JPH06506938A - Antibacterial mild liquid skin cleanser - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention relates to mild liquid skin cleansers. More specifically, the present invention provides antibacterial The present invention relates to a liquid skin cleanser.

Cleaning the skin with surfactant cleaning formulations has been the subject of great interest. coming. Many people scrub their skin several times a day with various surfactant preparations. . Liquid cleansers are highly preferred, especially for hand washing, due to their convenience and uncomplicatedness. anti Bacterial personal cleansers are preferred because they kill germs. mild par Sonal cleansers are desired to minimize skin irritation, dryness, etc. These 3 A non-sonal cleansing product with all the favorable properties is highly desirable. stomach.

Skin cleansers soften the skin without drying it out after frequent daily use. It is best to keep it clean and cause little or no irritation. A synthetic surfactant The agent is particularly mild. However, when prescribed for skin cleansing, The main drawback of mild liquid synthetic surfactant systems in foaming is poor foaming performance. It is. The best bar soap standards (bars that are rich in coconut soap and have excess fat content) and When compared, these conventional liquid surfactant formulations produce poor foam or poor skin. Has skin-friendly properties. As expected, foaming performance depends on the surfactant and its concentration. is a function of degree selection. Liquid surfactants formulated with or without skin feel agents The anticipated number of sex agent compositions is large. The rheology and prototype The phase properties are very wide (i.e., dilute solutions, gels, concentrated pastes, solutions, emulsions). ). The phase stability of the prototypes is mostly acceptable for short periods of time, but their Only a small fraction of them maintain their original properties and acceptability over long periods of time.

For example, U.S. Pat. No. 4,338 issued July 6, 1982 to 5aikos. , No. 211, No. 4,310, published in Sti+os on January 12, 1982. ．． No. 433 and U.S. Pat. No. 4,84 issued June 27, 1989. No. 2,850; all of the above patents are incorporated herein by reference.

Optimizing foamability as a single variable is a fairly straightforward process. Known high foam The combination of standing anionic surfactants and foam enhancers shows acceptable foaming capacity. . Unfortunately, the highest lathering anionic surfactants are usually also It is the best and the worst in terms of clinical mildness. Lauryl ether (12E O) most effective with minimal skin irritation such as ammonium sulfate (NH4AE125) Mild surfactants have extremely poor foaming properties. these two facts It alone makes the delicate balance between surfactant selection and foam enhancement optimization process. Make it an action that involves stress. See, for example, U.S. Pat. See specification No. 4,338,211.

The introduction of antimicrobial agents into the equation further improves the problem with regard to mildness, foaming properties and antimicrobial efficacy. Add to. Certain mild ethoxylated nonionic surfactants, such as Twee Tveano 80 CI CI Americas, Inc. (tcl America) s.

Inc.)] and lecithin is the preferred antibacterial agent triclosan (T+1clo+a n) (Irgasano DP300 is referred to as “Te3” here) It has been reported in commercial literature that it has an inactivating effect on the sterilizing properties of Ciba-Geig7. lrgasanoDP300.　Trade　 Bulletin, 1988〜Liquid shampoo and other personal cleansers The use of antibacterial agents in liquid products is well known, and at least two types of antibacterial agents are used in liquid disinfectants. LIQUID DIALo Antibacterial Soap and Soft Soap (5OFTSO AP ■) It is commercially available under the trade name of antibacterial moisturizing soap. Antibacterial liquid in the current market Body cleansing products are relatively harsh. Therefore, special It is highly desirable to improve mildness without impairing sterilization efficacy. specific antibacterial Liquid cleanser was issued to Bi+5elt and Bush on July 11, 1989. No. 4,847,072, issued July 3, 1990 by Degent. No. 4,939,284 issued to +a+dt and dated April 11, 1989 No. 4.820,698, issued to Degenha+dt. However, the above patents are incorporated herein by reference.

In short, limiting the selection of surfactants and antibacterial agents for skin cleansers. However, there are strict requirements, and as a result, a certain degree of compromise is required in the final antibacterial formulation. Ma Ildability is sacrificed in terms of either mildness, product stability, or both. Much is gained at the expense of effective disinfection or effective cleansing and foaming properties.

The present invention provides a valuable combination of desirable properties for liquid skin cleaning formulations. do.

Therefore, one object of the present invention is to provide improved mildness, better leanability, and The present invention is the development of a liquid skin cleaning composition that exhibits strong foaming properties and good sterilizing properties. .

Another object of the present invention is the development of a low cost liquid skin cleanser.

Other objectives will become apparent from the specific description below: improved mildness and A liquid skin cleanser composition with antibacterial properties is (0.5-5.75% by weight of Al mild ethoxylated surfactant; (B) Non-ethoxylated anionic, nonionic, zwitterionic and amphoteric surfactants and their 1 to 40% by weight of a cosurfactant selected from the group consisting of a mixture of these (cosurfactant) The surfactant has a harsh ratio of approximately 20:1 to 1:5.8 (hazhj co-surfactant to Harsh surfactants at levels that indicate the proportion of harsh ethoxylated surfactants including); (C) Preferably a halogenated aromatic antibacterial agent, octopirox and mixtures thereof 0.01-4% by weight of an antimicrobial agent selected from the group of substances.

FD) 0.05-5% by weight of water-soluble cationic polymer: and (El water 35-97% by weight Contains.

Detailed description of the invention The present invention provides a mild ethoxylic acid with the best sterilization and preferably the best foaming performance. surfactant liquid skin cleaning composition. Co-surfactants, preferred or have good suds-promoting power, typically harsh surfactants are improved. Used with the mild ethoxylated surfactants mentioned above to provide foaming properties. Ru.

Antimicrobial agents are compatible with cosurfactants, such as alkyl sulfates, with the exception of It is not very compatible with cold ethoxylated surfactants. However, the present invention further enhances the combination of two types of surfactants and antimicrobial agents.

A liquid skin cleanser composition with improved mildness and antibacterial properties is... (^) A polymer selected from the group consisting of anionic, nonionic and mixtures thereof. 0.5-5.75% of ethoxylated surfactant (preferably anionic) Alkyl ethoxy sulfate has 1 to 2 o ethoxy groups) (B) Non-ethoxy sulfate ・Xylated anionic, nonionic, dipolar and amphoteric surfactants and their mixtures from substances, preferably anionic systems with good cleaning properties, especially alkyl sulfates. 1 to 40% of an antibacterial agent compatible co-surfactant selected from the group consisting of; (C) Preferably a halogenated aromatic antibacterial agent, octopirox and mixtures thereof an antibacterial agent selected from the group of substances, more preferably triclosan (Te3) 0.01 ~4%.

(II) Water-soluble cationic polymer, preferably cationic guar gum 0.05 ~5%: and (E) Water 35-97%, preferably 50-95%, more preferably 75-90% Contains.

The total level of (A) and (B) is at least about 4% to keep the composition stable. It is enough.

A more detailed description of the levels and ranges of the ingredients of the present invention is shown in Tables 1 and 2 below. There is.

In particular, the ranges and levels shown in Tables 1 and 2 are approximate and can only be roughly interpreted. should be interpreted. Levels and ranges will vary depending on the particular selection of ingredients.

Co-interface Cationic system Zero book Activator MES Antibacterial agent Polymer Full range 1-4Gjf 0.5-5.8'A 0.05-4% 0.05-5% Preferred range 4-20% 24% 0.1-2% 0.1-2% More preferred 5-105f 3-4.5% 02-1% 0.2-1% co-surfactant Total ratio N/A 8011-1:6) 100:l-1:4 800:l-1: 5 Preferred ratio N/A 4011-112 200:l-3:l 200:l -3:1 more preferred IN/^ 2.111 5G:1-IQ:I 5Q:l-1 11:IMES” Total ratio *N/A 116・l-11811611-1110 Preferred ratio *N/A 50:I-3:I 5 [1:I-3+1 more preferred *N/A 2511-511 2511-511 Triclosan Total ratio * * N/A 8011-111N Preferred ratio * * N/A lO:I-1:10 More preferable * N/A 3:l-1:39 Other in the table indicated in the passage ■Mild ethoxylated surfactant Some preferred co-surfactant blends are: lauramide or cocoamide DEA ( 711-1ON O,5-5141-2% Cocoamidopropyl betaine 1-1 0% 0.5-5% 1-2% Total 3-40% 4-20% 6-12% Table 2 Further preferred levels and ratios Full range 1-20% 0.5-5.8% 0.05-4% 0.05-5% preferred Desirable range 3-10% 24% 0.10-2% Q, l-2% More preferred I5- 7% 2-5% 0.1-0.8jl O, 2-1% more preferred N/A 2 :l-1115[1:I-5:l 50.15:1 preferred ratio *N/ A 5011-3:l 501-31 more preferred *N/A 25・l-5 1125:l-5:18 Shown elsewhere in the table Ethoxylated surfactant The essential ingredient is an ethoxylated (or propoxylated) surfactant that is mild to the skin. It is a drug. Propoxylated surfactants are ethoxylated surfactants as defined herein. Essentially corresponds to a surfactant. Preferred mild ethoxylation (or propoxylation) silating) surfactants have a relative barrier breakdown inc of about 50 or less as defined below. It has a dex value (mildness). Rau, a mild ethoxylated surfactant Ammonium less-3 carboxylate (AE C-NH40H at pH 6.5) is approximately 5 It has an "index value" of 0. “Harsh” surfactants have an index of more than 50 Any surfactant or co-surfactant that has a

Ethoxylated mild surfactants improve the mildness of liquid compositions Therefore, it is conveniently used. For this purpose, the level is preferably about 0.5% to about 5.8%. Preferably, it is about 2% to about 5%. However, soil with higher levels of ethoxy Mild surfactants reduce the antimicrobial effectiveness of the composition.

Some examples of preferred surfactants are 1 mole C-C alcohol (e.g. tallow or coconut oil alcohol) and about 1 to 20, preferably 1 to 13, more preferably 2 The sulfate ester of the reaction product with ~6 moles of ethylene oxide (ethoxy group) alkali metal and ammonium salts. Jetanolamines are ethoxylated It is not a surfactant. CTFA names of some preferred ethoxylated surfactants Hani Anion type Ammonium laureth sulfate, CAS #32612-48-9 (generic name) Palace -15-7 carboxylic acid TE, A-oleamide PEG-n sulfosuccinate.

TEA = triethanolamine PPG-5-cethesu-10 phosphate, RD 8977061-611-9no Nion type polysorbate 80 Palace-15-5 PPG-8-Cetesu Ill, CAS #9 [187-53-D (generic) P EG-5M PEG-8 stearate, CAS #9004-99-3 (generic name) in vitro Kimbalia Penetration Test (mild) was published on March 14, 1989 by Small et al. Similar to the operations described in U.S. Pat. No. 4,812,253 issued in Although it can be used to evaluate the relative irritation of surfactants, the above patents Incorporated herein for consideration. The essential mild ethoxylated surfactant is 50 Preferably, it is selected to have a mildness index value of:

Many surfactants tend to improve cleaning properties, especially when making products milder. They also tend to have negative elements. Regarding relative barrier destruction Char 6 stones 1 , "Barrier destruction index value" ALS = 100; water = 0 relative barrier destruction chart Toma 1 Relative barrier destruction Surfactant index value Ammonium lauryl sulfate (ALS) 100 ammonium laureth-3 carboxylate Ammonium (pH=6.5) 50 laureth-3 ammonium sulfate (Ag2S) 3G Sodium lauroyl sarcosinate 25 cocoyl monoethanolamine Disodium sulfosuccinate 25 Non-oxyno-4 sodium sulfate 110 octyl glycerol ethersal Phate 10 lauryl polyglucose 210 2 Henke APG550 (1,7) co-surfactant Another essential ingredient of the liquid skin cleanser composition is one or more non-ethoxylic It is a “co-surfactant” that is used for its cleaning properties, foaming properties, cost or resistance. Preferably, the selection is made with respect to fungicide compatibility. Therefore, the selection of co-surfactants The term "co-surfactant" and "co-surfactant" should be interpreted broadly. known in the industry Higher foaming surfactants that are or can be tested are preferred.

The rule is that when it comes to foaming or cleaning properties, co-surfactants are The aim is to increase the foaming or cleaning power of the laser. Co-surfactants are also mild The choice can be made with respect to its properties and its cleaning or suds-promoting properties. However However, such co-surfactants are typically harsh (e.g. Value〉50). Compositions exhibiting the best balance of properties range from about 20.1 to about 15.8, preferably or about 51 to about 1:2, more preferably about 2:1 to about 1:1. It has a ratio of sex agent to mild ethoxylated surfactant.

Some preferred co-surfactant blends are shown after Table 1.

As used herein, the term "co-surfactant" is used in the liquid compositions of the present invention. represents any non-ethoxylated surfactant. Co-surfactants contain all non-ethyl Xylated surfactants, especially those that lather well, clean, and are compatible with antimicrobial agents. Including those that are more compatible than ethoxylated surfactants. Preferred co-world of the present invention Surfactants are alkyl sulfates derived from the sulfation of C8-C22 alcohols. Potassium metals (e.g. sodium or potassium) and ammonium, which Similarly derived alkyl betaines (dipolar) and alkylamides (nonio) of glycerides or other esters of tallow or coconut ura fatty acids combined with Synthetically induced or produced by reduction.

Preferred co-surfactants mentioned herein are alkyl sulfates (AS) . Preferred ethoxylated surfactants are alkyl ether sulfates (Ag2S ).

The U.S. patents incorporated herein by reference describe ethoxylated surfactants and cosurfactants. The broad and detailed list of antibacterial agents in both sex agents ranges from about 0.01% to about 4%, typically about 0.01% to about 4%. It can be present at a level of 1 to about 2%, preferably about 0.5 to about 1%. That level is selected to exhibit the desired level of antimicrobial activity and can be modified as desired. can. A preferred antimicrobial agent is 2-hydroxy-4,2',4'-trichlorodiphene. Nyl ether (Te3). Other halogenated antimicrobial agents are shown below. skilled in the art U.S. Patent Measures 3, which are known to the public and are incorporated by reference, e.g. Many of the antimicrobial agents disclosed in No. 835,057 and No. 4,714.563 or used.

Appropriate antibacterial agents include: 2-Hydroxy-4,2″,4′-trichlorodiphenyl ether (Te3): 2.6-dimethyl-4-hydroxychlorobenzene (PCMX); 3.4.4-1 Lichlorocarboanilide (TCC); 3-trifluoromethyl- 4,4'-dichlorocarboanilide (TFC); 2.2゛-dihydroxy-3,3-,5,5-,6゜6'-hexachlorodiphe Nylmethane; 2,2'-dihydroxy-3,3',5.5''-tetrachlorodif phenylmethane; 2.2'-dihydroxy-3,3'-dibromo-5゜5'-dichlorodiphenyl methane; 2-Hydroxy-4,4'-dichlorodiphenyl ether.

2-hydroxy-3,5-,4-h ribromodiphenyl ether; and 1-Hydroxy-4-methyl-6-(2,4,44-limethylpentyl)-2(I H) -Viridinone (including systems that do not contain octoethoxylated surfactants) The inclusion of an effective amount of water-soluble cationic polymer in any liquid antibacterial composition is mild. It is supposed to improve sex. Water-soluble cationic polymer skin compound essential to the present invention The daylighting agent is... (1) Cationic polysaccharides.

(11) Cationic copolymer of saccharide and synthetic cationic monomer; and (l　II　I)　(A) Cationic polyalkyleneimine (B) Cationic polyalkyleneimine Toxypolyalkyleneimines and (C) cationic poly[N-[3-(dimethyl)] tylammonio)propyl)-N--(3-(ethyleneoxyethylenedimethyl Ammonio)propyl urea dichloride a synthetic polymer selected from the group consisting of;

Hydrated cationic polymer skin conditioners found useful with compositions of the present invention - from about 0.05 to about 5%, preferably from about 0.1 to about 2% by weight of the active polymer. %. Liquid cleaning compositions containing relatively small amounts of these polymers are shows significantly improved clinical mildness compared to compositions without the polymer. profit The mildness of synthetic surfactant-based liquid antibacterial skinks on the current market Unexpectedly and amazingly better than with a ranging product.

Cationic polymers also provide a desirable silky, soft and smooth feel during use. Wear.

Cationic polymers have a mild effect and at the same time have good foaming characteristics. Highly acceptable in terms of foaming capacity, cleaning performance, rinsability, skin feel, odor, and sterilization. It can be used to maintain desired liquid cleansing product properties during use. child This is because cationic polymers are particularly effective at the high levels typically required to improve mildness. When used and when used without hydration as specified in the present invention, This is unexpected as it has a significant negative impact on sexuality. For example, those suppresses foaming capacity, changes its characteristics, makes it less rinsable, and has a negative impact on odor. has an impact.

The cationic polysaccharide class includes polymers based on 5- or 6-carbon sugars and polymers based on cationic polysaccharide backbones. and derivatives that are cationized by connecting the on moiety. They are one type of sugar or a copolymer of two or more types of sugars, i.e. the above derivatives and cationic substances. It may be The monomers may be in a linear or branched geometry. stomach. Examples of cationic polysaccharide polymers include the following. Cationic cellulose and hydrogen Droxyethyl cellulose: cationic starch and hydroxyalkyl starch based on arabinose monomers, such as those derived from arabinose plant gums. Cationic polymers; found in materials such as wood, straw, cottonseed husk and corn cob Cationic polymer derived from xylose polymer; component of living seaweed cell wall A cationic polymer derived from fucose polymers found in certain plants. Cationic polymers derived from fructose polymers such as inulin found in Limer; cationic system based on acid-containing sugars such as galacturonic acid and glucuronic acid Polymers: cations based on amine sugars such as galactosamine and glucosamine based polymers; cationic polymers based on 5- and 6-membered ring polyalcohols; Galactose monomers (cationic polymers based on galactose monomers present in mucus and mucus; Cationic polymers based on mannose monomers, such as those found in plants, yeast and red algae. galactomanna, also known as guar gum, obtained from the endosperm of guar beans Cationic polymers based on copolymers As a specific example of the cationic polysaccharide class (Union Carbide Co., Ltd.) (Union Carbide Corporation) cationic hydride Roxyethyl cellulose JR400; manufactured by Haley, Inc. cationic starch starch [Co., Ltd.] Stalok 100.200.300 and 400; Henkel fH Galaftasol (Galac+a+ol) by Enkel, Inc.) 800 series, by Rhone-Poalenc) Jaguar (Iagua+j series (e.g. Jaguar C-14 and C162) ) is a cationic galactomannan based on guar gum.

(II) Cationic copolymers of sugars and synthetic cationic monomers useful in the present invention include: Some contain sugars. Glucose, galactose, mannose, arabinose xylose, fucose, fructose, glucosamine, galactosamine, Lucuronic acid, galacturonic acid and 5- or 6-membered ring polyalcohols. The hole in the tube above Also included are roxymethyl, hydroxyethyl and hydroxypropyl derivatives. sugar When the groups are combined with each other in a copolymer, they are 1,4-α, 1,4-β , 1,3-α, 1°3-β and 1,6-linked chains. They may be joined with a difference. Synthetic cationic monomers useful in these copolymers and Dimethyldiallylammonium chloride, dimethylaminoethylmethylammonium Acrylate, diethyl diallylammonium chloride N.

Examples include N-diallyl-N,N-dialkyl ammonium 7% rides. preferred The strong cationic polymers are dimethyl diallylammonium chloride and acrylic acid. This is Me+quat 550, which is manufactured using midomonomer.

Examples of members of the class of copolymers of sugars and synthetic cationic monomers include National Starch Corporation Cellulose commercially available under the trade name Celquat from derivatives (e.g. hydroxyethylcellulose) and N,N-diallyl-N, Some are composed of N-dialkylammonium chloride.

(II+) Cationic synthetic polymers useful in the present invention include cationic polyalkyleneimines, Ethoxypolyalkyleneimines and polyCN-C3-(dimethylammonio) )propyl)-N--[3-(ethyleneoxyethylenedimethylammonio)propyl lopil [urea dichloride], the last of which is Milanol chemical. Milanol A- from the company (Mi+anol Chemical Coll1paB) 15, CAS Reg.

No. 68555-36-2.

Preferred cationic polymeric skin conditioning agents of the present invention have a molecular weight of 10 A cationic polysaccharide of the cationic guar gum class of 00 to 3,000,000. be.

A more preferred molecular weight is 2,500 to 350,000.

These polymers have a polysaccharide backbone composed of galactomannan units and anhydrocarbon having a degree of cationic substitution of about 0.04 to about 0.80 per glucose unit; The cationic group is 2,3-epoxypropyltrimethylammonium to the natural polysaccharide backbone. It is an adduct of muchloride.

An example is the Jaguar C-376-FA, C-1 sold by Loos-Bourank. 44, C-15, C-17, C162 and AD M'Q guar. part The preferred cationic guar gum has a temperature of about 125 to about 3500±500 c at 25°C. The aqueous solution has a viscosity of 1-2% of p+, and the aqueous solution has a pH of about 9-11.

The cationic guar gum polymer useful in the present invention is hydroxyethylcellulose. based cationic polymers (e.g. JR-based commercially available from Union Carbide Co., Ltd.) It was found to be a more effective skin conditioner than 40(1). Pa+ +an, It, U.S. Patent No. 3,761.418, British Patent Application GB 20 No. 94307A and Bar+olo and V/ filed on June 30, 1989. Referenced in General Assignment U.S. Patent Application Serial No. 07/374,315 of aIIg Cationic polymers are also useful in the present invention and the above patents and patent applications are incorporated by reference. Incorporated here for.

Cationic polymer containing anionic surfactant (sodium laurate) Solutions of Jaguar C-14-5 and JR-4[1[1] have been evaluated. skinko The skin condition was evaluated by visual evaluation of dryness and redness and skin condition ['Eff]. ects of Bat 5olp Con5tituen [t on Pro ductMildness’ (Effect of bar soap ingredients on product mildness) , Dah1g+en, Lukakavic, Michaels and V:5 scher.

P+oceediB+ of the 5econd World Confe ``ence on DeteBenH, Ln++eux, 5vNxe+l1nd , A, R, Bxldvin, Ed.

fAmerican Oil Chemists 5ociely, 1987) , pp. 127-134. ] Measured by equipment evaluation. The result is that cationic guar gum is IR-400. This shows that it is about twice as effective. For this reason, cationic guar gum More effective skin conditioning agent than ethyl cellulose paste cationic polymers and is the most preferred type of cationic polymer for use in the present invention.

aqueous carrier The skin cleanser is preferably in liquid or cream form with water as the main diluent. Delicious. The level of water in the composition typically ranges from about 60% to about 93% by weight, preferably Preferably, it is about 75 to about 90%. Purified water is preferred.

pt-i regulator The liquid skin cleanser composition has a pt-i of about 4 to about 1. O range, preferred preferably in the range of about 5 to about 8, more preferably in the range of about 6 to about 7. . The pH is within the acidic range to maintain the stability of the antibacterial agent TC8 and cationic guar. is maintained. Suitable pH adjusting agents include HCl, citric acid, phosphorus, among others. acids, succinic acid and sodium citrate/citric acid combinations.

Optional ingredients The present skin cleanser is suitable for a wide variety of non-essential and optional treatments to improve such compositions. It can contain a variety of ingredients. Thus, customary optional ingredients, such as 1 to HMDM hydantoin, benzyl alcohol available in the amount of 50000pI11 methylparaben, propylparaben, 3-isothiazines [Rohm Anne Ka+hon C sold by de Haas fRohm and Haas G], imidazolidinyl urea, methylchloroisothiazinone and methyliso Preservatives such as thiazolinones; sodium sulfate, polyethylene glycols, salts sodium chloride, ammonium chloride, carboxymethylcellulose, methylcellulose Thickeners and viscosity adjusters such as base, polyvinyl alcohol and ethyl alcohol agents; suspending agents such as magnesium/aluminum silicate; fragrances, pigments; glycol distearate, glycol monostearate, styrene acrylate Opaque materials such as copolymers, mica, behenic acid and calcium stearate agents; sequestering agents such as disodium ethylenediaminetetraacetate; glycerin emollients, humectants and various other skin treatment ingredients such as Buffers and builders such as phosphates are well known to those skilled in the art. If it exists If so, such agents will typically represent from 0.01% to about 5% by weight of the composition individually. .

Production method The liquid skin cleanser composition of the present invention can be prepared using the mixing techniques disclosed herein. Manufactured by The manufacturing method of the invention is illustrated in the following example.

Methods that can be used to make exemplary compositions of the invention are as follows: 1. The polymer is dispersed in purified water at ambient temperature to aid hydration, then quenched. The main mixture is removed by reducing the solution pH to about 6 with the addition of acid or other suitable acid. hydrated in a gas tank. Sodium sulfate is also a surfactant mixed with a polymer. Reduces the potential for polymer/surfactant coacervate formation when You can add it to make a difference.

2. Purified water, sodium alkyl sulfate, cocoamidopropyl betaine, Lauroa Another premium for midojetanolamine and ethylene glycol distearate at a temperature of approximately 76°C to crystallize ethylene glycol distearate. Mix and then cool to about 26-38°C. crystallized ethylene Recall distearate imparts a pearl-like appearance to the final product.

3. The contents of the premix in step (2) are added to the hydration pot in the main mix. Added to rimmer.

4. Sodium laureth-3 sulfate is added to the main mix.

5. Preservatives are added to the main mix.

6. Citric acid is added to adjust the pH of the final product to approximately pH 6.0-6.5. It will be done.

7. Te3 is pre-dissolved in perfume. This mix is then added to the main mix. It will be done.

8. Colorants are added to the main mix.

9. Adjust the viscosity of the final product to approximately 6000-9000 Cps using sodium sulfate. Added above.

Composition usage In its method, the present invention provides an effective amount of the present cleanser composition to cleanse the skin. skin by contacting the skin with the product and washing excess cleanser from the skin. Concerning how to clean. The effective amount for any individual ingredient is amount of dirt, type of dirt on the skin, surfactants in the cleanser composition. depends on variable factors such as the level of Typically, the effective amount is about 0.5 to about 5 g/use.

The following examples illustrate the invention, but are not to be considered in any way limiting thereof. do not have. All percentages, temperatures and data are approximate unless otherwise noted value or estimated value. Tables 3.4.6 and 7 were obtained using the minimum inhibitory concentration disc test. The sterilization results are cited, but the operations are shown below.

Minimum inhibitory concentration disk test The disinfecting performance of the product was determined using the Minimum Inhibitory Concentration Disk Test (“MI”) for antibacterial liquid soap products. Evaluation was made using "C test").

The MIC test is performed by clinical laboratories to determine the susceptibility of infectious organisms to antibiotics. This is a modification of the disk diffusion test method used. In this method, antibacterial products Add 50 μl of the 1% solution to a 13 mm diameter filter paper disc. then Apply the disc to the surface of an agar plate inoculated with microorganisms. disk When applied to an agar plate, the antimicrobial agent diffuses into the agar medium. The results are for each disk The gradient of the antimicrobial agent concentration in the surrounding agar. Not inhibited by antimicrobial agents The organisms grow on the agar plates, forming a visible growth field. Growth is antibacterial does not occur in the peridisc region where the agent is present at inhibitory concentrations. If the microorganism is susceptible and The more soluble the antimicrobial agent, the larger the zone of inhibition around the disc.

The agar plates in the test below contain Staphylococcus aureus and in some cases E. coli. Inoculated. Products are typically tested in a randomized block design. agar play inoculate over a period of 18-24 hours. Then the diameter of the inhibition annular zone is millimeter Measurements are taken in two directions with the 3-dimensional model and averaged to establish the zone of reported inhibition size. .

This may occur as a result of variation in the bacteria inoculated onto the agar plate. Compensate for variability in MIC test volume zone size for any given product. Because of this, products are only compared within similar studies.

Tables 5 and 7 cite clinical mildness results obtained using the following methods. Ru.

Mildness method Mildness was evaluated by conducting a 4-day forearm washing test with 40 panelists.

The method is “Fateatm Wash Te5tto Evalnat+the Cl1nical Mildnez 01 CleaningP+oauc ! +’ (Forearm washing test to evaluate the clinical mildness of cleansing products) , Lukakovic, Dunlop, Michael+.

Vis+che+ and Watson, 1. Sac, Ca1m, Cbem , , 39.355-366, Net/Dec, 198g:'Effect s of Bat 5 oap Con+tiluenl+ onProduct Mildne++’ (Effect of bar soap ingredients on product mildness), D ah1g+en, Lukakovic, Michael+ and Yi++ch ++、Proceedings of the 5th century L+1dCo nfe “ence On De+eBent+, MonHeox, 5w1txe +1and, A, R.

Baldwin, Ed, (American Oil Chemists 5o cietL1987).

It was the same as that described in pp. 127-134. After 4 days of treatment, the skin Visual grade for skin dryness and redness (0 = complete skin, 5m degraded skin) Ru. The electrical conductivity of the skin is also measured with a skiconi device (how high is the electrical conductivity? (indicating high moisture levels in the skin). Finally, Scopeman n) Visually assess skin condition using a fiber optic amplified video camera The video images were later grayed out using the same “dryness” scale as above. to become a computer.

A logical way to obtain a milder antibacterial liquid cleanser is to use a milder interface. The active agent vs. the harsher is increasing the level of co-surfactant. But long As Comparative Example E2 shows, this approach is comparable to Example 7 as shown in Table 6. In comparison, the sterilization properties were significantly reduced.

Additionally, doubling the level of antimicrobial agents compared to E3, as shown in the example in Table 7E4. This solves the problem of lack of sterilization. On the contrary, Examples 1 and 2 of Table 3 contain ethoxy Preferred levels of surfactant and co-surfactant are shown below. Example 1 is a comparative example A1 Shows sterilizing properties comparable to major commercially available antibacterial hand soaps. Example 2 is regarding sterilization. A”. Example 2 has 0.5% Te3, which is more than 0.2% of Example 1. . This increase in sterilization is unexpected and unexpected in view of E4 in Table 7. Table 4 Example 5 is a more preferred embodiment of the invention.

Table 3 Sterilization example 1.2 ma$, comparative composition A Ammonium lauryl sulfate - -7, GO sodium lauryl sulfate 6.00 6.00 - Sodium Laureth Sulfate 4.00 4.0O4,30 Cocoa Ami Dopropyl betaine 1.20 1.20 -Lauramide jetanolamine (DEA) 1.20 1.20 2.00 guar hydroxypropyl trimethy ammonium chloride 0125 0.25 - triclosan 0.20 o, 5o (1,2G ricinolamide MEA-disodium sulfosuccinate - -1,511 isostearamidopropylmorpholine lactate -1,20 g Lycerin - -1,00 Styrene/acrylate copolymer 0.40 0.4 [1-Sodium sulfate 0.75 0.75 - Sodium chloride - -0,50 Tetrasodium EDTA 0.10 0.10 0. lODMDM Hydantoin 0.20 0.20 0.20 total IH, [10100,00+00.001 Comparative Example "A" is an estimate of the main commercially available liquid antibacterial soap.

Difference from “A” -2,29+8.28 p-value: probability Difference equals zero 0.19 Average of 0.0097 iterations. The diameter of the zone is millimeters. Measured with a meter.

Sterilization examples 3-5v+ Comparative example A Ingredients Example 3 Example 4 Example 5 ammonium lauryl sulfate Sodium lauryl sulfate 6.00 6.00 6.00 Sodium laureth sulfate Mu 4,00 4.00 4.00 Cocoamidopropyl betaine 1.20 1 ．． 20 1.20 lauramide DEA, 1.20 1.20 1.20 guar Hydroxypropyltrimethylammonium chloride Q, 25 Q, 50 0 ．． 25 Triclosan 0.30 0.30 0.30 Ricinolamide MEA- Disodium sulfosuccinate - - Isostearamidopropylmorpholine lactate glycerin Ethylene glycol distearate--1,50 Difference from "A" -0,29+1 ．． 85 -0.14 Difference from Example 3 2.14 0.43 p-value probability Difference is equal to zero O, Gl O, average of 6357 iterations experiment Ammonium lauryl sulfate -7.0G Sodium lauryl sulfate 6.0G 6 ．． 00 - Sodium laureth sulfate 4.00 4.00 4.30 Cocoamide Propyl betaine 1.20 1.20 - Lauroamide DEA 1.20 + , 2G 2.00 Guar Hydroxypropyl Trimethylammonium Chloride 0 ．． 25 - Triclosan 0.20 0,20 0.20 Linolamide ME A-Disodium sulfosuccinate -1,50 isostearamide propyl Morpholine lactate) -1,20 Glycerin -1,00 Styrene/acrylate copolymer 0.40 - Sodium sulfate 0.75 0.75 - Sodium chloride -0,50 EDTA tetrasodium 0. +0 0.10 0.10pMDM hydantoin 0.20 G, 20 0.20 Fragrance 0.30 0JOO, 25 Dye 0.0+ 0.01 0. old Citric acid 0. H [+, 08 0.23 water] Eiyu I 85.96 81.5 top Total 100.0(l Ifl[1, HIH, Hl This is the same composition as in Example 1 be.

Mild results are reported below.

experiment Component Comparative Example E2 Example 7 ammonium lauryl sulfate Sodium lauryl sulfate 4.00 8.00 Sodium laureth sulfate 8.0 0 4. OQ Cocoamidopropyl Betaine 1.50 1.50 Lauroamide D EA 1.50 1.50 Polyquaternium-100,500,5G Trichrome Sun 0.20 0.20 ethylene glycol monostearate) 1.50 1.50 ricinolamide M EA-Disodium Sulfosuccinate Isostearamide Propyl Morpholine Lac tate glycerin Sodium acetate 0.40 - EDTA tetrasodium 0.10 0.10 DMDM hydantoin 0.20 0.20 Fragrance 0.25 0.25 Pigment 0.0+ 0.01 Citric acid o, oa o, oa Wednesday 82.76 83.26 Total 100.00 100.00 MIC test results Inhibition zone 32.91 35.09 Difference with E2 2.18 p-value: probability The difference in inhibition zone for E2 and Example 7 is equal to zero 0.01 M in Table 6 According to the IC test results, E2 vs. Example 7 is an ethoxylated surfactant with too much E2. Contains sodium lauryl sulfate. E2 has less inhibition zone It also has low sterilizing properties.

Ammonium lauryl sulfate 4. GO4,00 ammonium laureth sulfate 8. 00 8.00 Cocoamidopropyl betaine 1.50 1.50 Lauroamide DEA 1.50 1.5 [1 polyquaternium-100,500,50 tri Crosan (Te3) 0.25 0.50 ethylene glycol monostearate 1.5G 1.50 sodium acetate! Merit 0.40 0.40 EDTA4+Thorium f1. Ifl O, HIDMDMI = Dantoin 0.20 [1,20 fragrance 0.25 0.25 Pigment 0.01 0.01 Citric acid 0.08 0.08 Wednesday 82.76 82.26 Total 10G, 00 100.00 Regarding the comparative MIC performance below, the higher level of milder surfactant and the more Expected to be milder than “A” based on lower levels of harsher co-surfactants. Prescribe E3 and E4 as expected. However, their sterilization efficacy is compromised and will be reduced.

Experimental comparison example E3v + Experimental comparison example E4 Comparative MIC performance regarding Comparative example of 100% product concentration (N4) tested with Staphylococcus aureus - Deaf Comparative example A Average 49.75 48.50 62.75 p-value V! , E3 0.66 0 ．． 01p4a x, E4 0.00 Average 28.50 29.25 37.75P-value vt, E3 0.79 0 ．． 04p-value V(, E4 0.06 Conclusion: The point is that these formulations (E3 and E4) have high levels of antibacterial agents. Decreased disinfection due to increased levels of even milder ethoxylated surfactants It is important not to fix it. According to Table 6 and its MIC test results, Example 7v+ , E2 also demonstrates this point more clearly, with the only difference being the severity and This is a low surfactant level.

Paired comparative forearm clinical mildness test Visual dryness 2,00 1.16 0. N　O,000+' Scopman dryness 2.24 1.74 L5tl il, (1(IN' visual redness 2.16 1.37 0.79 0. IlO [12” ski controller 67.45 75.23 -7.78 0.0450” 895% confidence level significance Visual dryness 1.89 1.97 -0.08 0.6083 Scopman drying Degree 2, +4 2.11 0.03 0.8067 Visual redness 2,02 2. 35 -0.32 0.0746 Skicon 69.60 67.88 +, 72 0.7291 Visual dryness 1.15 +, 9+ -1], 7fi I], l] N2" Scopeman dryness 1.67 2.19 -0.52 0.GO15' Visual redness 1.47 1.94 -0.47 0.0736 Skicon? 5. 9 69, 62 6.28 0.3171195% confidence level significance 12 Intra-pair evaluation (Example 6 vs, El) - Obtained as the difference between (“A” vs, El) (Example 5 vs A"). The average is calculated by compensating for the difference in the average of El of the pair adjusted to

According to the MIC test results in Table 3, Example 1 had a bactericidal property equivalent to Comparative Example “A”. It has been proven. The liquid cleansing composition of the present invention was determined in a clinical mildness test. It has also demonstrated excellent mildness on skin that looks like it has been washed, and the results are comparable # 1 and #2 and comparison #3. These are related to sterilization and mildness. Significant improvements were found in the harsher co-surfactants versus the milder ethoxylated surfactants. This is unexpected and surprising considering the high ratio. Preferred implementations include cationic polymers. Examples 1.2 and 5. Specifically, pairwise comparison #1 is 0.25% Addition of Guar C-14-3 to similar surfactant base without polymer and opacifying agent It has been demonstrated that it improves the mildness compared to El formulated with. Pair comparison #2 demonstrates that El has the same mild performance as A''.Finally, the comparison #3 is the statistical evaluation between pairwise comparisons #1 and #2, and Example 1 (also known as Example 6 in Table 5) ) has been proven to be milder on the skin than "A".

It is important to note that cationic polymers also improve the antimicrobial activity of the product. Ru. Regarding Table 4, increasing the polymer level from 0.25% to 0.5% of TC8 Significant increases in antibacterial activity at a constant 0.3% level were shown in Examples 3 and 4. ing.

International Search Report OFT/IIc 02In29L7 Front Page Continuation (51) Int, C1,5 identification code Internal reference number ClID 3/37 3/48 9160-4H (81) Designated countries EP (AT, BE, CH, DE.

DK, ES, PR, GB, GR, IT, LU, MC, NL, SE), 0A (BP , BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG. ), AU, BB, BG, BR, CA, C3, FI, HU, JP.

KP, KR, LK, NiG, MN, MW, No, PL, RO, RU , S.D., S.E. FI (72) Inventor: Schmidt, Diane Grob, Ohio, USA Nshinachi, Hunters, Run, Rain, 9902

Claims (9)

[Claims] 1. (A) about 0.5 to about 5.8% mild ethoxylated surfactant; (B) about 1 to about 40% antimicrobial compatible non-ethoxylated cosurfactant; (C) antibacterial agent about 0.01 to about 4%; (D) About 0.05 to about 5% water-soluble cationic polymer (the above cationic polymer has a molecular weight of from 1000 to 3,000,000); and (E) water from about 35 to about 97% wherein the co-surfactant (B) has a harshness ratio of about 20:1 to about 1:5.8. The ratio of foaming surfactant to the above mild ethoxylated surfactant (A) is shown below. Contains a harsh foaming surfactant at a level such as an antibacterial liquid personal cleansing composition having a level of at least 4% by weight of the composition; A product. 2. (A) Mild ethoxylated surfactants are present at levels of about 2 to about 5% mild ethoxylated surfactants contain 1 mole of C8-C22 alcohol (e.g. for example, tallow or coconut oil alcohol) and about 1 to 20 moles of ethylene oxide ( Alkali metal and ammonium salts of sulfuric esters of reaction products with ethoxy groups) selected from the group consisting of; (B) the non-ethoxylated co-surfactant is present at a level of about 4 to about 20%; (C) the antimicrobial agent is present at a level of about 0.5% to about 2%; (D) the polymer is present at a level of about 0.5% to about 2%; present at a level of 1 to about 2%; and (E) Water is present at a level of about 50% to about 95%; a harsh foaming surfactant and The antimicrobial liquid person of claim 1, wherein the ratio of (A) is about 5:1 to about 1:2. cleansing composition. 3. (A) Mild ethoxylated surfactants are present at levels of about 3 to about 5% mild ethoxylated surfactants contain 1 mole of C8-C22 alcohol (e.g. for example, tallow or coconut oil alcohol) and about 1 to 13 moles of ethylene oxide ( Alkali metal and ammonium salts of sulfuric esters of reaction products with ethoxy groups) selected from the group consisting of; (B) the non-ethoxylated cosurfactant is present at a level of about 5% to about 10%; (C) the antimicrobial agent is present at a level of about 0.2% to about 1%; (D) the polymer is present at a level of about 0.2% to about 1%; present at a level of 2 to about 1%; and (E) Water is present at a level of about 75% to about 90%; harsh surfactants and 2. The antimicrobial liquid composition of claim 1, wherein (A) has a ratio of about 2:1 to about 1:1. - Sonal cleansing composition. 4. (A) Mild ethoxylated surfactants are anionic and nonionic. Mild anionic ethoxylated surfactants are selected from the group consisting of: 1 mole of mild anionic ethoxylated surfactants; of C8-C22 alcohol (e.g., tallow or coconut oil alcohol) and about 2 to The alkyl sulfate ester of the reaction product with 6 moles of ethylene oxide (ethoxy group) selected from the group consisting of potassium metal and ammonium salts; (B) non-ethoxylated; Cosurfactants are anionic, nonionic, zwitterionic and amphoteric surfactants and their selected from the group consisting of a mixture; (C) The antibacterial agent is 3,4,4'-trichlorocarboanilide (TCC), 3-trichlorocarboanilide Fluoromethyl-4,4'-dichlorocarboanilide (TFC), 2-hydroxy -4,2',4'-trichlorodiphenyl ether (TCS) and mixtures thereof (D) the polymer is selected from the group consisting of: (l) cationic polysaccharide; (ll) a cationic copolymer of a saccharide and a synthetic cationic monomer; and (lll) (A) Cationic polyalkyleneimines (B) Cationic ethoxy Polyalkyleneimines and (C) cationic poly[N-[3-(dimethylane)] monio)propyl]-N'-[3-(ethyleneoxyethylenedimethylammonio) e) Propyl urea dichloride according to claim 1, selected from the group consisting of synthetic polymers selected from the group consisting of The antibacterial liquid personal cleansing composition described. 5. Antibacterial agents include 3,4,4'-trichlorocarboanilide (TCC), 3-trif fluoromethyl-4,4'-dichlorocarboanilide (TFC), 2-hydroxy -4,2',4'-trichlorodiphenyl ether (TCS) and mixtures thereof 2. The composition of claim 1, wherein the composition is selected from the group consisting of: 6. The antibacterial agent is 2-hydroxy-4,2',4'-trichlorodiphenyl ether The composition according to claim 1, which is (TCS). 7. Cationic polymer is 1000~ Typical from about 125 to about 3200 cps at 1-2% with a molecular weight of 3,000,000 The cationic polymer has an aqueous viscosity: (l) cationic polysaccharide; (ll) a cationic copolymer of a saccharide and a synthetic cationic monomer; and (lll) (A) Cationic polyalkyleneimines (B) Cationic ethoxy Polyalkyleneimines and (C) cationic poly[N-[3-(dimethylane)] monio)propyl]-N'-[3-(ethyleneoxyethylenedimethylammonio) e) Propyl urea dichloride Claim 1 selected from the group consisting of synthetic polymers selected from the group consisting of 7. The composition according to 2, 3, 4, 5 or 6. 8. The polymer comprises a cationic guar gum polymer, preferably the polymer is Cationic guar gum and cationic guar with a molecular weight of 2500 to 350,000 Claim 1, 2, 3, 4, 5, 6 or 7 selected from the group consisting of composition. 9. The composition contains alkyl sulfates, alkyl glyceryl ether sulfones, salts, anionic acyl sarcosinates, methyl acyl taurates, N- Acyl glutamates, alkyl glucosides, acyl isethionates, alkaline Killsulfosuccinates, alkyl phosphate esters, ethoxylated acids Rukyl phosphate esters, methyl glucose esters, protein condensation Mixtures of compounds, ethoxylated alkyl sulfates and alkyl amine oxides compounds, betaines, sultaines, alkyl ether sulfates with 1 to 12 ethoxy groups from about 4 to about 20 total surfactants selected from the group consisting of esters and mixtures thereof. % (However, the above surfactant contains a C8-C12 alkyl chain, and preferably wherein the co-surfactant has an alkyl chain length of C10-C18), claim 1. , 2, 3, 4, 5, 6, 7 or 8.