JPH0632711A - Skin external preparation - Google Patents
Skin external preparationInfo
- Publication number
- JPH0632711A JPH0632711A JP22772992A JP22772992A JPH0632711A JP H0632711 A JPH0632711 A JP H0632711A JP 22772992 A JP22772992 A JP 22772992A JP 22772992 A JP22772992 A JP 22772992A JP H0632711 A JPH0632711 A JP H0632711A
- Authority
- JP
- Japan
- Prior art keywords
- retinol
- external preparation
- skin
- present
- skin external
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明はレチノールの安定性を著
しく向上させた皮膚外用剤に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin in which retinol stability is remarkably improved.
【０００２】[0002]
【従来の技術】レチノールは皮膚角化症等の予防、治療
や、皮膚老化の防止、回復に有効な成分であることが知
られている。2. Description of the Related Art Retinol is known to be an effective component for the prevention and treatment of cutaneous keratoses and the like, and the prevention and recovery of skin aging.
【０００３】しかしながらレチノールは構造的に極めて
不安定であり、光、空気、熱、金属イオン等により容易
に種々の異性化、分解、重合等を起こすため、安定に皮
膚外用剤に配合することが困難であった。安定化を目的
として脂肪酸エステル化などの手法が試みられている
が、エステル化は安定化には効果があるものの皮膚への
作用という面ではレチノール自身よりはるかに劣ってし
まう。However, retinol is structurally extremely unstable and easily undergoes various isomerizations, decompositions, polymerizations and the like due to light, air, heat, metal ions, etc., so that it can be stably compounded in an external preparation for skin. It was difficult. Although methods such as fatty acid esterification have been attempted for the purpose of stabilization, esterification is effective for stabilization but is far inferior to retinol itself in terms of action on the skin.
【０００４】[0004]
【発明が解決しようとする課題】本発明者らは係る事情
に鑑み鋭意研究の結果、レチノールとともに、ヒドロキ
シカルボン酸塩の一種または二種以上を含有させればレ
チノールおよび／またはその脂肪酸エステルの安定性が
著しく向上することを見出し、本発明を完成するに至っ
た。DISCLOSURE OF THE INVENTION As a result of earnest studies in view of such circumstances, the present inventors have found that if retinol and one or more hydroxycarboxylic acid salts are contained, the stability of retinol and / or its fatty acid ester is stabilized. The inventors have found that the properties are remarkably improved and have completed the present invention.
【０００５】[0005]
【課題を解決するための手段】すなわち本発明の要旨
は、レチノールとヒドロキシカルボン酸塩の一種または
二種以上を含有させることを特徴とする皮膚外用剤に存
在する。Means for Solving the Problems That is, the gist of the present invention resides in an external preparation for skin characterized by containing one or more kinds of retinol and a hydroxycarboxylic acid salt.
【０００６】以下、本発明の構成について詳述する。The structure of the present invention will be described in detail below.
【０００７】本発明にもちいられるレチノールは通称ビ
タミンＡと呼ばれ、末端が水酸基であるレチノール自身
を示し、その脂肪酸エステルは含まない。ａｌｌ−トラ
ンス型または１３−シス型であることが望ましく、それ
らの混合物であっても構わない。The retinol used in the present invention is commonly called vitamin A, which means retinol itself having a hydroxyl group at the terminal, and does not contain its fatty acid ester. All-trans type or 13-cis type is desirable, and a mixture thereof may be used.
【０００８】本発明に従って皮膚外用剤に含有される量
としては特に制限はないが、レチノールとしての肌への
効果を考えると０．０００１重量％以上であり、レチノ
ールの効果を強く訴求するためには好ましくは０．００
１重量％以上である。上限は皮膚外用剤としての性質上
好ましくは１重量％である。The amount contained in the external preparation for skin according to the present invention is not particularly limited, but considering the effect on the skin as retinol, it is 0.0001% by weight or more, and in order to strongly appeal the effect of retinol. Is preferably 0.00
It is 1% by weight or more. The upper limit is preferably 1% by weight in view of the property as an external preparation for skin.
【０００９】また本発明の効果を発揮する目的で皮膚外
用剤に含有させられるヒドロキシカルボン酸塩として
は、クエン酸、乳酸、リンゴ酸、酒石酸などのナトリウ
ム、カリウムなどの無機アルカリ塩、エタノールアミ
ン、塩基性アミノ酸などの有機アルカリ塩等で、モノ
塩、ジ塩、トリ塩が有名である。The hydroxycarboxylic acid salt contained in the external preparation for skin for the purpose of exerting the effects of the present invention includes citric acid, lactic acid, malic acid, tartaric acid and other inorganic alkali salts such as potassium and sodium, ethanolamine, Of the organic alkali salts such as basic amino acids, mono-salts, di-salts and tri-salts are famous.
【００１０】これらを一種または二種以上含有させる
が、本発明の効果を発揮する目的で含有せしめる量とし
ては０．００１重量％以上が必要であり、過剰に含有さ
せても本発明の効果を阻害するものではない。しかしな
がら著しく過剰に含有させた場合、皮膚外用剤としての
品質を損ねることがあるので注意が必要である。好まし
くは１重量％以下である。One kind or two or more kinds of these are contained, but the amount to be contained for the purpose of exerting the effect of the present invention is 0.001% by weight or more, and even if excessively contained, the effect of the present invention is obtained. It does not hinder. However, it should be noted that the content as a skin external preparation may be impaired if the content is excessively excessive. It is preferably 1% by weight or less.
【００１１】本発明においてレチノールとヒドロキシカ
ルボン酸塩を含有する皮膚外用剤基剤としては通常の皮
膚外用剤基剤ならばいずれのものも利用できる。すなわ
ち、液状、ゲル状、ペースト状、クリーム状、あるいは
粉末状、固状などのもので、皮膚外用剤を修飾する成分
として保湿剤、油分、界面活性剤、増粘剤、金属封鎖
剤、その他の紫外線吸収剤、薬剤、色素、香料などが併
用できることは言うまでもない。In the present invention, as a skin external preparation base containing retinol and a hydroxycarboxylic acid salt, any ordinary skin external preparation base can be used. That is, liquid, gel, paste, cream, powder, solid or the like, as a component for modifying the skin external preparation, a moisturizer, an oil, a surfactant, a thickener, a sequestering agent, etc. It goes without saying that the ultraviolet absorbers, drugs, dyes, fragrances, etc. can be used in combination.
【００１２】[0012]
【実施例】次に本発明をより多くの実施例で詳述するが
本発明はこれにより限定されるものではない。EXAMPLES The present invention will now be described in more detail with reference to more examples, but the present invention is not limited thereto.
【００１３】[0013]
【表１】 [Table 1]
【００１４】実施例１、２および３では比較例に比べレ
チノールの安定性が向上しているが、これは本発明に係
る効果である。In Examples 1, 2 and 3, the stability of retinol is improved as compared with Comparative Example, which is an effect according to the present invention.
【００１５】レチノールの定量方法 エタノールを溶媒として用いた３２５ｎｍでの吸光度測
定法により定量を実施した。なお計算にあたっては極大
吸収３２５ｎｍ Ｅ（１％，１ｃｍ）＝１８３５とし
た。本発明に係る効果である。 Quantitative Method of Retinol Quantitative analysis was carried out by an absorbance measuring method at 325 nm using ethanol as a solvent. In the calculation, the maximum absorption was 325 nm E (1%, 1 cm) = 1835. This is the effect according to the present invention.
【００１６】 実施例４ クリーム （重量％） Ａ．セタノール ３ グリセリルモノステアレート ２ ＰＯＥ（２５）セチルエーテル １ ステアリン酸 ３ ワセリン ３ オリーブ油 ３ イソプロピルパルミテート １ スクワラン ５ レチノール ０．１ ＢＨＴ ０．０５ 香料 適量 Ｂ．プロピレングリコール ３ 水酸化カリウム ０．２ クエン酸三ナトリウム １ 精製水 全体を１００とする量 Ａの油相部分とＢの水相部分をそれぞれ７０℃で加熱溶
解し、ＡをＢに加え乳化する。そののち冷却処理をして
クリームを得る。Example 4 Cream (wt%) A. Cetanol 3 Glyceryl monostearate 2 POE (25) cetyl ether 1 Stearic acid 3 Vaseline 3 Olive oil 3 Isopropyl palmitate 1 Squalane 5 Retinol 0.1 BHT 0.05 Perfume proper amount B. Propylene glycol 3 Potassium hydroxide 0.2 Trisodium citrate 1 Purified water 100 parts Amount of oil phase of A and water phase of B are dissolved by heating at 70 ° C. A is added to B and emulsified. Then, it is cooled to obtain a cream.
【００１７】 実施例５ 美容エッセンス （重量％） カルボキシビニルポリマー ０．４ グリセリン ５ プロピレングリコール ５ 乳酸ナトリウム ０．０５ トリエタノールアミン ３．８ ＰＯＥ（６０）硬化ヒマシ油 ０．５ レチノール ０．１ スクワラン １ α−トコフェロール ０．０５ メチルパラベン ０．２ エチルアルコール ６ 精製水 全体を１００とする量Example 5 Beauty Essence (wt%) Carboxyvinyl Polymer 0.4 Glycerin 5 Propylene Glycol 5 Sodium Lactate 0.05 Triethanolamine 3.8 POE (60) Hydrogenated Castor Oil 0.5 Retinol 0.1 Squalane 1 α-Tocopherol 0.05 Methylparaben 0.2 Ethyl alcohol 6 Purified water 100
【００１８】 実施例６ 化粧水 （重量％） グリセリン ２ エタノール ７ ＰＯＥ（５０）オレイルエーテル ０．５ オレイルアルコール ０．００２ レチノール ０．０００１ クエン酸三ナトリウム ０．１ メチルパラベン ０．１ 精製水 全体を１００とする量Example 6 Lotion (% by weight) Glycerin 2 Ethanol 7 POE (50) Oleyl ether 0.5 Oleyl alcohol 0.002 Retinol 0.0001 Trisodium citrate 0.1 Methylparaben 0.1 Purified water 100 in total Amount to
【００１９】 実施例７ オイルジェル （重量％） レチノール １ ２−エチルヘキサン酸トリグリセリド ４０ オリーブ油 １０ ＢＨＴ ０．１ ＢＨＡ ０．０５ ＰＯＥ（２０）オクチルドデシルエーテル １６ グリセリン １５ クエン酸二ナトリウム ０．１ 精製水 全体を１００とする量Example 7 Oil Gel (wt%) Retinol 1 2-Ethylhexanoic Acid Triglyceride 40 Olive Oil 10 BHT 0.1 BHA 0.05 POE (20) Octyldodecyl Ether 16 Glycerin 15 Disodium Citrate 0.1 Purified Water Amount of 100 as a whole
【００２０】 実施例８ ナイトクリーム （重量％） スクワラン １５ ２−エチルヘキサン酸トリグリセリド ５ ワセリン ５ ブチルパラベン ０．２ ジグリセリンジイソステアレート ２ ＰＥＧ４００ジイソステアレート ０．５ レチノール ０．１ グリセリン １０ クエン酸三ナトリウム ０．３ 乳酸ナトリウム ０．１ 乳酸 ０．１ 精製水 全体を１００とする量Example 8 Night Cream (wt%) Squalane 15 2-Ethylhexanoic Acid Triglyceride 5 Vaseline 5 Butylparaben 0.2 Diglycerin Diisostearate 2 PEG400 Diisostearate 0.5 Retinol 0.1 Glycerin 10 Quen Trisodium acid 0.3 Sodium lactate 0.1 Lactic acid 0.1 Purified water 100
【００２１】実施例４〜８の皮膚外用剤は日常的な使用
においてレチノールの安定性に優れたものであった。The external preparations for skin of Examples 4 to 8 were excellent in retinol stability in daily use.
【００２２】[0022]
【発明の効果】本発明の皮膚外用剤においてはヒドロキ
シカルボン酸塩を含有することによりレチノールの安定
性を著しく向上させることができる。INDUSTRIAL APPLICABILITY In the external preparation for skin of the present invention, the stability of retinol can be remarkably improved by containing a hydroxycarboxylic acid salt.
Claims (1)
酸塩を含有することを特徴とする皮膚外用剤。1. An external preparation for skin, which comprises a hydroxycarboxylic acid salt together with retinol.
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22772992A JP3455553B2 (en) | 1992-07-13 | 1992-07-13 | External preparation for skin |
| EP06075806A EP1714640A1 (en) | 1992-07-13 | 1993-07-13 | Stabilised external skin treatment composition comprising retinol. |
| EP04000012A EP1433477B1 (en) | 1992-07-13 | 1993-07-13 | Stabilised external skin treatment composition comprising retinol |
| US08/204,286 US5484816A (en) | 1992-07-13 | 1993-07-13 | External skin treatment composition |
| ES93914997T ES2221921T3 (en) | 1992-07-13 | 1993-07-13 | COMPOSITION FOR DERMATOLOGICAL PREPARATION. |
| DE1993634151 DE69334151T2 (en) | 1992-07-13 | 1993-07-13 | Retinol-containing, stabilized skin care product for external use |
| TW85115876A TW317502B (en) | 1992-07-13 | 1993-07-13 | |
| ES04000012T ES2289370T3 (en) | 1992-07-13 | 1993-07-13 | STABILIZED COMPOSITION FOR EXTERNAL SKIN TREATMENT THAT RETINOL INCLUDES. |
| AT93914997T ATE266999T1 (en) | 1992-07-13 | 1993-07-13 | DERMATOLOGICAL COMPOSITION |
| PCT/JP1993/000969 WO1994001074A1 (en) | 1992-07-13 | 1993-07-13 | Composition for dermatologic preparation |
| TW82105572A TW302284B (en) | 1992-07-13 | 1993-07-13 | |
| EP93914997A EP0608433B1 (en) | 1992-07-13 | 1993-07-13 | Composition for dermatologic preparation |
| KR1019940700795A KR100295030B1 (en) | 1992-07-13 | 1993-07-13 | Skin external composition |
| AT04000012T ATE365530T1 (en) | 1992-07-13 | 1993-07-13 | STABILIZED SKIN CARE PRODUCT CONTAINING RETINOL FOR EXTERNAL USE |
| DE69333526T DE69333526T2 (en) | 1992-07-13 | 1993-07-13 | DERMATOLOGICAL COMPOSITION |
| US08/429,905 US6024941A (en) | 1992-07-13 | 1995-04-27 | External skin treatment composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22772992A JP3455553B2 (en) | 1992-07-13 | 1992-07-13 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0632711A true JPH0632711A (en) | 1994-02-08 |
| JP3455553B2 JP3455553B2 (en) | 2003-10-14 |
Family
ID=16865446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22772992A Expired - Lifetime JP3455553B2 (en) | 1992-07-13 | 1992-07-13 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3455553B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07238010A (en) * | 1994-02-24 | 1995-09-12 | Kanebo Ltd | Skin cosmetic |
-
1992
- 1992-07-13 JP JP22772992A patent/JP3455553B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07238010A (en) * | 1994-02-24 | 1995-09-12 | Kanebo Ltd | Skin cosmetic |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3455553B2 (en) | 2003-10-14 |
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