JPH07115980A - 両種性ウイルスレセプター - Google Patents
両種性ウイルスレセプターInfo
- Publication number
- JPH07115980A JPH07115980A JP6097018A JP9701894A JPH07115980A JP H07115980 A JPH07115980 A JP H07115980A JP 6097018 A JP6097018 A JP 6097018A JP 9701894 A JP9701894 A JP 9701894A JP H07115980 A JPH07115980 A JP H07115980A
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- nucleic acid
- glvr2
- gene
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010066342 Virus Receptors Proteins 0.000 title claims abstract description 6
- 102000018265 Virus Receptors Human genes 0.000 title claims abstract description 6
- 108020003175 receptors Proteins 0.000 claims abstract description 48
- 102000005962 receptors Human genes 0.000 claims abstract description 47
- 101000869719 Homo sapiens Sodium-dependent phosphate transporter 2 Proteins 0.000 claims abstract description 27
- 102100032419 Sodium-dependent phosphate transporter 2 Human genes 0.000 claims abstract description 25
- 241001430294 unidentified retrovirus Species 0.000 claims abstract description 23
- 150000007523 nucleic acids Chemical group 0.000 claims abstract description 22
- 108010084724 gibbon ape leukemia virus receptor Proteins 0.000 claims abstract description 21
- 239000013598 vector Substances 0.000 claims abstract description 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 8
- 239000012634 fragment Substances 0.000 claims description 20
- 102100029797 Sodium-dependent phosphate transporter 1 Human genes 0.000 claims description 17
- 230000001177 retroviral effect Effects 0.000 claims description 8
- 238000010188 recombinant method Methods 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 29
- 102000004169 proteins and genes Human genes 0.000 abstract description 12
- 241000713813 Gibbon ape leukemia virus Species 0.000 abstract description 7
- 238000001415 gene therapy Methods 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 26
- 241000700605 Viruses Species 0.000 description 12
- 239000002299 complementary DNA Substances 0.000 description 12
- 150000001413 amino acids Chemical class 0.000 description 11
- 235000018102 proteins Nutrition 0.000 description 10
- 239000013612 plasmid Substances 0.000 description 9
- 239000000523 sample Substances 0.000 description 9
- 238000002955 isolation Methods 0.000 description 8
- 108700026244 Open Reading Frames Proteins 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 102220201851 rs143406017 Human genes 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 210000003917 human chromosome Anatomy 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 102100021696 Syncytin-1 Human genes 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- 101710121417 Envelope glycoprotein Proteins 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 108091026890 Coding region Proteins 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 3
- 239000013604 expression vector Substances 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000001890 transfection Methods 0.000 description 3
- 239000013603 viral vector Substances 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 238000002105 Southern blotting Methods 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000013613 expression plasmid Substances 0.000 description 2
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 description 2
- 210000004754 hybrid cell Anatomy 0.000 description 2
- 125000001165 hydrophobic group Chemical group 0.000 description 2
- 210000003000 inclusion body Anatomy 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 230000008488 polyadenylation Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 210000005253 yeast cell Anatomy 0.000 description 2
- 241000219498 Alnus glutinosa Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000620209 Escherichia coli DH5[alpha] Species 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 108091029865 Exogenous DNA Proteins 0.000 description 1
- 208000004729 Feline Leukemia Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 101000658545 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Type I restriction enyme HindI endonuclease subunit Proteins 0.000 description 1
- 101100148577 Homo sapiens SLC20A1 gene Proteins 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000714177 Murine leukemia virus Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 241001505332 Polyomavirus sp. Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 208000000389 T-cell leukemia Diseases 0.000 description 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine kinase Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 108070000030 Viral receptors Proteins 0.000 description 1
- 108010006886 Vitrogen Proteins 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000002230 centromere Anatomy 0.000 description 1
- 238000003200 chromosome mapping Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 150000001945 cysteines Chemical class 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 238000001476 gene delivery Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 102000049090 human SLC20A2 Human genes 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 208000025036 lymphosarcoma Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000025113 myeloid leukemia Diseases 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US050684 | 1993-04-16 | ||
| US08/050,684 US5550221A (en) | 1993-04-16 | 1993-04-16 | Nucleic acid molecule encoding the amphotropic virus receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07115980A true JPH07115980A (ja) | 1995-05-09 |
Family
ID=21966754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6097018A Pending JPH07115980A (ja) | 1993-04-16 | 1994-04-12 | 両種性ウイルスレセプター |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5550221A (enExample) |
| EP (1) | EP0622377A3 (enExample) |
| JP (1) | JPH07115980A (enExample) |
| AU (1) | AU666432B2 (enExample) |
| CA (1) | CA2121302A1 (enExample) |
| NZ (1) | NZ260326A (enExample) |
| TW (1) | TW275067B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550221A (en) * | 1993-04-16 | 1996-08-27 | American Cyanamid Company | Nucleic acid molecule encoding the amphotropic virus receptor |
| WO1998038203A1 (en) * | 1997-02-27 | 1998-09-03 | Emory University | Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness |
| US20040002079A1 (en) * | 1998-02-11 | 2004-01-01 | Gunn Robert B. | Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2071714T3 (es) * | 1989-08-24 | 1995-07-01 | American Cyanamid Co | Receptor del virus de la leucemia del mono gibon. |
| US5151361A (en) * | 1989-08-24 | 1992-09-29 | American Cyanamid Company | Host cells expressing gibbon ape leukemia virus receptor |
| US5550221A (en) * | 1993-04-16 | 1996-08-27 | American Cyanamid Company | Nucleic acid molecule encoding the amphotropic virus receptor |
-
1993
- 1993-04-16 US US08/050,684 patent/US5550221A/en not_active Expired - Fee Related
- 1993-05-14 TW TW082103787A patent/TW275067B/zh active
-
1994
- 1994-03-28 EP EP94104889A patent/EP0622377A3/en not_active Withdrawn
- 1994-04-12 JP JP6097018A patent/JPH07115980A/ja active Pending
- 1994-04-14 CA CA002121302A patent/CA2121302A1/en not_active Abandoned
- 1994-04-15 AU AU59493/94A patent/AU666432B2/en not_active Ceased
- 1994-04-15 NZ NZ260326A patent/NZ260326A/en unknown
-
1996
- 1996-01-04 US US08/582,719 patent/US5633348A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU666432B2 (en) | 1996-02-08 |
| AU5949394A (en) | 1994-10-20 |
| NZ260326A (en) | 1996-05-28 |
| US5633348A (en) | 1997-05-27 |
| CA2121302A1 (en) | 1994-10-17 |
| EP0622377A3 (en) | 1995-01-11 |
| TW275067B (enExample) | 1996-05-01 |
| EP0622377A2 (en) | 1994-11-02 |
| US5550221A (en) | 1996-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5886153A (en) | Antibodies directed against the alpha interferon receptor | |
| JPH07115980A (ja) | 両種性ウイルスレセプター | |
| WO1998033819A9 (en) | Cellular receptors for subgroup c adenoviruses and group b coxsackieviruses | |
| WO1998033819A1 (en) | Cellular receptors for subgroup c adenoviruses and group b coxsackieviruses | |
| US5874264A (en) | Gibbon ape leukemia virus receptor | |
| JPH10504714A (ja) | ヒトカリウムチャンネル１および２タンパク質 | |
| CN1193981A (zh) | 人g蛋白偶联受体(hetgq23) | |
| JPH11502119A (ja) | ヒトｂ細胞転座遺伝子−２及び３ | |
| JP3759168B2 (ja) | 内皮単球活性ポリペプチドｉｉｉ | |
| JP2001501464A (ja) | ヒトｂ細胞転座遺伝子―２および３ | |
| WO2001088112A1 (en) | A novel polypeptide, a human focal adhesion kinase (fak) 13 and the polynucleotide encoding the polypeptide | |
| WO2001064727A1 (fr) | Nouveau polypeptide, adenosinate cyclase soluble 25 de souris, et polynucleotide codant pour ce polypeptide | |
| WO2001090181A1 (en) | A novel polypeptide -human b cell protein tyrosine kinase 13 and a polynucleotide sequence encoding the same | |
| WO2001046238A1 (fr) | Nouveau polypeptide, alpha-1b-glycoproteine humaine 12, et polynucleotide codant pour ce polypeptide | |
| WO2001066724A1 (fr) | Nouveau polypeptide, actine humaine 14, et polynucleotide codant pour ce polypeptide | |
| WO2001075021A2 (fr) | Nouveau polypeptide, proteine humaine associee au transport de glucose 10, et polynucleotide codant pour ce polypeptide | |
| WO2001073004A1 (fr) | Nouveau polypeptide, proteine humaine de liaison du retinaldehyde 39, et polynucleotide codant pour ce polypeptide | |
| WO2001092518A1 (fr) | Nouveau polypeptide, proteine humaine 9.5 associee a la ccr4, et polynucleotide codant ce polypeptide | |
| WO2001046243A2 (fr) | Nouveau polypeptide, proteine annulaire 8, et polynucleotide codant pour ce polypeptide | |
| WO2001075036A2 (fr) | Nouveau polypeptide, immunophiline humaine 14, et polynucleotide codant pour ce polypeptide | |
| WO2001073005A1 (fr) | Nouveau polypeptide, canal potassique ionique humain 10 de redressement d'introversion couple a la proteine g, et polynucleotide codant pour ce polypeptide | |
| WO2001048211A1 (en) | A novel polypeptide, dna polymerase 13 and the polynucleotide encoding the polypeptide | |
| JP2002369685A (ja) | アポトーシス遺伝子１のヒトインヒビター | |
| WO2001075012A2 (fr) | Nouveau polypeptide, peptide signal humain 10 d'une proteine precurseur de la lipoproteine, et polynucleotide codant pour ce polypeptide | |
| WO2001083726A1 (en) | A novel polypeptide, a human kinase uridylate 12 and the polynucleotide encoding the polypeptide |