JPH0794470B2 - シクロヘキサペプチジルビスアミン化合物 - Google Patents

シクロヘキサペプチジルビスアミン化合物

Info

Publication number
JPH0794470B2
JPH0794470B2 JP4263717A JP26371792A JPH0794470B2 JP H0794470 B2 JPH0794470 B2 JP H0794470B2 JP 4263717 A JP4263717 A JP 4263717A JP 26371792 A JP26371792 A JP 26371792A JP H0794470 B2 JPH0794470 B2 JP H0794470B2
Authority
JP
Japan
Prior art keywords
compound
alkyl
chemical
seq
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP4263717A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05239094A (ja
Inventor
ロバート・エイ・ザンビアス
フランセス・アイリーン・ブーフアード
ジエームズ・エフ・ドロピンスキ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPH05239094A publication Critical patent/JPH05239094A/ja
Publication of JPH0794470B2 publication Critical patent/JPH0794470B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP4263717A 1991-10-01 1992-10-01 シクロヘキサペプチジルビスアミン化合物 Expired - Fee Related JPH0794470B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77102791A 1991-10-01 1991-10-01
US936558 1992-09-03
US07/936,558 US6030944A (en) 1991-10-01 1992-09-03 Cyclohexapeptidyl bisamine compounds
US771027 1992-09-03

Publications (2)

Publication Number Publication Date
JPH05239094A JPH05239094A (ja) 1993-09-17
JPH0794470B2 true JPH0794470B2 (ja) 1995-10-11

Family

ID=27118389

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4263717A Expired - Fee Related JPH0794470B2 (ja) 1991-10-01 1992-10-01 シクロヘキサペプチジルビスアミン化合物

Country Status (9)

Country Link
US (1) US6030944A (oth)
EP (1) EP0535967B1 (oth)
JP (1) JPH0794470B2 (oth)
AT (1) ATE162200T1 (oth)
CA (1) CA2079187C (oth)
DE (1) DE69224027T2 (oth)
DK (1) DK0535967T3 (oth)
ES (1) ES2111616T3 (oth)
GR (1) GR3025914T3 (oth)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
WO1996022784A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
EP0862579A1 (en) * 1995-11-09 1998-09-09 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20090324635A1 (en) * 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
WO2012119065A2 (en) * 2011-03-03 2012-09-07 Seachaid Pharmaceuticals, Inc. Antifungal agents and uses thereof
SI3677252T1 (sl) * 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
WO2016201283A1 (en) * 2015-06-12 2016-12-15 Cidara Therapeutics, Inc. Antifungal agents
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
JP7779651B2 (ja) 2017-07-12 2025-12-03 ナップ ファーマシューティカル グループ リミテッド 真菌感染症の処置のための組成物及び方法
EP3620462A1 (en) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Process for the preparation of caspofungin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173629A (en) * 1975-07-08 1979-11-06 Sandoz Ltd. Antibiotic S 31794/F-1
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320054A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912H nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4968608A (en) * 1987-10-07 1990-11-06 Merck & Co., Inc. Process for antifungal fermentation product
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
US5021403A (en) * 1990-03-19 1991-06-04 Merck & Co., Inc. Antibiotic agents
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii

Also Published As

Publication number Publication date
CA2079187A1 (en) 1993-04-02
DE69224027T2 (de) 1998-08-13
EP0535967A2 (en) 1993-04-07
ATE162200T1 (de) 1998-01-15
EP0535967A3 (oth) 1994-04-06
DK0535967T3 (da) 1998-02-09
GR3025914T3 (en) 1998-04-30
JPH05239094A (ja) 1993-09-17
EP0535967B1 (en) 1998-01-14
US6030944A (en) 2000-02-29
CA2079187C (en) 2000-09-19
ES2111616T3 (es) 1998-03-16
DE69224027D1 (de) 1998-02-19

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees