JPH064523B2 - Hair nourishment - Google Patents

Description

TECHNICAL FIELD The present invention relates to a hair nourishing agent having an excellent hair nourishing effect, which contains γ-linolenic acid tocopherol ester (vitamin E γ-linolenic acid ester).

(Prior Art) Numerous drugs have been applied to the treatment of male pattern baldness. That is, there are many examples of combining agents that promote blood circulation in the scalp, activate hair mother cells, suppress secretion of lipids in the scalp, and mix other amino acids and vitamins that are nutritional components of hair.

In recent years, an invention has been disclosed in which linolenic acid (9,12,15-octadecatrienoic acid) has a strong 5α-reductase inhibitory activity and exhibits a hair-growth effect (Japanese Patent Laid-Open No. 59-172411). However, its hair nourishing effect is still insufficient, and there is a problem of skin irritation when linolenic acid is used at a high concentration.

On the other hand, tocopherol is said to have a hair nourishing effect by promoting blood circulation in the scalp, but the effect is insufficient,
In addition, there are drawbacks such that it easily decomposes and discolors due to heating, light and long-term storage and has an odor.

Further, tocopherol acetate acetate is relatively easily hydrolyzed, an acetic acid odor is generated during hydrolysis, and its hair-feeding effect is still insufficient.

(Problems to be Solved by the Invention) That is, the present inventor is not the cause of androgenetic alopecia not only due to the imbalance of sex hormones, but at the same time causes blood circulation deficiency and decreased hair matrix cell activity. It is thought that they contribute to the cause, and as a result of earnest research on a drug that improves these symptoms, they found that a hair nourishing agent containing γ-linolenic acid tocopherol ester exerts a remarkable hair nourishing effect, etc., and completed the present invention. did.

(Means for Solving Problems) That is, the present invention is a hair nourishing agent characterized by containing γ-linolenic acid tocopherol ester.

The γ-linolenic acid tocopherol ester referred to in the present invention means γ-linolenic acid (also known as 6,9,12-octadecatrienoic acid) and α-tocopherol (dl-α-tocopherol, d-α-tocopherol, 1- α-tocopherol), β-tocopherol, γ-tocopherol, or δ-tocopherol alone or a mixture thereof. γ-linolenic acid tocopherol ester is γ-linolenic acid (also known as 6,9,12-
Octadecatrienoic acid) and tocopherol with N, N′-
It can be obtained by reacting in the presence of a condensing agent such as dicyclohexylcarbodiimide.

The amount of γ-linolenic acid tocopherol ester to be added to the hair nourishing agent is not particularly limited and can be selected within a wide range, but is usually 0.001 to 10% by weight, preferably 0.01 to the total weight of the composition. ~ 1% by weight.

The hair nourishing agent of the present invention can be prepared into a dosage form such as a hairnic, a hair lotion, and a hair cream according to a conventional method. Examples of the base material in the hair nourishing agent of the present invention include water, alcohols such as ethanol, polyhydric alcohols such as glycerin, liquid paraffin, higher fatty acids (stearic acid, etc.), fatty acid glycerides (glycerin monostearate, etc.), and higher grades. Alcohols, animal and vegetable oils, oily substances such as waxes, surfactants (emulsifiers, solubilizers), bactericides, keratolytic agents and the like may be appropriately added.

(Effect of the Invention) The hair nourishing agent of the present invention exerts a remarkably good hair growth promoting effect (hair nourishing effect) when applied to human or animal skin, and is stable even after long-term storage, and its commercial value. Is extremely high.

(Example) Hereinafter, the present invention will be described in detail based on the description of Examples and Comparative Examples. The test methods for the effect of promoting hair growth on white mice and the effect of promoting hair growth on human hair are shown below.

(1) Test method for mouse hair growth promoting effect: The back skin from the tail of a ddY white mouse (male, 6 weeks old, average weight 35 g) was shaved with an electric clipper, and then completely shaved with a depilatory cream. Each sample of Examples and Comparative Examples was applied to the skin of the test site twice daily in the morning and evening, and the amount of each animal was 0.
1 ml or 0.1 gr was applied. For each sample, 10 animals were used per group. The hair nourishing effect was judged by comparing the evaluation points of the macroscopic judgment according to the judgment criteria shown in Table 1, the hair length and the hair weight with the comparative example.

On the 15th day after the start of the experiment, the animals were sacrificed and visually evaluated according to the criteria shown in Table 1, and the evaluation points were totaled to obtain an average evaluation point per animal. Furthermore, the skin of the test site was excised, a skin of a certain area was punched out with a punch having a diameter of 12 mm, and the weight of the hair after drying was measured, and the length of 20 hairs therein was also measured, and the average value was obtained. And the standard deviation was calculated.

(2) Human hair growth promotion effect test method A sample of the control sample was prepared by shaving the hair at a position 5 cm above the ears of the heads of a predetermined number of test subjects at the left and right sides at a diameter of 1 cm at the test site on the left side. It was decided to be the right side, and about 3 ml was applied twice daily in the morning and evening. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved, and the average value (B) of the lengths of the 20 hairs on the left side was calculated from the length of the 20 hairs on the right side. The value was divided by the average value (A) and evaluated. (Judgment result of 10 test subjects
(Average value of (B) / (A)) The experimental methods and results of Examples and Comparative Examples are shown below. In addition,% shown below means weight%.

Example 1, Comparative Examples 1 to 4 (lotion type hair nourishing agent) (1) Formulation (2) Test A mouse hair growth promotion test was carried out using the above sample. The results are shown in Table 2.

As is clear from Table 2, both the hair length and the hair weight of Example 1 are larger than those of the Comparative Examples and the control, and the evaluation point by the naked eye also shows a high value, which shows that the hair growth promoting effect of the present invention is remarkable. Is recognized.

Example 2, Comparative Examples 5 to 8 (cream type hair nourishing agent) (1) Formulation (2) Test A mouse hair growth promotion test was carried out using the above sample. The results are shown in Table 3.

As is clear from Table 3, both the hair length and the hair weight when the hair nourishing agent of Example 1 was used were larger than those of the comparative examples and controls, and the evaluation points by the naked eye showed high values. It is recognized that the growth promoting effect is remarkable.

Example 3, Comparative Example 8 (Rotion type hair nourishing agent) (1) Formulation (2) Test The hair nourishing effect of this product was tested by 10 healthy males according to the “human hair growth promoting effect test method” described in the above test method. The results are shown in Table 4.

As is clear from Table 4, the hair growth promoting effect of the product of the present invention was found to be remarkable.

Example 4, Comparative Example 9 (lotion type hair nourishing agent) (1) Formulation (1) Test The hair-growth effect of this product was tested by 5 male androgenetic alopecia patients according to the above test method. The results are shown in Table 5.

As is clear from Table 5, the hair growth promoting effect of the product of the present invention was found to be remarkable.

Example 5 Instead of γ-linolenic acid-DL-α-tocopherol ester, γ-linolenic acid-β-tocopherol ester was used, and the lotion-type hair nourishing agent of the present invention was prepared in the same manner as in Example 3. Prepared. Example 3 of this hair nourishing agent
As a result of the same test, it was confirmed that the (B) / (A) average value was 1.14 and the hair-growth effect was excellent.

Example 6 Instead of γ-linolenic acid-DL-α-tocopherol ester, γ-linolenic acid-γ-tocopherol ester was used. Prepared. Example 3 of this hair nourishing agent
As a result of carrying out similarly to the above, it was confirmed that the (B) / (A) average value was 1.14 and the hair-growth effect was excellent.

Claims (1)

[Claims] 1. A hair nourishing agent comprising γ-linolenic acid tocopherol ester.