JPH0649701B1 - - Google Patents

Info

Publication number
JPH0649701B1
JPH0649701B1 JP63312576A JP31257688A JPH0649701B1 JP H0649701 B1 JPH0649701 B1 JP H0649701B1 JP 63312576 A JP63312576 A JP 63312576A JP 31257688 A JP31257688 A JP 31257688A JP H0649701 B1 JPH0649701 B1 JP H0649701B1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63312576A
Other languages
Japanese (ja)
Other versions
JPH0649701B2 (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848408292A external-priority patent/GB8408292D0/en
Priority claimed from GB848429710A external-priority patent/GB8429710D0/en
Application filed filed Critical
Publication of JPH0649701B1 publication Critical patent/JPH0649701B1/ja
Publication of JPH0649701B2 publication Critical patent/JPH0649701B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP63-312576A 1984-03-30 1985-03-29 キノリジノン化合物およびその製法 Expired - Lifetime JPH0649701B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8408292 1984-03-30
GB848408292A GB8408292D0 (en) 1984-03-30 1984-03-30 Quinolizinone compound
GB8429710 1984-11-23
GB848429710A GB8429710D0 (en) 1984-11-23 1984-11-23 Pharmaceutical composition

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP63100967A Division JPS63284174A (ja) 1984-03-30 1988-04-22 キノリジノン化合物およびその製造法

Publications (2)

Publication Number Publication Date
JPH0649701B1 true JPH0649701B1 (OSRAM) 1994-06-29
JPH0649701B2 JPH0649701B2 (ja) 1994-06-29

Family

ID=26287537

Family Applications (4)

Application Number Title Priority Date Filing Date
JP63-312576A Expired - Lifetime JPH0649701B2 (ja) 1984-03-30 1985-03-29 キノリジノン化合物およびその製法
JP63100967A Granted JPS63284174A (ja) 1984-03-30 1988-04-22 キノリジノン化合物およびその製造法
JP63312576A Pending JPH01193268A (ja) 1984-03-30 1988-12-09 キノリジノン化合物およびその製法
JP1133926A Granted JPH0215029A (ja) 1984-03-30 1989-05-25 キノリジノン化合物またはその塩を含有する抗潰瘍剤

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP63100967A Granted JPS63284174A (ja) 1984-03-30 1988-04-22 キノリジノン化合物およびその製造法
JP63312576A Pending JPH01193268A (ja) 1984-03-30 1988-12-09 キノリジノン化合物およびその製法
JP1133926A Granted JPH0215029A (ja) 1984-03-30 1989-05-25 キノリジノン化合物またはその塩を含有する抗潰瘍剤

Country Status (4)

Country Link
US (2) US4650804A (OSRAM)
EP (1) EP0157346B1 (OSRAM)
JP (4) JPH0649701B2 (OSRAM)
DE (1) DE3575724D1 (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889848A (en) * 1984-11-06 1989-12-26 Hoffmann-La Roche Inc. Tricyclic pyridine derivatives
CA1317945C (en) * 1985-12-13 1993-05-18 Ulf Fischer Tricyclic pyridazopyridone derivatives
US4877795A (en) * 1987-01-30 1989-10-31 Kissei Pharmaceutical Co., Ltd. 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like
EP0294599A3 (de) * 1987-06-12 1990-05-09 F. Hoffmann-La Roche Ag Tricyclische Pyridonderivate
US4806525A (en) * 1987-06-18 1989-02-21 Mavi S.R.L. Formulation comprising gelatin and glycine for treating the dryness of skin
ZA885263B (en) * 1987-07-28 1989-03-29 Fujisawa Pharmaceutical Co Crystalline monohydrate of sodium n-(1h-tetrazol-5-yl)-1-phenoxy-4h-quinolizin-4-one-3-carboxamide
US4921857A (en) * 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
US4904657A (en) * 1987-09-24 1990-02-27 Kissei Pharmaceutical Co., Ltd. 4H-quinolizin-4-one compounds exhibiting therapeutic activities
AU616916B2 (en) * 1987-11-20 1991-11-14 Kissei Pharmaceutical Co. Ltd. 4h-quinolizin-4-one compounds exhibiting therapeutic activities
US4940715A (en) * 1988-05-17 1990-07-10 Kissei Pharmaceutical Co., Ltd. 5H-pyrazolo[4,3-A] quinolizin-5-one compounds exhibiting therapeutic activities
US5726182A (en) * 1990-05-02 1998-03-10 Abbott Laboratories Quinolizinone type compounds
ATE195122T1 (de) * 1990-05-02 2000-08-15 Abbott Lab Verbindungen vom chinolizinon-typ
AU675645B2 (en) * 1992-04-27 1997-02-13 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having antiallergic effect
WO1994013289A1 (en) * 1992-12-10 1994-06-23 Tsentr Po Khimii Lekarstvennykh Sredstv Pharmaceutical compound with anti-ulcer properties
ES2155092T3 (es) * 1993-07-13 2001-05-01 Janssen Pharmaceutica Nv Imidazoazepinas antialergicas.
US5869500A (en) * 1996-12-13 1999-02-09 Hoffmann-La Roche Inc. Pyridone compounds useful in treating Alzheimer's disease
US6630488B1 (en) 1998-09-21 2003-10-07 Biochem Pharma, Inc. Quinolizinones as integrin inhibitors
US6706528B2 (en) * 2000-03-24 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent magnesium indicators
JP4497320B2 (ja) 2002-10-10 2010-07-07 小野薬品工業株式会社 内因性修復因子産生促進剤
US7745459B2 (en) * 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
US20060252819A1 (en) * 2005-04-07 2006-11-09 Astrum Therapeutics Pty Ltd Compounds to treat amyloidosis and prevent death of beta-cells in type 2 diabetes mellitus
EP2591784B1 (en) 2005-05-10 2016-09-14 Intermune, Inc. Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system
KR100785088B1 (ko) 2006-05-23 2007-12-12 한국과학기술연구원 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
TW200838534A (en) 2007-02-07 2008-10-01 Astellas Pharma Inc Treatment for irritable bowel syndrome
AU2009215111A1 (en) 2008-02-13 2009-08-20 Merck Sharp & Dohme Corp. Quinolizidinone M1 receptor positive allosteric modulators
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
CA2738812A1 (en) * 2008-10-06 2010-04-15 Merck Sharp & Dohme Corp. Quinolizidinone m1 receptor positive allosteric modulators
EP2501231B1 (en) * 2009-11-20 2016-12-21 Merck Sharp & Dohme Corp. Quinolizidinone carboxamide m1 receptor positive allosteric modulators
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JP6525437B2 (ja) 2014-04-02 2019-06-05 インターミューン， インコーポレイテッド 抗線維性ピリジノン

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1433151A (en) * 1973-04-05 1976-04-22 Allen & Hanburys Ltd Benzo-ij-quinolizines
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
J.CHEM.SOC=1965 *
J.HETEROCYCL.CHEM=1973 *
J.ORG CHEM=1978 *
MONATSH CHEM=1967 *
TETRAHEDRON=1967 *
Z.NATURFORSCH.B:ANORG CHEM,ORG CHEM=1979 *

Also Published As

Publication number Publication date
EP0157346A2 (en) 1985-10-09
EP0157346A3 (en) 1986-02-05
DE3575724D1 (de) 1990-03-08
JPH0649701B2 (ja) 1994-06-29
JPH039113B2 (OSRAM) 1991-02-07
EP0157346B1 (en) 1990-01-31
JPH039088B2 (OSRAM) 1991-02-07
US4650804A (en) 1987-03-17
US4698349A (en) 1987-10-06
JPH0215029A (ja) 1990-01-18
JPH01193268A (ja) 1989-08-03
JPS63284174A (ja) 1988-11-21

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