JPH0633260B2 - β―カルボリン、その製法および該化合物を含有する長期持続的作用を有する精神安定剤 - Google Patents

β―カルボリン、その製法および該化合物を含有する長期持続的作用を有する精神安定剤

Info

Publication number
JPH0633260B2
JPH0633260B2 JP58195407A JP19540783A JPH0633260B2 JP H0633260 B2 JPH0633260 B2 JP H0633260B2 JP 58195407 A JP58195407 A JP 58195407A JP 19540783 A JP19540783 A JP 19540783A JP H0633260 B2 JPH0633260 B2 JP H0633260B2
Authority
JP
Japan
Prior art keywords
carboline
iii
alkyl
acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58195407A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5989678A (ja
Inventor
アンドレアス・フ−ト
デイ−タ−・ラ−ツ
デイ−タ−・ザイデルマン
ラルフ・シユミ−ヒエン
ヘルム−ト・ビ−レ
クラウス・チコ・ブレストル−プ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS5989678A publication Critical patent/JPS5989678A/ja
Publication of JPH0633260B2 publication Critical patent/JPH0633260B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP58195407A 1982-10-29 1983-10-20 β―カルボリン、その製法および該化合物を含有する長期持続的作用を有する精神安定剤 Expired - Lifetime JPH0633260B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823240514 DE3240514A1 (de) 1982-10-29 1982-10-29 Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3240514.6 1982-10-29

Publications (2)

Publication Number Publication Date
JPS5989678A JPS5989678A (ja) 1984-05-23
JPH0633260B2 true JPH0633260B2 (ja) 1994-05-02

Family

ID=6177153

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58195407A Expired - Lifetime JPH0633260B2 (ja) 1982-10-29 1983-10-20 β―カルボリン、その製法および該化合物を含有する長期持続的作用を有する精神安定剤

Country Status (18)

Country Link
US (1) US4731358A (enEXAMPLES)
EP (1) EP0110814B1 (enEXAMPLES)
JP (1) JPH0633260B2 (enEXAMPLES)
AT (1) ATE48602T1 (enEXAMPLES)
AU (1) AU568513B2 (enEXAMPLES)
CA (1) CA1260475A (enEXAMPLES)
DD (1) DD213217A5 (enEXAMPLES)
DE (2) DE3240514A1 (enEXAMPLES)
DK (1) DK495683A (enEXAMPLES)
ES (1) ES8406477A1 (enEXAMPLES)
FI (1) FI833918A7 (enEXAMPLES)
GR (1) GR79637B (enEXAMPLES)
HU (1) HU198208B (enEXAMPLES)
IE (1) IE56155B1 (enEXAMPLES)
IL (1) IL70077A0 (enEXAMPLES)
NO (1) NO833942L (enEXAMPLES)
NZ (1) NZ205949A (enEXAMPLES)
ZA (1) ZA838072B (enEXAMPLES)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3240511A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinderivaten
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
US4631149A (en) * 1983-07-25 1986-12-23 University Of Illinois Antiviral eudistomins from a marine tunicate
DE3504045A1 (de) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinen durch dehydrierung
DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4952584A (en) * 1986-01-11 1990-08-28 Beecham Group P.L.C. 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
US4789676A (en) * 1986-03-05 1988-12-06 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives, usefull as anxiolytic agents
EP0304223A3 (en) * 1987-08-17 1990-10-24 Merck & Co. Inc. Beta-carbolines as cholecy-stokinin and gastrin antagonist
US5223509A (en) * 1987-08-17 1993-06-29 Merck & Co., Inc. β-carbolines as cholecystokinin and gastrin antagonists
AU619203B2 (en) * 1987-08-28 1992-01-23 Schering Aktiengesellschaft Isoxazole-beta-carboline derivatives
DE4029389A1 (de) * 1990-09-13 1992-03-26 Schering Ag Verfahren zur herstellung von (beta)-carbolin-derivaten
US5350750A (en) * 1991-04-27 1994-09-27 Schering Aktiengesellschaft β-carboline-3-hydroxyalkylcarboxylic acid ester derivatives, process for their production and their use in pharmaceutical agents
CN1148340A (zh) * 1994-03-11 1997-04-23 伊莱利利公司 治疗与5htzb受体有关病症的方法
ATE240955T1 (de) * 1996-08-09 2003-06-15 Boehringer Ingelheim Pharma 4-substituierte beta-carboline als immunomodulatoren
HUP0300894A3 (en) 2000-03-15 2008-05-28 Sanofi Aventis Deutschland Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
US20030045541A1 (en) * 2001-07-23 2003-03-06 Christopher Bruckner GABA-Receptor modulators with NMDA-Antagonistic activity
DE102007009264A1 (de) * 2007-02-26 2008-08-28 Ellneuroxx Ltd. 9-Alkyl-ß-Carboline zur Behandlung von neurodegenerativen Erkrankungen
SG181599A1 (en) 2009-12-28 2012-07-30 Audiocure Pharma Gmbh Beta-carbolines for use in the treatment of hearing loss and vertigo
CN102146080B (zh) * 2010-02-10 2013-01-30 新疆华世丹药业股份有限公司 β-咔啉碱衍生物类化合物及其应用
EP2455378A1 (en) * 2010-11-03 2012-05-23 Philip Morris Products S.A. Carbazole and carboline derivatives, and preparation and therapeutic applications thereof
CN102093347A (zh) * 2010-12-17 2011-06-15 中国药科大学 1,3,6-三取代-β-咔啉类细胞周期蛋白依赖性激酶2抑制剂及其用途
US11117893B2 (en) * 2018-09-24 2021-09-14 Union University Methods for preparation of substituted pyridines and related novel compounds
EP3860996A4 (en) 2018-10-02 2022-08-31 Northwestern University BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF HUMAN SEROTONIN RECEPTOR 2C (5-HT2C)
CN115335046A (zh) * 2020-03-25 2022-11-11 思研（Sri）国际顾问与咨询公司 脂肪氧合酶抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240511A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinderivaten
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)

Also Published As

Publication number Publication date
DE3380958D1 (de) 1990-01-18
IE56155B1 (en) 1991-05-08
DE3240514A1 (de) 1984-05-03
FI833918A0 (fi) 1983-10-26
DK495683D0 (da) 1983-10-28
DK495683A (da) 1984-04-30
EP0110814A3 (en) 1985-07-24
ES526896A0 (es) 1984-08-01
CA1260475A (en) 1989-09-26
EP0110814B1 (de) 1989-12-13
AU568513B2 (en) 1988-01-07
AU2069483A (en) 1984-05-03
JPS5989678A (ja) 1984-05-23
NO833942L (no) 1984-04-30
HU198208B (en) 1989-08-28
ES8406477A1 (es) 1984-08-01
ATE48602T1 (de) 1989-12-15
DD213217A5 (de) 1984-09-05
FI833918A7 (fi) 1984-04-30
EP0110814A2 (de) 1984-06-13
US4731358A (en) 1988-03-15
ZA838072B (en) 1984-06-27
IE832529L (en) 1984-04-29
GR79637B (enEXAMPLES) 1984-10-31
IL70077A0 (en) 1984-01-31
NZ205949A (en) 1987-03-31

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