ES2111616T3 - Compuestos de ciclohexapeptidil bisamina. - Google Patents

Compuestos de ciclohexapeptidil bisamina.

Info

Publication number
ES2111616T3
ES2111616T3 ES92308985T ES92308985T ES2111616T3 ES 2111616 T3 ES2111616 T3 ES 2111616T3 ES 92308985 T ES92308985 T ES 92308985T ES 92308985 T ES92308985 T ES 92308985T ES 2111616 T3 ES2111616 T3 ES 2111616T3
Authority
ES
Spain
Prior art keywords
cyclohexapeptidil
bisamine compounds
bisamine
compounds
cyclohexapeptidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92308985T
Other languages
English (en)
Inventor
Robert A Zambias
Frances Aileen Bouffard
James F Dropinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2111616T3 publication Critical patent/ES2111616T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTAN CIERTOS COMPUESTOS DE BISAMINO QUE TIENEN UN NUCLEO DE CICLOHEXAPEPTIDIL Y QUE PRESENTAN ACTIVIDAD ANTIBIOTICA CON PROPIEDADES FISICAS ADECUADAS PARA DIRIGIR SU USO A COMPOSICIONES TERAPEUTICAS. TAMBIEN SE PRESENTA UN NUEVO PROCESO PARA SU PREPARACION.
ES92308985T 1991-10-01 1992-10-01 Compuestos de ciclohexapeptidil bisamina. Expired - Lifetime ES2111616T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77102791A 1991-10-01 1991-10-01
US07/936,558 US6030944A (en) 1991-10-01 1992-09-03 Cyclohexapeptidyl bisamine compounds

Publications (1)

Publication Number Publication Date
ES2111616T3 true ES2111616T3 (es) 1998-03-16

Family

ID=27118389

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92308985T Expired - Lifetime ES2111616T3 (es) 1991-10-01 1992-10-01 Compuestos de ciclohexapeptidil bisamina.

Country Status (9)

Country Link
US (1) US6030944A (es)
EP (1) EP0535967B1 (es)
JP (1) JPH0794470B2 (es)
AT (1) ATE162200T1 (es)
CA (1) CA2079187C (es)
DE (1) DE69224027T2 (es)
DK (1) DK0535967T3 (es)
ES (1) ES2111616T3 (es)
GR (1) GR3025914T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
CA2211138A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
JP2000501076A (ja) * 1995-11-09 2000-02-02 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルビスアミン化合物、その化合物を含む組成物とその使用方法
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20090324635A1 (en) * 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
EP2240507A2 (en) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
RS56426B1 (sr) 2011-03-03 2018-01-31 Cidara Therapeutics Inc Antigljivična sredstva i njihova upotreba
KR102236462B1 (ko) * 2012-03-19 2021-04-08 시다라 세라퓨틱스, 인코포레이티드 에키노칸딘 계열의 화합물에 대한 투여 용법
WO2016201283A1 (en) * 2015-06-12 2016-12-15 Cidara Therapeutics, Inc. Antifungal agents
US10369188B2 (en) 2016-01-08 2019-08-06 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
JP2020529973A (ja) 2017-07-12 2020-10-15 シダラ セラピューティクス インコーポレーテッド 真菌感染症の処置のための組成物及び方法
EP3620462A1 (en) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Process for the preparation of caspofungin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173629A (en) * 1975-07-08 1979-11-06 Sandoz Ltd. Antibiotic S 31794/F-1
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4320054A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912H nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4968608A (en) * 1987-10-07 1990-11-06 Merck & Co., Inc. Process for antifungal fermentation product
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
US5021403A (en) * 1990-03-19 1991-06-04 Merck & Co., Inc. Antibiotic agents
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii

Also Published As

Publication number Publication date
DK0535967T3 (da) 1998-02-09
GR3025914T3 (en) 1998-04-30
JPH05239094A (ja) 1993-09-17
JPH0794470B2 (ja) 1995-10-11
DE69224027T2 (de) 1998-08-13
US6030944A (en) 2000-02-29
CA2079187A1 (en) 1993-04-02
CA2079187C (en) 2000-09-19
EP0535967A2 (en) 1993-04-07
EP0535967B1 (en) 1998-01-14
ATE162200T1 (de) 1998-01-15
DE69224027D1 (de) 1998-02-19
EP0535967A3 (es) 1994-04-06

Similar Documents

Publication Publication Date Title
ES2111616T3 (es) Compuestos de ciclohexapeptidil bisamina.
BR8802401A (pt) Incubadora infantil com cortina de ar
HU9202720D0 (en) Preparatives and methods qpplicables for treatment of infections caused by organismm being sensible to beta-lactame antibiotics
ES2098455T3 (es) Compuestos de ciclohexapeptidil propanolamina.
FR2669029B1 (fr) Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK0406745T3 (da) Antibiotiske GE 2270 faktorer A1, A2, A3 og H
DK0451486T3 (da) Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
DE68927055D1 (de) 2',5'-oligoadenylat-derivate zur verwendung als heilmittel
ES2113391T3 (es) Factor c2a de antibiotico ge 2270.
ES2195996T3 (es) Compuestos de hidroxipropionitrilo ciclohexapeptidilo.
ES2094757T3 (es) Un factor megacariocitopoyetico.
DK0675900T3 (da) Antibiotika GE 37468 A, B og C
FR2703048B1 (fr) Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
GR3004095T3 (es)
ATE72818T1 (de) Vancomycintyp-antibiotika.
FR2677647B1 (fr) Nouveaux derives de benzoate d'ethanolamine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DK627188A (da) Farmaceutisk komposition
ZA911347B (en) Compositions and methods for treating infections caused by organisms sensitive to"-lactam antibiotics
GR3024709T3 (en) Novel cytarabine derivatives, their production and use
BR1100204A (pt) Composição farmacêutica para tratar esquizofrenia
AU6725387A (en) Drugs for the treatment and cure of all infectious diseases caused by pathogenic virulent micro-organisms

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 535967

Country of ref document: ES