KR100320803B1 - 섬유아세포성장인자구조동족체 - Google Patents

섬유아세포성장인자구조동족체 Download PDF

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Publication number
KR100320803B1
KR100320803B1 KR1019940024025A KR19940024025A KR100320803B1 KR 100320803 B1 KR100320803 B1 KR 100320803B1 KR 1019940024025 A KR1019940024025 A KR 1019940024025A KR 19940024025 A KR19940024025 A KR 19940024025A KR 100320803 B1 KR100320803 B1 KR 100320803B1
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KR
South Korea
Prior art keywords
fgf
gln
heparin
seq
fibroblast growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019940024025A
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English (en)
Korean (ko)
Inventor
루-유안리
앤드류피이터세던
야코브글루즈만
피이터보렌
Original Assignee
윌리암 에이취 캘넌, 에곤 이 버그
아메리칸사이아나미드컴파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application granted granted Critical
Publication of KR100320803B1 publication Critical patent/KR100320803B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
KR1019940024025A 1993-09-24 1994-09-23 섬유아세포성장인자구조동족체 Expired - Fee Related KR100320803B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12697493A 1993-09-24 1993-09-24
US08/126.974 1993-09-24

Publications (1)

Publication Number Publication Date
KR100320803B1 true KR100320803B1 (ko) 2002-06-20

Family

ID=22427669

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940024025A Expired - Fee Related KR100320803B1 (ko) 1993-09-24 1994-09-23 섬유아세포성장인자구조동족체

Country Status (13)

Country Link
EP (1) EP0645451B1 (https=)
JP (1) JPH07149797A (https=)
KR (1) KR100320803B1 (https=)
AT (1) ATE204604T1 (https=)
AU (1) AU680533B2 (https=)
CA (1) CA2132668A1 (https=)
DE (1) DE69428013T2 (https=)
DK (1) DK0645451T3 (https=)
ES (1) ES2161233T3 (https=)
NZ (1) NZ264529A (https=)
PT (1) PT645451E (https=)
TW (1) TW275068B (https=)
ZA (1) ZA947454B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874565A (en) 1995-08-29 1999-02-23 Washington University Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
AU3170499A (en) * 1998-04-28 1999-11-16 Eisai Co. Ltd. Fibroblast growth factor mutein compositions and methods of use therefor
CA2796459C (en) 2010-04-16 2016-05-24 Salk Institute For Biological Studies Methods for treating metabolic disorders using fgf-1
US9475856B2 (en) 2012-03-02 2016-10-25 New York University Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders
US9474785B2 (en) 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
US9464126B2 (en) * 2012-06-07 2016-10-11 New York University Chimeric fibroblast growth factor 21 proteins and methods of use
US9550820B2 (en) 2013-02-22 2017-01-24 New York University Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use
WO2015061331A1 (en) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
AU2014340241B2 (en) 2013-10-21 2018-11-01 Salk Institute For Biological Studies Mutated fibroblast growth factor (FGF) 1 and methods of use
WO2017075260A1 (en) 2015-10-30 2017-05-04 Salk Institute For Biological Studies Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs
WO2017159943A1 (ko) * 2016-03-17 2017-09-21 중앙대학교 산학협력단 화학반응을 통하여 결합된 섬유아세포 증식인자-헤파린 복합체 및 이의 제조 방법
US11229681B2 (en) * 2017-07-14 2022-01-25 The Regents Of The University Of California Dominant-negative FGF2 antagonists
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
CN116042681A (zh) * 2022-08-01 2023-05-02 普纳思细胞(厦门)生物科技有限公司 一种bFGF热稳定性改造的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377579A1 (en) * 1987-07-07 1990-07-18 California Biotechnology, Inc. Recombinant fibroblast growth factors
WO1989004832A1 (en) * 1987-11-24 1989-06-01 Amgen Inc. Analogs of fibroblast growth factor
GB8821795D0 (en) * 1988-09-16 1988-10-19 Erba Carlo Spa New derivatives of human/bovine basic fibroplast growth factor

Also Published As

Publication number Publication date
AU680533B2 (en) 1997-07-31
EP0645451A1 (en) 1995-03-29
DK0645451T3 (da) 2001-10-08
ATE204604T1 (de) 2001-09-15
PT645451E (pt) 2001-12-28
DE69428013T2 (de) 2002-05-29
EP0645451B1 (en) 2001-08-22
TW275068B (https=) 1996-05-01
ES2161233T3 (es) 2001-12-01
NZ264529A (en) 1997-06-24
JPH07149797A (ja) 1995-06-13
CA2132668A1 (en) 1995-03-25
DE69428013D1 (de) 2001-09-27
ZA947454B (en) 1995-05-15
AU7418594A (en) 1995-04-06

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