JPH0667903B2 - ３―チオプロピオン酸誘導体の製造法 - Google Patents

３―チオプロピオン酸誘導体の製造法

Info

Publication number
JPH0667903B2
JPH0667903B2 JP64000821A JP82189A JPH0667903B2 JP H0667903 B2 JPH0667903 B2 JP H0667903B2 JP 64000821 A JP64000821 A JP 64000821A JP 82189 A JP82189 A JP 82189A JP H0667903 B2 JPH0667903 B2 JP H0667903B2
Authority
JP
Japan
Prior art keywords
proline
acid
product
mixture
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP64000821A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01246257A (ja
Inventor
ウォルター リュヤン ジェームス
チュング アルフレッド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Original Assignee
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami filed Critical University of Miami
Publication of JPH01246257A publication Critical patent/JPH01246257A/ja
Publication of JPH0667903B2 publication Critical patent/JPH0667903B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP64000821A 1980-03-10 1989-01-05 ３―チオプロピオン酸誘導体の製造法 Expired - Lifetime JPH0667903B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12895380A 1980-03-10 1980-03-10
US128953 1980-03-10
US15827880A 1980-06-10 1980-06-10
US158278 1980-06-10
AU73631/81A AU7363181A (en) 1980-03-10 1981-07-31 Anti-ace peptide preparative methods

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP3445781A Division JPS56164154A (en) 1980-03-10 1981-03-10 Manufacture of antihypertensive

Publications (2)

Publication Number Publication Date
JPH01246257A JPH01246257A (ja) 1989-10-02
JPH0667903B2 true JPH0667903B2 (ja) 1994-08-31

Family

ID=27156035

Family Applications (3)

Application Number Title Priority Date Filing Date
JP64000821A Expired - Lifetime JPH0667903B2 (ja) 1980-03-10 1989-01-05 ３―チオプロピオン酸誘導体の製造法
JP64000819A Expired - Lifetime JPH0667901B2 (ja) 1980-03-10 1989-01-05 ３―チオプロピオン酸誘導体の製造法
JP64000820A Expired - Lifetime JPH0667902B2 (ja) 1980-03-10 1989-01-05 ３―チオプロピオン酸誘導体の製造法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP64000819A Expired - Lifetime JPH0667901B2 (ja) 1980-03-10 1989-01-05 ３―チオプロピオン酸誘導体の製造法
JP64000820A Expired - Lifetime JPH0667902B2 (ja) 1980-03-10 1989-01-05 ３―チオプロピオン酸誘導体の製造法

Country Status (14)

Country Link
EP (1) EP0038117A1 (enExample)
JP (3) JPH0667903B2 (enExample)
KR (1) KR850001629B1 (enExample)
AU (1) AU7363181A (enExample)
CS (1) CS174581A2 (enExample)
DD (1) DD156805A5 (enExample)
DK (1) DK105981A (enExample)
ES (5) ES8305698A1 (enExample)
FI (1) FI810725L (enExample)
GR (1) GR74795B (enExample)
NO (5) NO156695C (enExample)
PL (1) PL230076A1 (enExample)
PT (1) PT72635B (enExample)
SU (1) SU1567125A3 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
CN111039838B (zh) * 2019-12-31 2022-04-05 杭州乐敦科技有限公司 一种3-乙酰巯基-2-甲基丙酸的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids

Also Published As

Publication number Publication date
DK105981A (da) 1981-09-11
JPH02209865A (ja) 1990-08-21
NO156695B (no) 1987-07-27
EP0038117A1 (en) 1981-10-21
GR74795B (enExample) 1984-07-12
PL230076A1 (enExample) 1982-09-13
CS174581A2 (en) 1990-09-12
JPH0667901B2 (ja) 1994-08-31
ES519564A0 (es) 1984-03-01
DD156805A5 (de) 1982-09-22
ES500254A0 (es) 1983-04-16
NO831112L (no) 1981-09-11
KR830005133A (ko) 1983-08-03
ES519567A0 (es) 1984-03-16
NO831114L (no) 1981-09-11
ES8403449A1 (es) 1984-03-16
ES519566A0 (es) 1984-03-16
NO156695C (no) 1987-11-04
SU1567125A3 (ru) 1990-05-23
PT72635B (en) 1982-03-19
FI810725A7 (fi) 1981-09-11
NO831111L (no) 1981-09-11
JPH0667902B2 (ja) 1994-08-31
JPH01246257A (ja) 1989-10-02
NO810795L (no) 1981-09-11
JPH01250344A (ja) 1989-10-05
ES8403450A1 (es) 1984-03-16
ES519565A0 (es) 1984-03-16
FI810725L (fi) 1981-09-11
ES8403448A1 (es) 1984-03-16
PT72635A (en) 1981-04-01
NO831113L (no) 1981-09-11
ES8305698A1 (es) 1983-04-16
ES8403104A1 (es) 1984-03-01
KR850001629B1 (ko) 1985-10-31
AU7363181A (en) 1983-02-03

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