palmitate, cholecasiferol, tocopheryl acetate, menatetrenone, panthenol, biotin, folic acid, thiamine hydrochloride, lipoflavin phosphate, pyridoxine hydrochloride, nicotinamide, Examples thereof include ascorbic acid.

An example of the present invention will be described below with reference to examples. Production Example 1 Infusion solutions having the component compositions shown in Table 1 were placed in the respective chambers shown in FIG. The volume of the second chamber in which the fat emulsion solution and the amino acid solution are contained is 550 ml, and 500 ml of the mixed infusion solution of the fat emulsion solution and the amino acid solution is contained. The volume of the first chamber in which the glucose solution and the electrolyte solution are stored is 1600 ml, and 1000 ml of the mixed infusion solution of the glucose solution and the electrolyte solution is stored. At the time of use, the partition strip is opened, the fat emulsion solution and the amino acid solution in the second chamber are allowed to flow out to the first chamber, and are mixed with the mixed solution of the glucose solution and the electrolyte solution in the first chamber. Then, the mixed infusion is injected into the human body through the drip set connected to the infusion port. The composition of Table 1 means that an infusion solution of approximately 1155 KCal. Has been injected into the human body. The appearance of each infusion container room after leaving the infusion container consisting of the components of each room in Table 1 at room temperature for 10 days was not different from the appearance at the time of manufacture.

[Table 1]

Production Example 2 An infusion solution was produced by adding the vitamins shown in Table 2 to the components in each chamber contained in Production Example 1 shown in Table 1.

[Table 2] The appearance of the infusion solution in each chamber was the same as that at the time of manufacture after the infusion container in which the vitamins of Table 2 were added to the components of Table 1 in each chamber was left at room temperature for 10 days.

[0014]

EFFECTS OF THE INVENTION The infusion container of the present invention mixes amino acid solution, glucose solution, electrolyte solution, fat emulsion solution, and vitamin solution in two chambers of the infusion container by mixing the components of these two chambers at the same time. The infusion solution in each room can be stored without any alteration until it is used.

[Brief description of drawings]

FIG. 1 is an explanatory view of an infusion container showing an embodiment of the present invention.

[Explanation of symbols]

 1 1st chamber 2 2nd chamber 3 Divider strip part 4 Infusion solution injection port 5 3rd divider band part 6 Infusion solution infusion port part

Claims (2)

[Claims] 1. An infusion container comprising an infusion container defined in a first chamber and a second chamber, wherein the first chamber contains bute sugar and an electrolyte, and the second chamber contains a fat emulsion and an amino acid. . 2. The infusion container according to claim 1, wherein the first chamber contains a water-soluble vitamin and the second chamber contains a fat-soluble vitamin.