JPH064523B2 - Hair nourishment - Google Patents
Hair nourishmentInfo
- Publication number
- JPH064523B2 JPH064523B2 JP17879185A JP17879185A JPH064523B2 JP H064523 B2 JPH064523 B2 JP H064523B2 JP 17879185 A JP17879185 A JP 17879185A JP 17879185 A JP17879185 A JP 17879185A JP H064523 B2 JPH064523 B2 JP H064523B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- effect
- tocopherol
- test
- linolenic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】 (産業上の利用分野) 本発明は、γ−リノレン酸トコフェロールエステル(ビ
タミンEγ−リノレン酸エステル)を含有して成る、優
れた養毛効果を有する養毛料に関する。TECHNICAL FIELD The present invention relates to a hair nourishing agent having an excellent hair nourishing effect, which contains γ-linolenic acid tocopherol ester (vitamin E γ-linolenic acid ester).
(従来の技術) 男性型脱毛症には数多くの薬剤がその治療に応用されて
いる。即ち、頭皮の血行を促進したり、毛母細胞を活性
化したり、頭皮の脂質の分泌を抑制する薬剤を組み合わ
せる例や、その他毛髪の栄養成分であるアミノ酸やビタ
ミン類を配合する例が多い。(Prior Art) Numerous drugs have been applied to the treatment of male pattern baldness. That is, there are many examples of combining agents that promote blood circulation in the scalp, activate hair mother cells, suppress secretion of lipids in the scalp, and mix other amino acids and vitamins that are nutritional components of hair.
近年、リノレン酸(9,12,15−オクタデカトリエ
ン酸)が強力な5α−リダクターゼ阻害活性を有すると
共に養毛効果を発揮するという発明が開示されている
(特開昭59−172411)。しかしながら、その養
毛効果はいまだ不十分であり、またリノレン酸を高濃度
に使用すると皮膚刺激の問題がある。In recent years, an invention has been disclosed in which linolenic acid (9,12,15-octadecatrienoic acid) has a strong 5α-reductase inhibitory activity and exhibits a hair-growth effect (Japanese Patent Laid-Open No. 59-172411). However, its hair nourishing effect is still insufficient, and there is a problem of skin irritation when linolenic acid is used at a high concentration.
一方、トコフェロールは、頭皮の血行促進により養毛効
果を有するとされているが、その効果は不十分であり、
また加熱、光及び長期保存により容易に分解変色し臭気
を有する等の欠点がある。On the other hand, tocopherol is said to have a hair nourishing effect by promoting blood circulation in the scalp, but the effect is insufficient,
In addition, there are drawbacks such that it easily decomposes and discolors due to heating, light and long-term storage and has an odor.
又、酢酸トコフェロールエステルは比較的加水分解し易
く、加水分解時に酢酸臭を発生し、しかもその養毛効果
もいまだ不十分である。Further, tocopherol acetate acetate is relatively easily hydrolyzed, an acetic acid odor is generated during hydrolysis, and its hair-feeding effect is still insufficient.
(発明が解決しようとする問題点) すなわち、本発明者は男性型脱毛症の原因は性ホルモン
のアンバランスのみに起因するのではなくて、血行の不
全や毛母細胞活性の低下等も同時に原因として寄与して
いると考え、これらの症状を改善する薬剤を鋭意研究し
た結果、γ−リノレン酸トコフェロールエステルを含有
した養毛料が著しい養毛効果を発現すること等を見出
し、本発明を完成した。(Problems to be Solved by the Invention) That is, the present inventor is not the cause of androgenetic alopecia not only due to the imbalance of sex hormones, but at the same time causes blood circulation deficiency and decreased hair matrix cell activity. It is thought that they contribute to the cause, and as a result of earnest research on a drug that improves these symptoms, they found that a hair nourishing agent containing γ-linolenic acid tocopherol ester exerts a remarkable hair nourishing effect, etc., and completed the present invention. did.
(問題点を解決するための手段) 即ち、本発明は、γ−リノレン酸トコフェロールエステ
ルを含有することを特徴とする養毛料である。(Means for Solving Problems) That is, the present invention is a hair nourishing agent characterized by containing γ-linolenic acid tocopherol ester.
本発明にいうγ−リノレン酸トコフェロールエステルと
は、γ−リノレン酸(別名6,9,12−オクタデカト
リエン酸)と、α−トコフェロール(dl−α−トコフェ
ロール、d−α−トコフェロール、l−α−トコフェロ
ール)、β−トコフェロール、γ−トコフェロール、ま
たはδ−トコフェロールとからなるエステルの単独、ま
たはこれらの混合物を指す。γ−リノレン酸トコフェロ
ールエステルは、γ−リノレン酸(別名6,9,12−
オクタデカトリエン酸)とトコフェロールとをN,N′−
ジシクロヘキシルカルボジイミド等の縮合剤存在下に反
応させることにより得られる。The γ-linolenic acid tocopherol ester referred to in the present invention means γ-linolenic acid (also known as 6,9,12-octadecatrienoic acid) and α-tocopherol (dl-α-tocopherol, d-α-tocopherol, 1- α-tocopherol), β-tocopherol, γ-tocopherol, or δ-tocopherol alone or a mixture thereof. γ-linolenic acid tocopherol ester is γ-linolenic acid (also known as 6,9,12-
Octadecatrienoic acid) and tocopherol with N, N′-
It can be obtained by reacting in the presence of a condensing agent such as dicyclohexylcarbodiimide.
γ−リノレン酸トコフェロールエステルの養毛料への配
合量は、特に限定されず広範囲に選択することができる
が、組成物の全量重量に対して通常0.001〜10重
量%、好ましくは0.01〜1重量%である。The amount of γ-linolenic acid tocopherol ester to be added to the hair nourishing agent is not particularly limited and can be selected within a wide range, but is usually 0.001 to 10% by weight, preferably 0.01 to the total weight of the composition. ~ 1% by weight.
本発明の養毛料は、常法に従って、ヘアートニック、ヘ
アーローション、ヘアークリーム等の剤型に調製するこ
とが可能である。本発明の養毛料における基材として
は、例えば水、エタノール等のアルコール類、グリセリ
ン等の多価アルコール類、流動パラフィン、高級脂肪酸
(ステアリン酸等)、脂肪酸グリセライド(グリセリン
モノステアレート等)、高級アルコール、動植物油、ワ
ックス類等の油性物質、界面活性剤(乳化剤、可溶化
剤)、殺菌剤、角質溶解剤等を適宜配合し得る。The hair nourishing agent of the present invention can be prepared into a dosage form such as a hairnic, a hair lotion, and a hair cream according to a conventional method. Examples of the base material in the hair nourishing agent of the present invention include water, alcohols such as ethanol, polyhydric alcohols such as glycerin, liquid paraffin, higher fatty acids (stearic acid, etc.), fatty acid glycerides (glycerin monostearate, etc.), and higher grades. Alcohols, animal and vegetable oils, oily substances such as waxes, surfactants (emulsifiers, solubilizers), bactericides, keratolytic agents and the like may be appropriately added.
(発明の効果) 本発明の養毛料は、ヒトまたは動物の皮膚に塗布すると
顕著良好な毛成長促進効果(養毛効果)を発揮し、かつ
長期保存しても安定であって、その商品価値は極めて高
い。(Effect of the Invention) The hair nourishing agent of the present invention exerts a remarkably good hair growth promoting effect (hair nourishing effect) when applied to human or animal skin, and is stable even after long-term storage, and its commercial value. Is extremely high.
(実施例) 以下、実施例、比較例の記載に基づいて本発明を詳説す
る。また、白色マウスに対する毛成長促進効果、ヒト頭
髪に対する毛成長促進効果等の試験方法を下記に示す。(Example) Hereinafter, the present invention will be described in detail based on the description of Examples and Comparative Examples. The test methods for the effect of promoting hair growth on white mice and the effect of promoting hair growth on human hair are shown below.
(1) マウス毛成長促進効果試験方法 ddY系白色マウス(雄、6週齢、平均体重35g)の
尾部よりの背部皮膚を電気バリカンで刈った後、脱毛ク
リームにより完全に除毛し、翌日より実施例及び比較例
の各試料を被験部皮膚に毎日朝夕2回、一匹当たり0.
1mlもしくは0.1grを塗布した。一試料に対して動物
は一群10匹使用した。養毛効果の判定は、第1表に示
す判定基準による肉眼判定の評価点と毛長、毛重量を比
較例と比較することにより行った。(1) Test method for mouse hair growth promoting effect: The back skin from the tail of a ddY white mouse (male, 6 weeks old, average weight 35 g) was shaved with an electric clipper, and then completely shaved with a depilatory cream. Each sample of Examples and Comparative Examples was applied to the skin of the test site twice daily in the morning and evening, and the amount of each animal was 0.
1 ml or 0.1 gr was applied. For each sample, 10 animals were used per group. The hair nourishing effect was judged by comparing the evaluation points of the macroscopic judgment according to the judgment criteria shown in Table 1, the hair length and the hair weight with the comparative example.
実験開始後15日目に動物を屠殺し第1表に示す判定基
準により肉眼判定し、その評価点を合計し、一匹当たり
の平均評価点を求めた。さらに、被験部の皮膚を切除
し、直径12mmのパンチで、一定面積の皮膚を打ち抜い
て、乾燥後毛の重量を測定し、その中の20本の毛の長
さについても測定し、平均値と標準偏差を算出した。On the 15th day after the start of the experiment, the animals were sacrificed and visually evaluated according to the criteria shown in Table 1, and the evaluation points were totaled to obtain an average evaluation point per animal. Furthermore, the skin of the test site was excised, a skin of a certain area was punched out with a punch having a diameter of 12 mm, and the weight of the hair after drying was measured, and the length of 20 hairs therein was also measured, and the average value was obtained. And the standard deviation was calculated.
(2) ヒト頭髪毛成長促進効果試験方法 所定人数の被試験者の頭部の耳の上5cmの位置の頭髪を
左右2ケ所を直径1cm剃毛した被験部位に試料を左側
に、対照例を右側と定めて毎日朝夕2回、約3ml塗布し
た。効果の判定は試験開始後28日目に、左右の被験部
位の毛髪各々20本ずつ剃毛し、左側の毛20本の長さ
の平均値(B)を右側の毛20本の長さの平均値(A)で除し
た値を求めて評価した。(判定結果 被試験者10名の
(B)/(A)の平均値) 以下に、実施例及び比較例の実験方法及び実験結果につ
いて示す。尚、以下に示す%とは重量%を意味する。 (2) Human hair growth promotion effect test method A sample of the control sample was prepared by shaving the hair at a position 5 cm above the ears of the heads of a predetermined number of test subjects at the left and right sides at a diameter of 1 cm at the test site on the left side. It was decided to be the right side, and about 3 ml was applied twice daily in the morning and evening. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved, and the average value (B) of the lengths of the 20 hairs on the left side was calculated from the length of the 20 hairs on the right side. The value was divided by the average value (A) and evaluated. (Judgment result of 10 test subjects
(Average value of (B) / (A)) The experimental methods and results of Examples and Comparative Examples are shown below. In addition,% shown below means weight%.
実施例1、比較例1〜4(ローション型養毛料) (1) 処方 (2) 試験 上記試料を用いてマウス毛成長促進試験を実施した。そ
の結果を第2表に示す。Example 1, Comparative Examples 1 to 4 (lotion type hair nourishing agent) (1) Formulation (2) Test A mouse hair growth promotion test was carried out using the above sample. The results are shown in Table 2.
第2表から明らかなように、実施例1の毛長、毛重量は
ともに比較例や対照より大きく、また肉眼判定による評
価点も高い値を示し、本発明の毛成長促進効果が著しい
事が認められる。 As is clear from Table 2, both the hair length and the hair weight of Example 1 are larger than those of the Comparative Examples and the control, and the evaluation point by the naked eye also shows a high value, which shows that the hair growth promoting effect of the present invention is remarkable. Is recognized.
実施例2、比較例5〜8(クリーム型養毛料) (1) 処方 (2) 試験 上記試料を用いてマウス毛成長促進試験を実施した。そ
の結果を第3表に示す。Example 2, Comparative Examples 5 to 8 (cream type hair nourishing agent) (1) Formulation (2) Test A mouse hair growth promotion test was carried out using the above sample. The results are shown in Table 3.
第3表から明らかなように、実施例1の養毛料を使用し
た場合の毛長、毛重量はともに比較例や対照より大き
く、また肉眼判定による評価点も高い値を示し、本発明
の毛成長促進効果が著しい事が認められる。 As is clear from Table 3, both the hair length and the hair weight when the hair nourishing agent of Example 1 was used were larger than those of the comparative examples and controls, and the evaluation points by the naked eye showed high values. It is recognized that the growth promoting effect is remarkable.
実施例3、比較例8(ローシヨン型養毛料) (1) 処方 (2) 試験 本品の養毛効果を健康な男子10名により、前記試験方
法記載の「ヒト頭髪毛成長促進効果試験方法」により行
なった。結果を第4表に示す。Example 3, Comparative Example 8 (Rotion type hair nourishing agent) (1) Formulation (2) Test The hair nourishing effect of this product was tested by 10 healthy males according to the “human hair growth promoting effect test method” described in the above test method. The results are shown in Table 4.
第4表から明らかな如く、本発明品の毛成長促進効果は
著しいことが判明した。 As is clear from Table 4, the hair growth promoting effect of the product of the present invention was found to be remarkable.
実施例4、比較例9(ローション型養毛料) (1) 処方 (1) 試験 本品の養毛効果を男性型脱毛症患者5名により、前記試
験方法で行なった。結果を第5表に示す。Example 4, Comparative Example 9 (lotion type hair nourishing agent) (1) Formulation (1) Test The hair-growth effect of this product was tested by 5 male androgenetic alopecia patients according to the above test method. The results are shown in Table 5.
第5表から明らかな如く、本発明品の毛成長促進効果は
著しいことが判明した。 As is clear from Table 5, the hair growth promoting effect of the product of the present invention was found to be remarkable.
実施例 5 γ−リノレン酸−DL−α−トコフェロールエステルの
代りに、γ−リノレン酸−β−トコフェロールエステル
を使用する他は、実施例3と同様に行なって、本発明の
ローション型養毛料を調製した。この養毛料を実施例3
と同様に試験した結果、(B)/(A)平均値が1.14と養
毛効果が優れていることが確認された。Example 5 Instead of γ-linolenic acid-DL-α-tocopherol ester, γ-linolenic acid-β-tocopherol ester was used, and the lotion-type hair nourishing agent of the present invention was prepared in the same manner as in Example 3. Prepared. Example 3 of this hair nourishing agent
As a result of the same test, it was confirmed that the (B) / (A) average value was 1.14 and the hair-growth effect was excellent.
実施例6 γ−リノレン酸−DL−α−トコフェロールエステルの
代りに、γ−リノレン酸−γ−トコフェロールエステル
を使用する他は、実施例3と同様に行なって、本発明の
ローション型養毛料を調製した。この養毛料を実施例3
と同様に行なった結果、(B)/(A)平均値が1.14と養
毛効果が優れていることが確認された。Example 6 Instead of γ-linolenic acid-DL-α-tocopherol ester, γ-linolenic acid-γ-tocopherol ester was used. Prepared. Example 3 of this hair nourishing agent
As a result of carrying out similarly to the above, it was confirmed that the (B) / (A) average value was 1.14 and the hair-growth effect was excellent.
Claims (1)
含有することを特徴とする養毛料。1. A hair nourishing agent comprising γ-linolenic acid tocopherol ester.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17879185A JPH064523B2 (en) | 1985-08-13 | 1985-08-13 | Hair nourishment |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17879185A JPH064523B2 (en) | 1985-08-13 | 1985-08-13 | Hair nourishment |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6239513A JPS6239513A (en) | 1987-02-20 |
JPH064523B2 true JPH064523B2 (en) | 1994-01-19 |
Family
ID=16054706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17879185A Expired - Lifetime JPH064523B2 (en) | 1985-08-13 | 1985-08-13 | Hair nourishment |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH064523B2 (en) |
-
1985
- 1985-08-13 JP JP17879185A patent/JPH064523B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS6239513A (en) | 1987-02-20 |
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