JPS6239513A - Hair nourishing agent - Google Patents

Abstract

PURPOSE:A hair nourishing agent showing improved hair growth promoting effect (hair nourishing effect) by applying it to the human or animal skin, having long-term stability and high commercial value, containing vitamin E-gamma -linolenic acid ester. CONSTITUTION:A hair nourishing agent containing vitamin E-gamma -linolenic acid(=gamma -linolenic acid tocopherol ester). The compound is obtained by reacting-lenolenic acid(=6,9,12-octadecatrienoic acid) with tocopherol in the presence of a conden sate of N,N'-dicyclohexylcarbodiimide, etc. The amount of the compound added to hair tonic is usually 0.001-10wt% based on the total amounts. The hair nourishing material can be prepared into a dosage form such as hair tonic, hair lotion, hair cream, etc., and may be properly blended with water, an alcohol such as ethanol, a higher fatty acid, liquid paraffin, vegetable oil, surface active agent, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a hair nourishing agent containing tocopherol γ-linolenic acid ester (vitamin E γ-linolenic acid ester) and having an excellent hair nourishing effect.

(Prior Art) Many drugs have been applied to treat androgenetic alopecia. That is, there are many examples in which drugs are combined that promote blood circulation in the scalp, activate hair matrix cells, and suppress the secretion of lipids in the scalp, and there are also cases in which amino acids and vitamins, which are nutrients for hair, are combined.

In recent years, an invention has been disclosed in which lylunic acid (9,12,15-octadecatrienoic acid) has a strong 6α-reductase inhibitory activity and also exhibits a hair-nourishing effect (Japanese Patent Application Laid-Open No. 172411-1983).

However, its hair-nurturing effect is still insufficient, and there is a problem of skin irritation when lylunic acid is used in high concentrations.

On the other hand, tocopherol is said to have a hair-nourishing effect by promoting blood circulation in the scalp, but its effect is insufficient.
Furthermore, it has drawbacks such as being easily decomposed and discolored by heating, light, and long-term storage, and having an odor.

Furthermore, tocopherol acetate is relatively easy to hydrolyze and generates an acetic acid odor upon hydrolysis, and its hair-nourishing effect is still insufficient.

(Problems to be Solved by the Invention) In other words, the present invention shows that the cause of androgenetic alopecia is not only caused by an imbalance of sex hormones (but also by problems such as poor blood circulation and decreased hair matrix cell activity). As a result of intensive research into drugs that improve these symptoms, we discovered that a hair nourishing agent containing γ-linolenic acid tocopherol ester exerts a significant hair nourishing effect. Completed the invention.

(Means for Solving the Problems) First, the present invention is a hair nourishment characterized by containing r-linolenic acid tospherol ester.

The r-linolenic acid tocopherol ester referred to in the present invention refers to γ-linolenic acid (also known as 6.9.12-octadecatrienoic acid) and α-tocopherol (dl-α-tocopherol, d-α-tocopherol, l- α-tocopherol), β-tocopherol, γ-tocopherol,
A single ester consisting of t or δ-tocopherol,
or a mixture of these. γ-linolenic acid tocopherol ester is γ-linolenic acid (also known as 6.9゜12
- octadecatrienoic acid) and tocopherol with N, d
-dicyclohexylcarboxylic acid [obtained by reaction in the presence of a condensing agent].

The amount of γ-linolenic 1-tocopherol ester added to the hair nourishment is not particularly limited and can be selected from a wide range, but it is usually 0.001 to 10% by weight, preferably 0.01% by weight based on the total weight of the composition. ~1% by weight.

The hair tonic of the present invention can be prepared into IJ! hair tonic, hair lotion, hair cream, etc. according to conventional methods. It is possible to make 4 pieces. Examples of the base in the hair nourishment of the present invention include water, alcohols such as ethanol, polyhydric alcohols such as glycerin, liquid paraffin, higher fatty acids (stearic acid, etc.), fatty acid glycerides (glycerin monostearate, etc.), higher Alcohol, animal and vegetable oils, oily substances such as waxes, surfactants (emulsifiers, solubilizers), bactericidal agents, keratolytic agents, etc. may be blended as appropriate.

(Effects of the Invention) The hair growth agent of the present invention exhibits a significantly good hair growth promoting effect (11 hair effect) when applied to human or animal skin,
Moreover, it is stable even after long-term storage, and its commercial value is extremely high.

(Examples) Hereinafter, the present invention will be explained in detail based on the descriptions of Examples and Comparative Examples. Further, the test methods for the hair growth promoting effect on white mice, the hair growth promoting effect on human hair, etc. are shown below.

(1) Mouse hair growth promoting effect test method ddY white mice (male, 6[fi, average weight 85f
) dorsal skin from the tail! After cutting with hair clippers, the hair was completely thinned with hair removal cream, and from the next day, each sample of the Example and Comparative Example was applied to the test skin twice a day in the morning and evening at a concentration of 0.1 Fm or 0.1 K per animal. . - A group of 10 animals were used for each sample. The hair-restoring effect was determined by comparing the visual evaluation score, hair length, and hair weight according to the criteria shown in Table 1 with those of the comparative example.

On the 15th day after the start of the experiment, the animals were sacrificed and evaluated visually according to the criteria shown in Table 1, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, a certain area of the skin was punched out using a punch with a diameter of 12 mm, the weight of the hair was measured after drying, and the length of 20 hairs among them was also measured, and the average value and the standard deviation was calculated.

Table 1 Judgment criteria for hair growth effect evaluation points Judgment standard 5 Boundary with surrounding non-hair removal area is unclear 4 Hair growth intensity 8 Hair growth moderate 2 Hair growth mild 1 Hair growth extreme (mild (2) ) Human Hair Growth Promotion Effect Test Method Hair at a position 5 cm above the ears on the head of a predetermined number of test subjects was cut off in two places on the left and right sides with a diameter of 1 cm and 1 g, and the sample was placed on the left side and the control example was placed on the right side. Approximately 8 hairs were applied twice a day in the morning and evening.Efficacy was determined on the 28th day after the start of the test by pricking 20 hairs each on the left and right test areas, and averaging the length of the 20 hairs on the left side. Evaluation was performed by dividing (B) by the average length of 20 hairs on the right side.(Judgment results)
)/average value) Below, the experimental methods and trial results of Examples and Comparative Examples are shown. Note that % below -1 means weight %.

Example 1, Comparative Examples 1 to 4 (Rosi-based hair protection product) (1)
Formulation (2) Test A mouse hair growth promotion test was conducted using the above sample. The results are shown in Table 2.

Table 2 Mouse hair growth promotion results As is clear from Table 2, the hair length and hair weight of Example 1 were both greater than those of the comparative example and the control, and the evaluation score by visual judgment was also high, indicating that the present invention It is recognized that it has a remarkable effect on promoting hair growth.

(Hereinafter referred to as Kumehaku) Example 2, Comparative Examples 5 to 8 (Cream-type hair nourishment) (1) Prescription (2) Test A mouse hair growth promotion test was conducted using the above sample. provided.

The results are shown in Table 8.

Table 8 Mouse hair growth promotion results As is clear from Table 8, when the hair growth agent of Example 1 was used, the hair length and hair weight were both greater than those of the comparative example and control, and the evaluation score by visual judgment was also high. It is recognized that the hair growth promoting effect of the present invention is remarkable.

Example 8, Comparative Example 8 (Rosi soda type hair tonic) (1)
Formulation (2) Test The hair growth effect of the crystal was tested on 10 healthy men using the "human hair growth promoting effect test method" described in the test method above. The results are shown in Table 4.

As is clear from Table 4, the hair growth promoting effect of the product of the present invention was found to be remarkable.

Example 4, Comparative Example 9 (Rosi Seinho Hair Tooth) (1)
Formulation (1) Test The hair growth effect of the crystal was tested on 5 patients with androgenetic alopecia using the test method described above. The results are shown in Table 5.

As is clear from Table 5, the hair growth promoting effect of the product of the present invention was found to be remarkable.

Example 5 The same procedure as in Example 3 was carried out except that γ-linolenic acid-β-tocopherol ester was used instead of γ-linolenic acid-DL-α-to-tocopherol ester. It was confirmed that a hair nourishing agent of the same type was prepared.

Example 6 The procedure of Example 3 was repeated except that r-linolenic acid-γ-tocopherol ester was used instead of γ-linolenic d-DL-α-tocopherol ester. Patent applicant for preparing hair nourishing agent □. □, 几,,.

Claims (1)

[Claims] A hair nourishing agent containing γ-linolenic acid tocopherol ester.