JPH07149797A - 繊維芽細胞成長因子のヘパリン結合部位構造アナログ - Google Patents

繊維芽細胞成長因子のヘパリン結合部位構造アナログ

Info

Publication number
JPH07149797A
JPH07149797A JP6252766A JP25276694A JPH07149797A JP H07149797 A JPH07149797 A JP H07149797A JP 6252766 A JP6252766 A JP 6252766A JP 25276694 A JP25276694 A JP 25276694A JP H07149797 A JPH07149797 A JP H07149797A
Authority
JP
Japan
Prior art keywords
fgf
growth factor
fibroblast growth
heparin
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6252766A
Other languages
English (en)
Japanese (ja)
Inventor
Lu-Yuan Li
ル−ユアン・リ
Andrew Peter Seddon
アンドリユー・ピーター・セツドン
Yakov Gluzman
ヤコブ・グルズマン
Peter Bohlen
ピーター・ボーレン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of JPH07149797A publication Critical patent/JPH07149797A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
JP6252766A 1993-09-24 1994-09-22 繊維芽細胞成長因子のヘパリン結合部位構造アナログ Pending JPH07149797A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12697493A 1993-09-24 1993-09-24
US126974 1998-07-31

Publications (1)

Publication Number Publication Date
JPH07149797A true JPH07149797A (ja) 1995-06-13

Family

ID=22427669

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6252766A Pending JPH07149797A (ja) 1993-09-24 1994-09-22 繊維芽細胞成長因子のヘパリン結合部位構造アナログ

Country Status (13)

Country Link
EP (1) EP0645451B1 (https=)
JP (1) JPH07149797A (https=)
KR (1) KR100320803B1 (https=)
AT (1) ATE204604T1 (https=)
AU (1) AU680533B2 (https=)
CA (1) CA2132668A1 (https=)
DE (1) DE69428013T2 (https=)
DK (1) DK0645451T3 (https=)
ES (1) ES2161233T3 (https=)
NZ (1) NZ264529A (https=)
PT (1) PT645451E (https=)
TW (1) TW275068B (https=)
ZA (1) ZA947454B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017159943A1 (ko) * 2016-03-17 2017-09-21 중앙대학교 산학협력단 화학반응을 통하여 결합된 섬유아세포 증식인자-헤파린 복합체 및 이의 제조 방법

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874565A (en) 1995-08-29 1999-02-23 Washington University Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
AU3170499A (en) * 1998-04-28 1999-11-16 Eisai Co. Ltd. Fibroblast growth factor mutein compositions and methods of use therefor
CA2796459C (en) 2010-04-16 2016-05-24 Salk Institute For Biological Studies Methods for treating metabolic disorders using fgf-1
US9475856B2 (en) 2012-03-02 2016-10-25 New York University Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders
US9474785B2 (en) 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
US9464126B2 (en) * 2012-06-07 2016-10-11 New York University Chimeric fibroblast growth factor 21 proteins and methods of use
US9550820B2 (en) 2013-02-22 2017-01-24 New York University Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use
WO2015061331A1 (en) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
AU2014340241B2 (en) 2013-10-21 2018-11-01 Salk Institute For Biological Studies Mutated fibroblast growth factor (FGF) 1 and methods of use
WO2017075260A1 (en) 2015-10-30 2017-05-04 Salk Institute For Biological Studies Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs
US11229681B2 (en) * 2017-07-14 2022-01-25 The Regents Of The University Of California Dominant-negative FGF2 antagonists
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
CN116042681A (zh) * 2022-08-01 2023-05-02 普纳思细胞(厦门)生物科技有限公司 一种bFGF热稳定性改造的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377579A1 (en) * 1987-07-07 1990-07-18 California Biotechnology, Inc. Recombinant fibroblast growth factors
WO1989004832A1 (en) * 1987-11-24 1989-06-01 Amgen Inc. Analogs of fibroblast growth factor
GB8821795D0 (en) * 1988-09-16 1988-10-19 Erba Carlo Spa New derivatives of human/bovine basic fibroplast growth factor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017159943A1 (ko) * 2016-03-17 2017-09-21 중앙대학교 산학협력단 화학반응을 통하여 결합된 섬유아세포 증식인자-헤파린 복합체 및 이의 제조 방법

Also Published As

Publication number Publication date
AU680533B2 (en) 1997-07-31
EP0645451A1 (en) 1995-03-29
DK0645451T3 (da) 2001-10-08
ATE204604T1 (de) 2001-09-15
PT645451E (pt) 2001-12-28
DE69428013T2 (de) 2002-05-29
EP0645451B1 (en) 2001-08-22
TW275068B (https=) 1996-05-01
KR100320803B1 (ko) 2002-06-20
ES2161233T3 (es) 2001-12-01
NZ264529A (en) 1997-06-24
CA2132668A1 (en) 1995-03-25
DE69428013D1 (de) 2001-09-27
ZA947454B (en) 1995-05-15
AU7418594A (en) 1995-04-06

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