JPH07114802B2 - 生物適合性ポリマー材料及びその製造方法 - Google Patents
生物適合性ポリマー材料及びその製造方法Info
- Publication number
- JPH07114802B2 JPH07114802B2 JP2185439A JP18543990A JPH07114802B2 JP H07114802 B2 JPH07114802 B2 JP H07114802B2 JP 2185439 A JP2185439 A JP 2185439A JP 18543990 A JP18543990 A JP 18543990A JP H07114802 B2 JPH07114802 B2 JP H07114802B2
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- acid
- solution
- water
- graft copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title description 5
- 229920000249 biocompatible polymer Polymers 0.000 title description 2
- 239000002861 polymer material Substances 0.000 title description 2
- 239000000463 material Substances 0.000 claims description 80
- 102000008186 Collagen Human genes 0.000 claims description 50
- 108010035532 Collagen Proteins 0.000 claims description 50
- 229920001436 collagen Polymers 0.000 claims description 50
- 239000002253 acid Substances 0.000 claims description 36
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 31
- 229920000642 polymer Polymers 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 21
- 239000000178 monomer Substances 0.000 claims description 20
- 238000001179 sorption measurement Methods 0.000 claims description 20
- 229920000578 graft copolymer Polymers 0.000 claims description 16
- 239000000047 product Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 11
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 10
- 230000005855 radiation Effects 0.000 claims description 10
- 238000007334 copolymerization reaction Methods 0.000 claims description 9
- 150000001768 cations Chemical class 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 210000003786 sclera Anatomy 0.000 claims description 8
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 7
- 102000003886 Glycoproteins Human genes 0.000 claims description 6
- 108090000288 Glycoproteins Proteins 0.000 claims description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 5
- 102000016611 Proteoglycans Human genes 0.000 claims description 5
- 108010067787 Proteoglycans Proteins 0.000 claims description 5
- 229910004298 SiO 2 Inorganic materials 0.000 claims description 5
- 150000001450 anions Chemical class 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 5
- 239000000049 pigment Substances 0.000 claims description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 5
- 229920002554 vinyl polymer Polymers 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- -1 hydrofluoric acid anions Chemical class 0.000 claims description 4
- 210000005252 bulbus oculi Anatomy 0.000 claims description 3
- 239000003929 acidic solution Substances 0.000 claims description 2
- 238000002144 chemical decomposition reaction Methods 0.000 claims description 2
- 238000002848 electrochemical method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 61
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 19
- 238000003756 stirring Methods 0.000 description 12
- 230000035699 permeability Effects 0.000 description 11
- 229940044192 2-hydroxyethyl methacrylate Drugs 0.000 description 9
- 102000004142 Trypsin Human genes 0.000 description 9
- 108090000631 Trypsin Proteins 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 239000012588 trypsin Substances 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 8
- 230000002378 acidificating effect Effects 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 238000000605 extraction Methods 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 210000004087 cornea Anatomy 0.000 description 4
- 210000001508 eye Anatomy 0.000 description 4
- 239000007943 implant Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 229910052573 porcelain Inorganic materials 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 4
- 239000002594 sorbent Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 3
- 239000004327 boric acid Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000003352 fibrogenic effect Effects 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010011033 Corneal oedema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000208317 Petroselinum Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000004778 corneal edema Diseases 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 102000013373 fibrillar collagen Human genes 0.000 description 1
- 108060002894 fibrillar collagen Proteins 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 159000000011 group IA salts Chemical class 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 235000011197 perejil Nutrition 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F292/00—Macromolecular compounds obtained by polymerising monomers on to inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Zoology (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Graft Or Block Polymers (AREA)
- Materials For Medical Uses (AREA)
- Eyeglasses (AREA)
- Polymerisation Methods In General (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU894745668A RU2033165C1 (ru) | 1989-10-13 | 1989-10-13 | Способ получения пластичного материала из коллагена |
| SU4745668 | 1989-10-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03146066A JPH03146066A (ja) | 1991-06-21 |
| JPH07114802B2 true JPH07114802B2 (ja) | 1995-12-13 |
Family
ID=21472834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2185439A Expired - Lifetime JPH07114802B2 (ja) | 1989-10-13 | 1990-07-16 | 生物適合性ポリマー材料及びその製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5286829A (https=) |
| JP (1) | JPH07114802B2 (https=) |
| CN (1) | CN1051918A (https=) |
| DE (1) | DE4020625A1 (https=) |
| RU (1) | RU2033165C1 (https=) |
| SE (1) | SE9002459L (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322889A (en) * | 1991-09-24 | 1994-06-21 | Mitsubishi Rayon Co., Ltd. | Composite composition having high transparency and process for producing same |
| CA2188563C (en) | 1994-04-29 | 2005-08-02 | Andrew W. Buirge | Stent with collagen |
| US5661218A (en) * | 1994-07-22 | 1997-08-26 | Staar Surgical Company, Inc. | Biocompatible optically transparent polymeric material based upon collagen and method of making |
| WO1996003456A1 (en) * | 1994-07-22 | 1996-02-08 | Vladimir Feingold | Biocompatible optically transparent polymeric material based upon collagen and method of making |
| RU2084468C1 (ru) * | 1995-02-17 | 1997-07-20 | Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Способ получения биосовместимого полимерного материала |
| NZ310832A (en) * | 1995-06-07 | 1999-11-29 | Alexei V Osipov | Biocompatible optically transparent polymeric material based upon collagen and acrylic or allelic monomers |
| RU2139017C1 (ru) * | 1997-10-23 | 1999-10-10 | Общество с ограниченной ответственностью Научно-экспериментальное производство "Микрохирургия глаза" | Способ получения биосовместимого материала |
| RU2150956C1 (ru) * | 1999-06-24 | 2000-06-20 | Общество с ограниченной ответственностью "Научно-экспериментальное производство "Микрохирургия глаза" | Способ получения биосовместимого материала |
| US6432137B1 (en) | 1999-09-08 | 2002-08-13 | Medennium, Inc. | High refractive index silicone for use in intraocular lenses |
| RU2161976C1 (ru) * | 2000-04-21 | 2001-01-20 | Панасюк Андрей Федорович | Способ получения коллагена из костной ткани |
| US20080081851A1 (en) * | 2006-09-01 | 2008-04-03 | Benz Patrick H | Optical polymers with higher refractive index |
| HUE024146T2 (en) * | 2008-05-07 | 2016-02-29 | Univ California | Medical filling and enrichment of eye surface lubrication |
| US8506944B2 (en) * | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
| AU2015203038B2 (en) * | 2010-02-08 | 2017-02-23 | Regents Of The University Of Minnesota | Silica-based composite ocular device and methods |
| AU2011213601A1 (en) * | 2010-02-08 | 2012-09-06 | Regents Of The University Of Minnesota | Silica-based composite ocular device and methods |
| KR102171529B1 (ko) | 2014-09-09 | 2020-10-30 | 스타 서지컬 컴퍼니 | 확장된 피사계 심도 및 향상된 원거리 시력의 안과용 임플란트 |
| US12127934B2 (en) | 2014-09-09 | 2024-10-29 | Staar Surgical Company | Method of Providing Modified Monovision to a Subject with a First Lens and a Second Lens |
| BR112018068184B1 (pt) | 2016-03-09 | 2023-02-14 | Staar Surgical Company | Lente configurada para implantação em um olho de um ser humano |
| KR102560250B1 (ko) | 2018-08-17 | 2023-07-27 | 스타 서지컬 컴퍼니 | 나노 구배의 굴절률을 나타내는 중합체 조성물 |
| WO2023060017A1 (en) | 2021-10-04 | 2023-04-13 | Staar Surgical Company | Ophthalmic implants for correcting vision with a tunable optic, and methods of manufacture and use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687820A (en) * | 1984-08-22 | 1987-08-18 | Cuno Incorporated | Modified polypeptide supports |
| US4731080A (en) * | 1985-01-18 | 1988-03-15 | Galin Miles A | Coated intraocular lens |
| US4978352A (en) * | 1989-06-07 | 1990-12-18 | Fedorov Svjatoslav N | Process for producing collagen-based cross-linked biopolymer, an implant from said biopolymer, method for producing said implant, and method for hermetization of corneal or scleral wounds involved in eye injuries, using said implant |
-
1989
- 1989-10-13 RU SU894745668A patent/RU2033165C1/ru active
-
1990
- 1990-06-28 DE DE4020625A patent/DE4020625A1/de active Granted
- 1990-07-06 US US07/549,452 patent/US5286829A/en not_active Expired - Fee Related
- 1990-07-16 JP JP2185439A patent/JPH07114802B2/ja not_active Expired - Lifetime
- 1990-07-18 SE SE9002459A patent/SE9002459L/xx not_active Application Discontinuation
- 1990-10-11 CN CN90109120A patent/CN1051918A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1051918A (zh) | 1991-06-05 |
| DE4020625C2 (https=) | 1993-04-15 |
| SE9002459D0 (sv) | 1990-07-18 |
| DE4020625A1 (de) | 1991-04-18 |
| RU2033165C1 (ru) | 1995-04-20 |
| JPH03146066A (ja) | 1991-06-21 |
| US5286829A (en) | 1994-02-15 |
| SE9002459L (sv) | 1991-04-14 |
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