JPH07502014A - 気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール - Google Patents

気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール

Info

Publication number
JPH07502014A
JPH07502014A JP5501313A JP50131393A JPH07502014A JP H07502014 A JPH07502014 A JP H07502014A JP 5501313 A JP5501313 A JP 5501313A JP 50131393 A JP50131393 A JP 50131393A JP H07502014 A JPH07502014 A JP H07502014A
Authority
JP
Japan
Prior art keywords
bis
piperazine
thiazol
aminocarbonyl
pyrrolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5501313A
Other languages
English (en)
Japanese (ja)
Inventor
デ　チリス，ジャン　ピエロ
ロング，ジォルジオ
ディ’アロ’，シモネッタ
ロッツィ，アントネラ
ガリコ，リチア
Original Assignee
ベーリンガー　マンハイム　イタリア　エス．ピー．エイ．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI911714A external-priority patent/IT1248526B/it
Priority claimed from ITMI920786A external-priority patent/IT1255077B/it
Application filed by ベーリンガー　マンハイム　イタリア　エス．ピー．エイ． filed Critical ベーリンガー　マンハイム　イタリア　エス．ピー．エイ．
Publication of JPH07502014A publication Critical patent/JPH07502014A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP5501313A 1991-06-21 1992-06-17 気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール Pending JPH07502014A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITMI911714A IT1248526B (it) 1991-06-21 1991-06-21 2-ammino-4-aril-tiazoli ad attivita' antiasmatica e antiinfiammatoria delle vie aeree
IT91A001714 1991-06-21
ITMI920786A IT1255077B (it) 1992-04-01 1992-04-01 2-ammino-4-aril-tiazoli ad attivita' antiasmatica e antiinfiammatoria delle vie aeree
IT92A000786 1992-04-01
PCT/EP1992/001377 WO1993000342A1 (en) 1991-06-21 1992-06-17 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract

Publications (1)

Publication Number Publication Date
JPH07502014A true JPH07502014A (ja) 1995-03-02

Family

ID=26330730

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5501313A Pending JPH07502014A (ja) 1991-06-21 1992-06-17 気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール

Country Status (8)

Country Link
EP (2) EP0519449A1 (OSRAM)
JP (1) JPH07502014A (OSRAM)
AU (1) AU2000092A (OSRAM)
IE (1) IE921972A1 (OSRAM)
MX (1) MX9202978A (OSRAM)
NZ (1) NZ243206A (OSRAM)
TW (1) TW206968B (OSRAM)
WO (1) WO1993000342A1 (OSRAM)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502623A (ja) * 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペラジンおよびジアゼパン
JP2006516611A (ja) * 2003-01-27 2006-07-06 アステラス製薬株式会社 チアゾール誘導体およびｖａｐ−１阻害剤としてのその使用
JP2007504109A (ja) * 2003-08-28 2007-03-01 ノバルティス アクチエンゲゼルシャフト 炎症性気道疾患の処置のための、ホスファチジルイノシトール３キナーゼ酵素（ｐｉ３）の阻害剤としての、５−フェニル−４−メチル−チアゾール−２−イル−アミン誘導体
JP2010511682A (ja) * 2006-12-04 2010-04-15 アストラゼネカ アクチボラグ 抗菌性の多環系尿素化合物
JP2014506897A (ja) * 2011-03-02 2014-03-20 ▲華▼中科技大学 ２−アミノチアゾール誘導体、その製剤方法および使用
JP2014506896A (ja) * 2011-03-02 2014-03-20 ▲華▼中科技大学同▲済▼医学院附属同▲済▼医院 アミノチアゾールｍｙｄ８８特異的阻害剤の薬学的な使用
JP2014526537A (ja) * 2011-09-23 2014-10-06 バイヤースドルフ・アクチエンゲゼルシヤフト 複素環カルボニルアミノチアゾール、それを含有する化粧用または皮膚科用製剤、および望ましくない皮膚の色素沈着を治療・予防するためのその使用

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
AU1608397A (en) 1996-02-02 1997-08-22 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
IL128428A0 (en) * 1996-08-14 2000-01-31 Zeneca Ltd Substituted pyrimidine derivatives and their pharmaceutical use
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
WO1998035956A1 (en) 1997-02-13 1998-08-20 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
US6391880B1 (en) 1997-02-13 2002-05-21 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
WO2003057693A1 (fr) * 2001-12-28 2003-07-17 Sumitomo Pharmaceuticals Co., Ltd. Composes cycliques a 5 chainons
CN100491361C (zh) * 2003-01-27 2009-05-27 安斯泰来制药有限公司 噻唑衍生物及其作为vap-1抑制剂的用途
FR2854158B1 (fr) 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
FR2872813B1 (fr) * 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
US7820654B2 (en) 2004-09-23 2010-10-26 Dr. Reddy's Laboratories Ltd. Pyrimidine compounds, process for their preparation and compositions containing them
FR2876692B1 (fr) 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
GB0428327D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Ab Method
BRPI0519288A2 (pt) * 2004-12-24 2009-01-06 Astrazeneca Ab compostos heterocÍclicos como antagonistas de ccr2b
DK2937341T3 (en) 2004-12-30 2017-09-11 Janssen Pharmaceutica Nv 4- (BENZYL) -PIPERAZINE-1-CARBOXYLIC ACID PHENYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID HYDROLASE (FAAH) FOR TREATING ANALYSIS, PAIN AND OTHER CONDITIONS
AU2006227833A1 (en) 2005-03-18 2006-09-28 The Regents Of The University Of California Compounds having activity in correcting mutant-CFTR processing and uses thereof
CA2618653A1 (en) * 2005-08-12 2007-02-22 Takeda Pharmaceutical Company Limited Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder
FR2895989B1 (fr) 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
BRPI0915471A2 (pt) 2008-06-04 2017-06-27 Astrazeneca Ab composto, composição farmacêutica, métodos de inibir dna girase bacteriana e/ou topoisomerase bacteriana iv, para produzir um efeito antibacteriano em um animal de sangue quente e para tratar uma infecção bacteriana em um animal de sangue quente, e, uso de um composto
TW201102065A (en) * 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CN102351854B (zh) * 2011-07-29 2014-06-04 华中科技大学 氨基噻唑衍生物及制备方法和医药用途
WO2022232919A1 (en) * 2021-05-03 2022-11-10 UNIVERSITé LAVAL Viral rna polymerase inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2602792A (en) * 1950-11-24 1952-07-08 American Cyanamid Co 1-carbocycliccarbamyl-4-heterocyclic-piperazines
US4217355A (en) * 1978-04-24 1980-08-12 Pfizer Inc. Amide therapeutic agents
FR2429210A1 (fr) * 1978-06-19 1980-01-18 Fabre Sa Pierre Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme
JPS57136579A (en) * 1981-01-21 1982-08-23 Mitsui Toatsu Chem Inc Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same
WO1982002383A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Novel thiazole compounds,process for their preparation,and medicinal composition containing same

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502623A (ja) * 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペラジンおよびジアゼパン
JP2006516611A (ja) * 2003-01-27 2006-07-06 アステラス製薬株式会社 チアゾール誘導体およびｖａｐ−１阻害剤としてのその使用
JP2007504109A (ja) * 2003-08-28 2007-03-01 ノバルティス アクチエンゲゼルシャフト 炎症性気道疾患の処置のための、ホスファチジルイノシトール３キナーゼ酵素（ｐｉ３）の阻害剤としての、５−フェニル−４−メチル−チアゾール−２−イル−アミン誘導体
JP2010511682A (ja) * 2006-12-04 2010-04-15 アストラゼネカ アクチボラグ 抗菌性の多環系尿素化合物
JP2014506897A (ja) * 2011-03-02 2014-03-20 ▲華▼中科技大学 ２−アミノチアゾール誘導体、その製剤方法および使用
JP2014506896A (ja) * 2011-03-02 2014-03-20 ▲華▼中科技大学同▲済▼医学院附属同▲済▼医院 アミノチアゾールｍｙｄ８８特異的阻害剤の薬学的な使用
JP2014526537A (ja) * 2011-09-23 2014-10-06 バイヤースドルフ・アクチエンゲゼルシヤフト 複素環カルボニルアミノチアゾール、それを含有する化粧用または皮膚科用製剤、および望ましくない皮膚の色素沈着を治療・予防するためのその使用

Also Published As

Publication number Publication date
WO1993000342A1 (en) 1993-01-07
TW206968B (OSRAM) 1993-06-01
EP0519449A1 (en) 1992-12-23
EP0589985A1 (en) 1994-04-06
IE921972A1 (en) 1992-12-30
AU2000092A (en) 1993-01-25
NZ243206A (en) 1994-07-26
MX9202978A (es) 1993-02-01

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