JPH064526B2 - Hair nourishment - Google Patents

Description

TECHNICAL FIELD The present invention relates to a hair nourishing agent containing dolichol and having an excellent hair nourishing effect.

(Prior Art) Numerous drugs have been applied to the treatment of male pattern baldness. That is, there are many examples of combining agents that promote blood circulation in the scalp, activate hair mother cells, suppress secretion of lipids in the scalp, and mix other amino acids and vitamins that are nutritional components of hair. In addition, recently, it has been proposed that an imbalance of sex hormones caused by excess male hormone is the cause of alopecia, and a hair nourishing agent containing an anti-androgen agent based on that theory has been devised.

(Problems to be Solved by the Invention) The present inventors have found that the cause of androgenetic alopecia is not only due to imbalance of sex hormones, but is also caused by blood circulation failure and reduction in hair mother cell activity. As a result of earnest research on drugs that improve these symptoms,
The present invention has been completed by finding that a hair nourishing agent containing dolichol (1) significantly promotes hair growth, (2) bristle hair becomes bristle, and (3) prevents hair loss.

(Means for Solving Problems) That is, the present invention is a hair nourishing agent containing dolichol.

Dolichol used in the present invention is a known compound,
For example, a method of extracting from pig liver [Biochemical, Journal, 88, 470 (1963) (J. Burgos, FWH
emming, JFPennock, RAMorton, Biochemical, Jourbal,
88, 470 (1963)].

The amount of dolichol added to the hair nourishing agent is not particularly limited and can be selected within a wide range, but is usually 0.005 to 3% by weight, preferably 0.05 to 1 with respect to the total weight of the composition.
% By weight.

The hair nourishing agent of the present invention can be prepared into a dosage form such as a hairnic, a hair lotion, and a hair cream according to a conventional method. Examples of the base material in the hair nourishing agent of the present invention include water, alcohols such as ethanol, polyhydric alcohols such as glycerin, liquid paraffin, higher fatty acids (stearic acid, etc.), fatty acid glycerides (glycerin monostearate, etc.), and higher grades. Alcohols, animal and vegetable oils, oily substances such as waxes, surfactants, (emulsifiers, solubilizers), bactericides, keratolytic agents and the like may be appropriately added.

(Effect of the Invention) The hair nourishing agent of the present invention exerts a remarkably good hair growth promoting effect (hair nourishing effect) when applied to human or animal skin, and is stable even after long-term storage. Is extremely high.

(Example) Hereinafter, the present invention will be described in detail based on the description of Examples and Comparative Examples. The test methods for the effect of promoting hair growth on white mice and the effect of promoting hair growth on human hair are shown below.

(1) Test method for mouse hair growth promoting effect: The back skin from the tail of a ddY white mouse (male, 6 weeks old, average weight 35 g) was shaved with an electric clipper, and then completely shaved with a depilatory cream. Each sample of Examples and Comparative Examples was applied to the skin of the test site twice daily in the morning and evening, and the amount of each animal was 0.
1 ml or 0.1 gr was applied. For each sample, 10 animals were used per group. The hair nourishing effect was judged by comparing the evaluation points of the macroscopic judgment according to the judgment criteria shown in Table 1, the hair length and the hair weight with the comparative example.

On the 15th day after the start of the experiment, the animals were sacrificed and visually evaluated according to the criteria shown in Table 1, and the evaluation points were totaled to obtain an average evaluation point per animal. Furthermore, the skin of the test site was excised, a skin of a certain area was punched out with a punch having a diameter of 12 mm, and the weight of the hair after drying was measured, and the length of 20 hairs therein was also measured, and the average value was obtained. Was calculated.

(2) Human hair growth promotion effect test method A sample of the control sample was prepared by shaving the hair at a position 5 cm above the ears of the heads of a predetermined number of test subjects at the left and right sides at a diameter of 1 cm at the test site on the left side. It was decided to be the right side, and about 3 ml was applied twice daily in the morning and evening. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved, and the average value (B) of the lengths of the 20 hairs on the left side was calculated from the length of the 20 hairs on the right side. The value was divided by the average value (A) and evaluated. (Judgment result of 10 test subjects
(Average value of (B) / (A)) The experimental methods and results of Examples and Comparative Examples are shown below. In addition,% shown below means weight%.

Example 1, Comparative Example 1 (lotion type hair nourishing agent) (1) Formulation (2) Test A mouse hair growth promotion test was carried out using the above sample. The results are shown in Table 2.

As is clear from Table 2, both the hair length and the hair weight of Example 1 are larger than those of Comparative Examples, and the evaluation point by the naked eye also shows a high value, which shows that the hair growth promoting effect of the present invention is remarkable. .

Example 2, Comparative Example 2 (Cream type hair nourishing agent) (1) Formulation (2) Test A mouse hair growth promotion test was carried out using the above sample. The results are shown in Table 3.

As is clear from Table 3, both the hair length and the hair weight when the hair nourishing agent of Example 2 was used were larger than those of Comparative Example 2, and the evaluation point by the naked eye showed a high value. It is recognized that the promotion effect is remarkable.

Example 3, Comparative Example 3 (Rotion type hair nourishing agent) (1) Formulation (2) Test The hair nourishing effect of this product was tested by 10 healthy males according to the “human hair growth promoting effect test method” described in the above test method. The results are shown in Table 4.

As is clear from Table 4, the hair growth promoting effect of the product of the present invention was found to be remarkable.

Example 4, Comparative Example 4 (lotion type hair nourishing agent) (1) Formulation (1) Test The hair-growth effect of this product was tested by 5 male androgenetic alopecia patients according to the above test method. The results are shown in Table 5.

As is clear from Table 5, the hair growth promoting effect of the product of the present invention was found to be remarkable.

Claims (1)

[Claims] 1. A hair nourishing agent containing dolichol.