JPH08155009A - Container for medical treatment - Google Patents

Container for medical treatment

Info

Publication number
JPH08155009A
JPH08155009A JP6298204A JP29820494A JPH08155009A JP H08155009 A JPH08155009 A JP H08155009A JP 6298204 A JP6298204 A JP 6298204A JP 29820494 A JP29820494 A JP 29820494A JP H08155009 A JPH08155009 A JP H08155009A
Authority
JP
Japan
Prior art keywords
medical container
group
bag
sealing
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6298204A
Other languages
Japanese (ja)
Inventor
Kenji Ishikawa
健次 石川
Masaomi Imai
正臣 今井
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP6298204A priority Critical patent/JPH08155009A/en
Publication of JPH08155009A publication Critical patent/JPH08155009A/en
Pending legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/50General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53Joining single elements to tubular articles, hollow articles or bars
    • B29C66/532Joining single elements to the wall of tubular articles, hollow articles or bars
    • B29C66/5326Joining single elements to the wall of tubular articles, hollow articles or bars said single elements being substantially flat
    • B29C66/53261Enclosing tubular articles between substantially flat elements
    • B29C66/53262Enclosing spouts between the walls of bags, e.g. of medical bags
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/04Dielectric heating, e.g. high-frequency welding, i.e. radio frequency welding of plastic materials having dielectric properties, e.g. PVC
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/05Particular design of joint configurations
    • B29C66/10Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112Single lapped joints
    • B29C66/1122Single lap to lap joints, i.e. overlap joints
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/70General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/70General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/72General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined
    • B29C66/723General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered
    • B29C66/7234General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered comprising a barrier layer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2009/00Use of rubber derived from conjugated dienes, as moulding material
    • B29K2009/06SB polymers, i.e. butadiene-styrene polymers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/04Polymers of ethylene
    • B29K2023/06PE, i.e. polyethylene
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29KINDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2025/00Use of polymers of vinyl-aromatic compounds or derivatives thereof as moulding material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2009/00Layered products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/712Containers; Packaging elements or accessories, Packages
    • B29L2031/7148Blood bags, medical bags

Abstract

PURPOSE: To improve the production efficiency of a container for medical treatment by sealing multilayer sheets of which the innermost layer is formed of a nylon material and the other layers consist of a material contg. a polymer blend composed of a block copolymer of a styrene, etc., and specific components, such as butadiene and resins, such as polyethylene, by high-frequency induction heating, thereby forming the container. CONSTITUTION: The innermost layer is formed of the nylon material. The block copolymer is formed of the part consisting essentially of at least one kind selected from a group consisting of styrene and a group consisting of ethylene and butadiene and isoprene and its hydrogen additive. The multilayer sheets are formed by using the material contg. the polymer blend composed of the copolymer and the resin consisting essentially of at least one kind selected from the group of the polyethylene, polypropylene and polybutene as the material for the other materials. The multilayer sheets are sealed 3 to each other or the multilayer sheets and the parts contg. the nylon material are sealed to each other by a high-frequency electrical heating method, by which the container is formed.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は、医療用容器に関する。
さらに詳しくは、血液および血液成分を収納するバッ
グ、あるいは骨髄やリンパ液、尿などの体液を収納する
バッグ、骨髄やリンパ球などの生体細胞を収納するバッ
グ、あるいは輸液バッグに関する。
FIELD OF THE INVENTION The present invention relates to a medical container.
More specifically, the present invention relates to a bag for storing blood and blood components, a bag for storing body fluids such as bone marrow, lymph and urine, a bag for storing living cells such as bone marrow and lymphocytes, or an infusion bag.

【0002】[0002]

【従来の技術】医療用容器には、血液および血液成分を
収納する「血液バッグ」、骨髄やリンパ球などの生体細
胞を収納する「細胞培養用バッグ」、尿を収納する「採
尿バッグ」、点滴用の薬液を収納する「輸液バッグ」、
中心静脈に直接投与するために栄養分を収納する「IV
Hバッグ」、経腸栄養剤を収納するバッグなど各種のバ
ッグがある。それらの内、血液バッグや輸液バッグなど
は、古くはガラスの容器が使われていた時代もあった
が、柔らかく、軽く、割れず、内容液を取り出すときに
通気針が不要であるといった特徴を持つ容器である、い
わゆるソフトバッグの出現により、これらに急速に変わ
っていった。このソフトバッグは、柔軟なプラスチック
シートあるいはフィルムをシールすることによって、容
器の形状を形作っているものである。そのシール方法
は、軟質ポリ塩化ビニル製あるいはエチレン−酢酸ビニ
ル共重合体製のシートの場合には、シート自身の内部発
熱を利用するいわゆる高周波誘電加熱法が主流であっ
た。また、ポリエチレン、ポリプロピレン、ポリブテ
ン、ポリブタジエンなどを主成分とするポリオレフィン
製のシートの場合や、スチレンおよびエチレンからなる
群から選ばれた少なくとも1種を主成分とする部分と、
ブタジエンおよびイソプレンおよびそれらの水素添加物
からなる群から選ばれた少なくとも1種からなる部分か
ら構成された共重合体と、ポリエチレンおよびポリプロ
ピレンおよびポリブテンからなる群から選ばれた少なく
とも1種を主体とする成分とのポリマーブレンドからな
るシートの場合、シート材料の内部から発熱させる高周
波誘電加熱法ではシールすることが事実上不可能であ
り、シートの外界面からシールに必要な熱を与える方法
であるヒートシール方法やインパルスシール方法が行わ
れていた。
2. Description of the Related Art Medical containers include "blood bag" for storing blood and blood components, "cell culture bag" for storing living cells such as bone marrow and lymphocytes, "urine collection bag" for storing urine, An "infusion bag" that contains the drug solution for infusion,
Stores nutrients for direct administration to the central vein.
There are various types of bags such as "H bag" and bags for storing enteral nutrition. Among them, blood bags and infusion bags used to be glass containers in the old days, but they are characterized by being soft, light, unbreakable, and needing no aeration needle to take out the contents. With the advent of so-called soft bags, which are the containers that they carry, they rapidly changed to these. The soft bag forms the shape of the container by sealing a flexible plastic sheet or film. As a sealing method, in the case of a sheet made of soft polyvinyl chloride or an ethylene-vinyl acetate copolymer, a so-called high frequency dielectric heating method which utilizes internal heat generation of the sheet itself has been mainly used. In the case of a polyolefin sheet containing polyethylene, polypropylene, polybutene, polybutadiene or the like as a main component, or a portion containing at least one selected from the group consisting of styrene and ethylene as a main component,
Mainly comprises a copolymer composed of a moiety consisting of at least one selected from the group consisting of butadiene, isoprene and hydrogenated products thereof, and at least one selected from the group consisting of polyethylene, polypropylene and polybutene. In the case of a sheet made of a polymer blend with the components, it is practically impossible to seal by the high frequency dielectric heating method in which heat is generated from the inside of the sheet material, and heat that is the method of giving the heat necessary for sealing from the outer interface of the sheet The sealing method and impulse sealing method were used.

【0003】以上述べたように、各種バッグ等医療用容
器は高周波誘電加熱シール法、ヒートシール法、インパ
ルスシール法などを材料の種類や形状などによって使い
分けていた。
As described above, for medical containers such as various bags, a high frequency dielectric heat sealing method, a heat sealing method, an impulse sealing method, etc. are properly used depending on the type and shape of the material.

【0004】高周波誘電加熱シール法は、シート材料の
内部の分子に直接作用させ、その分子運動から発熱させ
る方法なので、溶融が必要なシートとシートの界面がシ
ートのその他の部分より放熱が少ないため、最も高温と
なる。そのため、シール強度が高く、シールが美しく仕
上がる、シール時間(発熱させる時間と冷却時間の合
計)が短いなどの長所が、ヒートシール法、インパルス
シール法に比べてある。一方、高周波の発振に伴って発
生する電磁波が外部に漏れないようなシールドの設備が
必要、高周波の発振装置が高価であるなどの欠点があっ
た。
The high frequency dielectric heat seal method is a method in which molecules inside the sheet material are directly acted upon and heat is generated from the molecular motion, so that the interface between the sheets which needs to be melted releases less heat than other portions of the sheet. , The highest temperature. Therefore, it has advantages over the heat-sealing method and the impulse-sealing method in that the sealing strength is high, the sealing is beautifully finished, and the sealing time (the heat generation time and the cooling time) is short. On the other hand, there are drawbacks such as the need for shield equipment so that the electromagnetic waves generated by high-frequency oscillation do not leak outside, and the high-frequency oscillator is expensive.

【0005】高周波誘電加熱シール法の利点を活かすた
め、高周波によって内部発熱しない材料に、内部発熱を
誘因する高分子材料や金属材料を混合して必要な発熱量
を得る試みが行われていた。例えば、ポリエチレン中に
エチレン−酢酸ビニル共重合体やポリ酢酸ビニルをポリ
マーブレンドする方法が試みられているが、酢酸ビニル
単位換算の重量含率が約10%以上でないと十分な発熱
量は得られず、またその量を混合すると材料の成形温度
や軟化温度が低下しすぎ、医療用容器としては不適当で
あった。また、ポリエチレン中に鉄粉など金属粉体を混
合する方法も試みられているが、目視できる金属粉体が
シート中に分散され、その一部がシート表面に出てしま
うという状態でないと十分な発熱量が得られない。この
ため、この方法も医療用容器用のシートとしては不適当
である。更に、ポリエチレンシートなど内部発熱しない
材料シート同士をシールするために、そのシートと高周
波電極間に高周波誘電加熱可能なポリ塩化ビニルシート
などを挿入して高周波発振させて、発熱したポリ塩化ビ
ニルシートの熱をポリエチレンシートに伝導させてシー
ルし、その後に不要のポリ塩化ビニルシートを除去する
方法が試みられていた。これは、高周波発振器は用いて
はいるが、シールする機構はヒートシールと同様の外部
発熱法である。例えば、特公平3−56890には、上
記の方法を用いて医療用バッグのポート取り付け方法が
開示されている。
In order to utilize the advantages of the high frequency dielectric heat sealing method, attempts have been made to obtain a required amount of heat by mixing a material that does not internally generate heat due to high frequency with a polymer material or a metal material that induces internal heat generation. For example, a method of polymer-blending an ethylene-vinyl acetate copolymer or polyvinyl acetate into polyethylene has been attempted, but a sufficient heating value can be obtained unless the weight content in terms of vinyl acetate unit is about 10% or more. Moreover, when the amounts were mixed, the molding temperature and the softening temperature of the material were too low, and it was unsuitable as a medical container. Also, a method of mixing metal powder such as iron powder into polyethylene has been attempted, but it is sufficient if the visible metal powder is dispersed in the sheet and part of it is exposed on the sheet surface. No calorific value can be obtained. Therefore, this method is also unsuitable as a sheet for medical containers. Furthermore, in order to seal material sheets that do not generate heat internally, such as a polyethylene sheet, a polyvinyl chloride sheet capable of high-frequency dielectric heating is inserted between the sheets and the high-frequency electrode, and high-frequency oscillation is performed to generate a high-frequency polyvinyl chloride sheet. Attempts have been made to conduct heat to the polyethylene sheet to seal it and then remove the unwanted polyvinyl chloride sheet. Although this uses a high-frequency oscillator, the sealing mechanism is an external heating method similar to heat sealing. For example, Japanese Examined Patent Publication No. 3-56890 discloses a method of attaching a port of a medical bag using the above method.

【0006】ナイロンは高周波誘電加熱可能な材料であ
るため、単層のシートでは十分な発熱量が得られ、良好
なシールができるが、高周波誘電加熱可能でない材料と
の多層シートの場合には、特にそのナイロン層の厚みが
50%以下のシートの場合には、通常の方法では高周波
誘電加熱法ではシールできなかった。さらに、ナイロン
がポリエーテルナイロンである場合には高周波誘電加熱
法では発熱量がさらに少なくなるので、医療用容器に求
められるシール強度を得ることは難しかった。これらの
場合には、ヒートシール方法あるいはインパルスシール
方法によって医療用容器を製造するしかなかった。ま
た、ナイロン単層シートからなる医療用容器はナイロン
の水蒸気透過性が大きい点、柔軟性と強度のバランスが
取れない点、材料コストが高い点などのため、実用的な
医療用容器とはならず、実現されていなかった。
Since nylon is a material capable of high-frequency dielectric heating, a single layer sheet can generate a sufficient amount of heat generation and can perform good sealing, but in the case of a multi-layer sheet with a material that is not capable of high-frequency dielectric heating, In particular, in the case of a sheet having a nylon layer with a thickness of 50% or less, it was not possible to seal by a high frequency dielectric heating method by a usual method. Furthermore, when the nylon is polyether nylon, the amount of heat generated by the high frequency dielectric heating method is further reduced, and it is difficult to obtain the sealing strength required for medical containers. In these cases, there is no choice but to manufacture the medical container by the heat sealing method or the impulse sealing method. In addition, medical containers made of nylon single-layer sheets are not practical medical containers due to the high water vapor permeability of nylon, the inability to balance flexibility and strength, and the high material cost. It wasn't realized.

【0007】[0007]

【発明が解決しようとする課題】ヒートシール方法、イ
ンパルスシール方法はシートの外部からシートを通して
シール面までシールに必要な熱を与える方法なので、シ
ールに必要なシート界面が融解するのに必要な熱エネル
ギーが伝わる時間がかかる、またシール後の冷却時間が
かかるという問題、すなわち生産効率が悪いという問題
があった。また、シート界面が融解するまで、シートの
他の部分や融着すべき部材が形状を保てなくなるほど変
形してはならないため、材料に制約がある、といった問
題点があった。即ち、多層シートの場合には、シール面
の材料より耐熱性材料をシート外面に配置しなくてはな
らないという制約がある。また、形状が保てなくなるほ
どの変形ではないが、シール仕上がりが美しくないとい
う問題点があった。
The heat-sealing method and impulse-sealing method are methods for applying heat required for sealing from the outside of the sheet to the sealing surface through the sheet. Therefore, the heat required for melting the sheet interface required for sealing is used. There is a problem that it takes time to transfer energy, and it takes a cooling time after sealing, that is, there is a problem that production efficiency is poor. Further, there is a problem in that the material is restricted because the other parts of the sheet and the members to be fused must not be deformed to the extent that the shape cannot be maintained until the sheet interface is melted. That is, in the case of a multi-layer sheet, there is a restriction that a heat resistant material has to be arranged on the outer surface of the sheet rather than the material of the sealing surface. Further, although the deformation is not so large that the shape cannot be maintained, there is a problem in that the finish of the seal is not beautiful.

【0008】本発明の目的は以上述べたような問題点を
解決するもので、高周波誘電加熱法でナイロンを内面に
もつ多層シートなどを生産効率を上げて、美しくシール
して医療用容器を提供することにある。
The object of the present invention is to solve the above-mentioned problems, and to improve the production efficiency of a multilayer sheet having nylon on the inner surface by a high frequency dielectric heating method to provide a beautifully sealed medical container. To do.

【0009】[0009]

【課題を解決するための手段】上記問題点は、下記の本
発明により解決される。
The above problems can be solved by the present invention described below.

【0010】(1)ナイロン系材料を最内層とし、スチ
レンおよびエチレンからなる群から選ばれた少なくとも
1種を主成分とする部分と、ブタジエンおよびイソプレ
ンおよびそれらの水素添加物からなる群から選ばれた少
なくとも1種からなる部分から構成されるブロック共重
合体と、ポリエチレンおよびポリプロピレンおよびポリ
ブテンからなる群から選ばれた少なくとも1種を主成分
とする樹脂とのポリマーブレンドを含む材料をその他の
層とする多層シート同士あるいは、その多層シートとナ
イロン系材料を含む部品を高周波誘電加熱法によりシー
ルすることを特徴とする医療用容器。
(1) A portion containing a nylon material as the innermost layer and containing at least one selected from the group consisting of styrene and ethylene as a main component, and a group consisting of butadiene, isoprene and hydrogenated products thereof. And a layer containing a material containing a polymer blend of a block copolymer composed of at least one part and a resin containing at least one selected from the group consisting of polyethylene, polypropylene and polybutene as a main component. A medical container characterized in that the multi-layered sheets or the parts containing the multi-layered sheet and the nylon material are sealed by a high frequency dielectric heating method.

【0011】(2)前記多層シートの最内層の厚みが該
多層シートの厚みの50%以下である(1)に記載の医
療用容器。
(2) The medical container according to (1), wherein the innermost layer of the multilayer sheet has a thickness of 50% or less of the thickness of the multilayer sheet.

【0012】(3)前記多層シートの最内層の厚みが該
多層シートの厚みの20%以下である(2)に記載の医
療用容器。
(3) The medical container according to (2), wherein the thickness of the innermost layer of the multilayer sheet is 20% or less of the thickness of the multilayer sheet.

【0013】(4)前記ポリマーブレンドのスチレンお
よびエチレンからなる群から選ばれた少なくとも1種を
主成分とする部分とブタジエンおよびイソプレンおよび
それらの水素添加物からなる群から選ばれた少なくとも
1種からなる部分から構成されるブロック共重合体と、
ポリエチレンおよびポリプロピレンおよびポリブテンか
らなる群から選ばれた少なくとも1種を主成分とする樹
脂の組成比が、9:1〜1:9(重量比)であることを
特徴とする(1)〜(3)に記載の医療用容器。
(4) A portion of the polymer blend having at least one selected from the group consisting of styrene and ethylene as a main component, and at least one selected from the group consisting of butadiene, isoprene and hydrogenated products thereof. A block copolymer composed of
The composition ratio of the resin containing at least one selected from the group consisting of polyethylene, polypropylene and polybutene as a main component is 9: 1 to 1: 9 (weight ratio) (1) to (3) ) Medical container described in.

【0014】(5)前記ナイロン系材料がポリエーテル
ナイロンであることを特徴とする(1)〜(4)に記載
の医療用容器。
(5) The medical container according to any one of (1) to (4), wherein the nylon material is polyether nylon.

【0015】(6)前記医療用容器のシール部分のシー
ル強度が、0.1kgf/cm以上であることを特徴と
する(1)〜(5)に記載の医療用容器。
(6) The medical container according to any one of (1) to (5), wherein the sealing strength of the sealing portion of the medical container is 0.1 kgf / cm or more.

【0016】(7)前記医療用容器が血液および血液成
分を収納するバッグ、あるいは骨髄やリンパ液、尿など
の体液を収納するバッグ、骨髄やリンパ球などの生体細
胞を収納するバッグ、あるいは輸液バッグであることを
特徴とする(1)〜(6)に記載の医療用容器。
(7) The medical container is a bag for storing blood and blood components, a bag for storing body fluids such as bone marrow, lymph and urine, a bag for storing living cells such as bone marrow and lymphocytes, or an infusion bag. The medical container according to any one of (1) to (6), wherein

【0017】(8)前記医療用容器が血液および血液成
分を収納するバッグであることを特徴とする(8)に記
載の医療用容器。
(8) The medical container according to (8), wherein the medical container is a bag containing blood and blood components.

【0018】本発明の最内層のナイロン系材料は、ナイ
ロン46、ナイロン6、ナイロン66、ナイロン61
0、ナイロン11、ナイロン12などのホモポリマーあ
るいは交互共重合体でも、それら同士の共重合体や混合
物でも構わない。さらに、本発明のナイロン系材料はポ
リエーテルブロックとナイロンブロックからなるブロッ
ク共重合体即ちいわゆるポリエーテルナイロンでも構わ
ない。例えば、旭化成工業のレオナ、宇部興産のUBE
ナイロン、ダイセル・ヒュルスのダイアミド、大日本イ
ンキ化学工業のグリラックス、東レの東レナイロン、ペ
バックス、三菱化成のノバミッド、ユニチカのユニチカ
ナイロンなどである。
The nylon material of the innermost layer of the present invention is nylon 46, nylon 6, nylon 66, nylon 61.
It may be a homopolymer such as 0, nylon 11, or nylon 12, or an alternating copolymer, or a copolymer or mixture of them. Further, the nylon material of the present invention may be a block copolymer composed of a polyether block and a nylon block, that is, so-called polyether nylon. For example, Leona of Asahi Kasei Corporation and UBE of Ube Industries
Nylon, Daicel Hurus's Daiamide, Dainippon Ink and Chemicals' Gru Relax, Toray's Toray Nylon, Pebax, Mitsubishi Kasei's Novamid, and Unitika's Unitika nylon.

【0019】本発明のポリマーブレンドを構成するスチ
レンおよびエチレンからなる群から選ばれた少なくとも
1種を主成分とする部分と、ブタジエンおよびイソプレ
ンおよびそれらの水素添加物からなる群から選ばれた少
なくとも1種からなる部分から構成されるブロック共重
合体は、通常スチレン系エラストマー、スチレンブタジ
エンゴムあるいはそれらの水素添加タイプとして知られ
ているものである。さらに具体的に述べると、SBS、
SEBS、SIS、SEPS、EEBS、EEBE、
(SEB)n(但し、S:ポリスチレンブロック、B:
ポリブタジエンブロック、I:ポリイソプレンブロッ
ク、E:ポリエチレンブロック、EB:エチレン・ブチ
レンランダム共重合体ブロック、EP:エチレン・プロ
ピレンランダム共重合体ブロック、SEB:スチレン・
エチレン・ブチレン共重合体を意味する)と表現される
ブロック共重合体である。これらの製造法は特に問わな
いが、ブタジエンやイソプレンを重合した後水素添加し
て得る製造方法も有益である。これらの共重合体は、例
えば、シェル化学のクレイトン、クレイトンG、カリフ
レックス、日本合成ゴムのJSR−TR、JSR−SI
S、ダイナロン、三菱油化のラバロン、アロン化成のア
ロンAR、クラレのセプトン、住友化学工業の住友TP
Eなどである。
A portion containing at least one selected from the group consisting of styrene and ethylene constituting the polymer blend of the present invention as a main component, and at least one selected from the group consisting of butadiene, isoprene and hydrogenated products thereof. The block copolymer composed of the seed portion is generally known as a styrene elastomer, a styrene butadiene rubber or a hydrogenated type thereof. More specifically, SBS,
SEBS, SIS, SEPS, EEBS, EEBE,
(SEB) n (however, S: polystyrene block, B:
Polybutadiene block, I: polyisoprene block, E: polyethylene block, EB: ethylene / butylene random copolymer block, EP: ethylene / propylene random copolymer block, SEB: styrene /
It means a block copolymer represented by ethylene / butylene copolymer). The production method thereof is not particularly limited, but a production method obtained by polymerizing butadiene or isoprene and then hydrogenating is also useful. These copolymers are, for example, Clayton, Kreton G, Califlex of Shell Chemistry, JSR-TR, JSR-SI of Japan Synthetic Rubber.
S, Dynaron, Mitsubishi Yuka's Ravalon, Aron Kasei's Aron AR, Kuraray's Septon, Sumitomo Chemical's Sumitomo TP
E and so on.

【0020】本発明のポリマーブレンドを構成するポリ
エチレンは、低密度ポリエチレン(LDPE)、高密度
ポリエチレン(HDPE)、線状低密度ポリエチレン
(LLDPE)などが好ましい。また、ポリプロピレン
ではホモポリマー、ランダム共重合体、ブロック共重合
体が、あるいはアイソタクチックポリプロピレン、アタ
クチックポリプロピレン、シンジオタクチックポリプロ
ピレンなどが好ましい。さらに、ポリブテンもホモポリ
マー、ランダム共重合体、ブロック共重合体などが好ま
しい。
The polyethylene constituting the polymer blend of the present invention is preferably low density polyethylene (LDPE), high density polyethylene (HDPE), linear low density polyethylene (LLDPE) and the like. Further, as the polypropylene, a homopolymer, a random copolymer, a block copolymer, or isotactic polypropylene, atactic polypropylene, syndiotactic polypropylene, or the like is preferable. Furthermore, polybutene is also preferably a homopolymer, a random copolymer, a block copolymer, or the like.

【0021】本発明のポリマーブレンドは、上記スチレ
ンおよびエチレンからなる群から選ばれた少なくとも1
種を主成分とする部分と、ブタジエンおよびイソプレン
およびそれらの水素添加物からなる群から選ばれた少な
くとも1種からなる部分から構成されるブロック共重合
体と、上記ポリエチレンおよびポリプロピレンおよびポ
リブテンからなる群から選ばれた少なくとも1種を主成
分とする樹脂の組成比は、9:1〜1:9(重量比)が
好ましい。9:1より大きくなると医療用容器として強
度が不足し、1:9より小さくなると柔軟性が不十分と
なるので好ましくない。上述の適当な組成比のものは透
明で、柔軟な医療用バッグを提供できるものである。
The polymer blend of the present invention comprises at least one selected from the group consisting of styrene and ethylene described above.
A block copolymer composed of a portion containing a seed as a main component, a portion containing at least one selected from the group consisting of butadiene, isoprene and hydrogenated products thereof, and the group consisting of the polyethylene, polypropylene and polybutene. The composition ratio of the resin containing at least one selected from the above as a main component is preferably 9: 1 to 1: 9 (weight ratio). When it is larger than 9: 1, the strength as a medical container is insufficient, and when it is smaller than 1: 9, the flexibility is insufficient, which is not preferable. The above-mentioned suitable composition ratio can provide a transparent and flexible medical bag.

【0022】本発明の多層シートの構成材料は、医療用
容器の最内面に上述のナイロン系材料をその他の層に上
述のポリマーブレンド材料を配すること以外は特に限定
をしない。即ち、それらの2層の間や上述のポリマーブ
レンドのさらに外側に別の材料の層を設けても良い。例
えば、2層間に両者の接着をする接着剤や接着性樹脂を
設けることは好ましい。また、最外層にシートを保護す
る層を設けることも好ましい。
The constituent material of the multilayer sheet of the present invention is not particularly limited except that the above-mentioned nylon material is arranged on the innermost surface of the medical container and the above-mentioned polymer blend material is arranged on the other layers. That is, a layer of another material may be provided between the two layers or outside the polymer blend described above. For example, it is preferable to provide an adhesive or an adhesive resin for adhering the two layers between the two layers. It is also preferable to provide a layer for protecting the sheet as the outermost layer.

【0023】本発明のナイロン系材料からなる最内層の
厚みが、多層シートの厚みの50%以下であることが好
ましい。さらに、ナイロン系材料の厚みが全体の20%
以下であることがより好ましい。ナイロン系材料の厚み
が全体の50%以上であると医療用容器としての柔軟性
が損なわれ、また、材料コストの増加につながり好まし
くない。
The thickness of the innermost layer made of the nylon material of the present invention is preferably 50% or less of the thickness of the multilayer sheet. Furthermore, the thickness of nylon materials is 20% of the total
The following is more preferable. When the thickness of the nylon-based material is 50% or more of the total, the flexibility as a medical container is impaired and the material cost is increased, which is not preferable.

【0024】本発明で用いる多層シートの厚みは特に限
定されるものではないが、0.05mm以上、2mm以
下が好ましい。0.05mm以下であると、医療用容器
とした場合の強度が保てなくなる。また、2mm以上で
あると柔軟性に問題が出る。
The thickness of the multilayer sheet used in the present invention is not particularly limited, but is preferably 0.05 mm or more and 2 mm or less. If the thickness is 0.05 mm or less, the strength of the medical container cannot be maintained. If it is 2 mm or more, there is a problem in flexibility.

【0025】本発明の多層シートの製造工程は特に限定
されるものではない。例えば、ドライラミネーション、
ウェットラミネーション、共押出成形のいずれの方法で
も構わないし、その他の方法でも良い。
The manufacturing process of the multilayer sheet of the present invention is not particularly limited. For example, dry lamination,
Wet lamination, coextrusion molding, or any other method may be used.

【0026】本発明の高周波誘電加熱シール機は、軟質
塩化ビニルやエチレン・酢酸ビニル共重合体シートのシ
ールに使用されるものと同様の装置で十分である。但
し、シール条件としては発振時間と、マッチングを良好
にとり電流値を高めるためのコンデンサ容量を大きくす
る必要がある。
The high-frequency dielectric heat-sealing machine of the present invention may be of the same type as that used for sealing soft vinyl chloride or ethylene / vinyl acetate copolymer sheets. However, as a sealing condition, it is necessary to increase the capacitor capacity for achieving good matching with the oscillation time and increasing the current value.

【0027】本発明の医療用容器のシール強度は0.1
kgf/cm以上が好ましく、さらに好ましくは、0.
8kgf/cm以上である。このシール強度は、輸液や
薬液を入れてオートクレーブ滅菌を行ったり、血液を入
れて遠心分離を行う医療用容器の場合には特に注意しな
ければならない値である。0.1kgf/cm以下であ
ると、輸液や薬液を入れてオートクレーブ滅菌を行った
り、血液を入れて遠心分離を行う時にシール部が剥がれ
ることが起こり得る。なお、このシール強度試験方法を
図1に示しながら説明する。2枚のシート1、2のシー
ル3の長手方向と直角方向に幅2cmの短冊状に切り出
す。引張試験機(例えば島津製作所製オートグラフ、あ
るいは東洋精機製作所製ストログラフなど)のチャック
間を20mmとして、シート片1、2をチャックし、図
1の矢印方向に引張速度200mm/min.(23
℃)で試験片が破壊するまで引張ったときの最大値を2
で割って1cm幅当たりに換算して求める。
The seal strength of the medical container of the present invention is 0.1.
It is preferably at least kgf / cm, more preferably 0.
It is 8 kgf / cm or more. This seal strength is a value that needs to be particularly noted in the case of a medical container in which an infusion solution or a chemical solution is put in for autoclave sterilization, or blood is put in and subjected to centrifugation. If the pressure is 0.1 kgf / cm or less, the seal portion may be peeled off when an infusion solution or a chemical solution is added for autoclave sterilization or when blood is added for centrifugation. The seal strength test method will be described with reference to FIG. The two sheets 1 and 2 are cut into a strip having a width of 2 cm in a direction perpendicular to the longitudinal direction of the seal 3. The sheet pieces 1 and 2 are chucked with a chuck distance of a tensile tester (eg, Autograph manufactured by Shimadzu or Strograph manufactured by Toyo Seiki Co., Ltd.) set to 20 mm, and a tensile speed of 200 mm / min. (23
The maximum value when the test piece is pulled until it breaks at
Divide by and convert to 1 cm width.

【0028】本発明の医療用容器は医療の現場で使用す
るものであれば特に限定をする必要はない。例えば、血
液および血液成分を収納するバッグ、あるいは骨髄やリ
ンパ液、尿などの体液を収納するバッグ、あるいは輸液
バッグである。
The medical container of the present invention is not particularly limited as long as it is used in the medical field. For example, it is a bag for storing blood and blood components, a bag for storing body fluids such as bone marrow, lymph, and urine, or an infusion bag.

【0029】[0029]

【実施例】【Example】

(実施例1)三菱油化社製のポリプロピレンEX−6を
40.0wt%、シェル化学社製のスチレン系エラストマ
ー、クレイトンG1652を59.9wt%、チバガイギ
ーの酸化防止剤イルガノックス1010を0. 1wt%
を、2軸押出機(池貝鉄工(株)製、PCM)で混合
し、ストランドに押出した後、ペレタイザーで切断して
第1層の原料ペレットを得た。第2層の原料として住友
化学工業社製の接着性樹脂ボンダインTX−8030を
用意した。第3層の原料として東レ社製のナイロンエラ
ストマー、ペバックス4033SAを用意した。第1
層、第3層の原料が外層に、第2層(図示せず)の原料
が中間層になるようにダイ温度230℃で共押出成形
し、多層シートを得た。
Example 1 40.0 wt% of polypropylene EX-6 manufactured by Mitsubishi Petrochemical Co., 59.9 wt% of styrene-based elastomer manufactured by Shell Chemical Co., Inc., Kraton G1652, and 0.1 wt% of Irivanox 1010, an antioxidant of Ciba Geigy. %
Was mixed with a twin-screw extruder (PCM, manufactured by Ikegai Tekko KK), extruded into strands, and then cut with a pelletizer to obtain raw material pellets for the first layer. As a raw material for the second layer, an adhesive resin bondine TX-8030 manufactured by Sumitomo Chemical Co., Ltd. was prepared. As a raw material for the third layer, a nylon elastomer Pebax 4033SA manufactured by Toray Industries, Inc. was prepared. First
The raw materials for the layers and the third layer were coextruded at a die temperature of 230 ° C. so that the raw material for the second layer (not shown) was an intermediate layer and the raw material for the second layer (not shown) was an intermediate layer to obtain a multilayer sheet.

【0030】多層シートの総厚みは0.21mmで、第
1層、第2層、第3層の原料の厚み構成は75:10:
15であった。第3層の原料と同じ原料で図2に示すチ
ューブ部材を成形温度180℃で射出成形して得た。山
本ビニター(株)社製の高周波誘電加熱シール機YF60
00Aを用いて、高周波出力6KW、発振周波数40.
46Hz、プレス圧5kgf/cm2、発振時間3秒、
冷却時間2秒の条件で図2に示すバッグ形状にシールし
た。そのときの電流値は0.28〜0.40Aであっ
た。シートおよび部材の溶融状態は良く、全体としてバ
リもなくきれいにバッグ形状にシールできた。シール部
を幅2cmに切り出しシール強度を求めた。シール強
度、時間、美観の結果を表1に示す。バッグ内部に牛血
200mlを入れ、3000rpm−10分間遠心分離
(以下「遠心分離試験」という)を行ったが内容血液が
漏れるなどの問題はなかった。またバッグ内に生理食塩
水を500ml入れ、チューブを閉じた後、121℃−
20分間オートクレーブ滅菌を行った(以下「耐オート
クレーブ試験」という)が、内溶液が漏れるなどの問題
は無かった。
The total thickness of the multilayer sheet is 0.21 mm, and the thickness composition of the raw materials of the first layer, the second layer and the third layer is 75:10:
It was 15. A tube member shown in FIG. 2 was injection-molded at the molding temperature of 180 ° C. using the same raw material as the raw material for the third layer. High frequency dielectric heat sealing machine YF60 manufactured by Yamamoto Vinita Co., Ltd.
00A, high frequency output 6 kW, oscillation frequency 40.
46 Hz, press pressure 5 kgf / cm 2 , oscillation time 3 seconds,
The bag was sealed in the bag shape shown in FIG. 2 under the condition that the cooling time was 2 seconds. The current value at that time was 0.28 to 0.40 A. The sheets and members were in a good melted state, and as a whole, they could be neatly sealed in a bag shape without burrs. The seal portion was cut into a width of 2 cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. 200 ml of bovine blood was placed in the bag and centrifuged at 3000 rpm for 10 minutes (hereinafter referred to as "centrifugation test"), but there was no problem such as leakage of blood. In addition, after putting 500 ml of physiological saline in the bag and closing the tube, 121 ° C-
Autoclave sterilization was performed for 20 minutes (hereinafter referred to as "autoclave resistance test"), but there was no problem such as leakage of internal solution.

【0031】(実施例2)実施例1の第1層の原料中の
三菱油化社製のポリプロピレンEX−6の代わりに、三
菱油化社製のポリエチレンLM−31を用いた以外は実
施例1と同様にシートと部材を用意した。多層シートの
総厚みは0.24mm、厚み構成比は75:10:15
であった。実施例1と同様の装置で高周波出力6KW、
発振周波数40.46Hz、プレス圧5kgf/c
2、発振時間3秒、冷却時間2秒の条件でシールし
た。そのときの電流値は0.25〜0.35Aであっ
た。シートおよび部材の溶融状態は良く、全体としてバ
リもなくきれいにバッグ形状にシールできた。シール部
を幅2cmに切り出しシール強度を求めた。シール強
度、時間、美観の結果を表1に示す。遠心分離試験を行
ったが内容血液が漏れるなどの問題はなかった。
(Example 2) Example 3 was repeated except that polyethylene LM-31 manufactured by Mitsubishi Petrochemical Co., Ltd. was used instead of polypropylene EX-6 manufactured by Mitsubishi Petrochemical Co., Ltd. in the raw material for the first layer of Example 1. Sheets and members were prepared in the same manner as in 1. The total thickness of the multilayer sheet is 0.24 mm, and the thickness composition ratio is 75:10:15.
Met. With the same device as in Example 1, high frequency output 6 kW,
Oscillation frequency 40.46Hz, press pressure 5kgf / c
Sealing was performed under the conditions of m 2 , oscillation time of 3 seconds, and cooling time of 2 seconds. The current value at that time was 0.25 to 0.35A. The sheets and members were in a good melted state, and as a whole, they could be neatly sealed in a bag shape without burrs. The seal portion was cut into a width of 2 cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. A centrifuge test was conducted, but there was no problem such as leakage of blood content.

【0032】(実施例3)実施例1の第1層の原料中の
シェル化学社製のスチレン系エラストマー、クレイトン
G1652の代わりに、日本合成ゴム社製のダイナロン
E6100Pを用いた以外は実施例1と同様にシートと
部材を用意した。多層シートの総厚みは0.24mm、
厚み構成比は40:10:50であった。実施例1と同
様の装置で高周波出力6KW、発振周波数40.46H
z、プレス圧5kgf/cm2、発振時間1秒、冷却時
間2秒の条件でシールした。そのときの電流値は0.2
9〜0.41Aであった。シートおよび部材の溶融状態
は良く、全体としてバリもなくきれいにバッグ形状にシ
ールできた。シール部を幅2cmに切り出しシール強度
を求めた。シール強度、時間、美観の結果を表1に示
す。遠心分離試験および耐オートクレーブ試験を行った
が内容液が漏れるなどの問題はなかった。
Example 3 Example 1 was repeated except that Dynalon E6100P manufactured by Nippon Synthetic Rubber Co., Ltd. was used in place of the styrene-based elastomer Craton G1652 manufactured by Shell Chemical Co. in the raw material for the first layer of Example 1. A sheet and members were prepared in the same manner as in. The total thickness of the multilayer sheet is 0.24 mm,
The thickness composition ratio was 40:10:50. With the same device as in Example 1, a high frequency output of 6 kW and an oscillation frequency of 40.46 H
Sealing was performed under the conditions of z, press pressure 5 kgf / cm 2 , oscillation time 1 second, and cooling time 2 seconds. The current value at that time is 0.2
It was 9-0.41A. The sheets and members were in a good melted state, and as a whole, they could be neatly sealed in a bag shape without burrs. The seal portion was cut into a width of 2 cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. A centrifugation test and an autoclave resistance test were conducted, but there was no problem such as leakage of the content liquid.

【0033】(実施例4)実施例1の第1層の原料中の
クレイトンG1652とEX−6とイルガノックス10
10の重量比を89.9wt%、10.0wt%、0.
1wt%とした点と、ナイロンエラストマー、ペバック
ス4033SAの代わりに、宇部興産社製の宇部ナイロ
ン3035JU6を用いた以外は実施例1と同様にシー
トと部材を用意した。多層シートの総厚みは0.50m
m、厚み構成比は60:10:30であった。実施例1
と同様の装置で高周波出力6KW、発振周波数40.4
6Hz、プレス圧3kgf/cm2、発振時間3秒、冷
却時間3秒の条件でシールした。そのときの電流値は
0.25〜0.35Aであった。シートおよび部材の溶
融状態は良く、全体としてバリもなくきれいにバッグ形
状にシールできた。シール部を幅2cmに切り出しシー
ル強度を求めた。シール強度、時間、美観の結果を表1
に示す。遠心分離試験および耐オートクレーブ試験を行
ったが内容液が漏れるなどの問題はなかった。
Example 4 Kraton G1652, EX-6 and Irganox 10 in the raw material for the first layer of Example 1
The weight ratio of 10 is 89.9 wt%, 10.0 wt%, 0.
Sheets and members were prepared in the same manner as in Example 1 except that 1 wt% was used and Ube nylon 3035JU6 manufactured by Ube Industries, Ltd. was used instead of the nylon elastomer and Pebax 4033SA. The total thickness of the multilayer sheet is 0.50 m
m and the thickness composition ratio were 60:10:30. Example 1
High frequency output 6KW, oscillation frequency 40.4
Sealing was performed under the conditions of 6 Hz, pressing pressure 3 kgf / cm 2 , oscillation time 3 seconds, and cooling time 3 seconds. The current value at that time was 0.25 to 0.35A. The sheets and members were in a good melted state, and as a whole, they could be neatly sealed in a bag shape without burrs. The seal portion was cut into a width of 2 cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics.
Shown in A centrifugation test and an autoclave resistance test were conducted, but there was no problem such as leakage of the content liquid.

【0034】(実施例5)実施例2の第1層の原料中の
クレイトンG1652とLM−31とイルガノックス1
010の重量比を10.0wt%、89.9wt%、
0.1wt%とした以外は実施例2と同様にシートと部
材を用意した。多層シートの総厚みは0.05mm、厚
み構成比は40:10:50であった。実施例1と同様
の装置で高周波出力6KW、発振周波数40.46H
z、プレス圧2kgf/cm2、発振時間1秒、冷却時
間3秒の条件でシールした。そのときの電流値は0.1
5〜0.25Aであった。シートおよび部材の溶融状態
は良く、全体としてバリもなくきれいにバッグ形状にシ
ールできた。シール部を幅2cmに切り出しシール強度
を求めた。シール強度、時間、美観の結果を表1に示
す。遠心分離試験を行ったが内容液が漏れるなどの問題
はなかった。
(Example 5) Kraton G1652, LM-31 and Irganox 1 in the raw material for the first layer of Example 2
The weight ratio of 010 is 10.0 wt%, 89.9 wt%,
A sheet and a member were prepared in the same manner as in Example 2 except that the content was 0.1 wt%. The total thickness of the multilayer sheet was 0.05 mm, and the thickness composition ratio was 40:10:50. With the same device as in Example 1, a high frequency output of 6 kW and an oscillation frequency of 40.46 H
Sealing was performed under the conditions of z, press pressure 2 kgf / cm 2 , oscillation time 1 second, and cooling time 3 seconds. The current value at that time is 0.1
It was 5 to 0.25A. The sheets and members were in a good melted state, and as a whole, they could be neatly sealed in a bag shape without burrs. The seal portion was cut into a width of 2 cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. A centrifugation test was conducted, but there was no problem such as leakage of the content liquid.

【0035】(比較例1)実施例1と同様のシートおよ
び部材を、ヒートシール機を用いてバッグ形状にシール
した。シール条件は、金型温度260℃、シール時間1
5秒、冷却時間40秒であり、実施例1に比べて作業時
間が長かった。シールの仕上がり美感は、部材表面の溶
融にむらがあるため、リークなくシールする条件では大
きなバリが生じ良好とはいえなかった。シール部を幅2
cmに切り出しシール強度を求めた。シール強度、時
間、美観の結果を表1に示す。遠心分離試験および耐オ
ートクレーブ試験を行ったが内溶液が漏れるなどの問題
はなかった。
(Comparative Example 1) The same sheets and members as in Example 1 were sealed in a bag shape using a heat sealing machine. Sealing conditions are mold temperature 260 ℃, sealing time 1
The working time was 5 seconds and the cooling time was 40 seconds, which was longer than that in Example 1. The finished appearance of the seal was not good because of the uneven melting of the surface of the member, and large burrs were generated under the condition of sealing without leakage. Width of seal is 2
It was cut out to cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. A centrifuge test and an autoclave resistance test were conducted, but there was no problem such as leakage of the internal solution.

【0036】(比較例2)実施例2と同様のシートおよ
び部材を、ヒートシール機を用いてバッグ形状にシール
した。シール条件は、金型温度230℃、シール時間1
2秒、冷却時間40秒であり、実施例2に比べて作業時
間が長かった。シールの仕上がり美感は、部材表面の溶
融にむらがあるため、リークなくシールする条件では大
きなバリが生じ良好とはいえなかった。シール部を幅2
cmに切り出しシール強度を求めた。シール強度、時
間、美観の結果を表1に示す。遠心分離試験を行ったが
内溶液が漏れるなどの問題はなかった。
(Comparative Example 2) The same sheets and members as in Example 2 were sealed in a bag shape using a heat sealing machine. Sealing conditions are mold temperature 230 ℃, sealing time 1
The working time was 2 seconds and the cooling time was 40 seconds, which was longer than that in Example 2. The finished appearance of the seal was not good because of the uneven melting of the surface of the member, and large burrs were generated under the condition of sealing without leakage. Width of seal is 2
It was cut out to cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. A centrifugation test was conducted, but there was no problem such as leakage of the internal solution.

【0037】(比較例3)実施例3と同様のシートおよ
び部材を、ヒートシール機を用いてバッグ形状にシール
した。シール条件は、金型温度260℃、シール時間1
8秒、冷却時間35秒であり、実施例3に比べて作業時
間が長かった。シールの仕上がり美感は、部材表面の溶
融にむらがあるため、リークなくシールする条件では大
きなバリが生じ良好とはいえなかった。シール部を幅2
cmに切り出しシール強度を求めた。シール強度、時
間、美観の結果を表1に示す。遠心分離試験および耐オ
ートクレーブ試験を行ったが内溶液が漏れるなどの問題
はなかった。
(Comparative Example 3) The same sheets and members as in Example 3 were sealed in a bag shape using a heat sealing machine. Sealing conditions are mold temperature 260 ℃, sealing time 1
The working time was 8 seconds and the cooling time was 35 seconds, which was longer than that in Example 3. The finished appearance of the seal was not good because of the uneven melting of the surface of the member, and large burrs were generated under the condition of sealing without leakage. Width of seal is 2
It was cut out to cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. A centrifuge test and an autoclave resistance test were conducted, but there was no problem such as leakage of the internal solution.

【0038】(比較例4)実施例4と同様のシートおよ
び部材を、ヒートシール機を用いてバッグ形状にシール
した。シール条件は、金型温度260℃、シール時間2
0秒、冷却時間50秒であり、実施例4に比べて作業時
間が非常に長かった。シールの仕上がり美感は、部材表
面の溶融にむらがあるため、リークなくシールする条件
では大きなバリが生じ良好とはいえなかった。シール部
を幅2cmに切り出しシール強度を求めた。シール強
度、時間、美観の結果を表1に示す。遠心分離試験およ
び耐オートクレーブ試験を行ったが内溶液が漏れるなど
の問題はなかった。
(Comparative Example 4) The same sheets and members as in Example 4 were sealed in a bag shape using a heat sealing machine. Sealing conditions are mold temperature 260 ℃, sealing time 2
The working time was 0 seconds and the cooling time was 50 seconds, and the working time was extremely long as compared with Example 4. The finished appearance of the seal was not good because of the uneven melting of the surface of the member, and large burrs were generated under the condition of sealing without leakage. The seal portion was cut into a width of 2 cm and the seal strength was obtained. Table 1 shows the results of seal strength, time, and aesthetics. A centrifuge test and an autoclave resistance test were conducted, but there was no problem such as leakage of the internal solution.

【0039】(比較例5)実施例5と同様のシートおよ
び部材を、ヒートシール機を用いてバッグ形状にシール
した。シール条件は、金型温度230℃、シール時間5
秒、冷却時間23秒であり、実施例5に比べて作業時間
が非常に長かった。シールの仕上がり美感は、部材表面
の溶融にむらがあるため、リークなくシールする条件で
は大きなバリが生じ良好とはいえなかった。シール部を
幅2cmに切り出しシール強度を求めた。シール強度、
時間、美観の結果を表1に示す。遠心分離試験を行った
が内溶液が漏れるなどの問題はなかった。
Comparative Example 5 The same sheets and members as in Example 5 were sealed in a bag shape using a heat sealing machine. Sealing conditions are mold temperature 230 ℃, sealing time 5
Seconds, the cooling time was 23 seconds, and the working time was extremely long as compared with Example 5. The finished appearance of the seal was not good because of the uneven melting of the surface of the member, and large burrs were generated under the condition of sealing without leakage. The seal portion was cut into a width of 2 cm and the seal strength was obtained. Seal strength,
Table 1 shows the results of time and aesthetics. A centrifugation test was conducted, but there was no problem such as leakage of the internal solution.

【0040】[0040]

【表1】 [Table 1]

【0041】[0041]

【発明の効果】本発明の医療用容器は、高周波誘電加熱
法でシールすることにより、シール強度が高く、加熱お
よび冷却にかかる時間、即ちシール時間が短い、シール
の仕上がり美感が良好であるという効果をもたらすこと
ができる。
The medical container of the present invention has a high sealing strength by being sealed by the high frequency dielectric heating method, has a short heating and cooling time, that is, has a short sealing time, and has a good finished appearance of the seal. It can have an effect.

【図面の簡単な説明】[Brief description of drawings]

【図1】シール強度試験方法の略図。FIG. 1 is a schematic diagram of a seal strength test method.

【図2】バッグ形状にシールしたものの斜視図。FIG. 2 is a perspective view of what is sealed in a bag shape.

【図3】図2におけるA−A線断面図。3 is a cross-sectional view taken along the line AA in FIG.

【符号の説明】[Explanation of symbols]

1、2 シート 3 シール部 4 チューブ部材 5 第1層 6 第3層 1, 2 sheet 3 seal part 4 tube member 5 first layer 6 third layer

Claims (8)

【特許請求の範囲】[Claims] 【請求項1】 ナイロン系材料を最内層とし、スチレン
およびエチレンからなる群から選ばれた少なくとも1種
を主成分とする部分と、ブタジエンおよびイソプレンお
よびそれらの水素添加物からなる群から選ばれた少なく
とも1種からなる部分から構成されるブロック共重合体
と、ポリエチレンおよびポリプロピレンおよびポリブテ
ンからなる群から選ばれた少なくとも1種を主成分とす
る樹脂とのポリマーブレンドを含む材料をその他の層と
する多層シート同士あるいは、その多層シートとナイロ
ン系材料を含む部品を高周波誘電加熱法によりシールす
ることを特徴とする医療用容器。
1. A portion containing a nylon material as the innermost layer and containing at least one selected from the group consisting of styrene and ethylene as a main component, and a group consisting of butadiene, isoprene, and hydrogenated products thereof. The other layer is made of a material containing a polymer blend of a block copolymer composed of a portion composed of at least one kind and a resin containing at least one kind selected from the group consisting of polyethylene, polypropylene and polybutene as a main component. A medical container characterized in that multi-layer sheets or parts including the multi-layer sheet and a nylon material are sealed by a high frequency dielectric heating method.
【請求項2】 前記多層シートの最内層の厚みが該多層
シートの厚みの50%以下である請求項1に記載の医療
用容器。
2. The medical container according to claim 1, wherein the thickness of the innermost layer of the multilayer sheet is 50% or less of the thickness of the multilayer sheet.
【請求項3】 前記多層シートの最内層の厚みが該多層
シートの厚みの20%以下である請求項2に記載の医療
用容器。
3. The medical container according to claim 2, wherein the thickness of the innermost layer of the multilayer sheet is 20% or less of the thickness of the multilayer sheet.
【請求項4】 前記ポリマーブレンドのスチレンおよび
エチレンからなる群から選ばれた少なくとも1種を主成
分とする部分とブタジエンおよびイソプレンおよびそれ
らの水素添加物からなる群から選ばれた少なくとも1種
からなる部分から構成されるブロック共重合体と、ポリ
エチレンおよびポリプロピレンおよびポリブテンからな
る群から選ばれた少なくとも1種を主成分とする樹脂の
組成比が、9:1〜1:9(重量比)であることを特徴
とする請求項1〜3に記載の医療用容器。
4. A portion containing at least one selected from the group consisting of styrene and ethylene of the polymer blend as a main component, and at least one selected from the group consisting of butadiene, isoprene, and hydrogenated products thereof. The composition ratio of the block copolymer composed of parts and the resin containing at least one selected from the group consisting of polyethylene, polypropylene and polybutene as a main component is 9: 1 to 1: 9 (weight ratio). The medical container according to any one of claims 1 to 3, which is characterized in that.
【請求項5】 前記ナイロン系材料がポリエーテルナイ
ロンであることを特徴とする請求項1〜4に記載の医療
用容器。
5. The medical container according to claim 1, wherein the nylon material is polyether nylon.
【請求項6】 前記医療用容器のシール部分のシール強
度が、0.1kgf/cm以上であることを特徴とする
請求項1〜5に記載の医療用容器。
6. The medical container according to claim 1, wherein the sealing strength of the sealing portion of the medical container is 0.1 kgf / cm or more.
【請求項7】 前記医療用容器が血液および血液成分を
収納するバッグ、あるいは骨髄やリンパ液、尿などの体
液を収納するバッグ、骨髄やリンパ球などの生体細胞を
収納するバッグ、あるいは輸液バッグであることを特徴
とする請求項1〜6に記載の医療用容器。
7. The medical container is a bag for storing blood and blood components, a bag for storing body fluids such as bone marrow, lymph and urine, a bag for storing living cells such as bone marrow and lymphocytes, or an infusion bag. It exists, The medical container of Claims 1-6 characterized by the above-mentioned.
【請求項8】 前記医療用容器が血液および血液成分を
収納するバッグであることを特徴とする請求項7に記載
の医療用容器。
8. The medical container according to claim 7, wherein the medical container is a bag containing blood and blood components.
JP6298204A 1994-12-01 1994-12-01 Container for medical treatment Pending JPH08155009A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6298204A JPH08155009A (en) 1994-12-01 1994-12-01 Container for medical treatment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6298204A JPH08155009A (en) 1994-12-01 1994-12-01 Container for medical treatment

Publications (1)

Publication Number Publication Date
JPH08155009A true JPH08155009A (en) 1996-06-18

Family

ID=17856567

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6298204A Pending JPH08155009A (en) 1994-12-01 1994-12-01 Container for medical treatment

Country Status (1)

Country Link
JP (1) JPH08155009A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104589701A (en) * 2015-02-02 2015-05-06 长沙汇一制药机械有限公司 Forming tool for transfusion bag
JP2018059077A (en) * 2016-09-29 2018-04-12 三洋化成工業株式会社 Agent for imparting dielectric heating properties to polyolefin resin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104589701A (en) * 2015-02-02 2015-05-06 长沙汇一制药机械有限公司 Forming tool for transfusion bag
JP2018059077A (en) * 2016-09-29 2018-04-12 三洋化成工業株式会社 Agent for imparting dielectric heating properties to polyolefin resin

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