JPH06506248A - 新規な非抗凝固剤ヘパリン誘導体 - Google Patents

新規な非抗凝固剤ヘパリン誘導体

Info

Publication number
JPH06506248A
JPH06506248A JP4508854A JP50885492A JPH06506248A JP H06506248 A JPH06506248 A JP H06506248A JP 4508854 A JP4508854 A JP 4508854A JP 50885492 A JP50885492 A JP 50885492A JP H06506248 A JPH06506248 A JP H06506248A
Authority
JP
Japan
Prior art keywords
heparin
periodate
treating
derivative
hydrazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4508854A
Other languages
English (en)
Japanese (ja)
Inventor
コンラッド，エイチ．　エドワード
グオ，ユーチュアン
Original Assignee
グライコメッド　インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グライコメッド　インコーポレイテッド filed Critical グライコメッド　インコーポレイテッド
Publication of JPH06506248A publication Critical patent/JPH06506248A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP4508854A 1991-03-29 1992-03-27 新規な非抗凝固剤ヘパリン誘導体 Pending JPH06506248A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US677,737 1991-03-29
US07/677,737 US5250519A (en) 1991-03-29 1991-03-29 Non-anticoagulant heparin derivatives
PCT/US1992/002517 WO1992017188A1 (en) 1991-03-29 1992-03-27 New non-anticoagulant heparin derivatives

Publications (1)

Publication Number Publication Date
JPH06506248A true JPH06506248A (ja) 1994-07-14

Family

ID=24719922

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4508854A Pending JPH06506248A (ja) 1991-03-29 1992-03-27 新規な非抗凝固剤ヘパリン誘導体

Country Status (7)

Country Link
US (1) US5250519A (cg-RX-API-DMAC7.html)
EP (1) EP0577716A1 (cg-RX-API-DMAC7.html)
JP (1) JPH06506248A (cg-RX-API-DMAC7.html)
AU (1) AU1669592A (cg-RX-API-DMAC7.html)
CA (1) CA2107365A1 (cg-RX-API-DMAC7.html)
NO (1) NO933471L (cg-RX-API-DMAC7.html)
WO (1) WO1992017188A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4754137B2 (ja) * 1999-08-10 2011-08-24 生化学工業株式会社 グリコサミノグリカン誘導体およびその使用

Families Citing this family (39)

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GB9027200D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
AU5442594A (en) * 1992-10-13 1994-05-09 Virginia Commonwealth University Use of non-anticoagulant heparin for treating ischemia/reperfusion injury
US5620687A (en) * 1993-02-25 1997-04-15 Zymogenetics, Inc. Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors
US20020044933A1 (en) * 1993-02-25 2002-04-18 Hart Charles E. Inhibition of intimal hyperplasia using antibodies to PDGF receptors
US5976534A (en) * 1993-02-25 1999-11-02 Zymogenetics, Inc. Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
US5665591A (en) * 1994-12-06 1997-09-09 Trustees Of Boston University Regulation of smooth muscle cell proliferation
EP1609477B1 (en) * 1994-12-12 2011-11-09 Omeros Corporation Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5618837A (en) * 1995-06-07 1997-04-08 Zymogenetics, Inc. PDGF antagonists III
WO1997033593A1 (en) * 1996-03-15 1997-09-18 Takara Shuzo Co., Ltd. A product of heat treatment of uronic acid, food, drink or drug including the product
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
CA2367288A1 (en) * 1999-04-02 2000-10-12 Netech Inc. Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same
CZ20014665A3 (cs) * 1999-06-30 2002-05-15 Hamilton Civic Hospitals Research Development, Inc Prostředek s obsahem heparinu se střední molekulovou hmotností
MXPA03001986A (es) * 2000-09-08 2004-03-19 Hamilton Civic Hospitals Res Composiciones antitromboticas.
WO2003059265A2 (en) * 2001-12-21 2003-07-24 Cytokinetics, Inc. Compositions and methods for treating heart failure
JP2006501815A (ja) * 2002-04-25 2006-01-19 モメンタ ファーマシューティカルズ インコーポレイテッド 粘膜送達のための方法および製品
CA2540699A1 (en) * 2003-10-01 2005-04-14 Momenta Pharmaceuticals, Inc. Polysaccharides for pulmonary delivery of active agents
US20060040896A1 (en) * 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
JP4841546B2 (ja) * 2005-03-31 2011-12-21 生化学工業株式会社 新規抗ヘパラン硫酸抗体、ヘパラン硫酸の検出方法、及びヘパラン硫酸検出キット
WO2007019554A2 (en) * 2005-08-08 2007-02-15 Momenta Pharmaceuticals, Inc. Polysaccharides for delivery of active agents
US20090054374A1 (en) * 2007-02-28 2009-02-26 Paringenix, Inc. Methods of treating acute exacerbations of chronic obstructive pulmonary disease
JP2010534672A (ja) * 2007-07-23 2010-11-11 ユニバーシティ オブ ユタ リサーチ ファウンデーション 終末糖化産物受容体（ｒａｇｅ）の連結を阻止するための方法
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009059284A2 (en) 2007-11-02 2009-05-07 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US9387256B2 (en) 2010-04-16 2016-07-12 Momenta Pharmaceuticals, Inc. Tissue targeting
JP5905455B2 (ja) 2010-06-17 2016-04-20 モメンタ ファーマシューティカルズ インコーポレイテッド 発毛を促進する方法および組成物
DE102011077393A1 (de) * 2011-06-10 2012-12-13 Johannes Reinmüller Antiinfektives Mittel
WO2013095215A1 (en) * 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
WO2013095279A1 (en) 2011-12-19 2013-06-27 Dilafor Ab Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use
KR102452803B1 (ko) 2012-05-09 2022-10-07 캔텍스 파마슈티칼즈, 인크. 골수억제의 치료
CA2910837A1 (en) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
ITLO20130005A1 (it) * 2013-10-31 2015-05-01 He E Biochimiche G Ronzonr S R Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci
ITLO20130006A1 (it) 2013-11-06 2015-05-07 He E Biochimiche G Ronzoni S R Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
EP3258941A4 (en) 2015-02-17 2018-09-26 Cantex Pharmaceuticals, Inc. Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction
US20220227855A1 (en) * 2019-04-25 2022-07-21 The University Of Massachusetts Compositions and methods for treatment of angiogenesis related diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
US5032679A (en) * 1988-12-15 1991-07-16 Glycomed, Inc. Heparin fragments as inhibitors of smooth muscle cell proliferation
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4754137B2 (ja) * 1999-08-10 2011-08-24 生化学工業株式会社 グリコサミノグリカン誘導体およびその使用

Also Published As

Publication number Publication date
WO1992017188A1 (en) 1992-10-15
NO933471D0 (no) 1993-09-28
US5250519A (en) 1993-10-05
AU1669592A (en) 1992-11-02
EP0577716A1 (en) 1994-01-12
EP0577716A4 (cg-RX-API-DMAC7.html) 1994-02-23
CA2107365A1 (en) 1992-09-30
NO933471L (no) 1993-09-28

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