JPH06505990A - タンパク質のテクネチウム−９９ｍ標識 - Google Patents

タンパク質のテクネチウム−９９ｍ標識

Info

Publication number
JPH06505990A
JPH06505990A JP4507406A JP50740692A JPH06505990A JP H06505990 A JPH06505990 A JP H06505990A JP 4507406 A JP4507406 A JP 4507406A JP 50740692 A JP50740692 A JP 50740692A JP H06505990 A JPH06505990 A JP H06505990A
Authority
JP
Japan
Prior art keywords
technetium
reaction
protein
antibody
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4507406A
Other languages
English (en)
Japanese (ja)
Inventor
サブラメイニアン，ラマスワミー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JPH06505990A publication Critical patent/JPH06505990A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP4507406A 1991-02-27 1992-02-27 タンパク質のテクネチウム−９９ｍ標識 Pending JPH06505990A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66179391A 1991-02-27 1991-02-27
US661,793 1991-02-27
PCT/US1992/001577 WO1992015333A1 (en) 1991-02-27 1992-02-27 TECHNETIUM-99m LABELING OF PROTEINS

Publications (1)

Publication Number Publication Date
JPH06505990A true JPH06505990A (ja) 1994-07-07

Family

ID=24655142

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4507406A Pending JPH06505990A (ja) 1991-02-27 1992-02-27 タンパク質のテクネチウム−９９ｍ標識

Country Status (7)

Country Link
EP (1) EP0573577A1 (enExample)
JP (1) JPH06505990A (enExample)
KR (1) KR100238558B1 (enExample)
AU (1) AU658403B2 (enExample)
CA (1) CA2104943A1 (enExample)
FI (1) FI933760A7 (enExample)
WO (1) WO1992015333A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
US7232888B2 (en) 2002-07-01 2007-06-19 Massachusetts Institute Of Technology Antibodies against tumor surface antigens
EP3606664A1 (en) * 2017-04-05 2020-02-12 Archer Daniels Midland Co. Novel esterification catalyst and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
US5128119A (en) * 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
EP0486622B1 (en) * 1989-08-09 1998-11-04 Rhomed, Incorporated Direct radiolabeling of antibodies and other proteins with technetium or rhenium
CA1340250C (en) * 1989-09-18 1998-12-15 Hans J. Hansen Method for rapidly radiolabeling monovalent antibody fragments with technetium

Also Published As

Publication number Publication date
EP0573577A1 (en) 1993-12-15
AU658403B2 (en) 1995-04-13
AU1457692A (en) 1992-10-06
FI933760A0 (fi) 1993-08-26
WO1992015333A1 (en) 1992-09-17
CA2104943A1 (en) 1992-08-28
KR100238558B1 (ko) 2000-02-01
FI933760L (fi) 1993-08-26
FI933760A7 (fi) 1993-08-26
EP0573577A4 (enExample) 1994-03-02

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