ES2195996T3 - Compuestos de hidroxipropionitrilo ciclohexapeptidilo. - Google Patents

Compuestos de hidroxipropionitrilo ciclohexapeptidilo.

Info

Publication number
ES2195996T3
ES2195996T3 ES92308986T ES92308986T ES2195996T3 ES 2195996 T3 ES2195996 T3 ES 2195996T3 ES 92308986 T ES92308986 T ES 92308986T ES 92308986 T ES92308986 T ES 92308986T ES 2195996 T3 ES2195996 T3 ES 2195996T3
Authority
ES
Spain
Prior art keywords
compounds
hydroxipropionitrile
ciclohexapeptidilo
cyclohexapeptidyl
nucleus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92308986T
Other languages
English (en)
Inventor
James M Balkovec
Robert A Zambias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2195996T3 publication Critical patent/ES2195996T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE PRESENTAN CIERTOS COMPUESTOS DE PROPIONITRILO QUE TIENEN UN NUCLEO DE CICLOHEXAPEPTIDIL Y QUE PRESENTAN ACTIVIDAD ANTIBIOTICA CON PROPIEDADES FISICAS ADECUADAS PARA SU USO EN COMPOSICIONES TERAPEUTICAS. TAMBIEN SE PRESENTA UN NUEVO PROCESO PARA SU PREPARACION.
ES92308986T 1991-10-01 1992-10-01 Compuestos de hidroxipropionitrilo ciclohexapeptidilo. Expired - Lifetime ES2195996T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77101891A 1991-10-01 1991-10-01
US07/936,434 US5348940A (en) 1991-10-01 1992-09-03 Cyclohexapeptidyl hydroxypropionitrile compounds

Publications (1)

Publication Number Publication Date
ES2195996T3 true ES2195996T3 (es) 2003-12-16

Family

ID=27118385

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92308986T Expired - Lifetime ES2195996T3 (es) 1991-10-01 1992-10-01 Compuestos de hidroxipropionitrilo ciclohexapeptidilo.

Country Status (7)

Country Link
US (1) US5348940A (es)
EP (1) EP0535968B1 (es)
JP (1) JPH07100715B2 (es)
AT (1) ATE240350T1 (es)
CA (1) CA2079172C (es)
DE (1) DE69233058T2 (es)
ES (1) ES2195996T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL138432A0 (en) * 1998-04-23 2001-10-31 Aventis Pharma Gmbh A process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173629A (en) * 1975-07-08 1979-11-06 Sandoz Ltd. Antibiotic S 31794/F-1
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320054A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912H nucleus
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US4968608A (en) * 1987-10-07 1990-11-06 Merck & Co., Inc. Process for antifungal fermentation product
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5310873A (en) * 1990-03-12 1994-05-10 Merck & Co., Inc. Cyclohexapeptide compound
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
US5021403A (en) * 1990-03-19 1991-06-04 Merck & Co., Inc. Antibiotic agents
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii

Also Published As

Publication number Publication date
CA2079172A1 (en) 1993-04-02
JPH07100715B2 (ja) 1995-11-01
EP0535968A1 (en) 1993-04-07
ATE240350T1 (de) 2003-05-15
CA2079172C (en) 2001-04-24
EP0535968B1 (en) 2003-05-14
DE69233058D1 (de) 2003-06-18
US5348940A (en) 1994-09-20
DE69233058T2 (de) 2004-03-04
JPH06234794A (ja) 1994-08-23

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