KR100238558B1 - 단백질의 테크네튬-99m 표지화 - Google Patents

단백질의 테크네튬-99m 표지화 Download PDF

Info

Publication number
KR100238558B1
KR100238558B1 KR1019930702561A KR930702561A KR100238558B1 KR 100238558 B1 KR100238558 B1 KR 100238558B1 KR 1019930702561 A KR1019930702561 A KR 1019930702561A KR 930702561 A KR930702561 A KR 930702561A KR 100238558 B1 KR100238558 B1 KR 100238558B1
Authority
KR
South Korea
Prior art keywords
technetium
protein
antibody
labeling
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019930702561A
Other languages
English (en)
Korean (ko)
Inventor
라마스와미 수브라마니안
Original Assignee
에프.쥐.엠.헤르만스
악조 엔.브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프.쥐.엠.헤르만스, 악조 엔.브이. filed Critical 에프.쥐.엠.헤르만스
Application granted granted Critical
Publication of KR100238558B1 publication Critical patent/KR100238558B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1019930702561A 1991-02-27 1992-02-27 단백질의 테크네튬-99m 표지화 Expired - Fee Related KR100238558B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66179391A 1991-02-27 1991-02-27
US661,793 1991-02-27
PCT/US1992/001577 WO1992015333A1 (en) 1991-02-27 1992-02-27 TECHNETIUM-99m LABELING OF PROTEINS

Publications (1)

Publication Number Publication Date
KR100238558B1 true KR100238558B1 (ko) 2000-02-01

Family

ID=24655142

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930702561A Expired - Fee Related KR100238558B1 (ko) 1991-02-27 1992-02-27 단백질의 테크네튬-99m 표지화

Country Status (7)

Country Link
EP (1) EP0573577A1 (enExample)
JP (1) JPH06505990A (enExample)
KR (1) KR100238558B1 (enExample)
AU (1) AU658403B2 (enExample)
CA (1) CA2104943A1 (enExample)
FI (1) FI933760A7 (enExample)
WO (1) WO1992015333A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
US7232888B2 (en) 2002-07-01 2007-06-19 Massachusetts Institute Of Technology Antibodies against tumor surface antigens
WO2018187031A1 (en) * 2017-04-05 2018-10-11 Archer Daniels Midland Company Novel esterification catalyst and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
US5128119A (en) * 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
WO1991001754A1 (en) * 1989-08-09 1991-02-21 Rhodes Buck A Direct radiolabeling of antibodies and other proteins with technetium or rhenium
CA1340250C (en) * 1989-09-18 1998-12-15 Hans J. Hansen Method for rapidly radiolabeling monovalent antibody fragments with technetium

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion

Also Published As

Publication number Publication date
EP0573577A4 (enExample) 1994-03-02
EP0573577A1 (en) 1993-12-15
AU658403B2 (en) 1995-04-13
FI933760A0 (fi) 1993-08-26
CA2104943A1 (en) 1992-08-28
WO1992015333A1 (en) 1992-09-17
FI933760L (fi) 1993-08-26
AU1457692A (en) 1992-10-06
JPH06505990A (ja) 1994-07-07
FI933760A7 (fi) 1993-08-26

Similar Documents

Publication Publication Date Title
US4732864A (en) Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
JP3070763B2 (ja) テクネチウムまたはレニウムでの抗体または他のタンパク質の直接放射能標識
Paganelli et al. Monoclonal antibody pretargetting techniques for tumour localization: the avidin-biotin system
CA1335268C (en) Methods of technetium/rhenium labeling of proteins
US6010680A (en) Thiolation of proteins for radionuclide-based radioimmunodetection and radioimmunotherapy
US5202451A (en) Anchimeric radiometal chelating compounds
US5958374A (en) Method for preparing radionuclide-labeled chelating agent-ligand complexes
JP2550481B2 (ja) 診断助剤
JPH03504858A (ja) 蛋白質のラベリング方法
US6576746B2 (en) Site-specific labeling of disulfide-containing targeting vectors
EP0196669B1 (en) Improved method of conjugating metallothionein to biologically active molecules
US5082928A (en) Method of preparing conjugated antibodies
US5317091A (en) Technetium-99m labeling of proteins
US5723102A (en) Process for the preparation of an organ-specific substance labeled with technetium-99m
KR100238558B1 (ko) 단백질의 테크네튬-99m 표지화
CA2066031C (en) Methods for reducing non-target retention of immunoconjugates and metabolites thereof
JPH03163097A (ja) タンパク質又はポリペプチドをテクネチウム―９９ｍで標識する方法、生成複合体、画像処理剤としての用途、および複合体の再調製用キット
EP0831936B1 (en) Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
USH735H (en) Lead-203 as a label for radioimaging
JP4680387B2 (ja) ジスルフィド含有標的ベクターの部位特異的標識化
JPH10307138A (ja) 腫瘍診断剤および治療剤
JP2005517042A (ja) 生体分子を放射性標識する方法
Noujaim et al. Characterization and Selection Criteria of Monoclonal Antibodies for Tumor Imaging Studies
JPH05501107A (ja) 画像用放射標識抗体
IL113168A (en) Method and kit for radiolabeling a protein using a radioisotope of rhenium

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20021015

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20021015

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301