JPH06501686A - ポリアミン類を有する酸化窒素錯体 - Google Patents
ポリアミン類を有する酸化窒素錯体Info
- Publication number
- JPH06501686A JPH06501686A JP3516733A JP51673391A JPH06501686A JP H06501686 A JPH06501686 A JP H06501686A JP 3516733 A JP3516733 A JP 3516733A JP 51673391 A JP51673391 A JP 51673391A JP H06501686 A JPH06501686 A JP H06501686A
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- carbon atoms
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/04—N-nitroso compounds
- C07C243/06—N-nitroso-amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (26)
- 1.次の一般式 ▲数式、化学式、表等があります▼ 式中dおよびbは同じでも異なっていても良く、おのおの0または1であり;R 1、R2、R3、R4およびR5は同じでも異なっていても良く、おのおの水素 原子、炭素数3〜8のシクロアルキル基、炭素数1〜12の直鎖または分岐鎖の アルキル基、ベンジル基、ベンゾイル基、フタロイル基、アセチル基、トリフル オロアセチル基、p−トルイル基、t−ブトキシカルボニル基または2,2,2 −トリクロロ−t−ブトキシカルボニル基であり;x、yおよびzは同じでも異 なっていても良く、おのおの2〜12であり;但し、R2が水素原子、xが2、 bとdがそれぞれ0であるとき、R1とR3の双方がメチル基である化合物を除 く、で表される化合物または医薬的に許容できるその塩。
- 2.上記R1、R2、R3、R4およびR5は同じでも異なっていても良く、お のおの水素原子、炭素数5〜6のシクロアルキル基、炭素数1〜4の直鎖または 分岐鎖のアルキル基、ベンジル基またはアセチル基である請求項1に記載の化合 物。
- 3.上記R1、R2、R3、R4およびR5は同じでも異なっていても良く、お のおの水素原子、メチル基、エチル基、ベンジル基またはアセチル基であり;且 つx、yおよびzは同じでも異なっていても良く、おのおの2〜4である請求項 2に記載の化合物。
- 4.上記R1、R2、R3、R4およびR5は同じでも異なっていても良く、お のおの水素原子、メチル基、ベンジル基またはアセチル基である請求項3に記載 の化合物。
- 5.化合物が ▲数式、化学式、表等があります▼ または、 ▲数式、化学式、表等があります▼またはその互換異性体、または、 ▲数式、化学式、表等があります▼ または、 ▲数式、化学式、表等があります▼またはその互換異性体であるか、あるいは医 薬的に許容できるそれらの塩である請求項1に記載の化合物。
- 6.次の一般式 ▲数式、化学式、表等があります▼ 式中Bは ▲数式、化学式、表等があります▼ または ▲数式、化学式、表等があります▼ であり;R6およびR7は同じでも異なっていても良く、おのおの水素原子、炭 素数3〜8のシクロアルキル基、炭素数1〜12の直鎖または分岐鎖のアルキル 基、ベンジル基、ベンゾイル基、フタロイル基、アセチル基、トリフルオロアセ チル基、p−トルイル基、t−ブトキシカルボニル基または2,2,2−トリク ロロ−t−ブトキシカルボニル基であり;fは0〜12であるが、Bが▲数式、 化学式、表等があります▼で表される置換ピペラジン部分である場合には、fは 2〜12である;で表される化合物または医薬的に許容できるその塩。
- 7.R6およびR7は同じでも異なっていても良く、おのおの水素原子、炭素数 5〜6のシクロアルキル基、炭素数1〜4の直鎖または分岐鎖のアルキル基、ベ ンジル基またはアセチル基である請求項6に記載の化合物。
- 8.R6およびR7は同じでも異なっていても良く、おのおの水素原子、メチル 基、エチル基、ベンジル基またはアセチル基であり;fが2〜4である請求項7 に記載の化合物。
- 9.R6およびR7は同じでも異なっていても良く、おのおの水素原子、メチル 基またはアセチル基である請求項8に記載の化合物。
- 10.次の一般式 ▲数式、化学式、表等があります▼・▲数式、化学式、表等があります▼式中R 8は水素原子、炭素数3〜8のシクロアルキル基、炭素数1〜12の直鎖または 分岐鎖のアルキル基、ベンジル基、ベンゾイル基、フタロイル基、アセチル基、 トリフルオロアセチル基、p−トルイル基、t−ブトキシカルボニル基または2 ,2,2−トリクロロ−t−ブトキシカルボニル基であり;R9は水素原子また は炭素数1〜12の直鎖または分岐鎖のアルキル基であり;gは2〜6である; で表される化合物または医薬的に許容できるその塩。
- 11.上記R8は炭素数5〜6のシクロアルキル基、炭素数1〜4の直鎖または 分岐鎖のアルキル基、ベンジル基またはアセチル基である請求項10に記載の化 合物。
- 12.上記R8がメチル基、エチル基、ベンジル基またはアセチル基であり;上 記gが2〜4である請求項11に記載の化合物。
- 13.上記R8がメチル基またはアセチル基である請求項12に記載の化合物。
- 14.化合物が ▲数式、化学式、表等があります▼・▲数式、化学式、表等があります▼である か、または医薬的に許容できるその塩である請求項10に記載の化合物。
- 15.次の一般式 ▲数式、化学式、表等があります▼ 式中dおよびbは同じでも異なっていても良く、おのおの0または1であり;R 1、R2、R3、R4およびR5は同じでも異なっていても良く、おのおの水素 原子、炭素数3〜8のシクロアルキル基、炭素数1〜12の直鎖または分岐鎖の アルキル基、ベンジル基、ベンゾイル基、フタロイル基、アセチル基、トリフル オロアセチル基、p−トルイル基、t−ブトキシカルボニル基または2,2,2 −トリクロロ−t−ブトキシカルボニル基であり;x、yおよびzは同じでも異 なっていても良く、おのおの2〜12である;で表される化合物の医薬としての 使用。
- 16.上記R1、R2、R3、R4およびR5が同じでも異なっていても良く、 おのおの水素原子、炭素数5〜6のシクロアルキル基、炭素数1〜4の直鎖また は分岐鎖のアルキル基、ベンジル基またはアセチル基であることを特徴とする請 求項15に記載の使用。
- 17.上記R1、R2、R3、R4およびR5が同じでも異なっていても良く、 おのおの水素原子、メチル基、エチル基、ベンジル基またはアセチル基であり; x、yおよびzが同じでも異なっていても良く、おのおの2〜4であることを特 徴とする請求項15に記載の使用。
- 18.上記R1、R2、R3、R4およびR5が同じでも異なっていても良く、 おのおの水素原子、メチル基またはアセチル基であることを特徴とする請求項1 5に記載の使用。
- 19. ▲数式、化学式、表等があります▼ または、 ▲数式、化学式、表等があります▼またはその互換異性体、または、 ▲数式、化学式、表等があります▼ または、 ▲数式、化学式、表等があります▼またはその互換異性体として表される化合物 の医薬としての使用。
- 20.次の一般式 ▲数式、化学式、表等があります▼ 式中Bは▲数式、化学式、表等があります▼または▲数式、化学式、表等があり ます▼であり;R6およびR7は同じでも異なっていても良く、おのおの水素原 子、炭素数3〜8のシクロアルキル基、炭素数1〜12の直鎖または分岐鎖のア ルキル基、ベンジル基、ベンゾイル基、フタロイル基、アセチル基、トリフルオ ロアセチル基、p−トルイル基、t−ブトキシカルボニル基または2,2,2− トリクロロ−t−ブトキシ−カルボニル基であり;fは0〜12であるが、Bが ▲数式、化学式、表等があります▼で表される置換ピペフジン部 分である場合には、fは2〜12である;で表される化合物の医薬としての使用 。
- 21.次の一般式 ▲数式、化学式、表等があります▼・▲数式、化学式、表等があります▼式中R 8は水素原子、炭素数3〜8のシクロアルキル基、炭素数1〜12の直鎖または 分岐鎖のアルキル基、ベンジル基、ベンゾイル基、フタロイル基、アセチル基、 トリフルオロアセチル基、p−トルイル基、t−ブトキシカルボニル基または2 ,2,2−トリクロロ−t−ブトキシカルボニル基であり;R9は水素原子、ま たは炭素数1〜12の直鎖または分岐鎖のアルキル基であり;gは2〜6である ;で表される化合物の医薬としての使用。
- 22.次の一般式I: ▲数式、化学式、表等があります▼ 一般式I 式中dおよびbは同じでも異なっていても良く、おのおの0または1であり:R 1、R2、R3、R4、およびR5は同じでも異なっていても良く、おのおの水 素原子、炭素数3〜8のシクロアルキル基、炭素数1〜12の直鎖または分岐鎖 のアルキル基、ベンジル基、ベンゾイル基、フタロイル基、アセチル基、トリフ ルオロアセチル基、p−トルイル基、t−ブトキシカルボニル基または2,2, 2−トリクロロ−t−ブトキシカルボニル基であり;x、yおよびzは同じでも 異なっていても良く、おのおの2〜12である;で表される化合物または医薬的 に許容できるその塩の心臓血管系疾患治療有効量および医薬的に許容できる担体 を含有する医薬組成物。
- 23.上記R1、R2、R3、R4およびR5は同じでも異なっていても良く、 おのおの水素原子、炭素数5〜6のシクロアルキル基、炭素数1〜4の直鎖また は分岐鎖のアルキル基、ベンジル基またはアセチル基である請求項22に記載の 医薬組成物。
- 24.上記R1、R2、R3、R4およびR5は同じでも異なっていても良く、 おのおの水素原子、メチル基、エチル基、ベンジル基またはアセチル基であり; 且つx、yおよびzは同じでも異なっていても良く、おのおの2〜4である請求 項23に記載の医薬組成物。
- 25.上記R1、R2、R3、R4およびR5は同じでも異なっていても良く、 おのおの水素原子、メチル基またはアセチル基である請求項24に記載の医薬組 成物。
- 26.一般式Iの化合物が ▲数式、化学式、表等があります▼ または、 ▲数式、化学式、表等があります▼またはその互換異性体、または、 ▲数式、化学式、表等があります▼ または、 ▲数式、化学式、表等があります▼またはその互換異性体もしくは医薬的に許容 できるそれらの塩である請求項22に記載の医薬組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US585,793 | 1990-09-20 | ||
US07/585,793 US5155137A (en) | 1990-09-20 | 1990-09-20 | Complexes of nitric oxide with polyamines |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06501686A true JPH06501686A (ja) | 1994-02-24 |
JP2537445B2 JP2537445B2 (ja) | 1996-09-25 |
Family
ID=24342988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3516733A Expired - Lifetime JP2537445B2 (ja) | 1990-09-20 | 1991-09-20 | ポリアミン類を有する酸化窒素錯体 |
Country Status (9)
Country | Link |
---|---|
US (2) | US5155137A (ja) |
EP (1) | EP0549704B1 (ja) |
JP (1) | JP2537445B2 (ja) |
AT (1) | ATE140446T1 (ja) |
AU (1) | AU649739B2 (ja) |
CA (1) | CA2091994C (ja) |
DE (1) | DE69120955T2 (ja) |
ES (1) | ES2093108T3 (ja) |
WO (1) | WO1992005149A1 (ja) |
Families Citing this family (131)
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US5393757A (en) * | 1986-12-02 | 1995-02-28 | University Of Florida | Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment |
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US5683668A (en) * | 1990-09-20 | 1997-11-04 | The United States Of America As Represented By The Department Of Health And Human Services | Method of generating nitric oxide gas using nitric oxide complexes |
WO1994020415A1 (en) * | 1992-06-30 | 1994-09-15 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Method of generating nitric oxide gas using nitric oxide complexes |
CA2097823C (en) * | 1990-12-05 | 1999-06-29 | Warren M. Zapol | Therapy for pulmonary vasoconstriction and asthma |
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US5536241A (en) * | 1990-12-05 | 1996-07-16 | The General Hospital Corporation | Methods and devices for relaxing smooth muscle contractions |
US5185376A (en) * | 1991-09-24 | 1993-02-09 | The United States Of America As Represented By The Department Of Health And Human Services | Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof |
US5389675A (en) * | 1992-03-27 | 1995-02-14 | The United States Of America As Represented By The Department Of Health And Human Services | Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents |
WO1993020806A1 (en) * | 1992-04-13 | 1993-10-28 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of nitric oxide/nucleophile complexes for the treatment of cancer |
US5814666A (en) * | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
US5632981A (en) * | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5650447A (en) * | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
US5910316A (en) * | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
US6200558B1 (en) | 1993-09-14 | 2001-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5691423A (en) * | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
US5374710A (en) * | 1993-05-26 | 1994-12-20 | Regents Of The University Of California | Compounds which release nitric oxide upon illumination |
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AU7972294A (en) * | 1993-10-07 | 1995-05-01 | Entremed, Inc | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
US5840759A (en) * | 1993-10-08 | 1998-11-24 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents |
EP0722320B1 (en) * | 1993-10-08 | 2000-07-19 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Use of nitric oxide-releasing compounds as medicaments for hypoxic cell radiation sensitization |
DK0726768T3 (da) * | 1993-11-02 | 2000-10-02 | Us Health | Anvendelse af nitrogenoxidfrigørende forbindelser til fremstillingen af et medikament til beskyttelse i iskæmisk reperfusio |
US5482925A (en) * | 1994-03-17 | 1996-01-09 | Comedicus Incorporated | Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents |
US5519020A (en) * | 1994-10-28 | 1996-05-21 | The University Of Akron | Polymeric wound healing accelerators |
US5700830A (en) * | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
US5823180A (en) * | 1995-04-03 | 1998-10-20 | The General Hospital Corporation | Methods for treating pulmonary vasoconstriction and asthma |
US5698738A (en) * | 1995-05-15 | 1997-12-16 | Board Of Regents, The University Of Texas System | N-nitroso-N-substituted hydroxylamines as nitric oxide donors |
US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
JP2000510448A (ja) * | 1996-04-05 | 2000-08-15 | ザ ジェネラル ホスピタル コーポレーション | 異常ヘモグロビン症の治療 |
WO1998008496A1 (en) * | 1996-08-27 | 1998-03-05 | The University Of Akron | Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use |
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Publication number | Priority date | Publication date | Assignee | Title |
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US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
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1990
- 1990-09-20 US US07/585,793 patent/US5155137A/en not_active Expired - Lifetime
-
1991
- 1991-09-20 JP JP3516733A patent/JP2537445B2/ja not_active Expired - Lifetime
- 1991-09-20 AU AU87123/91A patent/AU649739B2/en not_active Expired
- 1991-09-20 EP EP91917752A patent/EP0549704B1/en not_active Expired - Lifetime
- 1991-09-20 CA CA002091994A patent/CA2091994C/en not_active Expired - Lifetime
- 1991-09-20 WO PCT/US1991/006736 patent/WO1992005149A1/en active IP Right Grant
- 1991-09-20 AT AT91917752T patent/ATE140446T1/de not_active IP Right Cessation
- 1991-09-20 DE DE69120955T patent/DE69120955T2/de not_active Expired - Lifetime
- 1991-09-20 ES ES91917752T patent/ES2093108T3/es not_active Expired - Lifetime
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1992
- 1992-06-30 US US07/906,479 patent/US5250550A/en not_active Expired - Lifetime
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DE69120955D1 (de) | 1996-08-22 |
DE69120955T2 (de) | 1996-11-21 |
EP0549704A1 (en) | 1993-07-07 |
CA2091994A1 (en) | 1992-03-21 |
US5250550A (en) | 1993-10-05 |
US5155137A (en) | 1992-10-13 |
AU649739B2 (en) | 1994-06-02 |
JP2537445B2 (ja) | 1996-09-25 |
ATE140446T1 (de) | 1996-08-15 |
EP0549704B1 (en) | 1996-07-17 |
CA2091994C (en) | 2000-01-25 |
AU8712391A (en) | 1992-04-15 |
EP0549704A4 (en) | 1994-04-27 |
WO1992005149A1 (en) | 1992-04-02 |
ES2093108T3 (es) | 1996-12-16 |
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