TW302284B - - Google Patents

Download PDF

Info

Publication number
TW302284B
TW302284B TW82105572A TW82105572A TW302284B TW 302284 B TW302284 B TW 302284B TW 82105572 A TW82105572 A TW 82105572A TW 82105572 A TW82105572 A TW 82105572A TW 302284 B TW302284 B TW 302284B
Authority
TW
Taiwan
Prior art keywords
acid
vitamin
weight
composition
oil
Prior art date
Application number
TW82105572A
Other languages
Chinese (zh)
Original Assignee
Shiseido Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP22773092A external-priority patent/JPH0632712A/en
Priority claimed from JP22772992A external-priority patent/JP3455553B2/en
Priority claimed from JP22772792A external-priority patent/JPH0632729A/en
Priority claimed from JP22772892A external-priority patent/JP3545429B2/en
Priority claimed from JP4227725A external-priority patent/JP2794252B2/en
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Application granted granted Critical
Publication of TW302284B publication Critical patent/TW302284B/zh

Links

Landscapes

  • Cosmetics (AREA)

Description

A7 B7 五、發明説明（1 ) 本發明有關一種可頚著提高雒生素A安定性之皮_外 用組成物。 請 先、 閱 讀 背 * -rr 填 窝盤 本衣 頁 維生素A據知為一種可有效治療、預防皮虜角質化等 、或預防、恢復皮虜老化之成分。 然而，維生素A在構迮上極為不安定，會因光、空氣 、熱、金靥離子等而容易引起各種異性化、分解、聚合等 ，故，很難安定地調配於皮虜外用劑中。 因此，本發明係藉由調配一種可提高維生素A安定性 之安定化劑* Μ顯著提昇維生素A安定性之皮虜外用組成 物0 若依本發明可提供一種皮霜外用組成物，其含有： 訂 (I >維生素A、及 (I)選自Μ下（1)〜（14)中至少一棰之安定劑； (1)蝥合剤及多糖類、 (2〉碘值70Μ上之油分、 (3) 聚乙二醇及/或聚丙二醇、 (4) 羥基羧酸鹽、 (5) 中性胺基酸、 經濟部中央標準局員工消费合作社印装 (6〉（t〉選自丁基羥基甲苯、丁基羥基苯甲醚、 7, δ-生育酚、去甲二氳愈創木酸、沒食子酸 丙酯、維生素C脂肪酸酷及山梨酸之群中至少 一種的油溶性抗氧化爾、 (u )至少一種之乙二胺四賭酸鹽及 (m )至少一種之二苯甲酮糸化合物、 4 本紙浪尺度適用中國國家標隼（CNS ) A4規格（210X297公釐） 3〇22δ4 Α7 Β7 五、 經濟部中央樣準局貝工消费合作社印裝 發明説明（ (7) (i)選自丁基羥基甲苯、丁基羥基苯甲醚、α,/9, 請 閱 讀 背 ι6 意 14 填 I絮 頁 7, δ-生育酚、去甲二氫愈創木酸、沒食子酸 丙酯、維生素C脂肪酸酯之群中至少一棰的油 溶性抗氧化劑、 (Li)抗壞血酸、抗壞血酸鹽、異抗壊血酸、異抗壊 血酸鹽、山梨酸及山梨酸鹽之至少一種及 (ui)至少一種之二苯甲酮条化合物、 (8) 包接抗氧化劑及/或紫外線吸收劑之環糊精、 (9) 至少一種之丁二醇及/或至少一種之油溶性抗氧化 劑、 (10) 至少一種之水溶性二苯甲酮条化合物、 (11) 鹼性胺基酸及其鹽之至少一種、 (12) 酸性胺基酸及酸性胺基酸鹽之至少一種、 (13) 選自季戊四醇脂肪睃酯及三甲醇丙烷脂肪酸酯之群 中至少一種之極性油成分、 (14) 至少一種之水陈潤性粘土礦物。 本發明人等有鑑於上述事情，經銳意硏究結果，發現 於維生素A中調配持定之安定化劑，可顯著提昇維生素A 之安定性*终至完成本發明。 以下，詳細說明有關本發明。 本發明中所使用之維生素A宜為維生素A (別稱： Retinol)、all-trans型或13-cis型，其等之混合物亦無 妨。 依本發明，皮虜外用組成物中所調配之量並無特別限 本紙伕尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） 302284 A7 B7 五、發明説明（ 經濟部中央樣準局貝工消費合作社印製 制，但，若考廉維生素A對肌虜之效果，於組成物全重量 中為0.0001重量％以上，為強烈訴求維生素A之效果，宜 爲0_001重量％以上。於皮霜外用組成物之性質上調配上 限宜爲8重置％。 依本發明之第1態樣可以組合蝥合劑及多糖類作為安 定化劑。 本發明中所使用之螯合劑可舉例如：乙二胺四醋酸之 鈉鹽、鉀鹽等之無機齡鹽、或、乙醇胺類等之有機鹽之一 鹽、二鹽、三鹽、四鹽中任一種、掙檬酸及掙檬酸之鈉鹽 、鉀等之無機鹼鹽、乙醇胺、鹼性胺基酸等之有機鹼鹽等 、單鹽、雙鹽、三鹽等、或偏磷酸翹、多磷酸鹽、酒石酸 鹽等。 本發明中所調配之螯合劑的置為0.001重量上， 調配之上限無特別限制，但，非常大量調配時雖無損於本 發明效果，但，因结晶之析出等無法確保皮虜外用組成物 之品質。宜在1重置％以下。 本發明中所使用之多糖類可舉例如：維素、 悖籽 、碕酸軟骨素、澱粉、半乳聚糖、dermatansulfate、醣 原、阿拉伯膠、硫酸乙醯肝素、透明質酸、黃#膠、硫酸 角質素、軟骨素、蒼耳烷穋、硫酸粘液素、瓜耳膠、糊精 硫酸角質、刺槐豆膠、琥珀酿葡聚糖、《聚糖等、及其等 之鹽。 於本發明皮慮外用組成物中多糖類之調配量’從本發 明之效果而言並無持別限制，但宜為o.ooool〜5.0重量％ 本紙張尺度適用中國國家櫟準（CNS ) A4規·格（21〇Χ 297公釐） 請 閱 讀 背 * 之 注 訂 妹 A7 B7 五、發明説明（ 請 先· 閲 讀 背 面 之 注 意 丹 填 寫 本 頁 本發明之第2態樣中，作為安定化劑所調配之碘值70 Μ上的油可舉例如：靥於乾油性植物油之亞麻油、梢油、 大豆油、紅花油、核桃油、朴樹油、月見草油、樱挑嘉納 油、葡萄籽油等、屬於不乾性油之胡麻油、菜籽油、绵實 油、棟油、小麥胚芽油等、或阿伏加德油、橄攬油、山茶 油、麥、第米亞核桃油等、靥於魚油者有沙丁魚油、鲭魚 油、鯡魚油、鱈魚肝油、牡蝙油等。 此等油之碘值，例如亞麻油為168〜190、大豆油爲114 〜138、紅花油爲122〜150、菜籽油為94〜107、綿實油爲 90〜121、橄攬油爲75〜90、山茶油爲73〜87、沙丁魚油 為136〜195、緋魚油為99〜119。 此外*源自此等油脂之游難脂肪酸或高级醇之中，碘 值70Μ上者可舉例如：油酸、肉豆蔻油酸、亞油酸、亞麻 酸、桐酸、7 -亞麻酸、花生四烯酸、花生五烯酸、油醇 等。 經濟部中央樣準局員工消费合作社印製 可調配此等油一種或二種以上，但，可發揮本發明效 果之目的所調配的量宜為〇.〇1重量％以上，調配過多亦不 會妨礙本發明之效果。但，明顯調配過多時，因會損及皮 虜外用組成物之品質，必須相當注意。調配量尤Μ 0.1〜 60重置％爲佳。 若依本發明之第3態樣，可調配聚乙二醇（PEG)及/ 或聚丙二醇（PPG) —棰或二棰以上作爲安定化劑。 又，本發明中所調配之PEG較常者為PEG200、PEG300 本紙伕尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） Α7 Β7 3〇2284 i、發明説明（5 ) (請先閱讀背面之注意事| 填寫本頁) 、PEG400、 PEG1500、 PEG4000、 PEG6000、 PEG20000 等、 而 PPG 有PPG400、 PPG750、 PPG1200、 PPG2000、 PPG3000 等。 可調配此等一種或二種Μ上，但，可發揮本發明效果 之目的所調配的量宜爲0.1重量％以上，調配過多亦無礙 於本發明之效果。但，明顯調配過多時，因會損及皮*外 用組成物之品質，故須注意，範圍尤Ml〜80重量％為佳 〇 本發明之第4態樣中，皮虜外用組成物中含有作為安 定化劑之羥基羧酸鹽常用者有：榫檬酸、乳酸、蘋果酸、 酒石酸等之納、鉀等的無機屬鹽、乙醇胺、鹼性胺基酸等 之有機鹼鹽等的單鹽、雙鹽、三鹽。 可含有此等一種或二種Μ上，但，可發揮本發明效果 之目的所含有的量宜為0.001重量％以上、邸使含有過多 亦無礙本發明之效果。然而，明顯含有過多時，因會損及 皮虜外用組成物之品質，故必須注意，尤Μ0.01〜1重量 %為佳。 經濟部中央標窣局員工消費合作社印裝 本發明之第5態樣，調配來作為安定化劑之中性胺基 酸可例示如：甘胺酸、丙胺酸、絲胺酸、白胺酸、苯基丙 胺酸、脯胺酸、羥脯胺酸等。 可調配此種1種或2棰以上，但，可發揮本發明效果 之目的所調配的量宜為0.001重量％，讕配過多亦無礙本 發明之效果。但*明顯調配過多時，分別超過其溶解度， 因結晶的析出會伴隨皮虜外用組成物品質的劣化，故必須 8 本紙張·尺度適用中國國家標準（CNS ) Α4現硌（210Χ297公釐） 經濟部中央標準局員工消費合作社印製 Α7 Β7 五、發明説明（6 ) 注意，尤以0.01〜10重量％為佳。 本發明之第6態樣，可調配來作為安定化劑之油酸性 抗氧化劑，丁基羥基甲苯（BHT)、丁基羥基苯甲謎（BHA) 、α,/3, 7, δ-生育酚、去甲二氫愈創相酸、沒食子酸丙 酯、維生素C脂肪酸酯、山梨酸。 本發明中所調配之量宜爲0.001重量上，0.01重 量％以上更佳。此外，可長期發揮本發明效果時宜爲0.03 重量％。調配上限依皮外用組成物之劑型而不同，可任 意調配而無限定，但*於皮膚外用組成物之性質上宜為10 重量％ Μ下。 本發明中所使用之乙二胺四醋酸鹽，可例示如：納鹽 、鉀鹽等之無機鹼鹽、或、乙醇胺類等之有機鹼鹽的一鹽 、二鹽、三鹽或四鹽等。 本發明中所調配之量為0.001重量％，調配上限並無 特別上限，但非常大量調配時，雖無損於本發明之效果， 但因結晶之析出等無法確保皮膚外用組成物之品質，宜為 0,005〜1重量％。 本發明中所使用之二苯甲酮条化合物，可例示如：2, 4-二羥基二苯甲酮（以下二苯甲酮-1) 、2,2’，4,4’-四羥 基二苯甲酮（Μ下二苯甲醑-2)、2-羥基-4-甲氧基二苯 甲嗣（以下二苯甲酮-3) 、2-羥基-4-甲氧基二苯甲酮-5 -磺酸（Κ下二苯甲醑-4) 、2-羥基-4-甲氧基二苯甲酮 -5-磺酸鈉（Μ下二苯甲酮-5)、2,2’_二羥基-4.4’-二 甲氧基二苯甲嗣（Μ下二苯甲酮-6) 、2-羥基-5-氮二苯 本紙張尺度適用中國國家梂準（CNS ) Α4規格（21 〇 X 297公慶） --!---Γ-----裝------訂----.--嫌 (請L閲讀背面之注意我灯填寫本頁) { 經濟部中央樣準局貝工消费合作社印製 Α7 Β7 五、發明説明（7 ) 甲嗣（M下二苯甲銅-7) 、2,2 -二經基-4-甲氧基一苯 甲飼（M下二苯甲銅、2,2 - —趕基-4’4 -一甲氧基 二苯甲嗣-5,5，-二磺酸二納（以下二苯甲酮-9) 、2_經基 4-甲氧基-4’-甲基二苯甲嗣（以下二笨甲酮-1〇)、擇基 -4-辛氧基二苯甲酮（以下二苯甲酮-12) ° 本發明之皮虜外用組成物所調配之量爲0.001重量％ Μ上，調配的上限並無特別限定’但非常大量調配時’雖 無損本發明之效果，但，會因結晶的析出而無法確保皮虜 外用組成物之品質，故宜為0.01〜10重量％。 本發明之第7態樣，係調配W下（Α)〜（C)作為安定薄I ，（Α)選自丁基羥基甲苯、丁基羥基苯甲醚、α， δ-'生育酚、去甲二氫愈創木酸、沒食子酸丙酯、维生素 C脂肪酸酯之群中至少一種的油溶性抗氧化劑、 '(B)抗壊血酸、抗壊血酸鹽、異抗壊血酸、異抗壊血酸鹽 、山梨酸及山梨酸鹽之至少一種、（C)至少一種之二苯甲 酮糸化合物。 依本發明之皮Λ外用組成物中所調配之油溶性抗氧化 劑可例示如：丁基羥基甲苯（ΒΗΤ)、丁基羥基苯甲醚（ΒΗΑ) 、α,/3, 7, δ-生育酚、去甲二氫愈創木睃、沒食子睃丙 酯、维生素C脂肪酸酯等。 本發明中所使用之量宜為0.001重量％以上，尤以 0.01重置上爲佳。此外，可長期發揮發明之效果時宜 爲0.03重量％。調配上限依皮着外用組成物之劑型而異， 可任意調配而無限定*但於皮霜外用組成物之性質上宜為 本紙浪尺度遑用中國國家標準（CNS ) A4現格（210X 297公釐） 10 --；---：-----裝------訂-------諫 (請t閱讀背面之注意^ ·:填寫本育) { 30 吻 4 Α7 Β7 五、發明説明（8 ) • 10重量％。 本發明中所使用之抗壤血酸（別稱維生素C)、異抗 壞血酸、山梨酸及其鹽可例示如：納鹽、鉀鹽等之無機鐮 金屬鹽、或、乙醇胺類或鹼性胺基酸等之有機驗金屬鹽等 。其中，Μ抗壤血酸、抗壊血酸鈉、異抗壊血酸、異抗壤 血酸納、山梨酸、山梨酸納、山梨酸鉀為宜。又*各別之 酸與鹼性物質合併使用*亦可於系中使鹽形成。 本發明中所調配之置爲0.001重量％以上，調配上限 並無特別限定，但，非常大量調配時，雖無損本發明之效 果，但因结晶之析出等會無法確保皮虜外用劑之品質。宜 爲10重量％以下。 經濟部中央橾準局貝工消費合作社印製 本發明中所使用之二苯甲酮条化合物可例示如：2,4_ 二羥基二苯甲嗣（Μ下二苯甲嗣-1)、2,2’，4,4’-四羥基 二苯甲嗣（Μ下二苯甲酮-2) 、2-羥基-4-甲氧基二苯甲 酮（以下二苯甲酮-3)、2-羥基-4-甲氧基二苯甲酮碌 酸（Κ下二苯甲嗣-4)、2-羥基-4-甲氧基二苯甲酮礙 酸納（Μ下二苯甲嗣-5)、2,2’-二羥基-4,4，-二甲氧基 二苯甲酮（以下二苯甲酮-6) 、2-羥基-5-氮二苯甲嗣（ Μ下二苯甲嗣-7) 、2,2，-二羥基-4-甲氧基二苯甲嗣（ 以下二苯甲豳-8) 、2,2，-二羥基-4,4，-二甲氣基二苯甲 酮-5,5，-二磺酸二納（以下二苯甲銅-9) 、2-羥基甲氧 基-4，-甲基二苯甲酮（以下二苯甲詷-1〇)、2-羥基-4-辛 氧基二苯甲銅（以下二苯甲酮-12) ° 本發明中所調配之量為0.001菫量％以上’ 10 11 (請先閲讀背面之注意事填寫本頁) 本紙張尺度適用中國國家標準（CNS ) Α4规格（210Χ 297公釐） 五、發明説明（9 ) A7 B7 經濟部中央橾準局員工消费合作社印裝 並無持別限定，但，非常大量調配時，雖無損本發明之效 果，但因結晶之析出等會無法確保皮虜外用劑之品質。宜 為10重量％以下。 本發明中所使用之環糊精（CD)為環狀寡糖，可例示如 依糖數之不同，具有α,/3,7構造之CD (ct-CD，/3-CD， 7-CD)*或，於其等中導入低级烷基之甲基CD(M-CD)、乙 基CD(E-CD〉、羥基烷基化之羥甲基CD(HM-CD)、羥乙基CD( HE-CD〉、羥丙基 CD(HP-CD)、羥丁基 CD(HB-CD〉等。 其中，a -CD及7 -CD雖對水之溶解度佳，但，乃薙澱 粉分解之製法，故產率低，且在成本上略不滿意。又》/3 -CD雖於成本上有利，但於溶解度上略爲不满意。不管如 何，只要熟知各別之性質加Μ利用，亦能充分得到本發明 之效果。 另一方面*若考廉溶解度與成本俱佳、對皮虜外用組 成物之汎用性者，宜爲甲基化CD、羥烷基化CD，尤以甲基 -/9 -CD、羥烷基-/8 -CD為佳。 於本發明之皮霜外用組成物中所調配之量任一者的CD 亦須0.01重量％以上，上限從本發明之效果而言並無特別 限定，但明顯大量調配時，雖不影IS本發明之效果，但因 结晶之析出等會損及皮虜外用组成物之品質。對於α，7 -CD宜為1〇重量％以下、對於/9-CD為1重量％以下、對 於低级垸基化CD、羥垸基化CD為30重量％ Μ下。 依本發明之皮虜外用組成物所調配之油溶性抗氧化劑 可例示如：去甲二氫愈創木酸、ΒΗΤ、ΒΗΑ、α,/3,7,5- 請 先. 聞 讀 背 之 注 意 Λ 寸 ii 绮 本紙張尺度適用中國國家樣準（CNS〉A4規格（2丨0X 297公釐） ΤΊ A7 B7 五、發明説明（10 ) • 生育酚類、沒食子酸丙酯、維生素c脂肪酸酯、山梨酸等 ，其中以611丁，81^，《,/3,7,3-生育酚類為佳。 本發明中所使用之量宜爲0.001重量％，更宜為0.01 重量％以上。可長期發揮本發明效果時*宜為0.03重量％ 。調配上限依皮膚外用組成物之劑型不同*可任意調配並 無限定，但，於皮虜外用組成物之性質上宜為1重量％。 本發明所使用之紫外線吸收剰可例示如：以2-羥基-4 -甲氧基二苯甲酮為代表之二苯甲酮条化合物、以辛甲氧 基桂皮酸酯、單/雙（甲氧基桂皮基）一單/3辛基甘油 酯為代表之桂皮酸糸化合物、以柳酸辛酯為代表之柳酸条 化合物、以對胺基安息香酸辛酯為代表之安息香酸糸化合 物、M4-第三丁基-4’-甲氧基二苯甲醢甲烷為代表之二苯 甲醯甲垸条化合物等。尤宜爲二笨甲酮条、桂皮酸糸、二 苯甲醢甲烷糸。 本發明中所使用之量宜為0.001重量％，更宜為0.01 重量％以上。可長期發揮本發明效果時，宜爲0.03重量％ 。調配上限依皮虜外用組成物之劑型不同，可任籯調配並 無限定，但，於皮虜外用組成物之性霣上宜為1重董％。 經濟部中央橾準局員工消費合作社印製 使抗氧化劑、紫外線吸收劑與前述CD類包接之方法， 一般，係於CD類之水溶液（20〜60重釐％ )中添加抗氧化 劑、紫外線吸收劑（相對於CD添加0.01〜0.2部），並於 20〜60t：下搜拌（50〜3000rpm)、約2〜12小時即可得包 接化合物。如此所得到之包接化合物係於水溶液中呈可溶 化或乳化狀態，可以此狀態應用於皮虜外用組成物，同時 13 (請先閲讀背面之注意j 卄填寫本頁) 本紙張尺度遑用中國國家標準（CNS ) A4規格（2IOX297公釐） 經濟部中央搮準局貝工消费合作社印装 Α7 Β7 五、發明説明（11 ) • *亦可藉凍結乾燥、噴霧乾燥等之方法將此溶液單離成粉 末來使用。 亦可分別單獨地將抗氧化劑、紫外線吸收劑與CD類調 配於皮膚外用組成物中，使之於皮)*外用組成物中一次包 接。 於本發明之第9態樣中，調配成安定化劑之丁二醇可 舉例如·· 1,2-丁二醇、1,3-丁二醇、1,4-丁二醇等。 可調配此種1種或2種Μ上，但，可發揮本發明效果 之目的所調配的量宜為0.01重量％以上，調配過多亦不會 阻礙本發明之效果。然而，明顯調配過多時，會損及皮膚 外用組成物之品質，必須注意，尤Μ 0.1〜40重量％為佳 0 本發明所調配之油溶性抗氧化劑可例如示：ΒΗΤ、ΒΑΤ 、ct,/3. 7. δ-生育酚類、去甲二氫愈創木酸、沒食子酸 丙酯、維生素C脂肪酸醋、山梨酸等。 調配董宜爲0.001重量％以上，更宜爲0.005重量％ 以上。又，為能更長期發揮發明之效果宜為〇.〇1重置％。 上限就發明效果而言並無特別限定*明頚過量時，會因結 晶析出等而損及皮虜外用組成物之品質，故必須注意，宜 為10重量％。 本發明之第10態樣中*使用來作為安定化劑之水溶性 二苯甲酮糸化合物可例示如：2-羥基-4-甲氧基二苯甲酮 -5-磺酸（以下二苯甲酮-4)及其鹽，2-羥基-4-甲氧基 二苯甲酮-5-磺酸納（以下二苯甲酮-5) 、2,2’-二羥基 本紙張尺度適用中國國家揉準（CNS ) A4規格（210X297公釐） 14 « (請先閲讀背面之注意l-rr填寫本頁) 、-° 302284 at B7 五、發明説明（12 ) -4,4’-二甲氧基二苯甲酮-5,5’-二磺酸納（以下二苯甲酮 -9)等。 本發明之皮虜外用組成物中所調配之量宜為0.001重 量％ Μ上，尤宜為0.01重量％以上，調配之上限並無特別 限定，但調配非常多量時，雖不損及本發明之效果，但· 會因结晶析出等而很難確保皮庸外用組成物品霣之處，故 宜為5重量％以下。 本發明之第11態樣中，調配來作為安定化劑之驗性胺 基酸及其鹽，可例示如：精胺酸、離胺酸、羥基離胺酸、 鳥胺酸等、或、其等之鹽、醏酸鹽、天冬胺酸、aft咯酮羧 酸鹽等，除此之外亦可於皮»外甩組成物中合併使用鹼性 胺基酸與其他之酸性物質，亦使之於糸中形成鹽。 可調配此種1種或2種以上，但，可發揮本發明效果 之目的所調配的量必須為0.001重量％以上《調配過多亦 不會阻礙本發明之效果。然而，明顯調配過多時，會因結 晶析出等而損及皮盧外用組成物之品質，故必須注意*但 宜為0.01〜5重置％。 較佳之条的PH為6以上*更佳者為上。 經濟部中央揉準局員工消费合作社印装 本發明之第12態樣中*可調配來作為安定化劑之睃性 胺基酸及酸性胺基酸鹽，可例示如：天冬胺酸、毅胺酸等 之睃性胺基酸及酸性胺基酸之納、鉀等的無機金羼鹽、乙 醇胺、鐮性胺基酸等之有機鹼金靥鹽等。又，亦可應用吡 咯酮羧酸及其鹽。 可調配此等1種或2種以上，但，可發揮本發明效果 15 (請先閲讀背面之注意事Γ 、填寫本頁) 本紙浪尺度逋用中國國家標準（CNS ) Λ4规格（210X297公釐） Α7 Β7 五、發明説明（13 ) • 之目的所調配的置宜為0.001重量％以上，更宜爲0.01重 量％以上，調配過量亦無阻礙本發明之效果。然而，明顯 調配過剩時，會超過各別之溶解度，因结晶之析出等而伴 隨皮虜外用組成物品質之劣化，故必須注意，但宜爲1〇重 量％以下。 本發明之第13態樣中，可使用來作為安定化劑之極性 油成分，乃為季戊四醇脂肪酸酯、宜為“〜（：〃之季戊四 醇脂肪酸酯、及三甲醇丙烷脂肪酸酯、宜選自Cs〜Cia之 三甲醇丙烷脂肪酸醋之群中的極性油成分，具醱而言可例 示如：季戊四醇-四（2-乙基己酸）酯、季戊四酵-四辛酸 酯、三甲酵丙烷-三（2-乙基己酸）酯、三甲醇丙烷-三辛 酸酯等。 經濟部中央棣準局貝工消費合作社印製 本發明中所調配之量，依皮虜外用組成物剤型而不同 ，並無特別限定，但，非常少量時，無法溶解维生素A或 油溶性抗氧化劑，而不能充分發揮本發明之效果。因此， 皮虜外用組成物中提高所調配之維生素A及油溶性抗氧化 劑之量和的置，宜為0.002重量％以上，更宜為0.1重置 %以上。調配之上限依皮虜外用組成物的_型而不同，並 無特別限定，但，從皮虜外用組成物全量減去本發明之油 溶性抗氧化劑與維生素A之量成為上限。 依本發明，調配於皮虜外用組成物之油溶性抗氣化剤 ，可例示如：ΒΗΤ、ΒΑΤ、α ,/3 , 7 , S -生育酚類、去甲二 氫愈創木酸、沒食子酸丙酯、維生素C脂肪酸酯、山梨酸 16 0 (請先閲讀背面之注意丹填寫本頁) 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 經濟部中央橾準局負工消费合作杜印製 A7 B7 五、發明説明（14 ) 本發明中所使用之量宜為0.001重量％以上，宜更為 0.01重量％以上。可長期發揮本發明之效果時宜為0.03重 量％。調配上限依皮*外用組成物之劑型亦不同，可任意 調配而無限定，但，在皮虜外用組成物之性質上宜爲10重 置96。 本發明之第14態樣中，可調配來作為安定化劑之水膨 潤性粘土礦物* 一般爲穋體性含水矽酸鋁之一種，具髏而 言，可例示如：嶺晶高嶺土群、铈黑簾石、緣高嶺土、路 皂石及水輝石等之天然或合成之綠土，而市面上販賣之物 品可舉例如克尼比、史遇克頓（均為國峰社製）、必膠（ 邦達必魯社製）、來波納（來波路得社裂）、氟化四矽雲 母（托比工業製）等，亦可應用Μ鈉西力克雲母、納或鋰 田尼歐萊特為名之合成雲母等。 本發明中所調配之置爲0.01重量％以上，宜為0.1重 量％以上》上限從本發明之效果而言，並無特別限定，但 ，明顯過多時，會產生凝膠化等，而使皮虜外用組成物之 品質變差，故必須注意。宜爲50重量下。 本發明中所調配之抗氧化劑可例示如：ΒΗΤ、ΒΑΤ、α ,/3,7,3-生育酚類、去甲二氫愈創木酸、沒食子酸丙酯 、維生素C脂肪酸醏、山梨酸、山梨酸鹽、異抗壞血酸、 異抗壤血酸馥、維生素C脂肪酸酯等。 本發明中所使用之量宜爲0.001重量％以上，更宜為 0.01重量％以上。此外，可長期發揮本發明效果時，宜爲 0.03重量％。 本紙張尺度適用中國國家榇準（CMS ) A4規格（210X 297公釐） -1( _ 0¾ (請先閱讀背面之注意t-TT填寫本頁) ，\se 經濟部中央標準局貝工消费合作社印裝 A7 B7 五、發明説明（15 ) 本發明中所使用之紫外線吸收劑可例示如：2-羥基_4 -甲氧基二苯甲酮、2-羥基-4-甲氧基二苯甲嗣-5-磺酸 ，以2,2’-二羥基-4,4’-二甲氧基二苯甲詷爲代表之二苯 甲辋糸化合物、辛甲氧基桂皮酸酯、以單/雙（甲氧基桂 皮基）-單/燹辛基甘油酯為代表之桂皮酸糸化合物、Μ 柳酸辛酯爲代表之柳酸条化合物、Μ對胺基安息香酸為代 表之安息香酸条化合物、Μ4-第三丁基-4’ -甲氧基二苯甲 酿甲烷爲代表之二苯甲瞌甲烷糸化合物。 可調配此種1種或2種以上，但可發揮本發明效果之 目的所調配的量必須爲0.001重量％以上，調配過多亦無 礙於本發明之效果。但，明顯調配過多時，會損及皮膚外 用組成物之品質，故必須注意。宜爲10重量％ Μ下。 本發明中利用來作為蝥合劑者，亦可應用乙二胺四醋 酸鹽之納鹽、鉀鹽等之無機鐮金羼鹽、或、乙醇胺類等之 有機鹼金颶鹽的一鹽、二鹽、三鹽、四鹽、檸檬酸及搾檬 酸之納、鉀等的無機蠊金羼鹽、乙醇胺、驗性胺基酸等之 有機餘金屬鹽等之單鹽、二鹽、三鹽等、或、備磷酸鹽、 聚磷酸鹽等。 可調配此種1锺或2種Μ上，但，可發揮本發明效果 之目的所調配的量，必須爲0.001重量％以上，調配過多 亦無礙本發明之效果。但，明顯調配過多時，會因結晶析 出而損及皮霜外用組成物之品質，故必須注意。宜為1重 量％ Μ下。 於本發明之皮虜外用組成物中，除前述之必須成分Μ 本紙張尺度遑用中國國家橾準（CNS ) Α4規格（21 ΟΧ 297公釐） - 1S - ------Μ-----裝------訂-------錄 (請L閲讀背面之注意裹 <填寫本頁) { S02284 A7 B7 五、發明説明（l6 ) 外，亦只要不損及本發明之效果可依需要而調配使用於通 常化妝品或醫藥外用品中之一般皮虜外用組成物基劑，及 ，其他的成分如保濕劑、界面活性劑、防腐劑、水、醇、 增粘劑、油分、藥劑、香料、色劑、紫外線吸收劑等。又 ，亦可使用成爲液狀、凝嘐狀、糊狀、霜狀、粉末狀、固 態狀等。 實施例 Μ下依貢施例更進一步詳細說明本發明，但，本發明 不限定於此等。 童施例卜1 . 1-2.及bh較例1-1 . 1-?夕靱法癍溫庠試 驗方法 於601；下完全溶解各油性成分後，於精製水中添加經 溶解之ΡΟΕ(1〇)油醚、乙二胺四乙酸鹽、乙酵、二丙二醇 ，冷卻至40它。其後，將維生素C完全溶解、密封於褐色 玻瓖製試樣管中，再Μ鋁箔包住完全遮光，保管於401：恒 溫槽中。 |_.---r-----III (請先閲讀背面之注意I+T填寫本頁) 訂 經濟部中央橾準局貝工消费合作社印袈 本紙浪尺度逋用中國國家橾準（CNS ) A4規格（21〇X297公釐） 19 A7 B7 五、發明説明（17 ) 裘1-1:彳h妝用油配方與雒生袤A定鼉结舆（重畺鉍、 實施例 1-1 實施例 1-2 比較例 1-1 維生素A 0.01 0.02 0.01 乙二胺四乙酸二鈉 0.001 0.005 - 透明質酸 0.001 0.001 - 精製水 0.1 0.2 - 2-乙基對羥苯甲酸 三甘油酯 殘餘 殘餘 殘餘 肉豆蔻酸異丙酯 10 35 10 角鯊烷 15 15 15 二丙二醇 15 15 15 乙醇 8 8 8 POE(IO)油醚 2 2 2 維生素A定量值 調製之後（％ ) 100 100 100 40t： 2週後（％) 93 98 56 i^n im^i t— {請LiMl讀背面之注意4-ΓΤ填寫本頁) --s 經濟部中央標準局貝工消费合作社印装 實施例1-1及1-2與比較例1-1相較，雖可提高維生素 A之安定性，但，此係有鼷本發明之效果。 维牛素A：>^曇方法 使用乙醇作為溶劑，M 325nm之吸光測定法進行定量 Ο 又，計算時使極大吸收325nm E ( 1% , lcm) = 1835。 本紙張尺度逋用中國國家標準（CNS ) A4規格（210X297公釐） 20 A7 B7 五、發明説明（is ) 經濟部中央標準局貝工消費合作社印裝 丟卜2 :乳液成方及維牛袤A宙鼉结里（簠詧鉍） 實施例 實施例 比較例 比較例 1-3 1-4 1-2 1—3 維生素A 0.03 0.001 0.03 0.001 乙二胺四乙酸二納 0.01 - - 掙樺酸二納 0.02 0.02 - - 異辛烷酸鲸蟠酯 10 γ 10 7 2-乙基己酸甘油酯 2 4 2 4 角鯊烷 2 2 2 2 鯨蟠醇 2 2 2 2 凡士林 1 1 1 1 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 P0E(60)硬化猪麻油 1.3 1.3 1.3 1.3 羧乙烯基聚合物 0.2 0.3 0.2 0.3 蒼耳烷穋 0.05 0.1 - - 苛性鉀 0.06 0.08 0.06 0.08 甘油 10 10 10 10 丙二醇 3 3 3 3 乙基對羥苯甲酸 0.2 0.2 0.2 0.2 精製水 使: έ黼爲100: 之置 維生素八定量值 調製之後（％) 100 100 100 100 401C 1傾月後（％) 95 97 31 38 (請先閱讀背面之注意:填寫本頁) •裝· 訂 絲 本紙伕尺度適用中國國家揉準（CN'S ) A4規格（210X297公釐） 21 302284 A7 B7 經濟部中央標準局負工消費合作杜印裝 五、發明説明（19 ) 實施例1-3及1-4與比較例相較，雖可提高維生素A之 安定性，但，此係有關本發明之效果。 砉1-3 :仆.妝氷及維牛袤畺结果（重鼉％) 實施例 實施例 實施例 比較例 1-5 1—6 1-7 1-4 乙二胺四乙酸二納 0.5 - 0.05 - 乙二胺四乙酸四鉀 - 0.3 0.05 - 透明質酸納 0.1 0.05 - - 硫酸軟骨素納 - - 0.2 - 乙醇 5.0 5.0 5.0 5.0 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 維生素A 0.0001 0.0001 0.0001 0.0001 辛基十二醇 0.001 0.001 0.001 0.001 P0E(60)硬化Μ麻油 0.4 0.4 0.4 0.4 乳酸 0.01 0.01 0.01 0.01 乳酸納 0.1 0.1 0.1 0.1 凡士林 0.2 2.0 2.0 2.0 精製水 使: έ體為100: 之量 維生素八定量值 調裂之後（％) 100 100 100 100 40Τ： 1個月後（％) 95 93 91 49 實施例卜5，1-6，卜7與比較例相較，雖可提高維生 素A之安定性，但，此係有關本發明之效果。 % (請先閱讀背面之注意策订填寫本頁) 言 22 本纸乐尺度適用中國國家橾準（CNS ) A4規格（210X 297公釐） 五、發明説明（20 A7 B7 經濟部中央榡準局員工消费合作社印製 奮掄例1 :仆，妝永 油醇 維生素A Ρ〇Ε(50Πώ!^ 乙二胺四乙酸三納 乳酸 乳酸納 軟骨素硫酸納 乙醇 甘油 甲基對羥苯甲酸（paraben) 精製水 奮旃例1 -9 :乳霜 角鯊烷 2-乙基己酸三甘油酯 肉豆蔻酸異丙酯 维生素A 凡士林 丁基對羥苯甲酸（paraben) 丙基對羥苯甲酸 油酸單甘油酯 二異硬脂酸二甘油酯 PEG400二油酸酯 甘油 (重S鉍） 0.005 0.0001 .01 .09 使全體為100之董 (重噩弘） 15 8 7 3 2 1 10 (請先閲讀背面之注意t t填寫本頁) 、\-3 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 23 五、發明説明（21 ) 绻維素粉末 二丙二醇 乙二胺四乙酸二納 三乙醇胺 精製水 奮掄例1 -〗0 :油精 2-乙基己酸三甘油酯 辛基十二醇 角鯊烷 維生素 二丁基鈦酸酯 乙醇 绻维素粉末 乙二胺四乙酸鈉 奮旃例1 -1 1 :油駿 2-乙基己酸三甘油酯 P0E(20)辛基十二醚 維生素A 甘油 透明質酸鈉 乙二胺四乙酸二納 精裂水 音掄例1 -1 2 :乳霜 A7 B7 1 5 0.01 0.02 使全髏為100之置 (重鼉 50 20 10 1 9 9.989 0.01 0.001 (重 a %) ----l-----^------IT----^--^ (請先閱讀背面之注意^C+3填寫本頁) ί 經濟部中央標準局員工消費合作社印裂 60 16 0. 1 16 0.01 0.05 使全體為100之置(重 a %) 希多硬脂醇（ceto stearyl alcohol) 3. 本纸浪尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） ΎΤ 五、發明説明（22 A7 B7 經濟部中央標準局員工消費合作社印裝 角鯊烷 蜜蟠 還原羊毛脂 乙基對羥苯甲酸 P〇E(50)油醇醚 硬脂酸單甘油Θ旨 乙二胺四乙酸之二乙醇胺鹽 香料 雒生素A dermatan sulfate 甘油 精製水 奮旆例1 -13 :敷險霜（DMk) 蒼耳烷膠 聚乙烯醇 丙二醇 乙醇 維生素A 乙二胺四乙酸之納一鹽 甲基對羥苯甲酸 P0E(60)硬化Μ麻油 香料 精製水 奮旃例1-1 4:因联白粉 30. 3. 5. 0.01 0.03 0.0001 0.1 15.0 其餘部分 (重量％ ) 1.0 10.0 7.0 10.0 0.01 0.1 0.05 0.2 0.05 其餘部分 (重營 (請先閱讀背面之注意束再填寫本頁) 本纸張尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） 25 A7 B7 經濟部中央樣準局員工消费合作社印製 發明説明（23 ) 維生素A 0.0005 滑石 8 5.4 硬脂酸 2.5 角鯊烷 3.5 山梨聚糖倍半油酸酯 1.8 三乙醇胺 1.2 悖籽 0.001 乙二胺四乙酸之二甲鹽 0.001 顔料 適量 香料 適量 弯旆例1 -1 5 : □奵 (重畺％ 維生素A 0.0000 撤晶蠟 3.0 蜜蠘 3.0 白地撖 5.0 流動石嫌 19.0 角鯊垸 20.0 巴西肉豆蔻 3.0 堪特利蟠 3.0 阿拉伯膠 0.01 乙二胺四乙酸之納一鹽 0.01 調色色劑 7.0 二丁基羥基甲苯 0.05 香料 適量 I-„---Γ-----^------ΐτ----‘--.^ (請先閲讀背面之注意裹、-ΓΓ填寫本頁) { 本紙浪尺度適用中國國家標準（CNS ) A4規格（；!I0X 297公釐） 6 五、發明説明（24 A7 B7 經濟部中央揉準局員工消費合作社印製 羊毛脂 奮旃俐1 -1 fi :乳液 維生素A 透明質酸 乙二胺四乙酸之三乙醇胺鹽 乙醇 甘油 丙二醇 羧乙烯聚合物 KOH 甲基對羥苯甲酸 鲸蟠醇 凡士林 角鯊烷 肉豆蔻酸異丙酯 單硬脂酸甘油酯 P0E(25)十六醚 精裂水 奮旃例1 -1 7 :乳液 維生素A 碕酸軟骨素 掙樣酸三納鹽 乙醇 甘油 其餘部分 1.0 0. 1 1. 0 2.0 10.0 3.0 2.0 10.0 5.02.0 2.0 其餘部分 (重署 0.3 0.01 0. 1 5.0 ----„------t------ΐτ----.--*線 (請先閱讀背面之注意*v冉填寫本頁) { 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） η 302284 A7 B7 五、發明説明（25 ) 丙二醇 5.0 羧乙烯基聚合物 0.2 Κ0Η 0.06 甲基對羥苯甲酸 0.2 P0E(60)硬化Μ麻油 1.0 角鯊烷 3.0 肉豆蔻酸異丙酯 3.0 精製水 其餘部分 實施例1-8〜卜17之皮膚外用組成物於日常使用上為 具維生素Α安定性佳者。 如上所述，本發明之皮*外用劑中調配螯合劑一種或 二種以上與透明質酸或硫餒軟骨素等之多糖類可使維生素 A之安定性顯著提昇。 審施例2-1〜及f~h較例2-1〜2-；； (請先閱讀背面之注意哀^填寫本頁) 經濟部中央標準局員工消費合作杜印製 本紙伕尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 28 經濟部中央標準局負工消費合作社印製 A7 B7 五、發明説明（26 ) 宪2-1 :夂潘油成分由>牛亲A夕右亩桦湖丨佘结罢（重蚤鉍) 實施例 實施例 實施例 比較例 比較例 2-1 2-2 2-3 2-1 2-2 橄欖油（IV=75〉 99 - _ - - 綿實油（IV=95) - 99 - - - 月見草油（IV=190) - - 50 - - 角鯊烷（ιν=ι) - - 49 49 99 椰子油（IV=12〉 - - - 50 - 維生素A 1 1 1 1 1 维生素A定量值 調製之後(％) 100 100 100 100 100 501C 10日後 93 98 97 58 39 實施例2-1，2-2及2-3與比較例相較，可提高維生素 A之安定性，此係本發明之效果。 維牛袤鼉方法 使用乙醇作爲溶劑，並藉325nm之吸光度測定法實施 定董。 又，計算時使極大吸收325nmE(l%，lcm) = 1835。 啻掄例2-4 :乳霜（nrsam) (重量96 ) A.鲸蟠醇 3 單硬脂酸甘油酯 2 P0E(25)十六醚 1 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） |_„--------t------、-ΙΊ----^——# (請先閱讀背面之注意t-TJ填寫本頁) { 29 五、發明説明（27 ) A7 B7 硬脂酸 3 凡士林 3 橄攬油（IV = :80) 3 綿實油（I V = =100) 1 角鯊烷 5 維生素A 0. 1 BHT 0.05 香料 適量 B.丙二醇 3 氫氧化鉀 精製水 使全體為100之置 經濟部中央標準局員工消费合作社印製 於70C下分別使A之油相部分與B之水相部分溶解 將A加人B中乳化，然後，冷卻處理即可得乳霜。 奮掄例？-5 :屏眘iost.ink) (重蚤) 固體石蟠 8 巴西肉豆蔻蟠 4 堪待地蟠 4 微晶蟠 6 含水羊毛脂 15 Μ 麻油（IV= 85) 46.7 牡蠼油 5 月見草油 3 維生素A 1 BHT 0.3 IK---„------i------IT-------.^ (請先閲讀背面之注意臬丹填寫本頁) ( 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 30 Α7 Β7 ---------裝-- (請先閲讀背面之注意^.丹填寫本頁) 線 經濟部中央標準局員工消費合作社印製 7 適量 於80t：下加熱溶解上述之各原料，然後倒入恃定之容 五、發明説明（28 ) 調合色劑（紅色糸） 香料 器即可得唇胥。 審旃例:彳卜,妝水 維生素A 油醇（IV = 80) α -生育酚 Ρ0Ε(20)辛基十二醇 乙醇 丙二醇 甘油 甲基對羥苯甲酸 乳酸 乳酸納 精製水 奮掄例2-7 :眼猱眘油 麥第米亞核桃油（IV= 75) 7 -亞麻酸三甘油酯（IV = 2-乙基己酸三甘油酯 紅花油（IV= 130) 角鯊烷 PEG600二油酸酯 δ -生育酚 (重詈 0.0001 0.01 0.005 0.8 8 3 1 0. 15 0.01 0.09 使全體爲100之董 (重噩％ ) 40 198) 1 25 20 10 2.8 1 31 本紙張尺度適用中國國家標準（CNS ) Α4規格（210乂297公釐） 302284 A7 B7 0.2 (W99^) 8 2 20 1 1 0. 15 2 0.25 10 0.2 使全涯為100之量 五、發明説明（29 )A7 B7 V. Description of the invention (1) The present invention relates to a skin-external composition capable of improving the stability of serotonin A. Please read the back first * -rr Fill the nest plate This clothing page Vitamin A is known to be an ingredient that can effectively treat and prevent skin keratinization, or prevent and restore skin aging. However, vitamin A is extremely unstable in structure, and it is easy to cause various anisotropy, decomposition, polymerization, etc. due to light, air, heat, gold ions, etc., so it is difficult to be stably formulated in Piru external preparations. Therefore, the present invention is a skin external composition that significantly improves the stability of vitamin A by formulating a stabilizer that can improve the stability of vitamin A. According to the present invention, a skin external composition can be provided, which contains: Set (I> Vitamin A, and (I) at least one stabilizer selected from (1) to (14) under Μ; (1) toxins and polysaccharides, (2> oil content at an iodine value of 70Μ , (3) Polyethylene glycol and / or polypropylene glycol, (4) Hydroxy carboxylate, (5) Neutral amino acid, Printed by the Employees ’Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs (6> (t> selected from butyl Oil-soluble anti-oxidant of at least one of the group consisting of hydroxytoluene, butylhydroxyanisole, 7, δ-tocopherol, nordiguaia guaiac acid, propyl gallate, vitamin C fatty acid and sorbic acid Oxygen, (u) at least one ethylenediamine tetraammonium salt and (m) at least one benzophenone compound, 4 The paper wave scale is applicable to the Chinese National Standard Falcon (CNS) A4 specification (210X297 mm) 3 〇22δ4 Α7 Β7 Fifth, the Ministry of Economic Affairs, Central Bureau of Samples and Printing Co., Ltd. printed invention description ((7) (i) selected from butyl hydroxymethyl Benzene, butyl hydroxyanisole, α, / 9, please read ι6 meaning 14 fill in page 7, δ-tocopherol, nordihydroguaiaretic acid, propyl gallate, vitamin C fat At least one of oil soluble antioxidants, (Li) ascorbic acid, ascorbate, isoascorbic acid, isoascorbic acid, sorbic acid and sorbate in the group of acid esters and (ui) at least one Benzophenone strip compounds, (8) cyclodextrins encapsulating antioxidants and / or ultraviolet absorbers, (9) at least one butanediol and / or at least one oil-soluble antioxidant, (10) at least A water-soluble benzophenone bar compound, (11) at least one of basic amino acid and its salt, (12) at least one of acidic amino acid and acidic amino acid salt, (13) selected from pentaerythritol fat At least one polar oil component in the group of esters and trimethylolpropane fatty acid esters, (14) at least one water-moisturizing clay mineral. The inventors have found the vitamins based on the above-mentioned issues, and after careful research The stable stabilizer in A can significantly improve the stability of vitamin A * Until the completion of the present invention. Hereinafter, the present invention will be described in detail. The vitamin A used in the present invention is preferably vitamin A (other name: Retinol), all-trans type, or 13-cis type, and mixtures of these may also be used. Invented, there is no special limit to the amount of the compound in the external composition of Piru. The paper size is applicable to the Chinese National Standard (CNS) Α4 specification (210Χ 297 mm) 302284 A7 B7 V. Description of the invention (Ministry of Economics Central Bureau of Standards and Engineering Printed by a consumer cooperative. However, if the effect of Kollin's vitamin A on muscles is 0.0001% by weight or more of the total weight of the composition, in order to strongly demand the effect of vitamin A, it should be 0_001% by weight or more. The upper limit should be adjusted to 8% of the composition of the skin cream external composition. According to the first aspect of the present invention, it is possible to combine a canthal mixture and polysaccharide as a stabilizer. Examples of the chelating agent used in the present invention include inorganic age salts such as sodium salt and potassium salt of ethylenediaminetetraacetic acid, or one of organic salts such as ethanolamines, di-salts, tri-salts, and tetra-salts. Any one, citric acid and inorganic alkali salts such as sodium and potassium citric acid, organic alkali salts such as ethanolamine, basic amino acids, etc., mono-salts, di-salts, tri-salts, etc., or metaphosphoric acid, Polyphosphate, tartrate, etc. The setting of the chelating agent prepared in the present invention is 0.001 weight, and the upper limit of the preparation is not particularly limited, but the preparation of a very large amount does not impair the effect of the present invention, but due to the precipitation of crystals, etc., the composition of the skin external composition cannot be guaranteed quality. It should be below 1% reset. The polysaccharides used in the present invention include, for example, vitamins, seeds, chondroitin, starch, galactan, dermatansulfate, glycogen, gum arabic, acetoheparin sulfate, hyaluronic acid, yellow gum , Keratan sulfate, chondroitin, xanthophyllum, mucin sulfate, guar gum, dextrin keratin sulfate, locust bean gum, amber glucan, glycans, etc., and their salts. The formulation amount of polysaccharides in the external composition of the present invention is not particularly limited in terms of the effect of the present invention, but it is preferably o.ooool ~ 5.0% by weight. The paper size is applicable to China National Oak Standard (CNS) A4 Regulation · grid (21〇Χ 297mm) Please read the note * A7 B7 of the back * V. Description of the invention (please read the note on the back first Dan fill in this page in the second aspect of the invention, as a stabilizer Examples of oils prepared with an iodine value of 70 Μ include: linseed oil, tip oil, soybean oil, safflower oil, walnut oil, hackberry oil, evening primrose oil, sakura oil, grape seed oil, etc. , Flax oil, rapeseed oil, cottonseed oil, dong oil, wheat germ oil, etc., which are non-drying oils, or Avogad oil, olive oil, camellia oil, wheat, Diamian walnut oil, etc., and fish oil There are sardine oil, mackerel oil, herring oil, cod liver oil, squid oil, etc. The iodine value of these oils, such as linseed oil is 168 ~ 190, soybean oil is 114 ~ 138, safflower oil is 122 ~ 150, rapeseed Oil is 94 ~ 107, cotton solid oil is 90 ~ 121, olive oil is 75 90. Camellia oil is 73 to 87, sardine oil is 136 to 195, cichlid oil is 99 to 119. In addition, among the fatty acids or higher alcohols derived from these oils and fats, those with an iodine value of 70M can be exemplified by oil Acid, nutmeg oleic acid, linoleic acid, linolenic acid, paulownic acid, 7-linolenic acid, arachidonic acid, arachidonic acid, oleyl alcohol, etc. Printed by the Ministry of Economic Affairs of the Central Bureau of Samples and Employee's Consumer Cooperative for this purpose One or two or more oils, but the amount to be formulated for the purpose of exerting the effect of the present invention is preferably 0.01% by weight or more, too much blending will not hinder the effect of the present invention. It is detrimental to the quality of Piru ’s external composition. It must be paid attention to. The amount of preparation is preferably 0.1 ~ 60% reset. If according to the third aspect of the present invention, polyethylene glycol (PEG) and / or Polypropylene glycol (PPG)-two or more millimeters are used as stabilizers. In addition, the PEGs formulated in the present invention are usually PEG200, PEG300. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X 297mm) Α7 Β7 3〇2284 i. Description of the invention (5) (Please read the back first Note | Fill in this page), PEG400, PEG1500, PEG4000, PEG6000, PEG20000, etc., and PPG has PPG400, PPG750, PPG1200, PPG2000, PPG3000, etc. One or two of these can be adjusted, but you can use this For the purpose of the effect of the invention, the amount to be formulated is preferably 0.1% by weight or more. Too much blending does not hinder the effect of the present invention. However, when too much blending is apparent, the quality of the skin * external composition will be damaged, so be careful. Particularly, Ml ~ 80% by weight is preferred. In the fourth aspect of the present invention, the hydroxy carboxylates used as stabilizers in the external composition of Piru are commonly used: citric acid, lactic acid, malic acid, tartaric acid, etc. Mono-, di-, and tri-salts of inorganic salts such as sodium and potassium, organic alkali salts such as ethanolamine, basic amino acids, etc. These one or two types of M may be contained. However, the amount to be used for the purpose of exerting the effect of the present invention is preferably 0.001% by weight or more. Too much content does not hinder the effect of the present invention. However, when it is excessively contained, the quality of Piru's external composition will be impaired, so care must be taken, especially 0.01 to 1% by weight is preferable. The 5th aspect of the invention is printed by the Employee Consumer Cooperative of the Central Standardization Bureau of the Ministry of Economic Affairs. The neutral amino acids formulated as stabilizers can be exemplified by: Glycine, Alanine, Serine, Leucine, Phenylalanine, proline, hydroxyproline, etc. One or two or more of these can be blended, but the amount to be blended for the purpose of exerting the effect of the present invention is preferably 0.001% by weight. Too much blending does not hinder the effect of the present invention. However, when it is obviously over-provisioned, its solubility is exceeded, respectively, because the precipitation of crystals will be accompanied by the deterioration of the quality of the external composition of the skin, so it must be 8 papers. A7 Β7 printed by the employee consumer cooperative of the Central Bureau of Standards V. Description of the invention (6) Note that 0.01 ~ 10% by weight is particularly preferred. According to the sixth aspect of the present invention, oleic acid antioxidants, butyl hydroxytoluene (BHT), butyl hydroxybenzoic acid (BHA), α, / 3, 7, δ-tocopherol can be formulated as stabilizers , Nordihydroguaiaric acid, propyl gallate, vitamin C fatty acid ester, sorbic acid. The amount formulated in the present invention is preferably 0.001% by weight, more preferably 0.01% by weight or more. In addition, when the effect of the present invention can be exerted for a long period of time, it is preferably 0.03% by weight. The upper limit of the formulation varies according to the dosage form of the composition for external skin application, and can be arbitrarily formulated without limitation, but * it should be 10% by weight or less in terms of the nature of the composition for external skin application. The ethylenediamine tetraacetate used in the present invention can be exemplified by inorganic alkali salts such as sodium salt, potassium salt, or organic alkali salts of ethanolamine, mono-, di-, tri-, or tetra-salt, etc. . The amount to be formulated in the present invention is 0.001% by weight, and there is no particular upper limit to the upper limit of formulation. However, when it is prepared in a large amount, although the effect of the present invention is not impaired, the quality of the composition for skin external use cannot be ensured due to precipitation of crystals, etc. 0,005 ~ 1% by weight. The benzophenone strip compound used in the present invention can be exemplified by 2,4-dihydroxybenzophenone (hereinafter benzophenone-1), 2,2 ', 4,4'-tetrahydroxydibenzone Benzophenone (benzophenone-2 under M), 2-hydroxy-4-methoxybenzophenone (hereinafter benzophenone-3), 2-hydroxy-4-methoxybenzophenone -5 -sulfonic acid (benzophenone-4 under K), sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate (benzophenone-5 under M), 2,2 ' _Dihydroxy-4.4'-dimethoxydibenzophenone (benzophenone-6 under Μ), 2-hydroxy-5-nitrodibenzophenone paper standards are applicable to China National Standards (CNS) A4 specifications (21 〇X 297 Gongqing)-! --- Γ ----- installed ------ ordered -----. (Please read the note on the back of the lamp and fill in this page) {Ministry of Economic Affairs Printed by the Central Prototype Bureau Beigong Consumer Cooperative Society Α7 Β7 V. Description of the invention (7) Meso (M-dibenzyl copper-7), 2,2-dibenzyl-4-methoxy-benzyl feed ( Under M, copper benzophenone, 2,2- -anal -4'4 -monomethoxy benzophenone -5,5, -disulfonic acid dinaphthalene (below benzophenone-9), 2_ Via 4-methoxy-4'-methyldibenzophenone (below benzophenone-1〇), Yl-4-octyloxybenzophenone (hereinafter benzophenone-12) ° The amount of the compound for external use of the present invention prepared is 0.001% by weight Μ, the upper limit of the formulation is not particularly limited 'but very Although it does not impair the effect of the present invention when it is prepared in a large amount, it is not possible to ensure the quality of the composition for external use due to the precipitation of crystals, so it is preferably 0.01 to 10% by weight. The seventh aspect of the present invention is the preparation of W (Α) ～ (C) As diazepam I, (Α) is selected from butylhydroxytoluene, butylhydroxyanisole, α, δ-'tocopherol, nordihydroguaiaretic acid, gallic acid At least one oil-soluble antioxidant from the group of propyl esters and vitamin C fatty acid esters, '(B) ascorbic acid, ascorbic acid salts, isoascorbic acid, isoascorbic acid salts, sorbic acid and At least one sorbate and (C) at least one benzophenone compound. Oil-soluble antioxidants formulated in the skin external composition according to the present invention can be exemplified by: butylhydroxytoluene (BΗΤ), butylene Hydroxyanisole (ΒΗΑ), α, / 3, 7, δ-tocopherol, nordihydroguaiac wood, propyl gallate, Vitamin C fatty acid esters, etc. The amount used in the present invention is preferably 0.001% by weight or more, particularly preferably 0.01 reset. In addition, it is preferably 0.03% by weight when the effect of the invention can be exerted for a long period of time. The dosage form of the composition varies, and can be arbitrarily formulated without limitation *, but for the nature of the external composition of the cream, it is appropriate to use the Chinese National Standard (CNS) A4 current format (210X 297 mm) for the paper wave scale 10-; ---: ----- installed ------ ordered ------- remonstration (please read the notes on the back ^ ·: fill in this education) {30 吻 4 Α7 Β7 V. Description of invention ( 8) • 10% by weight. The ascorbic acid (other name vitamin C), erythorbic acid, sorbic acid and their salts used in the present invention can be exemplified by inorganic sickle metal salts such as sodium salt, potassium salt, etc., or ethanolamines or basic amino acids Wait for the organic metal salt test. Among them, Μ ascorbic acid, sodium ascorbate, erythorbic acid, sodium erythorbic acid, sorbic acid, sodium sorbate, and potassium sorbate are suitable. Also * the combination of different acids and alkaline substances * can also form salts in the system. The setting in the present invention is 0.001% by weight or more, and the upper limit of the formulation is not particularly limited. However, in the case of a very large amount of preparation, although the effect of the present invention is not impaired, the quality of Piru external preparation cannot be ensured due to precipitation of crystals. It is preferably 10% by weight or less. The benzophenone strip compound used in the present invention printed by the Beigong Consumer Cooperative of the Central Bureau of Industry and Commerce of the Ministry of Economic Affairs can be exemplified as follows: 2,4_ dihydroxydibenzophenone (Μ 下 dibenzophenone-1), 2, 2 ', 4,4'-tetrahydroxybenzophenone (benzophenone-2 under M), 2-hydroxy-4-methoxybenzophenone (benzophenone-3 below), 2- Hydroxy-4-methoxybenzophenone acid (K-benzophenone-4), 2-hydroxy-4-methoxybenzophenone-sodium (Μ 下 benzophenone-5) , 2,2'-dihydroxy-4,4, -dimethoxybenzophenone (hereinafter benzophenone-6), 2-hydroxy-5-nitrobenzophenone (under benzophenone -7), 2,2, -dihydroxy-4-methoxydibenzophenone (hereinafter dibenzophenone-8), 2,2, -dihydroxy-4,4, -dimethylaminodiphenyl Ketone-5,5, -disulfonic acid dinaphthalene (hereinafter copper benzophenone-9), 2-hydroxymethoxy-4, -methylbenzophenone (hereinafter benzophenone-1〇), 2-Hydroxy-4-octyloxybenzophenone copper (hereinafter benzophenone-12) ° The amount formulated in the present invention is more than 0.001% by volume '10 11 (Please read the notes on the back to fill in this page ) This paper standard is applicable to the Chinese national standard Standard (CNS) Α4 specification (210Χ 297 mm) V. Description of the invention (9) A7 B7 The printing and printing of the Consumer Cooperative of the Central Bureau of Economic Affairs of the Ministry of Economic Affairs is not limited, but when it is very large, it does not damage the invention. Effect, but due to the precipitation of crystals, etc., the quality of Piru external preparations cannot be ensured. It is preferably 10% by weight or less. The cyclodextrin (CD) used in the present invention is a cyclic oligosaccharide, which can be exemplified as a CD (ct-CD, / 3-CD, 7-CD with α, / 3,7 structure depending on the number of sugars) ) * Or, introduce methyl CD (M-CD), ethyl CD (E-CD>, hydroxyalkylated hydroxymethyl CD (HM-CD), hydroxyethyl CD into the lower alkyl group (HE-CD>, hydroxypropyl CD (HP-CD), hydroxybutyl CD (HB-CD>, etc.) Among them, although a-CD and 7-CD have good solubility in water, they are decomposed by barley starch Production method, so the yield is low, and it is slightly unsatisfactory in cost. Furthermore, although / 3-CD is advantageous in cost, it is slightly unsatisfactory in solubility. No matter what, as long as you know the different properties and use it, The effects of the present invention can be fully obtained. On the other hand, if the solubility and cost are good, and the universality of the skin-use composition for external use is preferably methylated CD, hydroxyalkylated CD, especially methyl- / 9 -CD and hydroxyalkyl- / 8 -CD are preferred. The CD of any of the amounts formulated in the skin cream external composition of the present invention must also be 0.01% by weight or more, and the upper limit is from the effect of the present invention There is no special limitation, but when it is obviously deployed in large quantities, it does not affect IS The effect of the invention, but due to the precipitation of crystals, etc., will impair the quality of the composition for external use. For α, 7-CD is preferably 10% by weight or less, for / 9-CD is 1% by weight or less, for low-grade embankment The CD and the hydroxyalkylated CD are below 30% by weight M. The oil-soluble antioxidant formulated according to the skin external composition of the present invention can be exemplified by: nordihydroguaiaretic acid, BHT, BΗΑ, α, / 3,7,5- Please first. Note on reading the back Λ inch ii The size of the paper is applicable to the Chinese national standard (CNS> A4 specifications (2 丨 0X 297mm) ΤΊ A7 B7 V. Invention description (10) • Tocopherols, propyl gallate, vitamin c fatty acid esters, sorbic acid, etc. Among them, 611 butadiene, 81 ^, ", / 3,7,3-tocopherols are preferred. Used in the present invention The amount is preferably 0.001% by weight, more preferably 0.01% by weight or more. When the effect of the present invention can be exerted for a long period of time * it is preferably 0.03% by weight. The upper limit of formulation depends on the dosage form of the composition for external use of the skin * It can be arbitrarily formulated without limitation, but, In terms of the properties of the skin-use composition for external use, it is preferably 1% by weight. Examples of ultraviolet absorption used in the present invention Such as: 2-hydroxy-4-methoxybenzophenone represented by benzophenone strip compounds, octyl methoxycinnamate, mono / bis (methoxycinnamyl)-mono / 3 octyl Glycerol esters are represented by cinnamic acid oleic acid compounds, salicylic acid strip compounds represented by octyl salicylate, benzoic acid oleic compounds represented by p-aminobenzoic acid octyl ester, M4-third butyl-4'-methoxy Dibenzoylmethane is represented by dibenzoylmethane compounds, etc. Especially preferred are dibenzylketone, cinnamic acid and dibenzoylmethane. The amount used in the present invention is preferably 0.001% by weight, more preferably 0.01% by weight or more. When the effect of the present invention can be exerted for a long time, it is preferably 0.03% by weight. The upper limit of compounding depends on the dosage form of Piru's external composition, and it can be formulated without limitation. However, it should be 1% by weight on the properties of Piru's external composition. The method printed by the Consumer Cooperative of the Central Ministry of Economic Affairs of the Ministry of Economic Affairs to encapsulate antioxidants and UV absorbers with the aforementioned CDs. Generally, the antioxidants and UV absorbers are added to the aqueous solution of CDs (20 to 60% by weight) Agent (add 0.01 ~ 0.2 parts to CD), and search and mix at 20 ~ 60t (50 ~ 3000rpm) for about 2 ~ 12 hours to obtain the inclusion compound. The inclusion compound thus obtained is in a state of being soluble or emulsified in an aqueous solution, and can be applied to the external composition of Piru in this state, and at the same time (please read the note on the back side first j 卄 Fill in this page) National Standard (CNS) A4 specification (2IOX297mm) Printed by the Central Bureau of Economic Affairs of the Ministry of Economic Affairs Beigong Consumer Cooperative Association Α7 Β7 V. Description of the invention (11) • * This solution can also be ordered by freeze drying, spray drying, etc. Use as a powder. Antioxidants, ultraviolet absorbers, and CDs can also be separately formulated in the external composition for skin to make it to the skin) * The external composition is included at once. In the ninth aspect of the present invention, butanediol formulated as a stabilizer may include, for example, 1,2-butanediol, 1,3-butanediol, and 1,4-butanediol. Such one or two types of M can be formulated. However, the amount to be formulated for the purpose of exerting the effect of the present invention is preferably 0.01% by weight or more. Too much formulation will not hinder the effect of the present invention. However, it is obvious that if it is excessively formulated, the quality of the composition for external use on the skin will be impaired. It must be noted that 0.1-40% by weight is particularly preferred. 0 The oil-soluble antioxidant formulated in the present invention may, for example, show: ΒΗΤ 、 ΒΑΤ 、 ct, / 3. 7. Delta-tocopherols, nordihydroguaiaretic acid, propyl gallate, vitamin C fatty acid vinegar, sorbic acid, etc. It should be more than 0.001% by weight and more preferably 0.005% by weight. Moreover, in order to be able to exert the effect of the invention for a longer period of time, it is preferably 0.01% reset. The upper limit is not particularly limited as far as the effect of the invention is concerned. * Excessive amount of Ming Yan will damage the quality of the external composition for skin care due to crystal precipitation, etc. It must be noted that it is preferably 10% by weight. The water-soluble benzophenone compound used as the stabilizer in the tenth aspect of the present invention * can be exemplified by 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (the following diphenyl Methone-4) and its salt, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate (hereinafter benzophenone-5), 2,2'-dihydroxy This paper size is applicable to China National kneading (CNS) A4 specification (210X297mm) 14 «(please read the note on the back first l-rr to fill out this page),-° 302284 at B7 5. Description of the invention (12) -4,4'-two Oxybenzophenone-5,5'-disulfonate sodium (hereinafter benzophenone-9), etc. The amount of the compound for external application of the invention to be prepared is preferably 0.001% by weight or more, particularly preferably 0.01% by weight or more. The upper limit of the preparation is not particularly limited, but when it is prepared in a large amount, although it does not damage the invention The effect is, however, it is difficult to ensure the position of the product composition for external use of Pi Yong due to crystal precipitation, etc., so it is preferably 5 wt% or less. In the eleventh aspect of the present invention, the test amino acids and their salts formulated as stabilizers can be exemplified by arginine, lysine, hydroxylysine, ornithine, etc., or In addition, such as salt, oxalate, aspartic acid, aft ketone carboxylate, etc., in addition can also be used in combination with basic amino acids and other acidic substances To form salt in Shito. One or two or more of these can be blended, but the amount to be blended for the purpose of exerting the effects of the present invention must be 0.001% by weight or more. "Too much blending will not hinder the effects of the present invention. However, it is obvious that too much compounding will damage the quality of the Pirul external composition due to crystal precipitation, etc., so it is necessary to pay attention to * but it should be 0.01 ~ 5 reset%. The pH of the better bar is above 6 * the better is the top. The Ministry of Economic Affairs, Central Bureau of Accreditation and Employee's Consumer Cooperatives printed the 12th aspect of the invention * * can be used as stabilizers of amino acids and acidic amino acid salts, such as: aspartic acid, Yi Inorganic gold salts such as amino acids such as amino acids and sodium and potassium in acidic amino acids, organic alkali gold salts such as ethanolamine and sickle amino acids. In addition, pyrrolidone carboxylic acid and its salts can also be used. One or two or more of these can be adjusted, but the effects of the present invention can be exerted 15 (please read the notes on the back Γ and fill in this page first) This paper uses the Chinese National Standard (CNS) Λ4 specification (210X297mm ) Α7 Β7 5. Description of the invention (13) • The purpose of the preparation is preferably 0.001% by weight or more, and more preferably 0.01% by weight or more. Excessive preparation does not hinder the effect of the present invention. However, when the amount is excessively formulated, the respective solubility will be exceeded, and due to the precipitation of crystals, etc., accompanied by the deterioration of the quality of the Piru external composition, care must be taken, but it is preferably 10% by weight or less. In the thirteenth aspect of the present invention, the polar oil component that can be used as a stabilizer is a pentaerythritol fatty acid ester, preferably “~ (: 〃 of pentaerythritol fatty acid ester, and trimethanol propane fatty acid ester, suitable The polar oil component selected from the group of Cs ~ Cia trimethanol propane fatty acid vinegar can be exemplified as follows: pentaerythritol-tetrakis (2-ethylhexanoic acid) ester, pentaerythritol-tetraoctanoate, Trimethyl enzyme propane-tris (2-ethylhexanoic acid) ester, trimethanol propane-trioctanoic acid ester, etc. The Ministry of Economic Affairs, Central Bureau of Precision Industry, Beigong Consumer Cooperatives printed the amount formulated in the present invention, according to the external composition of Piru The type of substance varies and is not particularly limited. However, in a very small amount, vitamin A or oil-soluble antioxidants cannot be dissolved, and the effects of the present invention cannot be fully exhibited. Therefore, the vitamin A formulated in the skin care external composition is increased The amount of oil-soluble antioxidants should be 0.002% by weight or more, more preferably 0.1% or more. The upper limit of the formulation depends on the type of skin external composition and is not particularly limited, but, from The total amount of Piru external composition The amount of the oil-soluble antioxidant and vitamin A of the present invention becomes the upper limit. According to the present invention, the oil-soluble anti-gasification agent formulated in the external composition of Piru can be exemplified as: ΒΗΤ 、 ΒΑΤ 、 α, / 3, 7, S-tocopherols, nordihydroguaiaretic acid, propyl gallate, vitamin C fatty acid esters, sorbic acid 16 0 (please read the note on the back to fill in this page) Standard (CNS) Α4 specification (210X297mm) Duo printed A7 B7 by the Ministry of Economic Affairs, Central Bureau of Preservation and Consumer Cooperation V. Description of the invention (14) The amount used in the present invention should be more than 0.001% by weight, preferably more 0.01% by weight or more. 0.03% by weight is preferred when the effect of the present invention can be exerted for a long period of time. The upper limit of formulation is different depending on the dosage form of the skin * external composition, which can be arbitrarily formulated without limitation, but the nature of the skin external composition is suitable Reset 10 to 96. In the 14th aspect of the present invention, water-swellable clay minerals that can be used as stabilizers are generally a kind of hydrated aluminum silicate, which can be exemplified as follows: Lingjing kaolin group, cerium epidote Natural kaolin, kaolinite, hectorite and other natural or synthetic smectites, and the items sold in the market can be exemplified by Knibi, Struckton (all made by Guofeng), and Bakelite (Bundaby (Made by Lu She), Le Bona (Le Bo Lu De She cracked), fluorinated tetrasilica mica (made by Toby Industries), etc., synthetic mica named Μ sodium silic mica, Na or Litian Nioleite In the present invention, the setting is adjusted to be 0.01% by weight or more, preferably 0.1% by weight or more. The upper limit is not particularly limited in terms of the effect of the present invention, but when it is significantly excessive, gelation and the like may occur, and It is necessary to pay attention to the quality of the external composition of Piru. It should be under 50 weights. The antioxidants formulated in the present invention can be exemplified by: ΒΗΤ 、 ΒΑΤ 、 α, / 3,7,3-tocopherols, Nordihydroguaiaretic acid, propyl gallate, vitamin C fatty acid diacetate, sorbic acid, sorbate, isoascorbic acid, isoascorbic acid, vitamin C fatty acid esters, etc. The amount used in the present invention is preferably 0.001% by weight or more, and more preferably 0.01% by weight or more. In addition, when the effect of the present invention can be exerted for a long time, it is preferably 0.03% by weight. The size of this paper is applicable to the Chinese National Standard (CMS) A4 (210X 297mm) -1 (_ 0¾ (please read the note on the back t-TT to fill out this page), \ se Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs Printing A7 B7 5. Description of the invention (15) The ultraviolet absorber used in the present invention can be exemplified by: 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone Si-5-sulfonic acid, represented by 2,2'-dihydroxy-4,4'-dimethoxydibenzophenone, dibenzylbenzene compound, octylmethoxycinnamate, with mono / Bis (methoxycinnamyl) -mono / sinyl glyceryl ester is represented by cinnamic acid succinate compound, M octyl salicylate is represented by salicylic acid strip compound, M p-amino benzoic acid is represented by benzoic acid strip compound, Μ4-Third-butyl-4'-methoxydibenzoylmethane is a representative dibenzophenone methane compound. It can be formulated with one or more of these, but can be formulated for the purpose of exerting the effects of the present invention The amount must be 0.001% by weight or more, too much blending does not hinder the effect of the present invention. However, obviously too much blending will damage the skin for external use It is necessary to pay attention to the quality of the product. It is preferably 10% by weight M. Those used in the present invention as candidate admixtures can also use inorganic sickle salt, such as sodium salt and potassium salt of ethylenediamine tetraacetate, Mono-, di-, tri-, and tetra-organic salts of organic alkalis such as ethanolamines, inorganic salts of cockroaches, ethanolamines, and test amino acids Mono-, di-, and tri-salts of organic residual metal salts, etc., or prepared phosphates, polyphosphates, etc. This type of 1M or 2M can be formulated, but the purpose of the effects of the present invention can be achieved The amount of blending must be 0.001% by weight or more. Too much blending does not hinder the effect of the present invention. However, when too much blending is apparent, the quality of the external composition of the cream will be damaged due to crystal precipitation, so care must be taken. It is preferably 1 Under the weight% Μ. In the skin external composition of the present invention, in addition to the aforementioned essential components Μ this paper standard uses the Chinese National Standard (CNS) Α4 specification (21 ΟΧ 297 mm)-1S----- --Μ ----- install ------ order ------ record (please read the note wrap on the back < Fill in this page) {S02284 A7 B7 5. In addition to the description of the invention (l6), as long as it does not impair the effects of the present invention, it can be used as a general skin care external composition base for general cosmetics or pharmaceutical external supplies as needed Agents, and other ingredients such as humectants, surfactants, preservatives, water, alcohol, tackifiers, oils, medicaments, fragrances, colorants, ultraviolet absorbers, etc. In addition, liquid, gel, paste, cream, powder, solid, etc. can also be used. Examples The following examples of the Yigong Example further illustrate the present invention in detail, but the present invention is not limited to these. Tong Shi Example Bu 1. 1-2. And bh Comparative Example 1-1. 1-? Xidi method 癍 温 庠 Test method in 601; after completely dissolving each oily component, add the dissolved ΡΕΕ (1 〇) Oil ether, ethylenediaminetetraacetate, ethyl yeast, dipropylene glycol, cooled to 40 it. After that, the vitamin C was completely dissolved and sealed in a brown glass-made sample tube, and then covered with aluminum foil for complete shading, and stored in a 401: constant temperature bath. | _.--- r ----- III (please read the note I + T on the back to fill in this page first) Order the standard of the Chinese National Standards (China National Standards) CNS) A4 specification (21〇X297 mm) 19 A7 B7 V. Description of the invention (17) Qiu 1-1: Formula of makeup oil with Luo Shengji A Dingzhi (Yuan bismuth, Example 1- 1 Example 1-2 Comparative Example 1-1 Vitamin A 0.01 0.02 0.01 Disodium ethylenediaminetetraacetic acid 0.001 0.005-Hyaluronic acid 0.001 0.001-Refined water 0.1 0.2-Residual residues of 2-ethyltrihydroxybenzoic acid triglyceride Residual isopropyl myristate 10 35 10 Squalane 15 15 15 Dipropylene glycol 15 15 15 Ethanol 8 8 8 POE (IO) oleyl ether 2 2 2 After modulation of vitamin A quantitative value (%) 100 100 100 40t: 2 weeks After (%) 93 98 56 i ^ n im ^ it— (Please read the note on the back of LiMl 4-ΓΤ fill in this page) --s Printed Example 1-1 and 1- of the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 2 Compared with Comparative Example 1-1, although the stability of vitamin A can be improved, this has the effect of the present invention. Vitamin A:> ^ Tan method Using ethanol as a solvent, M 325nm absorbance method for quantification Ο In addition, the maximum absorption during calculation is 325nm E (1%, lcm) = 1835. This paper uses the Chinese National Standard (CNS) A4 specification (210X297 mm) 20 A7 B7 V. Description of the invention (is) Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 2: Emulsion Recipe and Beef Steak A-Zhoushangli (Gui Bi) Examples Examples Comparative Examples Comparative Examples 1-3 1-4 1-2 1-3 Vitamin A 0.03 0.001 0.03 0.001 Ethylenediaminetetraacetic acid dinaphthyl 0.01 Na 0.02 0.02--Cetyl isooctanoate 10 γ 10 7 Glyceryl 2-ethylhexanoate 2 4 2 4 Squalane 2 2 2 2 Cetyl alcohol 2 2 2 2 Vaseline 1 1 1 1 Monostearyl Glycerin 1.5 1.5 1.5 1.5 P0E (60) hardened lard oil 1.3 1.3 1.3 1.3 Carboxyvinyl polymer 0.2 0.3 0.2 0.3 Xanthane 0.05 0.05--Caustic Potassium 0.06 0.08 0.06 0.08 Glycerin 10 10 10 10 Propylene glycol 3 3 3 3 Ethyl p-hydroxybenzoic acid 0.2 0.2 0.2 0.2 Refined water: 100% 100% 100% 401C 1% after the month (%) 95 97 31 38 (please first Read the note on the back: fill out this page) • The size of the binding and binding silk paper is suitable for Chinese national kneading Standard (CN'S) A4 specification (210X297 mm) 21 302284 A7 B7 Duty-printed consumer cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs. 5. Description of the invention (19) Examples 1-3 and 1-4 are compared with the comparative examples, although The stability of vitamin A can be improved, but this is related to the effect of the present invention. Bian 1-3: servant. Makeup ice and oxenia rugosa results (weight%) Examples Examples Examples Comparative Examples 1-5 1-6 1-7 1-4 Ethylenediaminetetraacetic acid dina 0.5-0.05 -Tetrapotassium ethylenediaminetetraacetic acid-0.3 0.05-Sodium hyaluronate 0.1 0.05--Sodium chondroitin sulfate--0.2-Ethanol 5.0 5.0 5.0 5.0 Methylparaben 0.1 0.1 0.1 0.1 Vitamin A 0.0001 0.0001 0.0001 0.0001 Octane Dodecyl alcohol 0.001 0.001 0.001 0.001 P0E (60) hardened sesame oil 0.4 0.4 0.4 0.4 lactic acid 0.01 0.01 0.01 0.01 sodium lactate 0.1 0.1 0.1 0.1 petroleum jelly 0.2 2.0 2.0 2.0 Refined water: the amount of the body is 100: the amount of vitamin eight quantitative value After cracking (%) 100 100 100 100 40T: After 1 month (%) 95 93 91 49 Compared with the comparative example, the examples 5, 5, 1-6, 7 can improve the stability of vitamin A, but This is the effect of the present invention. % (Please read the notice on the back and make a decision to fill out this page). Statement 22 This paper music standard is applicable to the Chinese National Standard (CNS) A4 (210X 297mm). 5. Description of the invention (20 A7 B7 Central Bureau of Economics Employee Consumer Cooperative Printed Fen Duan Example 1: Servant, Makeup Permanent Fatty Alcohol Vitamin A Ρ〇Ε (50Πώ! ^ Ethylenediaminetetraacetic acid trinalactic acid sodium chondroitin sodium chondroitin sodium alcohol glycerol methyl paraben) Refined water extract Example 1-9: Cream squalane 2-ethylhexanoic acid triglyceride isopropyl myristate Vitamin A Vaseline Butylparaben Propylparaben Oleic acid mono Glycerol diisostearate diglyceride PEG400 dioleate glycerol (heavy S bismuth) 0.005 0.0001 .01 .09 The total number is 100 Dong (Heavy nightmare) 15 8 7 3 2 1 10 (please read the back first Note ttFill in this page), \ -3 The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 23 V. Description of the invention (21) Avicel powder dipropylene glycol ethylenediaminetetraacetic acid di Natriethanolamine Refined Water Phenol Example 1-〗 0: olein 2-ethylhexanoic acid triglyceride caprylic acid Dodecanol squalane vitamin dibutyl titanate ethanol trimethoprim powder sodium ethylenediamine tetraacetate Example 1 -1 1: Olein 2-ethylhexanoate triglyceride P0E (20) octyl Dodecyl ether vitamin A, glycerin sodium hyaluronate, ethylenediaminetetraacetic acid, bisacrylic acid, split water, syrup Example 1 -1 2: Cream A7 B7 1 5 0.01 0.02 Make the whole skeleton set to 100 (heavy red 50 20 10 1 9 9.989 0.01 0.001 (weight a%) ---- l ----- ^ ------ IT ---- ^-^ (please read the note on the back ^ C + 3 to fill in this page) ί Employee Cooperative of the Central Bureau of Standards, Ministry of Economic Affairs, printed 60 60 0. 1 16 0.01 0.05 Make the whole set to 100 (weight a%) ceto stearyl alcohol 3. This paper wave scale is applicable to Chinese national standards (CNS) Α4 specification (210Χ297mm) ΎΤ V. Description of invention (22 A7 B7 Employee Cooperative of Central Standards Bureau, Ministry of Economic Affairs Printed squalane honey flat reduced lanolin ethyl p-hydroxybenzoic acid P〇E (50) oil Alcohol ether stearic acid monoglycerol Θ Purpose Ethylenediaminetetraacetic acid diethanolamine salt perfume A dermatan sulfate Glycerin purified water Fenbeng Example 1 -13: Dangerous cream (DMk) Xanthane gum polyvinyl alcohol propylene di Ethanol Vitamin A Sodium monosalt of ethylenediaminetetraacetic acid Methyl p-hydroxybenzoic acid P0E (60) Hardening M Sesame oil flavor Refined water Example 1-1 4: Yinlian white powder 30. 3. 5. 0.01 0.03 0.0001 0.1 15.0 The rest (wt%) 1.0 10.0 7.0 10.0 0.01 0.1 0.05 0.2 0.05 The rest (heavy camp (please read the note on the back and then fill in this page) This paper scale is applicable to China National Standard (CNS) Α4 specification (210Χ 297 25) A7 B7 Printed description of inventions by the Employees ’Consumer Cooperative of the Central Bureau of Samples and Economics of the Ministry of Economic Affairs (23) Vitamin A 0.0005 Talc 8 5.4 Stearic acid 2.5 Squalane 3.5 Sorbitan sesquioleate 1.8 Triethanolamine 1.2 Paraquat 0.001 Ethylenediaminetetraacetic acid, dimethyl salt 0.001, appropriate amount of pigment, appropriate amount of perfume, Example 1 -1 5: □ 奵 (weight)% vitamin A 0.0000 crystal removal wax 3.0 honey beetle 3.0 white ground 5.0 flowing stone suspect 19.0 shark shark 20.0 Brazil Nutmeg 3.0 Canterley flat 3.0 Acacia gum 0.01 Sodium salt of ethylenediaminetetraacetic acid 0.01 Color toner 7.0 Dibutylhydroxytoluene 0.05 Perfume amount I-„--- Γ ----- ^ --- --- Ιτ ----'--. ^ (please First read the note on the back, -ΓΓ fill in this page) {This paper wave scale is applicable to the Chinese National Standard (CNS) A4 specification (! I0X 297mm) 6 V. Description of invention (24 A7 B7 Employee of the Central Bureau of Economic Development of the Ministry of Economic Affairs Printed lanolin by Consumer Cooperatives 1 -1 fi: Emulsion Vitamin A Hyaluronic acid Ethylenediaminetetraacetic acid triethanolamine salt Ethanol glycerin propylene glycol carboxyvinyl polymer KOH Methylparaben cetyl alcohol cetyl alcohol Vaseline squalane Isopropyl myristate monoglyceride monostearate P0E (25) hexadecyl ether splitting water strenuously Example 1 -1 7: Emulsion Vitamin A chondroitin anganoic acid triacyl salt ethanol glycerol rest 1.0 0. 1 1. 0 2.0 10.0 3.0 2.0 10.0 5.02.0 2.0 The rest (reissued 0.3 0.01 0. 1 5.0 ---- „------ t ------ lτ ----.-- * Line (please read the note on the back * v Ran to fill out this page) {This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297mm) η 302284 A7 B7 V. Description of invention (25) Propylene glycol 5.0 carboxyvinyl Polymer 0.2 Κ0Η 0.06 Methyl paraben 0.2 P0E (60) hardened M sesame oil 1.0 Squalane 3.0 Isomyristic acid EXAMPLE 17 Bu 1-8~ skin external preparation of esters 3.0 purified water remaining part of the composition to the embodiment as having good stability of vitamin Α who daily use. As described above, the skin * external preparation of the present invention is formulated with one or more chelating agents and polysaccharides such as hyaluronic acid or thiochondroitin, which can significantly improve the stability of vitamin A. Examination examples 2-1 ~ and f ~ h compared with examples 2-1 ~ 2-; (Please read the note on the back ^ fill in this page) Employee consumption cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs Du Printed Paper This standard is applicable to China National Standards (CNS) A4 specifications (210X 297 mm) 28 Printed by the Ministry of Economic Affairs Central Standards Bureau Negative Consumers Cooperative A7 B7 V. Description of the invention (26) Constitution 2-1: Pan Pan oil composition by > Niu Qin A Xi Right Muhua Lake 丨 She Jiezhi (Heavy flea bismuth) Examples Examples Examples Examples Comparative examples Comparative examples 2-1 2-2 2-3 2-1 2-2 Olive oil (IV = 75> 99-_-- Cotton oil (IV = 95)-99---Evening primrose oil (IV = 190)--50--Squalane (ιν = ι)--49 49 99 Coconut oil (IV = 12〉---50- Vitamin A 1 1 1 1 1 After modulation of vitamin A quantitative value (%) 100 100 100 100 100 501C 10 days later 93 98 97 58 39 Examples 2-1, 2-2 and 2-3 can be improved compared with the comparative example The stability of vitamin A is the effect of the present invention. The method of using oxenia rugosa using ethanol as the solvent and the implementation of the determination by the absorbance measurement method of 325nm. In addition, the calculation makes the maximum absorption 325nmE (l%, lcm) = 1835 . Example 2-4: Cream (nrsam) (weight 96) A. Cetyl alcohol 3 Glyceryl monostearate 2 P0E (25) hexadecyl ether 1 This paper size is applicable to China National Standard (CNS) Α4 specifications (210X 297 mm) | _ „-------- t ------ 、-ΙΊ ---- ^ —— # (Please read the note on the back t-TJ to fill in this page) {29 5 Description of the invention (27) A7 B7 stearic acid 3 petrolatum 3 olive oil (IV =: 80) 3 cotton solid oil (IV = = 100) 1 squalane 5 vitamin A 0. 1 BHT 0.05 appropriate amount of fragrance B. propylene glycol 3 Potassium hydroxide purified water was printed at 100C and printed at 70C under the Ministry of Economic Affairs Central Standards Bureau employee consumer cooperative. The oil phase part of A and the water phase part of B were dissolved separately. A was added to B and emulsified, and then cooled The cream can be obtained after treatment. Examples of endeavor? -5: Pingshen iost.ink) (heavy fleas) Solid panax 8 Brazilian nutmeg pan 4 Panax panic 4 Microcrystalline pan 6 Water-containing lanolin 15 Μ sesame oil (IV = 85) 46.7 Periwinkle oil May evening primrose oil 3 Vitamin A 1 BHT 0.3 IK --- „------ i ------ IT -------. ^ (Please read the back Please note that Dandan fills in this page) (This paper standard is applicable to China National Standard (CNS) A4 size (210 X 297 mm) 30 Α7 Β7 --------- installed (please read the note on the back ^. Dan fills in this page) Printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 7 Appropriate amount under 80t: Heat to dissolve the above-mentioned raw materials, and then pour into the content of the setting. V. Description of the invention (28) Blending color agent (red 糸) Perfume device can get lip abs. Examination cases: 潳 卜, makeup water Vitamin A oleyl alcohol (IV = 80) α-tocopherol Ρ0Ε (20) octyl dodecanol ethanol propylene glycol glycerol methyl p-hydroxybenzoic acid lactic acid lactic acid sodium purified water for example 2- 7: Yan Yan Shen oil, medimi walnut oil (IV = 75) 7-linolenic acid triglyceride (IV = 2-ethylhexanoic acid triglyceride safflower oil (IV = 130) squalane PEG600 dioleate δ -Tocopherol (Heavy weight 0.0001 0.01 0.005 0.8 8 3 1 0. 15 0.01 0.09 The total number of directors is 100 (Heavy night%) 40 198) 1 25 20 10 2.8 1 31 This paper scale is subject to the Chinese National Standard (CNS) Α4 specification (210 mm 297 mm) 302284 A7 B7 0.2 (W99 ^) 8 2 20 1 1 0. 15 2 0.25 10 0.2 Make the whole world a quantity of 100 V. Description of the invention (29)

維生素A W Mr Μ 2-8 ： IS (night craaa) 橄攬油（iv= 80) 月見草油（IV= 85) 角鯊烷 PEG400二異硬脂酸酯 二油酸二甘油酯 甲基對羥苯甲酸 油酸單甘油酯 維生素A 甘油 硫酸鎂 精裂水 實施例2-4〜2-8之皮骞外用組成物於曰常生活使用中 為具維生素A之安定性佳者。 如上所述，本發明之皮*外用組成物中可調配碘值70 以上之油成分以明顯提高維生素A之安定性。 __^---r-----1------IT----.——# (請先閔讀背面之注意i.+r填寫本頁) f 例 掄 * 例 hh 經濟部中央標隼局貝工消费合作杜印製 李 標 家 國 國 中 用 逋 度 尺 一張 -紙 本 格 |規 A4 ¥ 公 7 9 2 2 3 A7 B7 五、發明説明（30 ) 弃.VI :幺埵某割中：>牛袤A ：>在宙袢測宙结奥（重暑鉍） 實施例 實施例 實施例 比較例 比較例 3-1 3-2 3-3 3-1 3-2 PEG400 99.9 - - - - PEG 1500 - 99.9 - - - PPG 1200 - - 50 - - 丙二醇 - - 49.9 29.9 - 角鯊烷 - - - 70 99.9 維生素A 0.1 0.1 0.1 0.1 0.1 維生素A定量值 調製之後(％) 100 100 100 100 100 50t 5日後(％) 92 93 90 58 39 -------受 1 (請先閲讀背面之注意事{'-f<填寫本頁) -'♦3 經濟部中央標準局員工消费合作社印製 實施例3-1、3-2及3-3與比較例相較，可提高維生素 A之安定性，此係本發明之效果。 維牛麦A ：>亩鼉方法 使用乙酵作為溶劑並藉325nm之吸光度測定法實施定 量。 又，於計算時，使極大吸收325na E(1 %，1 c通）= 1835 ° 實施例3-4 :乳霜(重畺％ ) A.鯨蟠酵 3 單硬脂酸甘油酯 2 P〇E(25)十六醚 1 本紙張尺度適用中國國家揉準（CNS ) A4規格（210X297公釐） 33 五、發明説明（31 ) 硬脂酸 凡士林 肉豆蔻酸異丙酯 角鯊烷 雒生素A BHT 香料 B.PEG1500 甘油 氫氧化鉀 精製水 A7 B7 3 3 5 40.1 0.05 適量 3 90.2 使全體為100之量 批衣 訂 線 (請先閱讀背面之注意^:丹填寫本頁) ( 經濟部中央標準局員工消費合作社印製 於701C下分別加熱溶解A之油相部分與B之水相部分 將A加入B乳化之。然後，經冷郤處理即可得乳霜。Vitamin AW Mr Μ 2-8: IS (night craaa) olive oil (iv = 80) evening primrose oil (IV = 85) squalane PEG400 diisostearate dioleate diglyceride methyl paraben Oleic acid monoglyceride vitamin A glycerin magnesium sulphate refined water Example 2-4 ~ 2-8 The skin skin external composition in daily life use is one with good vitamin A stability. As described above, an oil component with an iodine value of 70 or more can be formulated in the skin * external composition of the present invention to significantly improve the stability of vitamin A. __ ^ --- r ----- 1 ------ IT ----.---- # (Please read the notes on the back i. + r to fill in this page) f Example 抡 * Example hh Economy Ministry of Central Standard Falcon Bureau Shell Industry Consumer Cooperation Du Printed Li Biaojia Guozhong Middle School with a ruler-paper grid | Regulation A4 ¥ public 7 9 2 2 3 A7 B7 V. Description of invention (30) Discarded. VI: Yao In a certain cut: > Niu Shou A: > Measurement of the sacred celestial body (Zhushu bismuth) in the sacral jacket Examples Examples Examples Examples Comparative Examples 3-1 3-2 3-3 3-1 3-2 PEG400 99.9----PEG 1500-99.9---PPG 1200--50--Propylene glycol--49.9 29.9-Squalane---70 99.9 Vitamin A 0.1 0.1 0.1 0.1 0.1 After modulation of vitamin A quantitative value (%) 100 100 100 100 100 50t 5 days later (%) 92 93 90 58 39 ------- Received 1 (please read the notes on the back first ('-f < fill in this page)-' ♦ 3 Ministry of Economic Affairs Central Standard Compared with the comparative example, examples 3-1, 3-2, and 3-3 printed by the Bureau Staff Consumer Cooperative can improve the stability of vitamin A, which is the effect of the present invention. Wei Niu Mai A: > Mu Ai method Using ethyl yeast as a solvent and carrying out quantification by absorbance measurement at 325 nm. In addition, in the calculation, the maximum absorption 325na E (1%, 1 c pass) = 1835 ° Example 3-4: Cream (weight%) A. whale fermentation 3 glyceryl monostearate 2 P. E (25) hexadecyl ether 1 This paper scale is suitable for China National Standard (CNS) A4 specification (210X297 mm) 33 V. Description of invention (31) Vaseline stearate isopropyl myristate squalane squalene A BHT perfume B. PEG1500 glycerin potassium hydroxide purified water A7 B7 3 3 5 40.1 0.05 Appropriate amount 3 90.2 Appropriate amount of 100 for the whole line (please read the note on the back ^: Dan fill in this page) (Central Ministry of Economic Affairs Printed by the Staff Consumer Cooperative of the Bureau of Standards under 701C, heat and dissolve the oil phase part of A and the water phase part of B respectively, emulsify A by adding B. Then, after cooling, the cream can be obtained.

奮旃例3-5 :辑驀（1 iost ick) 固體石蟠 巴西肉豆蔻蟠 堪持地蟠 徹晶蠘 含水羊毛脂 肉豆蔻酸異丙酯 二異硬脂酸甘油酯 PPG3000 維生素A BHT (重 a 8 2 4 6 15 使全體為100之置 30 15 本紙伕尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 34 302284 A7 B7 五、發明説明（32 經濟部中央揉準局員工消費合作社印製Endeavour Example 3-5: 1 iost ick solid stone pan Brazil nutmeg flat perseveringly hydrated lanolin isopropyl myristate diglyceryl diisostearate PPG3000 vitamin A BHT (heavy a 8 2 4 6 15 Make the whole set to 100 30 15 The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) 34 302284 A7 B7 V. Description of invention (32 Employee Consumer Cooperative of the Central Bureau of Economic Development of the Ministry of Economic Affairs Print

調合色劑（紅色集） 香料 於80t：下加熱溶解上述各原料 内即可得唇胥。 奮旆例爿-fi :化妝水 維生素A 油醇 α -生育酚 P0E(20)辛基十二醇 乙醇 PEG300 PEG1500 甲基對羥苯甲酸 乳酸 乳酸鈉 精製水 奮旃例.1-7 :眼缌驀油 橄攬油 2-乙基己酸三甘油酯 角鯊烷 PEG4000 PEG20000 δ -生育酚 維生素A 7 適量 然後倒入特定之容器 (重 S % ) 0.0001 0.001 0.005 0.8 8 3 1 0. 15 0.03 0.07 使全體為100之置 (重鼉％ ) 40 26 30 (請先閱讀背面之注意.¾.填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） -3 五、發明説明（33 ) A7 B7 經濟部中央標準局負工消费合作社印製 啻掄例3-8 :羔亥驀（caste) PEG300 PEG1500 PEG4000 維生素A 肉豆蔻酸異丙酯 POE (25)十六醇 硬脂酸 精裂水 啻掄M _?-g :芮狺（ni ght cream) 角鯊烷 肉豆蔻酸異丙酯 二氧化矽 凡士林 單異硬脂酸甘油酯 P〇E(7)硬化E麻油 丙基對羥苯甲酸 維生素A PEG6000 PEG400 甘油 精製水 _(重S弘、 30 40 10 0.3 5 2 5 使全蘐為100之量 重暑鉍） 15 5 3 6 3 3 17 使全鼸為100之量 實施例3-4〜3-9之皮虜外用組成物於曰常生活使用上 爲具維生素A之安定性佳者。 本紙法尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 36 ---------装-- (請先閲讀背面之注意事填寫本頁)Mixed coloring agent (red set) Spices Dissolve the above raw materials by heating under 80t: to obtain labyrinth. Perfume case-fi: lotion vitamin A oleyl alcohol α-tocopherol P0E (20) octyl dodecanol ethanol PEG300 PEG1500 methyl paraben lactic acid sodium lactate refined water perfume case. 1-7: Eyes loosing Oil olive oil 2-ethylhexanoic acid triglyceride squalane PEG4000 PEG20000 δ-tocopherol vitamin A 7 amount and then poured into a specific container (weight S%) 0.0001 0.001 0.005 0.8 8 3 1 0. 15 0.03 0.07 so The whole set is 100 (weight%) 40 26 30 (please read the notes on the back first. ¾. Fill in this page) The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) -3 V. Description of the invention (33) A7 B7 Printed by the Central Bureau of Standards, Ministry of Economic Affairs, Consumer Cooperative Case 3-8: Caste PEG300 PEG1500 PEG4000 Vitamin A isopropyl myristate POE (25) Cetyl alcohol hard Fatty acid split water M _?-G: ni ght cream squalane isopropyl myristate silicon dioxide petrolatum monoisostearate glyceride P〇E (7) hardened E sesame oil propylene P-hydroxybenzoic acid, vitamin A, PEG6000, PEG400, glycerin purified water _ (Zhong Shong, 30 40 10 0.3 5 2 5 makes the total amount of 100 Summer weight bismuth) 155363317 Krupp external skin so that the whole Xian embodiments 3-4~3-9 in an amount of 100 of the embodiment of said composition to a person with a good stability of the vitamin A used in everyday life. The size of this paper method is applicable to the Chinese National Standard (CNS) A4 specification (210X 297mm) 36 --------- installed-- (please read the notes on the back to fill in this page)

-1T 線 X-- 發 i説明（34 ) A7 B7 如上所述，於本發明之皮虜外用組成物中可調配聚乙 二醇及/或聚丙二醇Μ使維生素A之安定性顯著提高。 管雄例4· -1〜4 Ί及卜上較例4 -1 經濟部中央標準局員工消費合作社印装 :乳液由之雒生袤A的安亩袢潮亩结果（重暑免） 實施例 4-1 實施例 4-2 實施例 4-3 比較例 4-1 精裂水 使， έ體爲100. 之量 甘油 10 10 10 10 羧乙烯基聚合物 0.2 0.2 0.2 0.2 苛性鉀 0.03 0.03 0.06 0.06 乙醇 5 5 5 5 甲基對羥苯甲酸1 0.1 0.1 0.1 0.1 鲸蠟醇 2 2 2 2 凡士林 3 3 3 3 角鯊烷 5 5 5 5 肉豆蔻酸異丙酯 4 4 4 4 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 PEO(60)硬化m麻油 2 2 2 2 擰攆酸三納 0.08 - 0.04 - 乳酸納 - 0.09 0.05 - 維生素A 0.3 0.3 0.3 0.3 维生素A定董值 調製之後（％) 100 100 100 100 40t 2週後（％) 98 93 95 75 ----：------裝— (請先閲讀背面之注意良奸填寫本頁) ,17 本纸張尺度遑用中國國家標準（CNS M4規格（210X297公釐） 37 302284 at B7 經濟部中央橾準局員工消费合作社印装 五、發明説明（35 ) 實施例4-1* 4-2及4-3與比較例相較，可提高缍生素 A之安定性，此係本發明之效果。 雄Φ素A之定置方法 使用乙酵作為溶剤，並藉32 5nm之吸光度測定法實施 定量。 又，計算時，使極大吸收325nra E( 1 % , 1 CiB) = 1835 ° 啻倫俐4-4 :乳霜（crftam) A. 鲸蟠醇 單硬脂酸甘油酯 P0E(25)十六 _ 硬脂酸 凡士林 橄欖油 肉豆蔻酸異丙酯 角鯊烷 維生素A BHT 香料 B. 丙二酵 氧化鉀 檸樺酸三納 精製水 (重鼉鉍） 3 2 1 3 3 3 1 50.1 0.05 適童 3 使全醱為100之量 於701下分別使A之油相部分與B之水相部分加熱溶 本紙張尺度適用中國國家標準（CNS ) A4说格（210X 297公釐） 38 I.„---r-----^------1T-------^ (請先閱讀背面之注意表-nr填寫本頁) { 經濟部中央樣準局員工消费合作社印製 A7 B7 五、發明説明（36 ) 解，將Α加入Β中乳化之。然後， 蓄施例4-5 :笔容精油（essAnnfO 冷卻處理即可得乳霜‘ f重營％) 羧乙烯基聚合物 0.4 甘油 5 丙二醇 5 乳酸納 0.05 三乙醇胺 3.8 P0E(60)硬化Μ麻油 0.5 維生素A 0.1 角鯊烷 1 α -生育酚 0.05 甲基對羥苯甲酸 0.2 乙醇 6 精製水 使全體為100之量 啻掄例4-6 :化妝太 imm%) 甘油 2 乙醇 7 Ρ0Ε(50)油醚 0.5 油醇 0.02 維生素A 0.0001 掙檬酸納 0.1 甲基對羥苯甲酸 0.1 精製水 使全髏爲100之量 奩旆柄U-7 :油圃（〇Π πΡ (重鼉％) (請先閲讀背面之注意事《，，填寫本頁) -裝·-1T line X-- hair i explanation (34) A7 B7 As mentioned above, the polyethylene and / or polypropylene glycol M can be blended into the skin external composition of the present invention to significantly improve the stability of vitamin A. Guan Xiong Example 4 -1 ~ 4 Ί and BU Comparative Example 4 -1 Printed by Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs: The lotion is produced by the Amu Aji Tide Mu results from the A (Available from summer heat) 4-1 Example 4-2 Example 4-3 Comparative Example 4-1 Refined water, the amount of the body is 100. Glycerin 10 10 10 10 Carboxyvinyl polymer 0.2 0.2 0.2 0.2 Caustic potash 0.03 0.03 0.06 0.06 Ethanol 5 5 5 5 Methylparaben 1 0.1 0.1 0.1 0.1 Cetyl alcohol 2 2 2 2 Vaseline 3 3 3 3 Squalane 5 5 5 5 Isopropyl myristate 4 4 4 4 Glycerol monostearate Ester 1.5 1.5 1.5 1.5 PEO (60) hardened m sesame oil 2 2 2 2 Trisodium fumarate 0.08-0.04-sodium lactate-0.09 0.05-Vitamin A 0.3 0.3 0.3 0.3 After modulation of vitamin A fixed value (%) 100 100 100 100 40t 2 weeks later (%) 98 93 95 75 ----: ------ installed — (please read the note on the back to fill in this page), 17 paper standards are not in accordance with Chinese national standards ( CNS M4 specification (210X297 mm) 37 302284 at B7 Printed by the Central Consumers ’Bureau of the Ministry of Economic Affairs Employee Consumer Cooperative V. Description of the invention (35) Example 4-1 * 4-2 and 4-3 Compared with the comparative example, it can improve the stability of 砍 素 A, which is the effect of the present invention. The method of setting the male Φ A uses ethyl yeast as a dissolving agent, and quantification is carried out by the absorbance measurement method of 32.5 nm. , Make the maximum absorption 325nra E (1%, 1 CiB) = 1835 ° 傻 伦丽 4-4: cream (crftam) A. cetyl alcohol glyceryl monostearate P0E (25) hexadecyl stearate petrolatum Olive oil, isopropyl myristate, squalane, vitamin A, BHT, fragrance B. Malonanase, potassium oxide, citraconic acid, trina purified water (bismuth bismuth) 3 2 1 3 3 3 1 50.1 0.05 suitable for children 3 The amount of 100 under 701 makes the oil phase part of A and the water phase part of B heat and dissolve. The paper size is applicable to the Chinese National Standard (CNS) A4 grid (210X 297mm) 38 I. "--- r-- --- ^ ------ 1T ------- ^ (please read the note form on the back -nr to fill out this page) {Printed A7 B7 by Employee Consumer Cooperative of the Central Bureau of Samples of the Ministry of Economy V. Inventions Explanation (36) Solution, add A to B to emulsify it. Then, Example 4-5: Pen-content essential oil (essAnnfO can be obtained after cooling treatment)% Carboxyvinyl polymer 0.4 Glycerol 5 Propylene glycol 5 Sodium lactate 0.05 Triethanolamine 3.8 P0E (60) hardened sesame oil 0.5 Vitamin A 0.1 Squalane 1 Alpha-tocopherol 0.05 Methyl paraben 0.2 Ethanol 6 Refined water to make the whole amount 100% Example 4-6: Makeup too imm%) Glycerin 2 Ethanol 7 Ρ0Ε (50) Oleyl ether 0.5 oleyl alcohol 0.02 vitamin A 0.0001 sodium citrate 0.1 methyl p-hydroxybenzoic acid 0.1 purified water so that the total amount of the skull is 100 U-7: oil garden (〇Π πΡ (weight%)) (please Read the notes on the back first ", fill in this page)-installed ·

，1T 本紙張尺度適用中國國家標準（CNS)A4規格U10X297公*) - 39 * 五、發明説明（37 ) A7 B7 經濟部中央樣率局員工消費合作社印製 維生素A 2-乙基己酸三甘油酯 橄攬油 BHT BHA P0E(20)辛基十二醚 甘油 檸檬酸二納 精製水 W M 35 (night, grftam) 角鯊烷 2-乙基己酸三甘油酯 凡士林 丁基對羥苯甲酸 異硬脂酸二甘油酯 P0E400二異硬脂酸酯 維生素A 甘油 檸檬酸三納 乳酸鈉 乳酸 精製水 1 40 100.0, 16 15 05 使全體為100之量 (重署 15 10 使全體為100之量 實施例4-4〜4-S之皮虜外用組成物於日常使用上為具 維生素A之安定性佳者。 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 40 裝 '—訂 線 (請先閱讀背面之注意^打填寫本頁) { A7 B7 五、發明説明（38 ), 如上所述，本發明之皮膚外用組成物可含羥羧酸鹽以 顯著提高雒生素A之安定性。 審掄Μ 5 -1〜5 較例5 -1 經濟部中央揉準局貝工消費合作社印製 弃S-1 : 商由夕維生袤A的左宙袢測亩结罢（重量 實施例 5-1 實施例 5-2 實施例 5-3 比較例 5— 1 精製水 使: έ體為100: 之量 甘油 10 10 10 10 羧乙烯基聚合物 0.2 0.2 0.2 0.2 苛性鉀 0.06 0.06 0.06 0.06 乙醇 5 5 5 5 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 鲸蟠醇 2 2 2 2 鯊肝醇 1 1 1 1 凡士林 3 3 3 3 角鯊烷 5 5 5 5 肉豆蔻睃異丙酯 4 4 4 4 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 PE0(60)硬化m麻油 2 2 2 2 BHT 0.03 0.03 0.03 0.03 甘胺酸 1 - - - 羥脯胺酸 1 0.5 0.01 - 维生素A 0.3 0.3 0.3 0.3 维生素A定量值 調製之後（％) 100 100 100 100 40t： 2週後（％) 98 96 88 55 裝 訂 線 (請先閱讀背面之注意t .丹填寫本頁) < 本紙張尺度逋用中國國家標準（CNS ) A4規格（210X 297公釐） 41 五、 A7 B7_ 發明説明（39 ) 實施例5-1，5-2及5-3與比較例相較’可提高維生素 A之安定性，此係本發明之效果。 雄牟亩量方法 使用乙醇作為溶劑並藉325nm之吸光測定法資施定量 又，計算時*使極大吸收325ηιπ E ( 1 % 1835。 cm) 經濟部中央樣準局員工消費合作杜印製 奮淪俐5-4 :乳15 A.鲸镧醇 單硬脂酸甘油酯 POE (25)十六醚 硬脂酸 凡士林 橄攬油 肉豆蔻酸異丙酯 角鯊垸 維生素A BHT 香料 B·丙二醇 氫氧化鉀 丙胺酸 羥脯胺酸 精裂水 (重冊 3 2 1 3 3 3 1 5 0. 1 0.05 適量 3 使全體為100之量 I-^---^-----藥------ΐτ-------^ (請先閱讀背面之注意t填寫本頁) { 本紙張尺度ϋ财ϋ g家梯準（CNS ) A4規格（210:< 297公慶） 42 302284 A7 B7 五、發明説明（40 ) 於70t：下分別使A之油相部分與B之水柑部分加熱溶 解，將A加入B中乳化之，然後，冷郤處理之邸得乳霜。 謇掄Μ 5-5 :幸容’培油ssenee) (垂 a%) 經濟部中央標準局貝工消费合作社印製 羧乙烯基聚合物 凡士林 丙二醇 丙胺酸 三乙酵胺 P0E(60)硬化S麻油 雒生素A 角鯊烷 α -生育酚 甲基對羥苯甲酸 乙酵 精裂水 實施例5-R :化妝水 甘油 乙酵 Ρ〇Ε(50)油醚 油醇 维生素A 絲胺酸 白胺睃 乳酸 0.4 5 5 1 3.4 0.50.1 1 10.2 6 使全體為100之置 (重鼉％ ) 2 7 0.50.020.0001 0.3 0 .02 ---------穿-- (請先閱讀背面之注意支，：填寫本頁) *τ 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） 43 五、發明説明（41 ) A7 B7 經濟部中央標準局員工消費合作社印製 乳酸納 甲基對羥苯甲酸 精製水 啻旃例5-7 :油暖 維生素A 2-乙基己酸三甘油酯 橄攬油 BHT BHA POE (20)辛基十二醚 甘油 甘胺酸 精製水 奮施例 5-8:疼霜（night c r r a πι) 流動石孅 2-乙基己酸三甘油酯 凡士林 固態石撖 二油酸二甘油酯 二異硬脂酸三甘油酯 維生素A 丙基對羥苯甲酸 丙二醇 甘油 0.07 0. 1 使全醱為100之置 (重噩 1 40 100.2 0.05 16 150.1 使全髏為100之量 (重 S % ) 15 7 6 2 1.5 1.5 0.1 0.2 4 15 ---------Μ------IT----^--# (請先閱讀背面之注意i·»·)-填寫本頁) {, 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 44 A7 B7 五、發明説明（42 ) 甘胺酸 1 精製水 1 精裂水 使全髏爲100之* 實施例5-4〜5-8之皮虜外用組成物於日常使用上，爲 具維生素A之安定性佳者。 如上所述，本發明之皮虜外用組成物可調配中性胺基 睃以明顯提高維生素A之安定性。 ---------^------tT-------^ (請先閱讀背面之注意事f P,填寫本頁) { 經濟部中央標準局員工消費合作社印製 45 本紙法尺度適用中國準（CNS)八4規格（210以97公缓） A7 B7 43 經濟部中央樣準局員工消费合作社印製 五、發明説明（ 審施例6-1〜6-2¾ bh較例6-1〜6-2 羌6-〗：化妝用油配方趄雒牛袤A亩晉结果（重鼉 實施洌 6-1 實施例 6-2 比較例 6 - 1 比較例 6-2 維生素A 0.01 0.2 0.01 0.2 BHT 0.005 0.03 0.005 0.03 dl-α -生育酚 - 0.01 - 0.01 二苯甲酮-3 0.05 0.1 - - 辛基甲氧基桂皮酸S旨 - - 0.05 0.1 乙二胺四乙酸二鈉 0.001 0.005 - 0.005 精製水 0.1 0.2 - 0.2 2-乙基己酸三甘油酯 45 20 45 20 甘油酯 肉豆蔻酸異丙酯 10 35 10 35 角鯊烷 24.834 24.455 24.935 24.455 二丙二醇 10 10 10 10 乙醇 8 8 8 8 POE(IO)油醚 2 2 2 2 维生素A定量值 調製之後（％〉 100 100 100 100 401 2個月後（％) 93 98 68 82 ---------裝— (請先閱讀背面之注意填寫本頁), 1T This paper scale is applicable to China National Standard (CNS) A4 specification U10X297 *)-39 * V. Description of the invention (37) A7 B7 The Central Sample Bureau of the Ministry of Economic Affairs of the People ’s Consumer Cooperative printed vitamin A 2-ethylhexanoic acid tri Glycerol ester oil BHT BHA P0E (20) octyl dodecyl glycerol citric acid dina purified water WM 35 (night, grftam) squalane 2-ethylhexanoic acid triglyceride petrolatum butyl paraben iso Diglyceryl stearate P0E400 diisostearic acid vitamin A glycerol citrate trina sodium lactate lactic acid purified water 1 40 100.0, 16 15 05 The total amount is 100 (Re-deployment 15 10 The total amount is 100 Example The external composition of 4-4 ~ 4-S skin-rubber is good for the stability of vitamin A in daily use. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 40 packs'— Threading (please read the note on the back ^ hit fill in this page first) {A7 B7 V. Description of the invention (38). As mentioned above, the skin external composition of the present invention may contain hydroxy carboxylate to significantly improve Luosheng A Stability. Examination of Μ 5 -1 ~ 5 Comparative Example 5 -1 Central Ministry of Economic Affairs Consumer Cooperative Printing and Discarding S-1: Shang Youxi Weisheng Bao A's Zuo Zhoufu Measuring Mujie (Weight Example 5-1 Example 5-2 Example 5-3 Comparative Example 5-1 Refined Water Use: The body is 100: the amount of glycerin 10 10 10 10 carboxyvinyl polymer 0.2 0.2 0.2 0.2 caustic potash 0.06 0.06 0.06 0.06 ethanol 5 5 5 5 methyl paraben 0.1 0.1 0.1 0.1 cetyl alcohol 2 2 2 2 shark liver Alcohol 1 1 1 1 Vaseline 3 3 3 3 Squalane 5 5 5 5 isopropyl myristate 4 4 4 4 glyceryl monostearate 1.5 1.5 1.5 1.5 PE0 (60) hardened sesame oil 2 2 2 2 BHT 0.03 0.03 0.03 0.03 Glycine 1---Hydroxyproline 1 0.5 0.01-Vitamin A 0.3 0.3 0.3 0.3 After modulation of vitamin A quantitative value (%) 100 100 100 100 40t: After 2 weeks (%) 98 96 88 55 Binding Line (please read the note on the back first. Dan fills in this page) < This paper uses the Chinese National Standard (CNS) A4 specification (210X 297mm) 41 V. A7 B7_ Description of invention (39) Example 5- Compared with the comparative examples, 1, 5-2 and 5-3 can improve the stability of vitamin A, which is the effect of the present invention. The Xiongmu Mu method uses ethanol as a solvent and borrows 325nm absorbance measurement method to quantify the amount. When calculating, it makes the maximum absorption 325ηιπ E (1% 1835. cm) Employee consumption cooperation of the Central Sample Bureau of the Ministry of Economy. Li 5-4: Milk 15 A. Cetyl lanthanol glyceryl monostearate POE (25) cetyl ether stearate petrolatum olive oil isopropyl myristate squalene vitamin A BHT fragrance B. propylene glycol hydroxide Potassium alanine hydroxyproline fine split water (Reprint 3 2 1 3 3 3 1 5 0. 1 0.05 Appropriate amount 3 Make the whole amount to 100 I-^ --- ^ ----- medicine ---- --llτ ------- ^ (please read the note on the back first to fill in this page) {This paper size ϋ financial ϋ g home ladder standard (CNS) A4 specifications (210: & 297 gong) 42 302284 A7 B7 V. Description of the invention (40) At 70t :, the oil phase part of A and the water mandarin part of B are heated and dissolved respectively, A is added to B to emulsify it, and then the cream is obtained by cooling the residence. 謇 抡Μ 5-5: Xing Rong's oil (ssenee) (vertical a%) Printed carboxyvinyl polymer Vaseline propylene glycol alanine triethylenzyme P0E (60) hardened S sesame oil Luo A: Squalane α-tocopherol methyl paraben ethoxylated spermated water Example 5-R: lotion glycerin ethyl acetate POE (50) oleyl ether oleyl alcohol vitamin A serine leukoamine lactic acid 0.4 5 5 1 3.4 0.50.1 1 10.2 6 Make the whole set to 100 (weight percent) 2 7 0.50.020.0001 0.3 0 .02 --------- wear-(please read the notes on the back first Support: fill out this page) * τ This paper standard is applicable to the Chinese National Standard (CNS) Α4 specification (210Χ 297 mm) 43 V. Description of invention (41) A7 B7 The Ministry of Economic Affairs Central Standards Bureau Employee's Consumer Cooperative Printed Lactic Acid Example 5-7: Oil warming vitamin A 2-ethylhexanoic acid triglyceride olive oil BHT BHA POE (20) octyl dodecyl ether glycerylglycine acid purified water 5-8: night cream (night crra π) mobile stone 2-ethylhexanoic acid triglyceride petroleum jelly solid petrolatum dioleate diglyceride diisostearate triglyceride vitamin A propyl p-hydroxybenzoate propylene glycol Glycerin 0.07 0.1 Set the total weight to 100 (Heavy 1 40 100.2 0.05 16 150.1 Set the total cross to 100 (weight S%) 15 7 6 2 1.5 1.5 0.1 0.2 4 15 --------- Μ ------ IT ---- ^-# (Please read the notes on the back first i · »·) -fill in this page) {, the paper size is applicable to China National standard (CNS) A4 specification (210X 297mm) 44 A7 B7 5. Description of invention (42) Glycine 1 Refined water 1 Refined water makes the whole skeleton 100 * Examples 5-4 ~ 5-8 The skin-use external composition is used for daily use, and has good stability of vitamin A. As described above, the skin external composition of the present invention can be formulated with neutral amine groups to significantly improve the stability of vitamin A. --------- ^ ------ tT ------- ^ (Please read the notes on the back f P first, fill out this page) {Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs The standard of this paper is 45. The Chinese Standard (CNS) 8.4 specification is applied (210 to 97). A7 B7 43 Printed by the Central Consumer Standards Bureau of the Ministry of Economic Affairs Employee Consumer Cooperative V. Invention Description (Examination Example 6-1 ~ 6-2¾ bh Comparative Examples 6-1 ~ 6-2 Qiang 6-〗: Makeup oil formula 銄 龒 牛 蹤 Amu Jin results (Heavy snail implementation 6-6 Example 6-2 Comparative Example 6-1 Comparative Example 6-2 Vitamin A 0.01 0.2 0.01 0.2 BHT 0.005 0.03 0.005 0.03 dl-α -tocopherol- 0.01-0.01 Benzophenone-3 0.05 0.1--Octylmethoxycinnamic acid S--0.05 0.1 Ethylenediaminetetraacetic acid di Sodium 0.001 0.005-0.005 Purified water 0.1 0.2-0.2 Triethylglycerol 2-ethylhexanoate 45 20 45 20 Isopropyl myristate 10 35 10 35 Squalane 24.834 24.455 24.935 24.455 Dipropylene glycol 10 10 10 10 Ethanol 8 8 8 8 POE (IO) oil ether 2 2 2 2 After modulation of vitamin A quantitative value (%> 100 100 100 100 401 2 months later (%) 93 98 68 82 --------- (Please read the back first (Pay attention to fill this page)

'1T 46 本纸乐尺度適用中國國家標準（CNS ) Λ4規格（210:<：!df ) 經濟部中央橾準局貝工消费合作社印製 A7 _B7___ 五、發明説明（44 ) 實施例6-1，6-2與比較例相較，可提高維生素A之安 定性，此係本發明之效果。 奮旃例fi-1 . 好吒龄例fi-1 . 梨法逛溫庠試賒 方法 於60C下將BHT、生育酚、二苯甲嗣、及辛基甲氧基 肉桂酸酯完全溶解於各油成分中後，添加已溶解於水中之 乙二胺四乙酸鹽、乙醇、二丙二醇，冷卻至401C。然後， 完全溶解維生素A，密封於褐色玻瑰製試樣管中，再Μ鋁 箔包住完全遮光，保管於40t：恒溫槽内。 雒牛袤A夕宙醫方法 使用乙醇作為溶劑，並藉325nm之吸光度測定法實施 定董。 又，計黧時，使極大吸收325nm E(l%，lcm) = 1835 ° 窨旃例hh齡例餺法斑溫麻試驗 於70=下將BHT、生育酚及二苯甲醑-2完全溶解於各 油成分與界面活性劑中後，於乳化之前使維生素A完全溶 解成為油相。 將甘油、丙二酵、羧乙烯基聚合物、苛性鉀、乙二胺 四乙酸三納及二苯甲詷完全溶解於精製水中，加溫至70X： ，將油性加入水相中，並藉均質混合型乳化機進行乳化。 其次，藉熱交換機施行冷卻處理至30¾，而得乳液。 將乳液充填至塗有金羼模之玻瓖瓶內，密封之並保存 於40t：恒溫槽中。 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） ----------^------1T----；--^ (請先閲讀背面之注意κί填寫本頁) { -47 - 302284 A7 B7 五、發明説明（45 ) 經濟部中央標準局員工消費合作社印製 砉6-2 :凯液5F方及維牛袤A亩鼉结果（重詧呢） 實施例 6—3 實施例 6—4 比較例 6-3 比較例 6 — 4 維生素A 0.3 0.01 0.3 0.01 BHT 0.05 0.01 0.05 0.01 d 1- oc _生育紛 0.01 0.02 0.01 0.02 乙二胺四乙酸三鈉 0.02 0.02 0.02 - 二苯甲詷-2 0.1 0.05 - 0.02 二苯甲銅-5 - 0.05 - _ 異辛酸鲸撖S旨 10 7 10 7 肉豆蔻酸異丙酯 2 4 2 4 角鯊烷 2 2 2 2 鲸擷醇 2 2 2 2 凡士林 1 1 1 1 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 P0E(60)硬化E麻油 1.3 1.3 1.3 1.3 羧乙烯基聚合物 0.2 0.3 0.2 0.3 荷性鉀 0.06 0.08 0.06 0.08 甘油 10 10 10 10 丙二醇 3 3 3 3 乙基對羥苯甲酸 0.2 0.2 0.2 0.2 精製水 έ體為100: 之量 維生素A定量值 調製之後（％) 100 100 100 100 40t 1値月後（％) 97 99 29 22 本紙乐尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 48 A7 B7 經濟部中央橾準局員工消費合作杜印製 五、發明説明（46 實施例6-3及6-4與比較例相較，可提高維生素A之安 定性，此係本發明之效果。 雒牛袤A署方法 使用乙醇，並藉325nm之吸光度測定法進行测定。分 別從實施例、比較例，調裂除去維生素A後之試料。測定 32 5nra之吸收，修正作為基劑之吸光度。 (實施例、比較例之試料325nm的吸光度）-（除去 品之吸光度）=維生素A之吸光度 於計算時，使吸收極大325nm，E(l%，lcm)=1835。 謇旃例R-5 :仆.妝氽 油醇 二苯甲酮-12 α -生育酚 維生素A P〇E(50)油謎 乳酸 乳酸納 乙酵 甘油 甲基對羥苯甲酸 乙二胺四乙酸三納 精製水 奮施例6-6:油繪（。；1 essence) 2-乙基己酸三甘油酯 (mm%) 0.002 0.001 0.001 0.0001 0.70.1 0.9 0.01 使全體爲100之量 (輦鼉％) 30 49 本紙張尺度適用中國國家標準（CNS M4規格（210X 297公釐） 五、發明説明（47 ) A7 B7 經濟部中央樣準局貝工消費合作社印製 辛基十二醇 20 角鯊烷 12 ΒΗΤ 1 α -生育酚 9 維生素A 8 二丙二醇 12.899 乙醇 5 二苯甲酮-8 0.1 乙二胺四乙酸二納 0.001 蓄旆例fi-7 :乳霜 (重鼉％ 角鯊烷 15 2-乙基己酸三甘油酯 8 肉豆蔻酸異丙酯 7 BHT 0.05 BHA 0.01 α -生育酚 0.01 維生素A 0.3 凡士林 2 丁基對羥苯甲酸 0. 1 丙基對羥苯甲酸 0.1 油酸單甘油酯 3 二異硬脂酸二甘油酯 2 PEG400二油酸酯 1 甘油 10 ---------^------1T------# » (請先閱讀背面之注意κ打填寫本頁) { 本紙乐尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） 50 302284 A7 B7 五、發明説明（48 ) 經濟部中央標準局員工消費合作社印製 二丙二醇 乙二胺四乙酸二鈉 二苯甲酮-6 二苯甲酮-4 三乙醇胺 精製水 奮旆例:油焙 肉豆蔻酸異丙酯 辛基十二醇 角鯊烷 BHT α -生育酚 维生素A 二丁基肽酸酯 乙醇 二苯甲嗣-12 二苯甲嗣-6 乙二胺四乙酸鈉 奮旃例fi-9 :油暖 2-乙基己酸三甘油酯 POE(20)辛基十二醚 維生素A 二苯甲嗣-12 甘油 0.001 0.1 0.03 0.04 使全醱爲100之量 (重昼％ ) 10 20 30 1 9 1 9 9.999 7 3 0.001 (重鼉％ ) 60 16 16 (請先閱讀背面之注意< 丹填寫本頁) 本紙張尺度適用中國國家揉準（CNS ) A4規格（210 X 297公釐） 51 五、發明説明（49 二苯甲嗣-5 乙二胺四乙酸三鈉 BHA BHT 精製水 A7 B7 0.05 0.02 0.01 0.01 使全體為100之量 經濟部中央標準局貝工消费合作社印裝 實施例6-5〜6-9之皮膚外用組成物於日常使用上為具 維生素A之安定性佳者。 如上所述，本發明之皮虜外用組成物可調配（A)選自 丁基羥基甲苯、丁基羥基苯甲醚、α，点，7, 5 -生育酚 、去甲二氫愈創木酸、沒食子酸丙酯、維生素C脂肪酸酯 及山梨酸之群中至少一種的油溶性抗氧化劑、（Β)乙二胺 四醋酸鹽之一種或二種以上、（C)二苯甲酮条化合物之一 種或二種Μ上，以明顯提高维生素Α之安定性。 奮掄俐7-1 . 7-2¾ Hh齡例7-1 . 7-2夕靱法铒溫麻試驗方法 於60t：下將BHT、生育酚、二苯甲酮、及辛基甲氧基 桂皮酸醏完全溶解於各油成分中後*添加入溶解於山梨酸 及二丙二醇中之乙醇，並冷郤至401C。然後，将维生素A 完全溶解*而密封於褐色玻瑱裂試樣管中，再Μ鋁箔包住 以完全遮光，而保存於40C恆溫槽中。 1 I I I ! I 絲 Ψ (請先閱讀背面之注意良.丹填寫本頁) ( 本紙張尺度逋用中國國家標準（CNS ) Α4規格（210Χ 297公釐） A7 B7 五、發明説明（50 ) 經濟部中央標準局員工消费合作社印袈 砉7-1 :彳h妝用油SP方逛雒牛袤A亩畺结里（重署鉍） 實施例 7-1 實施例 7-2 比較例 7-1 比較例 7-2 維生素A 0.01 0.2 0.01 0.2 BHT Q.005 0.03 0.005 0.03 dl-α -生育酚 - 0.01 - 0.01 二苯甲嗣-3 0.05 0.1 - - 辛基甲氧基桂皮酸酯 - - 0.05 0.1 山梨酸 0.001 0.005 — 0.005 2-乙基己酸三甘油酯 45 20 45 20 甘油酯 肉豆蔻酸異丙酯 10 35 10 35 角鯊烷 吏全體爲 )0之量 二丙二醇 10 10 10 10 乙醇 8 8 8 8 P0E(10〉油醚 2 2 2 2 維生素A定量值 調製之後（％〉 100 100 100 100 40t 2個月後（％) 95 96 71 69 雒牛袤A署方法 批衣 訂 务 * (請先閱讀背面之注意^ί 卉填寫本頁) ( 本紙張尺度適用中國國家標準（CNS ) Α4規格（2丨0>< 297公釐） 53 Α7 Β7 五、發明説明（51 ) 依日本藥局方（第十一修正）維生素A定置法第2法 ，使用異丙醇之吸光測定法進行測定。 實施例7-1及7-2與比較例相較，可提高維生素A之安 定性，此係本發明之效果。 窗掄例7-.?、7-4及出較例7-.Ί、7-4：>製法£5溫麽試.験方法 於70=下將BHT、生育酚及二苯甲酮-2溶解於各油成 分與界面活性劑中後，乳化之前，將维生素Α完全溶解成 油相。 將甘油、丙二醇、羧乙烯基聚化合物、苛性鉀、抗壤 血酸及二苯甲嗣-5完全溶解於精製水中，並將油相加入經 加溫至70X：之水中，以均質混合型乳化機乳化。其次，藉 熱交換器實施冷卻處理至30°C，而得乳液。 將乳液充镇至塗覆有金屬膜之玻璃瓶內，密封之，而 保存於40C恆溫槽。 ---------^------tT------^ (請先閱讀背面之注意^ί .再填寫本頁) ( 經濟部中央標準局員工消費合作杜印製 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） -54 - 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（52 ) 弃7-2 :乳液ffi方及雏牛袤A宙g结果f重醫弘） 實施例 7-3 實施例 7-4 比較例 7-3 比較例 7-4 维生素A 0.B 0.01 0.3 0.01 BHT 0.05 0.01 0.05 0.01 dl- oc -生育_ 0.01 0.02 0.01 0.02 乙二胺四乙酸三納 0.05 0.02 0.02 - 二苯甲酮-2 0.1 0.05 - 0.02 二苯甲醑-5 〜 0.05 - - 異辛酸鲸蟠酯 10 7 10 7 角鯊烷 5 2 2 2 鲸蟠醇 2 2 2 2 凡士林 1 1 1 1 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 P0E(60)硬化g麻油 1.3 1.3 1.3 1.3 羧乙烯基聚合物 0.2 0.3 0.2 0.3 荷性鉀 0.06 0.08 0.06 0.08 甘油 10 10 10 10 丙二酵 3 3 3 3 乙基對羥苯甲酸 0.2 0.2 0.2 0.2 精製水 使: έ體為100: 之量 維生素A定董值 調裂之後（％〉 100 100 100 100 40= 1画月後（％〉 96 98 47 41 裝 I ;舌 線 (請先閲讀背面之注意t...舟填寫本頁) ( 本纸浪尺度適用中國國家標準（(：.\’5)八4規格（210\29，公釐） -55 - 經濟部中央橾準局員工消費合作社印製 302284 A7 B7 •^、發明説明（53 ) 實施例7-3及7-4與比較例相較，可提高維生素A之安 定性，此係本發明之效杲。 雄牛袤A之定鼉方法 使用乙醇，並藉325cm之吸光度測定法進行測定。分 別從買施例、比較例調裂除去維生素A後之試料。測定於 325nm之吸收作為修正基劑之吸光度。 於計算時，使吸收極大325nm E(l%，lcm)= 1835。 啻旃例7-5 :化妝水 (重暑 油醇 0.002 二苯甲嗣-12 0.001 ct -生育酚 0.001 維生素A 0.0001 POE(50)油醚 0.7 乳酸 0.1 乳酸納 0.9 乙醇 8 甘油 2 甲基對羥苯甲酸 0.2 異抗壤血酸納 0.5 精製水 使全體為100之量 奮掄例7-ft :油鴆 (重畺％) 2-乙基己酸三甘油酯 10 辛基十二醇 20 角鯊烷 39 本紙張尺度適用中國國家標準（CNS ) A4規格（2IOX 297公釐） 56 ---------裝— (請先閣讀背面之注意^再填寫本頁) 訂 線 五、發明説明（54 A7 B7 經濟部中央標準局員工消費合作社印策 BHT α -生育酚 維生素A 二丙二醇 乙醇 二苯甲酮-6 山梨酸 奮掄例7-7 : 3丨，霜 角鯊烷 2-乙基己酸三甘油酯 肉豆蔻酸異丙酯 BHT BHA α -生育酚 维生素A 凡士林 丁基對羥苯甲睃 丙基對羥苯甲酸 油酸單甘油酯 二異硬脂酸二甘油酯 PEG400二油酸酯 甘油 二丙二醇 抗壊血酸納 1 9 1 12.89 50.10.01 (重畺 15 8 7 0.050.010.01 1 10 .01 請先閲讀背面之注意 备填寫本1) 裝. 訂 線 本紙張尺度適用中國國家梯準（CN’S ) Λ4規洛（21〇:<297公變） 57 302284 A7 B7 五、發明説明（55 ) 經濟部中央標準局員工消費合作社印製 二苯甲嗣-8 0.1 二苯甲酮-4 0.03 三乙醇胺 0.04 精製水 使全體為100之量 奮旃例7-8 :差容焙油 (重畺鉍） 甘油 30 丙二醇 10 橄欖油 2 BHT 0.1 α -生育酚 0.1 維生素A 0. 1 乙醇 4 抗壊血酸 10 山梨酸鉀 0.1 蒼耳烷膠 0.8 P0E(60)硬化虽麻油 0.6 精製水 使全醱為100之置 窨旃例7-9 :油睡暖 (重鼉弘） 2-乙基己酸三甘油酯 60 P0E(20〉辛基十二醚 16 維生素A 0.1 二苯甲酮-12 0.1 甘油 16 異抗壊血酸 0.05 |_^--------批衣------ΪΤ------.^ (請先閱讀背面之注意4:再填寫本頁) ( 本纸伕尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 53 經濟部中央橾準局員工消费合作社印製'1T 46 This paper music standard is applicable to the Chinese National Standard (CNS) Λ4 specification (210: <:! Df) A7 _B7___ printed by the Beigong Consumer Cooperative of the Central Bureau of Economic Affairs of the Ministry of Economy V. Description of the invention (44) Example 6- Compared with the comparative example, 1, 6-2 can improve the stability of vitamin A, which is the effect of the present invention. Endeavour example fi-1. Good age case example fi-1. Pear method shopping temperature test method at 60C to completely dissolve BHT, tocopherol, dibenzophenone, and octyl methoxycinnamate in each After the oil component is added, ethylenediaminetetraacetate, ethanol, and dipropylene glycol dissolved in water are added, and cooled to 401C. Then, the vitamin A was completely dissolved, sealed in a brown glass rosette sample tube, and then covered with aluminum foil for complete shading, and stored in a 40t: constant temperature bath. Luo Niubao A Xi Zhou Medicine Method Using ethanol as a solvent, and using the absorbance measurement method of 325nm to implement Ding Dong. In addition, when counting, make the maximum absorption 325nm E (l%, lcm) = 1835 ° 搨 漃 case hh age case 禎 method plaque temperature anesthesia test at 70 = under the BHT, tocopherol and dibenzophenone-2 completely dissolved After each oil component and surfactant, vitamin A is completely dissolved into an oil phase before emulsification. Completely dissolve glycerin, malonate, carboxyvinyl polymer, caustic potash, ethylenediaminetetraacetic acid trisodium and benzophenone in purified water, warm to 70X:, add oiliness to the water phase, and homogenize The emulsification is carried out by a hybrid emulsifier. Secondly, use the heat exchanger to perform cooling treatment to 30¾, and get the emulsion. Fill the lotion into a glass bottle coated with a gold mold, seal it, and store it in a 40t: constant temperature bath. This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X 297mm) ---------- ^ ------ 1T ----;-^ (please read the back page first (Note κί fill in this page) {-47-302284 A7 B7 V. Description of invention (45) Ink 6-2 printed by Employee Consumer Cooperative of Central Bureau of Standards, Ministry of Economic Affairs 6-2: Kaiye 5F and Wei Niu 螤 A mu of the results ) Example 6-3 Example 6-4 Comparative Example 6-3 Comparative Example 6-4 Vitamin A 0.3 0.01 0.3 0.01 BHT 0.05 0.01 0.05 0.01 d 1- oc _ Fertility 0.01 0.02 0.01 0.02 Ethylenediaminetetraacetic acid triacetate Sodium 0.02 0.02 0.02-Dibenzophenone-2 0.1 0.05-0.02 Copper dibenzoate-5-0.05-_ Isooctanoic acid whale extract 10 7 10 7 Isopropyl myristate 2 4 2 4 Squalane 2 2 2 2 Cetyl alcohol 2 2 2 2 Vaseline 1 1 1 1 Glycerol monostearate 1.5 1.5 1.5 1.5 P0E (60) hardened E sesame oil 1.3 1.3 1.3 1.3 Carboxyvinyl polymer 0.2 0.3 0.2 0.3 Potassium potassium 0.06 0.08 0.06 0.08 Glycerin 10 10 10 10 Propylene glycol 3 3 3 3 Ethyl p-hydroxybenzoic acid 0.2 0.2 0.2 0.2 The amount of purified water is 100: the amount of vitamin A quantitative value after modulation (%) 100 1 00 100 100 40t after 1 month (%) 97 99 29 22 The standard of paper music is in accordance with the Chinese National Standard (CNS) A4 specification (210X297 mm) 48 A7 B7 The Ministry of Economic Affairs Central Bureau of Privileges and Expenditure Cooperative Printing by Employees Description (46 Examples 6-3 and 6-4 can improve the stability of vitamin A compared to the comparative example, which is the effect of the present invention. The method of Luo Niubao A Department uses ethanol and is measured by absorbance at 325 nm Measurement. The samples after removing vitamin A from the Examples and Comparative Examples, respectively. The absorption of 325 nra was measured, and the absorbance as a base was corrected. (The absorbance of 325 nm of the samples of Examples and Comparative Examples)-(absorbance of the removed product ) = The absorbance of vitamin A is calculated to maximize absorption 325 nm, E (l%, lcm) = 1835. Example R-5: Serum. Makeup oil benzophenone-12α-tocopherol vitamin AP 〇E (50) oil mystery lactic acid lactate sodium ethyl acetate glycerol methyl p-hydroxybenzoate ethylenediaminetetraacetic acid three sodium refined water Fenshi Example 6-6: oil painting (. ; 1 essence) 2-Ethylhexanoic acid triglyceride (mm%) 0.002 0.001 0.001 0.0001 0.70.1 0.9 0.01 The total amount is 100 (Ying%) 30 49 This paper scale is applicable to the Chinese national standard (CNS M4 specification) (210X 297 mm) V. Description of the invention (47) A7 B7 Central Bureau of Samples of the Ministry of Economic Affairs Printed by Octagon Dodecyl Alcohol 20 Squalane 12 ΒΗΤ 1 α -Tocopherol 9 Vitamin A 8 Dipropylene glycol 12.899 Ethanol 5 Benzophenone-8 0.1 Ethylenediaminetetraacetic acid dinaphthalene 0.001 Storage example fi-7: Cream (% of weight) Squalane 15 2-Ethylhexanoic acid triglyceride 8 Isopropyl myristate 7 BHT 0.05 BHA 0.01 α-tocopherol 0.01 Vitamin A 0.3 Vaseline 2 Butyl p-hydroxybenzoic acid 0.1 Propyl p-hydroxybenzoic acid 0.1 Monoglyceryl oleate 3 Diglyceryl diisostearate 2 PEG400 Dioleic acid Ester 1 Glycerin 10 --------- ^ ------ 1T ------ # »(please read the notes on the back first and fill in this page) {This paper music standard is applicable to Chinese national standards (CNS) Α4 specification (210Χ 297mm) 50 302284 A7 B7 V. Description of invention (48) Employee consumption cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs Printed dipropylene glycol ethylenediaminetetraacetic acid disodium benzophenone-6 benzophenone-4 triethanolamine purified water. Examples: oil roasted isopropyl myristate octyldodecyl squalane BHT α- Tocopherol Vitamin A Dibutyl Peptide Ethyl Alcohol Dibenzophenone-12 Dibenzophenone-6 Ethylenediaminetetraacetate Sodium Example fi-9: Oil-warm 2-ethylhexanoic acid triglyceride POE (20 ) Octyl dodecyl ether vitamin A dibenzoyl -12 glycerol 0.001 0.1 0.03 0.04 to make the total amount of 100 (weight day%) 10 20 30 1 9 1 9 9.999 7 3 0.001 (weight%) 60 16 16 (Please read the note on the back first & Dan fills in this page) This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 51 5. Description of the invention (49 dibenzomethan-5 ethylenediamine Trisodium tetraacetate BHA BHT purified water A7 B7 0.05 0.02 0.01 0.01 Make the whole amount 100 The Ministry of Economic Affairs Central Standards Bureau Beigong Consumer Cooperative Printed Example 6-5 ~ 6-9 The skin external composition for daily use is Those with good stability of vitamin A. As mentioned above, the skin composition for external use of the present invention can be formulated (A) selected from butylhydroxytoluene and butylhydroxy Anisole, alpha, point, 7, 5-tocopherol, nordihydroguaiaretic acid, propyl gallate, at least one oil-soluble antioxidant of the group of vitamin C fatty acid esters and sorbic acid, (B) one or two or more of ethylenediamine tetraacetate, (C) one or two of M of benzophenone bar compounds, to significantly improve the stability of vitamin A. Fen Lili 7-1. 7-2¾ Hh age example 7-1. 7-2 Xitu method erbium warm anesthesia test method at 60t: BHT, tocopherol, benzophenone, and octyl methoxy cinnamon After the acetic acid is completely dissolved in each oil component *, add ethanol dissolved in sorbic acid and dipropylene glycol, and cool to 401C. Then, the vitamin A was completely dissolved * and sealed in a brown glass cracking sample tube, and then wrapped in aluminum foil to completely block the light, and stored in a 40C constant temperature bath. 1 III! I silk Ψ (please read the note on the back first. Dan fills in this page) (This paper uses the Chinese National Standard (CNS) Α4 specification (210Χ 297 mm) A7 B7 V. Invention description (50) Economy Ministry of Central Bureau of Standards Employee Consumer Cooperatives 碈 砉 7-1: Shih makeup oil SP side shopping Luo Niu 袤 A mu 緺 Keli (Re-bismuth) Example 7-1 Example 7-2 Comparative Example 7-1 Comparative Example 7-2 Vitamin A 0.01 0.2 0.01 0.2 BHT Q.005 0.03 0.005 0.03 dl-α-tocopherol- 0.01-0.01 Dibenzophenone-3 0.05 0.1--Octylmethoxycinnamate--0.05 0.1 Sorbic acid 0.001 0.005 — 0.005 2-Ethylhexanoic acid triglyceride 45 20 45 20 Glycerol isopropyl myristate 10 35 10 35 Squalane (total amount) 0 The amount of dipropylene glycol 10 10 10 10 Ethanol 8 8 8 8 P0E (10> oleyl ether 2 2 2 2 After the preparation of the quantitative value of vitamin A (%> 100 100 100 100 40t 2 months (%) 95 96 71 69 Read the notes on the back first ^ ί Hui fill in this page) (This paper scale is applicable to China National Standard (CNS) Α4 specifications (2 丨 0 > < 297 mm) 53 Α7 Β7 V. Description of the invention (51) According to the second method of the Japanese Pharmacopoeia (Eleventh Amendment) Vitamin A placement method, the measurement is performed using the isopropyl alcohol absorption method. Example 7 Compared with the comparative examples, -1 and 7-2 can improve the stability of vitamin A, which is the effect of the present invention. The window 7-7.?, 7-4 and the comparative examples 7-.Ί, 7-4 :> Method of preparation: £ 5 temperature test. The method of dissolving BHT, tocopherol, and benzophenone-2 in various oil components and surfactants under 70 =, before dissolving vitamin A completely into oil before emulsification Phase: Completely dissolve glycerin, propylene glycol, carboxyvinyl polycompound, caustic potassium, ascorbic acid and dibenzoyl-5 in purified water, and add the oil phase to the water heated to 70X: and mix it homogeneous Type emulsifier emulsification. Secondly, the heat exchanger is cooled to 30 ° C to obtain an emulsion. Fill the emulsion into a glass bottle coated with a metal film, seal it, and store it in a 40C constant temperature bath. ------- ^ ------ tT ------ ^ (Please read the notes on the back ^ ί. Then fill out this page) (Employee Consumption Cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs The size of the paper used is in accordance with the Chinese National Standard (CNS) Α4 specification (210X297 mm) -54-A7 B7 printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs V. Description of the invention (52) Discarded 7-2: Emulsion ffi side and calf jacket Zhou g results f Chongyihong) Example 7-3 Example 7-4 Comparative Example 7-3 Comparative Example 7-4 Vitamin A 0.B 0.01 0.3 0.01 BHT 0.05 0.01 0.05 0.01 dl-oc-Fertility_ 0.01 0.02 0.01 0.02 Trisodium EDTA 0.05 0.02 0.02-Benzophenone-2 0.1 0.05-0.02 Dibenzophenone-5 ~ 0.05--Cetyl isooctanoate 10 7 10 7 Squalane 5 2 2 2 Cetane Alcohol 2 2 2 2 Vaseline 1 1 1 1 Glycerol monostearate 1.5 1.5 1.5 1.5 P0E (60) hardened g Sesame oil 1.3 1.3 1.3 1.3 Carboxyvinyl polymer 0.2 0.3 0.2 0.3 Potassium potassium 0.06 0.08 0.06 0.08 Glycerin 10 10 10 10 Malonate 3 3 3 3 Ethyl p-hydroxybenzoic acid 0.2 0.2 0.2 0.2 Refined water: 100% of the amount of vitamin A after setting the cracking rate (%> 100 100 100 100 40 = 1 month After (%> 96 98 47 41 installed I; tongue line (please read the note on the back t ... boat fill in this page) ( This paper wave scale is applicable to the Chinese national standard ((:. \ '5) 84 specifications (210 \ 29, mm) -55-302284 A7 B7 printed by the Employee Consumer Cooperative of the Central Standardization Bureau of the Ministry of Economic Affairs 53) Compared with Comparative Examples, Examples 7-3 and 7-4 can improve the stability of vitamin A, which is the effect of the present invention. Method for decoction of male ox-cob A Using ethanol, it was measured by the absorbance measurement method of 325cm. Samples after removing vitamin A from the Examples and Comparative Examples. The absorbance at 325 nm was measured as the correction base absorbance. In the calculation, make the absorption maximum 325nm E (l%, lcm) = 1835. Example 7-5: Make-up water (sweet oleyl alcohol 0.002 benzophenone-12 0.001 ct-tocopherol 0.001 vitamin A 0.0001 POE (50) oleyl ether 0.7 lactic acid 0.1 sodium lactate 0.9 ethanol 8 glycerol 2 methyl-p-hydroxyl Benzoic acid 0.2 Sodium erythorate 0.5 Refined water to make the whole amount 100% Example 7-ft: Oil threshing (weight%) 2-Ethylhexanoic acid triglyceride 10 Octyl dodecanol 20 shark Alkane 39 This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (2IOX 297mm) 56 --------- installed — (please read the note on the back ^ first and then fill out this page) Description of the invention (54 A7 B7, Ministry of Economic Affairs, Central Standards Bureau, Employee Consumer Cooperative, Inspiration BHT α-tocopherol, vitamin A, dipropylene glycol, ethanol, benzophenone, 6 sorbic acid, and fencan. Example 7-7: 3 丨, frost squalane 2- Ethylhexanoic acid triglyceride isopropyl myristate BHT BHA α-tocopherol vitamin A Vaseline butyl paraben propyl paraben oleic acid monoglyceride diisostearate diglyceride PEG400 di Oleic acid glycerol dipropylene glycol sodium ascorbate 1 9 1 12.89 50.10.01 (weight 15 8 7 0.050.010.01 1 10 .01 please Please read the notes on the back and fill in this book. 1) Binding. The paper size of the binding book is applicable to the Chinese National Standard (CN'S) Λ4 gauge Luo (21〇: < 297 public change) 57 302284 A7 B7 V. Description of invention (55) Ministry of Economic Affairs Dibenzophenone-8 printed by the Central Bureau of Standards' Employees Consumer Cooperative 0.1 0.1 Benzophenone-4 0.03 Triethanolamine 0.04 Refined water for a total of 100% Example 7-8: Tolerance roasting oil (heavy bismuth) glycerin 30 Propylene glycol 10 Olive oil 2 BHT 0.1 Alpha-tocopherol 0.1 Vitamin A 0.1 Ethanol 4 Ascorbic acid 10 Potassium sorbate 0.1 Xanthan gum 0.8 P0E (60) hardened although sesame oil 0.6 Refined water makes the whole mixture 100 Example 7-9: Oily Sleeping Warmth (Heavy Root) 2-Ethyl Triglyceride 60 P0E (20> Octyl Dodecyl Ether 16 Vitamin A 0.1 Benzophenone-12 0.1 Glycerol 16 Differential Antibody峊 血 酸 0.05 | _ ^ -------- approved clothing ------ ΪΤ ------. ^ (Please read Note 4 on the back first: then fill out this page) (This paper 伕The scale is applicable to the Chinese National Standard (CNS) A4 specification (210X 297mm) 53 Printed by the Employee Consumer Cooperative of the Central Bureau of Economic Affairs of the Ministry of Economic Affairs

AT _B7_____ 五、發明説明（56 > 二苯甲酮-5 0.05 BHA 〇-〇1 BHT 0-01 精製水 使全體爲100之量 實施例7-5〜7-9之皮*外用組成物於日常使用中爲具 維生素A之安定性佳者。 本發明之皮虜外用组成物中係調配（A)選自丁基羥基 甲苯、丁基羥基苯甲Κ、α，/3.7 ,5 -生育酚、去甲二 氫愈創木酸、沒食子酸丙醋、雒生素C脂肪酸酯之群中至 少一種的油溶性抗氧化劑、（Β)抗壊血酸、抗壞血酸鹽、 異抗壊血酸、異抗壊血酸鹽、山梨酸及山梨酸鹽之一棰或 二種以上、（C)二苯甲銅条化合物之一種或二種Μ上，可 顯著提高維生素Α之安定性。 實掄例S-1〜S-?孖屮»拥S-1〜8-2 9 5 ▲紙浪尺度適用中國國家棣準（CNS ) A.4規格（21.〇χ29.7公釐） A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（57 ) 英只-1 :乳液由：>雄牛袤A的夯亩袢_亩结菓（雷昼鉍） 實施例 8-1 實施例 8-2 比較例 8-1 比較例 8-2 精裂水 使: έ髏為100. 之量 甘油 10 10 10 10 羧乙烯基聚合物 0.2 0.2 0.2 0.2 苛性鉀 0.06 0.06 0.06 0.06 乙醇 5 5 5 5 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 鯨蠘醇 2 3 2 2 凡士林 3 3 3 3 角鯊烷 5 5 5 5 肉豆盏酸異丙酯 4 4 4 4 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 ΡΕ0(60)硬化里麻油 2 2 2 2 HP-/S -CD 5 5 - - BHT 0.05 - 0.05 - 辛基甲氧基桂皮酸θ旨 - 0.05 - 0.05 维生素A 0.Β 0.3 0.3 0.3 維生素A定量 調製之後（％ 100 100 100 100 401C 2遇後（％) 98 93 95 75 實施例8-1、8-2與比較例相較，可提高維生素A之安 定性，此係本發明之效果。 維生袤A ：>宙醫方沽 使用乙酵*並藉325ηιιι之吸光度測定法進行測定。分 別從實施例8-2、比較例8-2中調裂除去維生素A後之試料 本纸伕尺度適用中國國家標準（CNS ) Λ4規格（210X297公釐) :6n _ ---------#------IT------.^ * (請先閲讀背面之注意wc,.丹填寫本頁) ί 經濟部中央標準局貝工消費合作杜印製 302284 A7 B7 五、發明説明（58 ) ，測定325nm之吸收*以修正作爲基劑之吸光度。 (實施例、比較例試料之325nm的吸光度）-(除去 品之吸光度）=維生素A之吸光度 於計算時，使吸收極大325mn，E(l%，lcm) = 1835。 丟8-2 :乳液SR方好雄牛袤A宙昼结果（重鼉％) 實施例 8-3 實施例 8-4 比較例 8-3 比較例 8-4 β -M-CD 1 1 — - a -CD 3 1 - - 7 -CD 2 1 - - ΒΗΤ 0.05 0.01 0.05 0.01 dl-α -生育酚 0.01 0.02 0.01 0.02 維生素A 0.3 0.01 0.3 0.01 異辛酸鲸蟠酯 10 7 10 7 角鯊烷 5 2 5 2 鲸蠟醇 2 2 2 2 凡士林 1 1 1 1 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 P0E(60)硬化苠麻油 1.3 1.3 1.3 1.3 羧乙烯基聚合物 0.2 0.2 0.2 0.2 苛性鉀 0.06 0.06 0.06 0.06 甘油 10 10 10 10 丙二醇 3 3 3 3 乙基對羥苯甲酸 0.2 0.2 0.2 0.2 精裂水 使: έ醱為100: 之悬 維生素A定量 調製之後（％ 100 100 100 100 40= 1個月後（％> 97 94 60 59 本紙浪尺度適用中國國家梂準（CNS) A4規格（：10:<::9:公釐） ---------装------V------m ♦ (請先閲讀背面之注意f..丹填寫本頁) ( 61 五、 發明説明（59 ) Α7 Β7 買施例8-3及8-4與比較例相較，可提高維生素A之安 定性，此係本發明之效果。 雄Φ^Α：>宙醫方法 依日本藥局方（第十一修正）維生素Α定量法第2法 ，使用異丙醇並藉吸光度測定法實施定置。 審掄俐8-5 :化妝氷 (重畺 油醇 0.002 經濟部中央樣準局貝工消費合作社印装 β -CD BHA 雄生素A P0E(50)油醚 乳酸 乳酸鈉 乙醇 甘油 甲基對羥苯甲酸 精製水 奮掄例kR:罜兹鴆油 HP-/3 -CD BHT 維生素A 肉豆蔻酸異丙酯 P0E(60)硬化Μ麻油 Ρ0Ε (60)山梨聚糖月桂酸酯 0.01 0.001 0.0001 0.7 0.01 0.09 5 10.2 使全鼸為100之S (簠鼉鉍） 30 1 1 10 1 1 (請先閱讀背面之注意篆/再填寫本頁) .-° 線 本纸浪尺度適用中國國家標率（CNS ) A4規格（210X 297公釐） 62 A7B7 五、發明説明（60 ) 羧乙烯基聚合物 三乙醇胺 乙醇 甲基對羥苯甲酸 精製水 經濟部中央標準局員工消費合作社印製AT _B7_____ V. Description of the invention (56 > Benzophenone-5 0.05 BHA 〇-〇1 BHT 0-01 Purified water so that the total amount is 100 The skin of Example 7-5 ~ 7-9 * External composition in It has good stability of vitamin A in daily use. The skin external composition of the present invention is formulated with (A) selected from butylhydroxytoluene, butylhydroxybenzyl ketone, α, /3.7,5-tocopherol , At least one oil-soluble antioxidant from the group of nordihydroguaiaretic acid, propionate gallate, and saponin C fatty acid esters, (B) ascorbic acid, ascorbate, erythorbic acid One or more types of acid, erythorbic acid salt, sorbic acid and sorbate, (C) one or two types of M of dibenzyl copper compound, can significantly improve the stability of vitamin A.务 例 S-1〜S-? 孖 屮 »鎮 S-1〜8-2 9 5 ▲ The paper wave scale is applicable to the Chinese National Standard (CNS) A.4 specifications (21.〇 × 29.7mm) A7 B7 Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 5. Description of the invention (57) Yingzhi-1: Emulsion from: > Tongmu jacket A's rammed acre _ acre results (Lei Bi) Example 8-1 Implementation Example 8-2 Comparative Example 8-1 Comparative Example 8-2 The splitting water is: the amount of skeletal is 100. The amount of glycerin 10 10 10 10 carboxyvinyl polymer 0.2 0.2 0.2 0.2 caustic potash 0.06 0.06 0.06 0.06 ethanol 5 5 5 5 methyl pairs Hydroxybenzoic acid 0.1 0.1 0.1 0.1 Cetyl alcohol 2 3 2 2 Vaseline 3 3 3 3 Squalane 5 5 5 5 Isopropyl myristate 4 4 4 4 Glyceryl monostearate 1.5 1.5 1.5 1.5 PE0 (60 ) Hardened sesame oil 2 2 2 2 HP- / S -CD 5 5--BHT 0.05-0.05-octyl methoxycinnamic acid θ purpose-0.05-0.05 Vitamin A 0.B 0.3 0.3 0.3 After quantitative vitamin A preparation ( % 100 100 100 100 401C After 2 encounters (%) 98 93 95 75 Examples 8-1 and 8-2 can improve the stability of vitamin A compared with the comparative example, which is the effect of the present invention. ： ≫ Zhou Yifang Gu used ethyl yeast * and measured by 325 nm absorbance measurement method. Samples after removing vitamin A from Example 8-2 and Comparative Example 8-2 are suitable for China Standard (CNS) Λ4 specification (210X297mm): 6n _ --------- # ------ IT ------. ^ * (Please read the note wc on the back first. Dan fills in P) du Bureau of Standards consumption HIGHLAND ί Economic Cooperation printed 302284 A7 B7 five portions described (58) to the invention, the absorption was measured 325nm * to correct the absorbance of the agent group. (Absorbance at 325 nm of samples of Examples and Comparative Examples)-(Absorbance of removed product) = Absorbance of vitamin A In the calculation, the absorption is maximized at 325mn, and E (l%, lcm) = 1835. Throw 8-2: Emulsion SR Fang Hao Niu Xiu A Zhou Day Results (Heavy Tuft%) Example 8-3 Example 8-4 Comparative Example 8-3 Comparative Example 8-4 β -M-CD 1 1 —-a -CD 3 1--7 -CD 2 1--ΒΗΤ 0.05 0.01 0.05 0.01 dl-α -tocopherol 0.01 0.02 0.01 0.02 Vitamin A 0.3 0.01 0.3 0.01 cetyl isooctanoate 10 7 10 7 squalane 5 2 5 2 Cetyl alcohol 2 2 2 2 Vaseline 1 1 1 1 Glycerol monostearate 1.5 1.5 1.5 1.5 P0E (60) hardened ramie oil 1.3 1.3 1.3 1.3 Carboxyvinyl polymer 0.2 0.2 0.2 0.2 Caustic potash 0.06 0.06 0.06 0.06 Glycerin 10 10 10 10 Propylene glycol 3 3 3 3 Ethyl p-hydroxybenzoic acid 0.2 0.2 0.2 0.2 Refined water: 100% of the suspended vitamin A after quantitative preparation (% 100 100 100 100 40 = 1 month later (% > 97 94 60 59 This paper wave scale is applicable to China National Standards (CNS) A4 specifications (： 10: < :: 9: mm) --------- installed ------ V-- ---- m ♦ (Please read the note on the back f .. Dan to fill in this page first) (61 V. Description of the invention (59) Α7 Β7 Buying Examples 8-3 and 8-4 can be improved compared with the comparative examples The stability of vitamin A, this is the invention Effect: Male Φ ^ Α:> The method of eucalyptus is based on the second method of the Japanese Pharmacopoeia (Eleventh Amendment) Vitamin A quantification method, using isopropyl alcohol and performing the setting by the absorbance measurement method. Juanli 8-5: Make-up ice (Heavy oleyl alcohol 0.002 Printed by β-CD BHA androgen A P0E (50) Oil ether lactic acid sodium lactate ethanol glycerol methyl p-hydroxybenzoic acid refining water in the central sample bureau of the Ministry of Economic Affairs Beigong Consumer Cooperatives kR: Rhizoma oil HP- / 3 -CD BHT Vitamin A isopropyl myristate P0E (60) hardened M hemp oil P0E (60) sorbitan laurate 0.01 0.001 0.0001 0.7 0.01 0.09 5 10.2 Make the whole shrew 100 S (簠 鍍 Bi) 30 1 1 10 1 1 (please read the note on the back first / then fill out this page) .- ° The size of the line paper is applicable to the Chinese National Standard Rate (CNS) A4 specification (210X 297 mm) 62 A7B7 V. Description of the invention (60) Printed by carboxyvinyl polymer triethanolamine, ethanol, methyl, and p-hydroxybenzoic acid, printed by the Employee Consumer Cooperative of the Ministry of Economic Affairs, Central Standards Bureau

啻旃例8-7 :乳霜 HE-/9 -CD BHT 2_羥基—甲氧基二苯甲酮 維生素A 2-乙基己酸三甘油酯 凡士林 角鯊烷 丁基對羥苯甲酸 丙基對羥苯甲酸 油酸單甘油酯 二異硬脂酸二甘油酯 PEG400二油酸酯 甘油 二丙二醇 精裂水 窨旃例H仆妝水 維生素A BHT包接-/3 -HPCD 3 0.1 使全體爲100之量(mm%) 3 0.01 0.02 0.3 10 2 18 0. 1 0.1 3 2 1 10 5 使全體爲100之量(重 a %) 0.001 ---------Μ-- (請先閱讀背面之注意t ·.舟填寫本頁) 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐 -6 3 _ 五、發明説明（61Example 8-7: Cream HE- / 9 -CD BHT 2_hydroxy-methoxybenzophenone vitamin A 2-ethylhexanoic acid triglyceride petrolatum squalane butyl paraben Paraben oleic acid monoglyceride diisostearic acid diglyceride PEG400 dioleate glycerin dipropylene glycol schizohydrogen sample H servicing water vitamin A BHT inclusion- / 3 -HPCD 3 0.1 make the whole for The amount of 100 (mm%) 3 0.01 0.02 0.3 10 2 18 0. 1 0.1 3 2 1 10 5 The amount of 100 (weight a%) 0.001 --------- M-- (please first Read the notes on the back t .. Zhou fills in this page) The paper size of the binding book is applicable to the Chinese National Standard (CNS) A4 specification (210X 297mm-6 3 _ V. Description of the invention (61

(BHT ： β -HPCD= 1 ： 100) 甘油 搾棵酸 檸檬酸三納 乙醇 二甲基對羥苯甲酸 精製水 謇掄例8-9 :弟窓紛 雒生素A A7 B7 03 07 使全體爲100之量 (雷量鉍） 0.3 10 ---------裝-- (請先閲讀背面之注意k :*填寫本S· 經濟部中央橾準局員工消費合作社印製 ct -生育酚包接-cc -CD (ct -生育酚：ct -CD= 1:150) 紫外線吸收劑包接-y3 -HPCD1· (紫外線吸收劑：/9 -HPCD= 1:150〉 D-甘露糖 * :紫外線吸收劑：辛基甲氧基桂皮酸酯 紫外線8-5〜8-9之皮虜外用組成物於日常使用中為具 維生素A之安定性佳者。 如上所述：本發明之皮*外用組成物中調配包接有抗 氧化劑及/或紫外線吸收劑之環糊精，可明顯提高維生素 A之安定性。 童施例fl-Ι〜9-?好[~h龄俐g-Ι〜Q-9 30 使全鼸為100之麗 本紙浪尺度逋用中國國家標準（CNS )八4現格（210X 297公釐） 64 五、發明説明（62 ) A7 B7 經濟部中央橾準局員工消费合作社印裝 表3-1 :乳液Φ：>雄牛袤A的安宙袢制佘结里（重鼉呢! 實施例 實施例 比較例 比較例 9-1 9-2 9一1 9-2 精製水 使' έ體為100. 之量 甘油 10 10 10 10 羧乙烯基聚合物 0.2 0.2 0.2 0.2 苛性鉀 0.06 0.06 0.06 0.06 乙醇 5 5 5 5 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 鲸蟠醇 2 2 2 2 凡士林 3 3 3 3 角鯊烷 5 5 5 5 肉豆蔻酸異丙酯 4 4 4 4 丁基羥基甲苯 0.05 1.05 0.05 0.05 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 PE0(60)硬化E麻油 2 2 2 2 1,3-丁二酵 0.01 5 - 丙二醇 - - 5 - 二丙二醇 - - - 5 維生素A 0.3 0.3 0.3 0.3 . 维生素A定量 調裂之後 100 100 100 100 40它1個月後（％) 93 92 65 69 ---------^------IT------# (請先閱讀背面之注意K..舟填寫本頁) { 本纸乐又度適用中國國家標準（CNS ) Λ4規格（210X 297公釐） 302284 A7 B7 五、發明説明（63 ) 實施例9-1及9-2與比較例相較，可提高維生素A之安 定性，此係本發明之效果。 雄牛宙噩方法 依曰本藥局方（第十一修正）維生素A定量法第2法 ，使用異丙醇並藉圾光度測定法實施定量。 經濟部中央標準局負工消费合作社印繁 奩掄俐:乳35 A. 鲸播醇 單硬脂酸甘油酯 P0E(25)十六醚 硬脂酸 凡士林 橄攬油 肉豆蔻酸異丙酯 角鯊烷 維生素A BHT 香料 B. 1,2-丁二醇 1.3- 丁二醇 1.4- 丁二醇 氫氧化鉀 精製水 (重署 3 2 1 3 3 3 1 50.1 0.05 適量 3 3 3 0.2 使全體為100之量 於701下分別加熱溶解A之油相部分與B之水相部分 ，將A加入B乳化之。然後進行冷卻處理而得乳霜。 本紙张尺度適用中國國家標準（CNS ) Λ4規格210 X 297公釐） 66 1 I I I n 訂 n I 矣 (請先閲讀背面之注意再填寫本頁) ί A7 B7 五、發明説明（64 經濟部中央標準局員工消費合作社印製 謇旃例？}-4 : #窓焙油 (重醫鉍1 羧乙烯基聚合物 0.3 1,3-丁二醇 25 1,4-丁二醇 15 甘油 30 三乙醇胺 3.5 p〇e(6〇)硬化m麻油 0.5 維生素A 0.1 角鯊烷 1 α -生育酚 0.01 甲基對羥苯甲酸 0.2 乙醇 6 精製水 使全體為100 奮旃例g-s :仆妝水 (重暑％ ) 1,3-丁二醇 5 乙醇 7 P0E(50)油醚 0.5 油醇 0.002 維生素A 0.0001 BHT 0.001 檸檬酸 0.03 檸橡酸三鈉 0.07 甲基對羥苯甲酸 0. 1 乙二胺四乙酸二納 0.03 (請先聞讀背面之注意良存填寫本頁) •裝·(BHT: β-HPCD = 1: 100) Glycerol squeezed acid citric acid trina-ethanol dimethyl p-hydroxybenzoic acid purified water syrup Example 8-9: Adigen A A7 B7 03 07 The amount of 100 (Lei bismuth) 0.3 10 --------- installed-(please read the note k on the back first: * fill in this S · Printed by the Consumer Cooperative of the Central Central Bureau of Economics of the Ministry of Economy ct-fertility Phenol encapsulation -cc -CD (ct -tocopherol: ct -CD = 1: 150) UV absorber encapsulation -y3 -HPCD1 · (UV absorber: / 9 -HPCD = 1: 150> D-mannose * : Ultraviolet absorber: Octyl methoxy cinnamic acid ester Ultraviolet 8-5 ~ 8-9 The skin-use external composition has good stability of vitamin A in daily use. As mentioned above: The skin of the present invention * The preparation of cyclodextrin with an antioxidant and / or ultraviolet absorber in the external composition can significantly improve the stability of vitamin A. Tong Shi Example fl-Ι ~ 9-? 好 [~ h 龄 俐 g-Ι ～ Q-9 30 Make the whole bead to be 100% of the original paper wave scale to use the Chinese National Standard (CNS) 84 4 grid (210X 297 mm) 64 V. Description of invention (62) A7 B7 Employee consumption of Central Central Bureau of Economic Affairs Cooperative printing 3-1: Emulsion Φ: > Anzoo made by the male cowboy A (Heavy!) Examples Examples Comparative Examples Comparative Examples 9-1 9-2 9-1 1 9-2 Purified water The amount is 100. The amount of glycerin 10 10 10 10 Carboxyvinyl polymer 0.2 0.2 0.2 0.2 Caustic potash 0.06 0.06 0.06 0.06 Ethanol 5 5 5 5 Methylparaben 0.1 0.1 0.1 0.1 Cetyl alcohol 2 2 2 2 Vaseline 3 3 3 3 Squalane 5 5 5 5 isopropyl myristate 4 4 4 4 butylhydroxytoluene 0.05 1.05 0.05 0.05 glyceryl monostearate 1.5 1.5 1.5 1.5 PE0 (60) hardened E sesame oil 2 2 2 2 1,3-Butanediol 0.01 5-Propylene Glycol--5-Dipropylene Glycol---5 Vitamin A 0.3 0.3 0.3 0.3. Vitamin A after quantitative cracking 100 100 100 100 40 It is 1 month later (%) 93 92 65 69 --------- ^ ------ IT ------ # (Please read the note on the back of K .. Zhou to fill out this page) {This paper music is again applicable to Chinese national standards (CNS) Λ4 specification (210X 297mm) 302284 A7 B7 V. Description of the invention (63) Compared with the comparative example, examples 9-1 and 9-2 can improve the stability of vitamin A, which is the effect of the present invention . The method of the male bully night is based on the second method of the Vitamin A quantification method of the Pharmacopoeia (Eleventh Amendment), which uses isopropyl alcohol and quantifies it by the photometric method. The Ministry of Economic Affairs, Central Bureau of Standards, Consumer Labor Cooperative, Yin Fanli: Milk 35 A. Cetyl alcohol glyceryl monostearate P0E (25) hexadecyl ether stearic acid petrolatum olive oil isopropyl myristate shark Alkane Vitamin A BHT Perfume B. 1,2-Butanediol 1.3- Butanediol 1.4- Butanediol Potassium Hydroxide Refined Water (Revised 3 2 1 3 3 3 1 50.1 0.05 Appropriate amount 3 3 3 0.2 Make the whole 100 The amount is heated to dissolve the oil phase part of A and the water phase part of B under 701, and A is added to B to emulsify it. Then it is cooled to obtain a cream. The paper scale is applicable to China National Standard (CNS) Λ4 specification 210 X 297 mm) 66 1 III n set n I (please read the notes on the back before filling in this page) ί A7 B7 5. Description of invention (64 Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs Printed examples?}-4 : # 窓 Roasted oil (Bismuth 1 Bis carboxyvinyl polymer 0.3 1,3-butanediol 25 1,4-butanediol 15 glycerin 30 triethanolamine 3.5 p〇e (6〇) hardened m sesame oil 0.5 vitamin A 0.1 Squalane 1 α-tocopherol 0.01 Methyl paraben 0.2 Ethanol 6 Refined water makes the whole 100 for example Gs: Water (severe heat%) 1,3-butanediol 5 ethanol 7 P0E (50) oleyl ether 0.5 oleyl alcohol 0.002 vitamin A 0.0001 BHT 0.001 citric acid 0.03 citrate trisodium 0.07 methyl paraben 0.1 Diaminotetraacetic acid dinaphthyl 0.03 (please read the notes on the back and fill in this page) • Install ·

1T 絲 本紙杀尺度通用中國國家標準（CNS ) A4規格（21〇Χ29?公釐） 五、發明説明（651T silk paper killing standard General Chinese National Standard (CNS) A4 specification (21〇Χ29? Mm) V. Invention description (65

精製水 啻掄例Q-fi :油焙 維生素A 2-乙基己酸三甘油酯 橄攬油 BHT α -生育酚 1,3-丁二醇 角鯊烷 蓄施例9-7 :夜霜 凡士林 角鯊烷 流動石蟠 辛酸鲸撖酯 單油酸甘油酯 Ρ〇Ε(5)硬化Μ麻油 丁基對羥苯甲酸 維生素A A7 B7 使全體為100之置 (重暑弘） 1 69 10 1 9 5 5 (重鼉％ ) 4 15 5 5 4 1 0.2 ---------批衣------、1T------^ » (請先閱讀背面之注意*..丹填寫本頁) < 經濟部中央標準局員工消費合作杜印製 1,4-丁二醇 2 1，3-丁二醇 8 甘油 12 乙二胺四乙酸三鈉 0.03 精製水 使全醱為100之置 實施例9-3〜9-7之皮*外用組成物於日常生活使用中 本纸張尺度適用中國國家標準（CN’S 1 Α4規格（210Χ 297公釐） 68 A7 B7 五、發明説明（66 ) 為具維生素A之安定性佳者。 如上所述》本發明之皮虜外用組成物中調配丁二醇與 油溶性抗氧化剤可顯著提高维生素A之安定性。 審淪 M 1Q-1 . 10-2¾ hh 較例 10-1 . 10-2 於40t下將生育酚、辛基甲氧基桂皮酸酯、油醇、甲 基對羥苯甲酸、P0E(20)辛基十二醚完全溶解於乙酵中後 ，迅速冷卻成為醇部，使其他成分溶解於精製水中而成為 水部，將醇部加入水部後，密封於褐色玻璃製試樣管内， 再以鋁箔包住完全遮光，而保存於4〇1〇丨§溫槽中。 ---------t ! * (請先閲讀背面之注意事P卉填寫本頁) 訂------^ 經濟部中央標準局員工消費合作杜印褽 本紙張尺度適用中國國家揉準（CNS ) A4現格（210x:97公廣） 302284 at B7 五、發明説明（67 ) 弃10-1 :化妝水中：> 雑牛袤A的右宙袢測宙结里（重g弘） 實施例 實施例 比較例 比較例 10- 1 10-2 10-2 10-1 雄生素A 0.001 0.001 0.001 0.001 油醇 0.005 0.005 0.005 0.005 辛基甲氧基桂皮酸酯 - -2 0.001 - 二苯甲酮-5 0.001 0.01 - - 二苯甲嗣-3 - - - 0.01 P0E(20)辛基十二基醚 0.8 0.8 0.8 0.8 乙醇 18 18 18 18 甘油 3 3 3 3 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 榨檬酸 0.03 0.03 0.03 0.03 檸樣酸三鈉 0.07 0.07 0.07 0.07 乙二胺四乙酸三鈉 0.02 0.02 0.02 0.02 精裂水 使: έ體爲100: 之量 維生素A定量值 調製之後（％) 100 100 100 100 40C 1個月後（％) 92 95 49 52 維生亩署方法 ---------私本------tl------# (請先閲讀背面之注意t..-tr填寫本頁) { 經濟部中央標準局負工消费合作杜印裝 依曰本蕖局方（第十一修正）維生素A定量法第2法 ，使用異丙酵並藉吸光度測定法實施定量。 實施例10-1及10-2與比較例相較，可提高維生素A之 安定性，此係依本發明添加水溶性二苯甲酮化合物後之效 果。 70 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） A7 B7 經濟部中央標準局員工消費合作社印製 五、發明说明（68 ) 押伸;刺10-·?〜10-4哥卜較例10-3〜1Ω-4 審1Ω-?:乳液配方及雒生素A宙畺结里（重 實施例 實施例 比較例 比較例 10- 3 10- 4 10- 3 10- 4 維生素A 0.3 0.01 0.3 0.01 BHT 0.05 0.01 0.05 0.01 dl-a -生育紛 0.01 0.02 0.01 0.02 二苯甲嗣-5 0.1 0.05 - - 二苯甲醑-9 - 0.05 - - 辛基甲氧基桂皮酸醋 - - 0.1 - 甲氧基苯甲醯基甲烷· - - 0.1 異辛酸鲸蟠酯 10 7 10 7 角鯊烷 5 5 5 5 鲸蟠醇 2 2 2 2 凡士林 I I I I 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 P0E(60)硬化S麻油 1.3 1.3 1.3 1.3 羧乙烯基聚合物 0.2 0.3 0.2 0.3 荷性鉀 0.06 0.08 0.06 0.08 甘油 10 10 10 10 丙二酵 3 3 3 3 乙基對羥苯甲酸 0.2 0.2 0.2 0.2 精裂水 使' έ趙為100. 之Μ 維生素A定量值 調裂之後（％) 100 100 100 100 40t： I餹月後（％) 97 99 29 22 (1,1-二甲基乙基）-4·-甲氧基二苯甲酿甲按 ---------裝I # (請先閲讀背面之注意1^„再填寫本頁 訂 71 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 302284 A7 B7 五、發明説明（69 ) 經濟部中央標隼局負工消費合作社印製 於7〇υ下将含BHT、生育酚之各油性成分與界面活性 劑完全溶解後，乳化之前，將維生素Α完全溶解成為油相 〇 將甘油、丙二醇、羧乙烯基聚合物、苛性鉀、二苯甲 酮-9及二苯甲銅-5完全溶解於精製水中，並加溫至7010而 成水相，將油相加入水相後Μ均質型乳化機乳化之，然後 ，Μ熱交換機進行冷卻處理至30t：，而得乳液。 將乳液充《至塗覆有金屬膜之玻瓖瓶，密封之而保存 於40=0恆溫槽中。 實施例10-3及10-4與比較例相較，可提高雒生素A之 安定性，此係本發明之效果。 雄半宙鼉方法 使用乙醇，並藉325nn之吸光度測定法進行測定。分 別從實施例、比較例調製除去维生素A後之試料，測定 325nn之吸收，以修正作為基劑之吸光度。 (實施例、比較例試料之325nra的吸光度）-（除去 品之吸光度）=維生素A之吸光度 於計算時，使吸收極大325nm，E(l%，lcm)= 1835。 審掄例10-5 :化妝永 (重鼉％ ) 油酵 0.002 維生素A 0.0001 P0E(50> 油謎 0.07 乳酸 0.001 檸檬酸三納 0.09 本紙張尺度適用中國國家橾準（CNS ) A4規格（210 X 公釐） 72 (請先閱讀背面之注意Wv,丹填寫本頁) 302284 A7 B7 五、發明説明（70 ) 經濟部中央橾準局員工消費合作杜印製 乙醇 甘油 甲基對羥苯甲酸 二苯甲嗣-12 二苯甲嗣-5 精製水 奮旃例1 Ο-fi :油揞 2-乙基己酸三甘油酯 肉豆蔻酸異丙酯 肽酸二丁酯 维生素A 二異硬脂酸二甘油酯 二丙二醇 二苯甲酮-4 檸檬酸三納 窨掄俐1 fl-7 :乳m 角鯊烷 2-乙基己酸三甘油酯 肉豆蔻酸異丙酯 ct -生育酚 維生素A 凡士林 丁基對羥苯甲酸 丙基對羥苯甲酸 2.5 使全體為100之童 (重冊％ ) 34 35 10 1 5 14.997 0.001 0.002 (重畺 15 8 7 0.05 0.3 ---------批衣------t------@ * (請先閱讀背面之注意«.,..舟填寫本頁) 一 本纸張尺度適用中國國家標準（CMS ) A4規格（210X 297公釐） 73 A7 B7 五、發明説明（71 ) 油酸單甘油酯 3 二異硬脂酸二甘油酯 2 PEG400二油酸酯 1 甘油 10 二丙二醇 5 乙二胺四乙酸二納 0.01 二苯甲酮-4 0.03 三乙醇胺 0.04 精製水 使全體為100之量 窗旆例10-8 :油凝暖 (重噩备） 2-乙基己酸三甘油酯 60 P0E(20)辛基十二醚 16 维生素A 0.1 甘油 16 二苯甲銅-5 0.05 精製水 使全髓為100之量 (請先閲讀背面之注意事i+<填寫本頁) 、-'β 經濟部中央標準局員工消費合作社印製 實施例10-5〜10-8之皮虜外用組成物在曰常的使用上 為具維生素A之安定性佳者。 如上所述，本發明之皮虜外用組成物中調配水溶性二 苯甲酮条化合物可明顯提高雒生素A之安定性。 窨掄期m -1〜ή 屮較例li-i 本紙浪尺度適用中國國家標率（CNS ) A4規格（210X29”公釐） 74 五、發明説明（72 ) A7 B7 經濟部中央揉準局員工消费合作社印製 表11-1 :乳液雄牛袤A的安宙袢測宙结里（重谨 實施例 11-1 資施例 11-2 實施例 11-3 比較例 11 - 1 精製水 使: έ髏爲100. 之量 甘油 10 10 10 10 羧乙烯基聚合物 0.2 0.2 0.2 0.2 精胺酸 0.21 0.28 0.42 0.06 苛性鉀 - - - 0.06 乙醇 5 5 5 5 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 鲸嫌醇 2 2 2 2 凡士林 3 3 3 3 角鯊烷 5 5 5 5 肉豆盏酸異丙酯 4 4 4 4 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 PE0(60)硬化Μ麻油 2 2 2 2 丁基羥基甲苯 0.05 0.05 0.05 0.05 維生素A 0.3 0.3 0.3 0.3 pH(25t：) 5.7 6.6 7.4 5.8 維生素A定Λ值 調製之後（％> 100 100 100 100 401C 1個月後（％) 90 92 95 71 實施例1卜1、11-2及11-3與比較例相較，可提高维 生素A之安定性，此係本發明之效果。 本纸乐尺度適用中國國家標準（CNS ) A4規格（210X %公釐） ~ -ί 0 ~ ---------t------IT------.^ (請先閲讀背面之注意1 再填寫本頁) < A7 B7 五、發明説明（73 雄牛j£A：>亩鼉方法 依曰本藥局方（第十一修正）維生素A定量法第2法 ，使用異丙醇並藉吸光度測定法進行定量。 經濟部中夬標準局員工消費合作社印策 奮掄例1卜4:乳15 A. 鲸蟠酵 單硬脂酸甘油酯 P0E(25)十六醚 硬脂酸 凡士林 橄攬油 肉豆蔻睃異丙酯 角鯊烷Example of purified water Q-fi: oil baking vitamin A 2-ethylhexanoic acid triglyceride olive oil BHT α-tocopherol 1,3-butanediol squalane storage Example 9-7: night cream petrolatum Squalane mobile squalene octanoate cetyl ester glycerol monooleate P〇E (5) hardening Μ sesame oil butyl p-hydroxybenzoate vitamin A A7 B7 set the whole to 100 (Shishuhiro) 1 69 10 1 9 5 5 (weight percent) 4 15 5 5 4 1 0.2 --------- batch clothing ------, 1T ------ ^ »(please read the notes on the back first *. . Dan fills in this page) < Employee consumption cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs Du Printed 1,4-Butanediol 2 1,3-Butanediol 8 Glycerin 12 Ethylenediaminetetraacetic acid trisodium 0.03 Refined water to make full It is 100 for the skins of Examples 9-3 to 9-7. The external composition is used in daily life. The paper standard is applicable to the Chinese national standard (CN'S 1 Α4 specification (210Χ 297 mm) 68 A7 B7 V. Description of the invention (66) It is the one with good stability of vitamin A. As mentioned above, the stability of vitamin A can be significantly improved by blending butanediol and oil-soluble antioxidants in the skin-use external composition of the present invention. Judgment M 1Q- 1. 10-2¾ hh Comparative example 10-1. 10- 2 Dissolve tocopherol, octyl methoxycinnamic acid ester, oleyl alcohol, methylparaben, and POE (20) octyl dodecyl ether in ethyl fermentation at 40t, then quickly cool into the alcohol part. The other components were dissolved in purified water to become the water part. After the alcohol part was added to the water part, it was sealed in a brown glass sample tube, and then covered with aluminum foil to completely shield it from light, and then stored in a 4010 ° C warm bath. --------- t! * (please read the notes on the back of P Hui to fill in this page first) Order -------- ^ Employee consumption cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs National Rubbing Standard (CNS) A4 present grid (210x: 97 public broadcasting) 302284 at B7 5. Description of the invention (67) Discard 10-1: Make-up water: > The right side of the 雑 牛 褤 A measuring the knot (weight ghong) Examples Examples Comparative Examples Comparative Examples 10- 1 10-2 10-2 10-1 Androgen A 0.001 0.001 0.001 0.001 Oleyl alcohol 0.005 0.005 0.005 0.005 Octylmethoxycinnamate--2 0.001-di Benzophenone-5 0.001 0.01--Dibenzophenone -3---0.01 P0E (20) octyl dodecyl ether 0.8 0.8 0.8 0.8 Ethanol 18 18 18 18 Glycerin 3 3 3 3 A Paraben 0.1 0.1 0.1 0.1 Citric acid 0.03 0.03 0.03 0.03 Trisodium citrate 0.07 0.07 0.07 0.07 Trisodium ethylenediaminetetraacetic acid 0.02 0.02 0.02 0.02 Severe water makes: the body is 100: the amount of vitamin A is quantitative After value modulation (%) 100 100 100 100 40C 1 month later (%) 92 95 49 52 Method of living acreage --------- private book ------ tl ----- -# (Please read the notes on the back t ..- tr to fill in this page) {The Central Standards Bureau of the Ministry of Economic Affairs, the negative labor consumption cooperation, Du Yinzhuang, according to the Japanese Bureau (Eleventh Amendment) Quantitative Method of Vitamin A Method 2 , Using isopropyl fermentation and quantification by absorbance measurement. Compared with Comparative Examples, Examples 10-1 and 10-2 can improve the stability of vitamin A. This is the effect of adding a water-soluble benzophenone compound according to the present invention. 70 This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 mm) A7 B7 Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of invention (68) Extrusion; thorn 10-? ~ 10-- 4Comparative example 10-3 ~ 1Ω-4 Examination 1Ω- ?: Emulsion formulation and serotonin A Zhoujili (heavy example embodiment example comparative example comparative example 10- 3 10- 4 10- 3 10- 4 Vitamin A 0.3 0.01 0.3 0.01 BHT 0.05 0.01 0.05 0.01 dl-a-Fertility 0.01 0.01 0.02 0.01 0.02 Dibenzophenone-5 0.1 0.05--Dibenzophenone-9-0.05--Octylmethoxycinnamate- -0.1-Methoxybenzyl methane ·--0.1 Cetyl isooctanoate 10 7 10 7 Squalane 5 5 5 5 Cetyl alcohol 2 2 2 2 Vaseline IIII Glyceryl monostearate 1.5 1.5 1.5 1.5 P0E (60) hardened S sesame oil 1.3 1.3 1.3 1.3 Carboxyvinyl polymer 0.2 0.3 0.2 0.3 Potassium potassium 0.06 0.08 0.06 0.08 Glycerin 10 10 10 10 Malonase 3 3 3 3 Ethyl paraben 0.2 0.2 0.2 0.2 refined Splitting the water 'Ezhao is 100. The quantitative value of M vitamin A after cracking (%) 100 100 100 100 40t: after I month (%) 97 99 29 22 (1,1-Dimethylethyl) -4 · -Methoxydibenzyl alcohol Press --------- install I # (please read the notes on the back 1 ^ „ Fill in this page to order 71. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X 297mm) 302284 A7 B7 V. Description of invention (69) Printed under 7〇υ by the Ministry of Economic Affairs Central Standard Falcon Bureau Unemployment Consumer Cooperative After completely dissolving the oily ingredients containing BHT and tocopherol and the surfactant, before emulsification, completely dissolve vitamin A into the oil phase. Glycerin, propylene glycol, carboxyvinyl polymer, caustic potassium, benzophenone-9 And copper dibenzoate-5 is completely dissolved in purified water and heated to 7010 to form an aqueous phase. After the oil phase is added to the aqueous phase, the M homogeneous emulsifier emulsifies it, and then the M heat exchanger is cooled to 30t :, The emulsion is obtained. Fill the emulsion into a glass flask coated with a metal film, seal it and store it in a 40 = 0 constant temperature bath. Compared with the comparative example, Examples 10-3 and 10-4 can improve the growth The stability of element A is the effect of the present invention. The method of male half-sperm is using ethanol and measured by the absorbance method of 325nn. The samples after removing vitamin A were prepared from Examples and Comparative Examples, respectively, and the absorption of 325nn was measured to correct the absorbance as a base. (Absorbance of 325nra of the samples of Examples and Comparative Examples)-(absorbance of the removed product) = absorbance of vitamin A In the calculation, the absorption is maximized at 325nm, and E (l%, lcm) = 1835. Examination Example 10-5: Makeup Yong (% of weight) Oily yeast 0.002 Vitamin A 0.0001 P0E (50 > oil mystery 0.07 lactic acid 0.001 citric acid three sodium 0.09 This paper scale is applicable to China National Standards (CNS) A4 specifications (210 X Mm) 72 (please read the note on the back of Wv, Dan fills in this page first) 302284 A7 B7 V. Description of invention (70) Employee consumption cooperation of Central Central Bureau of Economic Affairs of the Ministry of Economic Affairs to produce ethanol diglycerin methylparaben diphenyl Meji-12 Dibenzophenone-5 Refined water Example 1 Ο-fi: oleo 2-ethylhexanoic acid triglyceride isopropyl myristate peptidic acid dibutyl ester vitamin A diisostearic acid di Glycerol dipropylene glycol benzophenone-4 citrate trinaphthalene 1 fl-7: milk m squalane 2-ethylhexanoic acid triglyceride isopropyl myristate ct-tocopherol vitamin A petrolatum Based on para-hydroxybenzoic acid Propyl para-hydroxybenzoic acid 2.5 Make the whole child 100 (rebook%) 34 35 10 1 5 14.997 0.001 0.002 (Heavy weight 15 8 7 0.05 0.3 ----- ------ t ------ @ * (please read the notes on the back «.... to fill out this page) A paper standard is applicable to the Chinese National Standard (CMS) A4 specification (21 0X 297 mm) 73 A7 B7 V. Description of the invention (71) Monoglyceride oleate 3 Diglyceryl diisostearate 2 PEG400 dioleate 1 Glycerin 10 Dipropylene glycol 5 Ethylenediaminetetraacetic acid bis0.01 0.01 Benzophenone-4 0.03 Triethanolamine 0.04 Refined water to make the total amount of 100 window example 10-8: oil condensing warm (heavy preparation) 2-ethylhexanoic acid triglyceride 60 P0E (20) octyl twelve Ether 16 Vitamin A 0.1 Glycerin 16 Copper dibenzoate-5 0.05 Refined water to make the whole pith amount to 100 (please read the notes on the back first i + < fill in this page), -'β Ministry of Economy Central Standards Bureau employee consumption Cooperatives printed examples 10-5 to 10-8 of the skin-use composition for external use, which has good stability in vitamin A. As mentioned above, the skin-use composition for external use of the present invention is formulated with water solubility The benzophenone strip compound can significantly improve the stability of Luoshengsu A. The period of m-1 -1 ~ ή 屮 Comparative example li-i This paper wave scale is applicable to China ’s national standard rate (CNS) A4 specification (210X29 ”mm) 74 V. Description of the invention (72) A7 B7 Printed watch 11-1 by the Employee Consumer Cooperative of the Central Kneading Bureau of the Ministry of Economy: Emulsion The measurement of the anxiety of the wormhole A (the example 11-1, the example 11-2, the example 11-3, the comparison example 11-1, the purified water: 100% of the glycerin 10 10 10 10 Carboxyvinyl polymer 0.2 0.2 0.2 0.2 Arginine 0.21 0.28 0.42 0.06 Caustic Potassium---0.06 Ethanol 5 5 5 5 Methylparaben 0.1 0.1 0.1 0.1 Cetyl alcohol 2 2 2 2 Vaseline 3 3 3 3 Angle Squalane 5 5 5 5 isopropyl myristate 4 4 4 4 glyceryl monostearate 1.5 1.5 1.5 1.5 PE0 (60) hardened sesame oil 2 2 2 2 butylhydroxytoluene 0.05 0.05 0.05 0.05 vitamin A 0.3 0.3 0.3 0.3 pH (25t :) 5.7 6.6 7.4 5.8 After modulation of vitamin A set Λ value (%> 100 100 100 100 401C 1 month later (%) 90 92 95 71 Example 1 Bu 1, 11-2 and 11- 3 Compared with the comparative example, the stability of vitamin A can be improved, which is the effect of the present invention. This paper music scale is applicable to China National Standard (CNS) A4 specification (210X% mm) ~ -ί 0 ~ --------- t ------ IT ------. ^ ( Please read Note 1 on the back first and then fill out this page) < A7 B7 V. Description of invention (73 male cattle j £ A: > Mulu method according to the Japanese Pharmacopoeia (Eleventh Amendment) Vitamin A Quantification Method Method 2, using isopropanol and quantification by absorbance measurement. Ministry of Economic Affairs, China Bureau of Standards and Employee Consumer Cooperatives, printed policy examples 1 Bu 4: milk 15 A. Whale fermented glyceryl monostearate P0E (25) Cetyl ether stearate petrolatum olive oil nutmeg isopropyl squalane

維生素AVitamin A

BHT 香料 B. 丙二酵 氫氧化鉀 精胺酸 精製水 (重噩鉍） 3 2 2 3 2 3 3 5 0. 1 0.05 適置 3 0.27 0.001 使全鼸為100之量 於701C下分別加熱溶解A之油相部分與B之水相部分 ，將A加入B乳化之。然後進行冷卻處理而得乳霜。（pH =7.3) 童施例114 :羔兹纗油 (n%%\ 羧乙烯基聚合物 0.4 ,6 一 本紙張尺度適用中國國家標準（CNS ) A4現格（210X 297公釐） 五、發明説明（74 ) A7 B7 經濟部中央標隼局員工消费合作社印裝 甘油 丙二醇 離胺酸 精胺酸 P0E(60)硬化E麻油 維生素A 角鯊烷 α -生育酚 甲基對羥苯甲酸 乙醇 精製水 窨施例11 -fi :仆，妝太 甘油 乙醇 P0E(50)油醚 油醇 維生素A 乳酸 精胺酸 鳥胺酸鹽酸鹽 甲基對羥苯甲酸 精製水 5 50, .05 .05 0.2 6 使全驩為100之量 (請先閱讀背面之注意C.奸填寫本頁) .裝. pH = 6 pH = 6 本纸伕尺度適用中國國家標準（CNS ) Λ4規格（210X 297公釐） -9 70. .002 .0001 .003 使全鼸為100之量 77 線 五、發明説明（75 A7 B7 經濟部中央標準局員工消費合作社印製 奮掄例1 1 -7 :油魅暖 維生素A 2-乙基己酸三甘油酯 橄欖油 BHT BHA P0E(20)辛基十二醚 離胺酸鹽酸鹽 精製水 奮旃例1 1 -8 :海箝 固髏石蟠 撤晶蟠 蜂蟠 角鯊烷 2-乙基己酸三甘油酯 二異肉豆蔻酸二甘油酯 PEG400二異硬脂酸 丙基對羥苯甲酸 維生素A 甘油 丙二醇 精胺酸 吡咯酮羧酸 PH= 5.5 0.5 40 10 0.1 0.05 16 15 使全醱為100之量 (重優％ ) 1 2 1 15 10 3 1 10 4 裝1τ·" (請先閱讀背面之注意t I填寫本頁) ( 本紙張尺度適用中國國家揉準（CMS ) A4規格（210 X 297公釐） 78 302284 A7 B7 五、發明説明（76 ) 精製水 使全髏爲100之量 實施例11-4〜11-8之皮虜外用組成物於日常生活使用 上爲具维生素A之安定性佳者。 本發明之皮虜外用組成物中調配鹼性胺基賅及/或其 鹽可明顯提高維生素A之安定性。 審瀹俐12-1〜12-.?好卜hi?例12-1 弃12-1 :乳液中：>嫌牛袤A的夯宙袢潮宝结果（重噩 實施例 12-1 實施例 12-2 實施例 12-3 比較例 12- 1 精製水 使: έ體為100: 之量 甘油 10 10 10 10 羧乙烯基聚合物 0.2 0.2 0.2 0.2 苛性鉀 0.06 0.06 0.06 0.06 乙醇 5 5 5 5 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 鲸蠘醇 2 2 2 2 鯊肝醇 1 1 1 1 凡士林 3 3 3 3 角鯊烷 5 5 5 5 肉豆蔻酸異丙酯 4 4 4 4 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 PE0(60>硬化m麻油 2 2 2 2 BHT 0.03 0.03 0.03 0.03 乙二胺四乙酸三鈉 0.02 - - - 天冬胺酸精胺酸鹽 0.03 0.5 0.01 - 穀胺酸單納 - 0.3 0.3 0.3 維生素A 0.3 0.3 0.3 0.3 維生素A定量值 調製之後（％) 100 100 100 100 40t： 2値月後（％) 90 96 90 69 實施例12-1、12-2及12-3與比較例相較，可提高维生 經濟部中央標準局員工消费合作杜印裝 79 (請先閱讀背面之注意事/办填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 五、發明説明（77 A7 B7 素A之安定性，此係本發明之效果。 維牛袤A夕亩晉方法 依曰本薄局方（第十一修正）維生素A定量法第2法 ，使用異丙醇並藉吸光度測定法進行定量。 裝"I各 (請先Μ讀背面之注意更·'填寫本頁) ( 經濟部中央標準局員工消費合作社印装 謇掄例 12-4:31. 35 A. 鲸蟠醇 單硬脂酸甘油S旨 P0E(25)十六醚 硬脂酸 凡士林 橄攬油 肉豆蔻酸異丙酯 角鯊烷 維生素A BHT 香料 B. 丙二酵 氫氧化押 毅胺酸單納 精製水 f重鼉％ ) 3 2 13 3 3 15 0.1 0.05 適董 3 0.2 5 使全®為100之量 於7010下分別將A之油相部分與B之水相部分完全溶 解，將A加入B乳化之，然後，冷卻處理而得乳箱。 竇旃例12-S :笔鸾鴆油 (重量％ ) 羧乙烯基聚合物 〇.4 本紙張尺度逋用中國國家標準（CN'S ) Α4規格（2Ι0Χ：^公釐） 80 五、發明説明（78 ) A7 B7 經濟部中央標準局員工消费合作杜印製 甘油 丙二醇 天冬胺酸精胺酸鹽 三乙醇胺 P0E(60)硬化Μ麻油 維生素A 角鯊烷 α -生育酚 甲基對羥苯甲酸 乙醇 精製水 啻旆例1 2-ft :仆妝水 甘油 乙醇 P0E(50)油醚 油醇 維生素A 乳酸 天冬胺酸 乳酸 乳酸納 甲基對羥苯甲酸 精製水 奮掄例12-7 :油凝圃 .001 3.4 0.5 0.001 1 10.2 6 使全體爲100之量 (重鼉％ ) 2 0.002 0.0001 0.003 0.001 0.02 使全體為100之量 (重量％ ) ---------1------IT------.^ * (請先閲讀背面之注意事 { ^填寫本頁) { 本紙張尺度適用中國國家標準（CNS ) Λ4規格（210X 297公釐） 81 302284 A7 B7 五、發明説明（79 ) 經濟部中央標準局員工消費合作社印製 維生素A 1 2-乙基己酸三甘油酯 40 橄攬油 19 BHT 0. 1 BHA 0.05 P0E(20)辛基十二醚 16 甘油 15 穀胺酸鈉 0.01 精製水 使全體爲100之 奮旃例1 2-8 : _裒液 (重鼉) 維生素A 0.3 肉豆蔻酸異丙酯 3 P0E(60)硬化居麻油 0.6 蒼耳烷膠 0.8 甘油 30 丙二醇 5 吡咯酮羧睃納（50%液） 20 乙醇 6 乙基對羥苯甲酸 0.1 精製水 使全體為100之 *旃例1 2-9 :疼霜 (mm%) 角鯊烷 15 撤晶蟠 4 肉豆蔻酸異丙酯 5 (請先閱讀背面之注意事{"'填寫本頁) 本紙張尺度適用中國國家標準（CN'S ) A4規格ί 210X 297公釐） 82 五、發明説明（80 凡士林 辛基十二醇 丁基對羥苯甲酸 雒生素A 二異硬脂酸二甘油酯 甘油 甘油 丙二醇 穀胺酸單納 精製水 A7 B7 4 2 15 4 3 12 3 1 使全體為100之量 實施例12-4〜12-9之皮虜外用組成物於日常生活使用 上為具維生素A之安定性佳者。 本發明之皮庸外用組成物中調配酸性胺基酸及其鹽可 明顯提高維生素A之安定性。 奮旆例1 3-1〜1 酧例1.VI〜1 3-2 ---------t------ΐτ------# (請先閱讀背面之注意良 <：填寫本頁) 《 經濟部中央標準局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 83 經濟部中央標準局員工消費合作社印装 A7 B7 五'、發明説明（81 ) 券1.V1 :油成分由：>維生袤A：>安亩袢潮宙结里（簠暑鉍) 實施例 實施例 實施例 比較例 比較例 13-1 13-2 13-3 13-1 13-2 維生素A 1 1 1 1 1 季戊四醇g盲 99 49 - - - 三甲醇基丙烷酯 - 50 99 - - 角鯊烷 異辛酸鯨蟠酯 - - - 99 99 維生素A定量值 調製之後(％) 99 100 99 100 100 40T 1個月後(％) 96 94 92 40 51 季戊四酵酯：季戊四醇-四（2-乙基己酸）酯 三甲醇丙烷酯：三甲酵丙烷-三（2-乙基己酸）酯 雒Φ袤A：>^噩方法 依曰本藥局方（第十一修正）維生素A定量法第2法 ，使用異丙醇並藉吸光度測定法實施測定。 實施例13-1、13-2及13-3與比較例相較，可提高維生 素A之安定性，此係本發明之效果。 奮淪俐1.?-夂 13-5¾屮齡例13-3、1 3-4 於601C下将BHT及生育酚完全溶解於各油成分中後， 冷卻至401C。然後將維生素A完全溶解，密封於褐色玻璃 製試樣管中，保存於40C恆溫槽内。 本紙浪尺度適用中國國家橾準（CNS ) A4規格（210X：：97公釐） I 裝 111 訂 11 I Λ&. (請先閲讀背面之注意事t-f.填寫本頁) ( 84 A7 B7 五、發明説明（82 ) 券1.?-?.:化妝油5R方及維生素宙袢湖亩结罢（簠霣鉍） 實施例 13-4 實施例 13-5 比較例 13-3 比較例 13-4 三甲醇基丙院 75 10 - - 三（2-乙基己酸）酯 季戊四醇四（2-乙基 - 80 - - 己酸）酯 二甲基聚矽氧垸 - 9.76 - 39.76 肉豆蔻酸異丙酯酸酯 - - 15 60 角鯊烷 24.985 - 84.985 - 维生素A 0.01 0.2 0.01 0.2 BHT 0.005 0.03 0.005 0.03 d 1- ot -生育紛 - 0.01 - 0.01 維生素A定量值 調裂之後（％) 100 100 100 100 401C 2痼月後（％) 96 97 59 73 -- —— 豸 (請先閱讀背面之注意事t-h填寫本頁) -a 經濟部中央標準局員工消费合作社印装 實施例13-4及13-5與比較例相較，可提高維生素A之 安定性*此係本發明之效果。 奮施例13-6、1·?-7好hh »期M.H 靱法盅a麽 試输方法 於70t：下將BHT、生育酚及各油性成分與界面活性劑 完全溶解後，乳化之前，将维生素Α完全溶解而成油相。 將甘油、丙二酵、羧乙烯基聚合物、苛性鉀完全溶解 本紙浪尺度適用中國國家標隼（CNS ) A4規格（2I0X297公釐） 85 A7 B7 五、發明説明（83 ) 於精製水中，於加溫至70C之水相中加入油相，以均質型 乳化機乳化之。然後，以熱交換機實施冷郤處理至301C， 而得乳液。 將乳液充镇至塗覆有金屬膜之玻璃瓶内，密封後保存 於4〇υ恆溫槽中。 經濟部中央樣準局員工消費合作杜印製 羌:乳液配方好維牛袤a亩鼉结果（重a%) 實施例 實施例 比較例 比較例 13-6 13- 7 13-5 13- 6 三甲醇基丙烷 三（2-乙基己酸）酯 10 4 - - 季戊四酵三（2-乙 基己酸）S旨 ~ 3 — BHT 0.05 0.01 0.05 0.01 dl-cc -生育酚 0.01 0.02 0.01 0.02 維生素A 0.3 0.01 0.3 0.01 異辛酸鲸蟠酯 - 10 7 角鯊烷 5 2 2 2 鲸蟠醇 2 2 2 2 凡士林 1 1 1 1 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 P0E(60)硬化g麻油 1.3 1.3 1.3 1.3 羧乙烯基聚合物 0.2 0.3 0.2 0.2 荷性鉀 0.06 0.06 0.06 0.06 甘油 10 10 10 10 丙二醇 乙基對羥苯甲酸 0, 0, 0, 0, 精製水 使: έ體爲100: 之量 維生素A定量值 調製之後（％) 100 100 100 100 40t 1値月後（％〉 98 96 32 25 實施例13-6及13-7與比較例相較，可提高維生素A之 (請先閲讀背面之注意事r-·-».填寫本頁) 本紙浪尺度適用中國國家橾準（CNS ) Λ4規格（210X297公簦） 86 302284 A7 B7 五、發明説明（84 ) 安定性，此係本發明之效果。 雄Φ表A之定鼉方法 使用乙醇，藉325nm之吸光度測定法進行測定。於計 經濟部中央橾準局員工消費合作社印製 請先閲讀背面之注意事i-t.填寫本頁) 算時，使吸收極大值325nm，E(l%， 1cm)= 1835 0 *掄《im-8 :化妝水 (簠暑私） 季戊四醇四癸酸酯 0.002 δ -生育酚 0.001 α -生育®) 0.0005 維生素A 0.0001 P0E(50)油醚 0.7 乳酸 0.1 乳酸鈉 0.9 乙醇 5 甘油 1 甲基對羥苯甲酸 0.2 乙二胺四乙酸三納 0.01 精製水 使全體為100之置 奮掄例13-9油1 ί重詧私） 季戊四醇四（2-乙基己醴〉酯 60 三甲醇丙烷三己酸酯 10 角鯊烷 10 BHT 1 α -生育酚 9 維生素A 5 本紙張尺度適用中國國家標準（CNS ) A4規格（21 〇 X 297公I ) 87 -Q 7 - 五、發明説明（85 審旆例1.1-10 :乳m 2-乙基己酸三甘油酯 季戊四醇四（2-乙基己酸〉酯 BHT BHA α -生育酚 維生素A 凡士林 角鯊烷 丁基對羥苯甲酸 丙基對羥苯甲酸 油酸單甘油酯 二異硬脂酸二單油酯 PEG400二油酸酯 甘油 二丙二醇 精製水 A7 B7 (番署鉍） 10 15 0.05 0.010.01 8 0.1 0. 1 3 2 1 10 5 使全黼為100之置BHT spice B. Malonanase potassium hydroxide arginine acid purified water (heavy bismuth) 3 2 2 3 2 3 3 5 0. 1 0.05 suitable 3 0.27 0.001 Make the whole mule amount to 100 and heat and dissolve separately at 701C Add the oil phase part of A and the water phase part of B to A to emulsify it. Then it is cooled to obtain a cream. (PH = 7.3) Tong Shi Example 114: Lazizi oil (n %% \ carboxyvinyl polymer 0.4, 6) A paper standard is applicable to the Chinese National Standard (CNS) A4 (210X 297mm). V. Invention Description (74) A7 B7 Printed Glycerin Propylene Glycol Imine Amino Acid Arginine P0E (60) Hardened E Sesame Oil Vitamin A Squalane Alpha-Tocopherol Methyl Parabens Refined Water Example 11 -fi: Serum, makeup too glycerol ethanol P0E (50) oil ether oleyl alcohol vitamin A lactic acid arginine ornithine hydrochloride methyl p-hydroxybenzoic acid purified water 5 50, .05 .05 0.2 6 Make Quanhuan a quantity of 100 (please read the note C on the back to fill in this page). Pack. PH = 6 pH = 6 The paper size is applicable to China National Standard (CNS) Λ4 specification (210X 297mm)- 9 70. .002 .0001 .003 Make the total amount of 100 yuan 77. Line five. Description of the invention (75 A7 B7 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. Examples 1 1 -7: Oil Charm. Vitamin A 2 -Ethylhexanoic acid triglyceride olive oil BHT BHA P0E (20) octyl dodecyl ether amine hydrochloride purified water hard example 1 1 -8: Sea clamp Stone flat withdrawing crystal flat bee squalane 2-ethylhexanoic acid triglyceride diisomyristic acid diglyceride PEG400 diisostearic acid propyl p-hydroxybenzoic acid vitamin A glycerin propylene glycol arginine pyrrolidone carboxylic acid PH = 5.5 0.5 40 10 0.1 0.05 16 15 Make the total amount of 100 (weight excellent%) 1 2 1 15 10 3 1 10 4 Install 1τ " (please read the note on the back t I fill in this page) ( This paper scale is applicable to the Chinese National Crushing (CMS) A4 specification (210 X 297 mm) 78 302284 A7 B7 V. Description of the invention (76) Refined water so that the total amount of bones is 100 Example 11-4 ~ 11-8 The skin-use external composition has good stability for vitamin A in daily use. The preparation of the skin-use external composition of the present invention can improve the stability of vitamin A by blending basic amine base and / or its salt. Li 12-1 ~ 12-.? Haobu hi? Example 12-1 Discarded 12-1: In the emulsion: > The result of the tampering of the trousers with the suspicion of the cowboy A (Heavy Example 12-1 Example 12 -2 Example 12-3 Comparative Example 12- 1 Purified water: 100% of the body: 10 10 10 10 Carboxyvinyl polymer 0.2 0.2 0.2 0.2 Caustic potash 0.06 0.06 0 .06 0.06 Ethanol 5 5 5 5 Methyl paraben 0.1 0.1 0.1 0.1 Cetyl alcohol 2 2 2 2 Shark liver alcohol 1 1 1 1 Vaseline 3 3 3 3 Squalane 5 5 5 5 Isopropyl myristate 4 4 4 4 glyceryl monostearate 1.5 1.5 1.5 1.5 PE0 (60> hardened sesame oil 2 2 2 2 BHT 0.03 0.03 0.03 0.03 trisodium ethylenediaminetetraacetic acid 0.02---aspartic acid spermine salt 0.03 0.5 0.01-Monoglutamine-0.3 0.3 0.3 Vitamin A 0.3 0.3 0.3 0.3 After the quantitative value of Vitamin A is adjusted (%) 100 100 100 100 40t: After 2 months (%) 90 96 90 69 Example 12-1, Compared with the comparative example, 12-2 and 12-3 can improve the consumption cooperation of the Central Standards Bureau of the Ministry of Economic Affairs and Economics. Du Printed 79 (please read the precautions on the back / fill out this page) This paper standard is applicable to Chinese national standards (CNS) A4 specification (210X297mm) V. Description of the invention (77 A7 B7 The stability of element A is the effect of the present invention. Wei Niu 螤 A Ximujin Method According to the second method of vitamin A quantification method of the thin local prescription (eleventh amendment), isopropyl alcohol was used and quantification was carried out by absorbance measurement. Pack " I (please read the note on the back first and fill in this page) (The Ministry of Economic Affairs Central Standards Bureau Employee Consumer Cooperative Printed Printed Case 12-4: 31. 35 A. Cetyl alcohol monostearic acid Glycerol S purpose P0E (25) cetyl ether stearate petrolatum olive oil isopropyl myristate squalane vitamin A BHT perfume B. malonylase benzalkonium hydroxide mono sodium purified water f%) 3 2 13 3 3 15 0.1 0.05 Suitable Dong 3 0.2 5 Make the total amount of 100 at 7010 to completely dissolve the oil phase part of A and the water phase part of B respectively, add A to B to emulsify it, and then cool it down And get a milk box. Dou Han Case 12-S: Pen Luan oil (% by weight) Carboxyvinyl polymer 0.4 This paper uses the Chinese National Standard (CN'S) Α4 specifications (2Ι0Χ: ^ mm) 80 V. Invention description (78 ) A7 B7 Ministry of Economic Affairs Central Standards Bureau employee consumption cooperation du printing glycerin propylene glycol aspartate spermine triethanolamine P0E (60) hardening M sesame oil vitamin A squalane α-tocopherol methyl parabens ethanol purification Example 1 2-ft: Serum glycerin ethanol P0E (50) oil ether oleyl alcohol vitamin A lactic aspartic acid lactic acid sodium methyl parabens purified water Example 12-7: oil condensate garden .001 3.4 0.5 0.001 1 10.2 6 Make the whole amount 100 (weight percent) 2 0.002 0.0001 0.003 0.001 0.02 Make the whole amount 100 (weight percent) --------- 1 ----- -IT ------. ^ * (Please read the notes on the back first {^ Fill in this page) {This paper size is applicable to China National Standard (CNS) Λ4 specifications (210X 297mm) 81 302284 A7 B7 V. Description of the invention (79) Printed vitamin A 1 2-ethylhexanoic acid triglyceride 40 olive oil 19 BHT 0. 1 BHA 0.05 P0E (20) octyl dodecyl ether 16 glycerol 15 sodium glutamate 0.01 purified water to make the whole 100 work hard Example 1 2-8: _ 裒 液 (重 鼍) Vitamin A 0.3 myristic acid Isopropyl ester 3 P0E (60) hardened sesame oil 0.6 Xanthan gum 0.8 Glycerin 30 Propylene glycol 5 Pyrrolidone Carboxylate (50% solution) 20 Ethanol 6 Ethyl p-hydroxybenzoic acid 0.1 Purified water to make the whole 100 * Example 1 2-9: Pain cream (mm%) Squalane 15 Removal crystal 4 Isopropyl myristate 5 (Please read the notes on the back first {" 'fill in this page) This paper size is applicable to Chinese national standards (CN'S) A4 specification ί 210X 297 mm 82 V. Description of the invention (80 Vaseline octyl dodecyl butyl p-hydroxybenzoate serotonin A diisostearate diglyceride glycerol glycerol propylene glycol glutamic acid mono sodium Purified water A7 B7 4 2 15 4 3 12 3 1 The total amount is 100. The skin external compositions of Examples 12-4 to 12-9 have the stability of vitamin A for daily use. The present invention Mixing acidic amino acid and its salt in Zhiyong external composition can obviously improve the stability of vitamin A. Example 1 3-1 ~ 1 Example 1.VI ~ 1 3-2 --------- t ------ lsτ ------ # (Please read the notes on the back first Liang <: fill out this page) "The paper standards printed by the Employees’ Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs are applicable to the Chinese National Standard (CNS) Α4 specifications (210X297 mm) 83 The A7 B7 printed by the Employees ’Consumer Cooperative of the Central Bureau of Standards 'Description of the invention (81) Voucher 1. V1: Oil composition: > Vitamin K: A > Anmuqi Chaozhou Jieli (Yishu Bismuth) Examples Examples Examples Examples Comparative Examples Comparative Examples 13-1 13-2 13-3 13-1 13-2 Vitamin A 1 1 1 1 1 Pentaerythritol g blind 99 49---Trimethanol propane ester-50 99--Squalane isooctanoate cetyl ester---99 99 After modulation of vitamin A quantitative value (%) 99 100 99 100 100 40T 1 month later (%) 96 94 92 40 51 Pentaerythritol ester: Pentaerythritol-tetrakis (2-ethylhexanoic acid) ester Trimethanol propane ester: Trimethylpropane-tris (2-ethylhexanoic acid) ester 雒 Φ 袤 A: > ^ The bad way is according to the Japanese Pharmacopoeia (Eleventh Amendment) Vitamin A Quantification Method 2nd method, using isopropanol The measurement is carried out by the absorbance measurement method. Compared with Comparative Examples, Examples 13-1, 13-2 and 13-3 can improve the stability of vitamin A, which is the effect of the present invention. Fenlunli 1.?- 夂 13-5 ¾ age example 13-3, 1 3-4 BHT and tocopherol were completely dissolved in each oil component at 601C, then cooled to 401C. Then, the vitamin A was completely dissolved, sealed in a brown glass sample tube, and stored in a 40C constant temperature bath. This paper wave scale is applicable to the Chinese National Standard (CNS) A4 (210X :: 97mm) I installed 111 ordered 11 I Λ &. (please read the notes on the back tf. Fill in this page) (84 A7 B7 V. Description of the invention (82) Voucher 1.?-?.: Cosmetic oil 5R and vitamin Chouhu Lake Mujie (簠 霣 bismuth) Example 13-4 Example 13-5 Comparative Example 13-3 Comparative Example 13-4 Trimethylolpropionate 75 10--Tris (2-ethylhexanoic acid) ester pentaerythritol tetrakis (2-ethyl- 80--hexanoic acid) ester dimethylpolysiloxane-9.76-39.76 isopropyl myristate Ester esters--15 60 Squalane 24.985-84.985-Vitamin A 0.01 0.2 0.01 0.2 BHT 0.005 0.03 0.005 0.03 d 1- ot-Fertility-0.01-0.01 After quantification of vitamin A quantitative value (%) 100 100 100 100 401C 2 months later (%) 96 97 59 73-—— 豸 (please read the precautions on the back first and fill in this page) -a Examples 13-4 and 13- Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5Compared with the comparative example, it can improve the stability of vitamin A * This is the effect of the present invention. Fen Shi Examples 13-6, 1 ·? -7 good hh »period MH 靱Cup test method at 70t: after completely dissolving BHT, tocopherol and each oily component and surfactant, before emulsification, vitamin A is completely dissolved to form an oil phase. Glycerin, malonylase, carboxyvinyl The polymer and caustic potash are completely dissolved. The paper wave scale is applicable to the Chinese national standard falcon (CNS) A4 specification (2I0X297mm) 85 A7 B7 5. Description of the invention (83) In purified water, add oil to the water phase heated to 70C Phase, emulsify it with a homogenizing emulsifier. Then, use a heat exchanger to cool to 301C to obtain an emulsion. Fill the emulsion into a glass bottle coated with a metal film, seal it and store it in a 4〇υ constant temperature bath Medium. Employee consumption cooperation of the Central Bureau of Samples of the Ministry of Economic Affairs, Du Yinqiang: Good emulsion formula, ox-bull, acres, and acres (weight a%) Examples Examples Comparative Examples Comparative Examples 13-6 13- 7 13-5 13- 6 Trimethanol propane tris (2-ethylhexanoic acid) ester 10 4--Pentaerythritol tris (2-ethylhexanoic acid) S purpose ~ 3 — BHT 0.05 0.01 0.05 0.01 dl-cc -tocopherol 0.01 0.02 0.01 0.02 Vitamin A 0.3 0.01 0.3 0.01 Cetyl Isooctanoate-10 7 Squalane 5 2 2 2 Cetyl alcohol 2 2 2 2 Vaseline 1 1 1 1 Glyceryl monostearate 1.5 1.5 1.5 1.5 P0E (60) hardened g sesame oil 1.3 1.3 1.3 1.3 Carboxyvinyl polymer 0.2 0.3 0.2 0.2 Potassium Potassium 0.06 0.06 0.06 0.06 Glycerin 10 10 10 10 Propylene Glycol Ethyl Paraben 0, 0, 0, 0, Purified water: 100%: The amount of vitamin A after modulation (%) 100 100 100 100 40t after 1 month (%> 98 96 32 25 Examples 13-6 and 13-7 are compared with the comparative example, which can increase vitamin A (please read the notes on the back r- ·-»first. Fill in this page ) This paper wave scale is applicable to China National Standard (CNS) Λ4 specification (210X297 gong) 86 302284 A7 B7 V. Description of invention (84) Stability, this is the effect of the present invention. The method for the determination of the male Φ in Table A is to use ethanol to measure by absorbance at 325 nm. Printed by the Central Committee of the Ministry of Economic Affairs and Employee Consumer Cooperatives, please read the notes on the back of it. Fill in this page) When calculating, make the absorption maximum 325nm, E (l%, 1cm) = 1835 0 * 抡 《im- 8: Make-up water (sweetness) Pentaerythritol tetradecanoate 0.002 δ -tocopherol 0.001 α -tocopherol®) 0.0005 Vitamin A 0.0001 P0E (50) oleyl ether 0.7 Lactate 0.1 Sodium lactate 0.9 Ethanol 5 Glycerol 1 Methylparaben 0.2 Ethylenediaminetetraacetic acid trisodium 0.01 Purified water to make the whole set to 100. Example 13-9 Oil 1 ί 重 詧 private) Pentaerythritol tetrakis (2-ethylhexyl alcohol) ester 60 Trimethanol propane trihexanoate 10 Squalane 10 BHT 1 α-tocopherol 9 Vitamin A 5 This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (21 〇X 297 public I) 87 -Q 7-V. Description of the invention (85 review examples 1.1- 10: Milk m 2-ethylhexanoic acid triglyceride pentaerythritol tetrakis (2-ethylhexanoic acid> ester BHT BHA α-tocopherol vitamin A Vaseline squalane butyl paraben propyl paraben oleic acid Monoglyceride diisostearate dimonooleate PEG400 dioleate glycerol dipropylene glycol Water A7 B7 (Fan Department bismuth) 0.010.01 10 15 0.05 8 0.1 of 0. The 1,321,105 device 100 so that the whole of the embroidery

--〔-------^------、玎------.^ (請先閱讀背面之注意事ί+,填寫本頁) I 經濟部中央橾準局員工消費合作杜印製 實施例13-8〜13-1Θ之皮虜外用組成物於曰常的使用 本紙浪尺度適用中國國家標隼（CNS ) Λ4規格（2!ΟΧ297公釐） 88 A7 B7 五、發明説明（86 ) 上為具维生素A之安定性佳者。 本發明之皮慮外用组成物中調配選自季戊四醇脂肪酸 脂、及三甲醇丙烷脂肪酸S旨之群中一棰或二棰以上的極性 油成分，可顙著提高雒生素A之安定性。 若依本發明，進而選自季戊四醇脂肪酸、及三甲醇丙 烷脂肪酸酯之群中極性油成份的一種或二種Μ上、與選自 丁基羥基甲苯、丁基羥基苯甲醚、α，/9.7.3 -生育酌 、去甲二氫愈創木酸、沒食子酸丙酯、維生素C脂肪酸醋 及山梨酸之群中至少一棰的油溶性抗氧化劑，可更明顯提 高維生素Α之安定性。 奮旃MU-1〜龄例14-1〜14-2 裝 i 絲 (請先閲讀背面之注意事t-1,填寫本頁) 一 經濟部中央標準局員工消费合作社印裝 S9 本紙浪尺度適用中國國家榡準（CNS ) A4規格（2丨0X297公t ) 302284 A7 B7 五、發明説明（87 ) 実1A-1 :乳液中：>雄半S A的》g袢潮宙结果（童噩9^ 實施例 14-1 實施例 14-2 比較例 14-1 比較例 14-2 精製水 使: έ體為100: 之量 甘油 10 10 10 10 乙醇 5 5 5 5 甲基對羥苯甲酸 0.1 0.1 0.1 0.1 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 POE(60)硬化苠麻油 2 2 2 2 鯨嫌醇 2 2 2 2 肉豆蔻酸異丙酯 4 4 4 4 凡士林 3 3 3 3 角鯊烷 5 5 5 5 BHT - 0.05 - 0.05 乙二胺四乙酸三納 - 0.03 - 0.03 天然撤晶高嶺土群 2 2 - - 維生素A 0.3 0.3 0.3 0.3 維生素A定量值 調製之後（％) 100 100 100 100 40¾ 1傾月後（％) 90 95 53 68 *天然微晶高嶺土群：商品名克尼比G-4 經濟部中央棣準局員工消費合作社印| (請先閲讀背面之注意花'·填寫本頁) 雄牛宙S方法 依曰本第局方（第十—修正）维生素A定量法第2法 ，使用異丙酵並以吸光測定法實施定量。 實施例14-1，14-2與比較例相較’可提高維生素A之 本紙張尺度適用中國國家標準（CMS ) A4规格（210X297公釐） 90 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（88 ) 安定性，此係本發明之效果。 粜U-2:乳麻配方场維牛袤众宙畺结里（重量鉍） 實施例 實施例 比較例 比較例 14-3 14-4 14-3 14-4 天然皂石 3 3 - - (必穋HV) 抗壊血酸 0.1 - 0.1 — ΒΗΤ 0.05 0.01 0.05 0.01 dl-α -生育紛 0.01 0.02 0.01 0.02 維生素A 0.3 0.01 0.3 0.01 異辛酸鲸蟠酯 10 7 10 7 角鯊烷 5 2 5 2 鲸镅醇 2 2 2 2 凡士林 1 1 1 1 單硬脂酸甘油酯 1.5 1.5 1.5 1.5 P0E(60)硬化昆麻油 1.3 1.3 1.3 1.3 甘油 10 10 10 10 丙二醇 甲基對羥苯甲酸 3 0.2 3 0.2 0, 0, 精製水 使: έ體為100: 之量 维生素A定量值 調製之後（％) 100 100 100 100 4010 1個月後（％) 95 92 63 51 g ^ Μ 1 A-.R :31. m ( £,¾ % ) A.鲸蟣醇 單硬脂酸甘油酯 P〇E(25)十六醚 硬脂酸 凡士林 (請先閱讀背面之注意事(.-Ϊ.填寫本頁) 、τ 本紙張尺度逋用中國國家橾準（CNS ) Α4规格（210x297公釐） 91 302284 A7 B7 3 1 5 0.1 0.05 適量 3 0.2 0. 1 0.001 使全體爲100之量 五、發明説明（89 橄攬油 肉豆蔻酸異丙酯 角鯊烷 維生素A BHT 香料 B.丙二醇 氫氧化鉀 合成皂石（商品名：史邁克頓SA) 檸檬酸 精製水 於70下分別將A之油相部分與B之水相部分加熱溶 解，將A加入B中乳化之。然後，冷郤龚理即可得乳霜。 (請先閱讀背面之注意r·再填寫本頁) 經濟部中央標準局員工消費合作社印製 啻旃例14-fi : _亥凝暖 合成水輝石（商品名：來波納XLG) 甘油 丙二醇 掙檬酸 三乙醇胺 2-羥基-4-甲氧基二苯甲嗣-5-磺酸鈉 POE(60〉硬化Μ麻油 維生素A 辛基甲氧基桂皮酸酯 甲基對羥苯甲酸 (mm%) 10 15 5 0.5 1.8 1 9 0. 92 本紙法尺度通用中國國家標準（CNS ) A4規格（210X 297公釐） 302284 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（90 ) 乙醇 3 精製水 使全體爲100之量 奮旃例14-7 :彳卜，妝水 (重鼉弘） 甘油 2 乙醇 7 P0E(50)油醚 0.5 油醇 0.002 維生素A 0.001 合成皂石（商品名：史遇克頓SA) 0.01 乳酸 0.01 乳酸納 0.09 甲基對羥苯甲酸 0.1 精製水 使全髏為100之量 奮掄俐14-8 :乳霜 (® 啬 角鯊烷 15 2-乙基己酸三甘油酯 10 橄攬油 10 丁基對羥苯甲酸 0.2 二異硬脂酸二甘油酯 2 單油酸甘油酯 2 天然皂石（商品名：必膠HV) 3 氯化二甲基二硬脂酸銨 1.0 维生素A 0.5 BHT 0.1 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐； -93 - 302284 A7 B7 五、發明説明（91 ) 經濟部中央標準局員工消费合作社印製 乙二胺四乙酸二鈉 抗壊血酸 異抗壊血酸納 2-羥基-4-甲氧基二苯甲嗣 甘油 苯氧基乙醇 精製水 窨掄例14-Q :油凝瞜 維生素A 2-乙基己酸三甘油酯 α -生育酚 角鯊烷 天然徹晶高嶺土群（商品名：克尼比G) 天然皂石（商品名：必膠HV) ΒΗΤ 對二甲基胺息香酸2-乙基己酯 ΡΟΕ(20)硬化里麻油 精製水 奮掄例1 4-1 0 :差容粉 合成水輝石（商品名：來波頓XLG) D-甘露糖 肉豆蔻酸異丙酯 維生素A 弯旆例1 4 - 1 1 :幸容 '培油 0.010.010.01 0.3 100.1 使全髏爲100之置 (重署鉍） 1 40 9 10 10 10 1 10 6 4 (重醫％ ) 50 48 1.9 0.1 (重 a 裝 訂 線 (請先閱讀背面之注意"丹填寫本頁) 一 本纸張尺度適用中國國家標準（CNS ) Λ4規格（2!ΟΧ297公釐） 94 302284 A7 B7 五、發明説明（92 ) 合成水輝石（商品名：來波頓XLG) 合成皂石（商品名：史遇克頓） 甘油 丙二醇 檸攆酸 榨檬三鈉 α -生育酚 2-羥基-4-甲氧基二苯甲酮-5-磺酸納 4-第三丁基-4’-甲氧基二苯甲醯甲烷 Ρ0Ε(60〉硬化Μ麻油 维生素A 六镐磷酸鈉 甲基對羥苯甲酸 乙醇 精製水 3 1 20 5 .03 .07 1 0.1 0.50.1 0.020.2 3 使全體為100之置 (請先閲讀背面之注意有丹填寫本頁) -裝·-〔------- ^ ------ 、 玎 ------. ^ (Please read the notes on the back first +, fill out this page) I Staff of the Central Bureau of the Ministry of Economic Affairs Consumer Cooperation Du Printed Example 13-8 ~ 13-1Θ The skin-use external composition is used as usual. This paper wave scale is applicable to the China National Standard Falcon (CNS) Λ4 specification (2! ΟΧ297 mm) 88 A7 B7 5. The description of the invention (86) is one with vitamin A stability. In the skin external composition of the present invention, a polar oil component selected from the group consisting of pentaerythritol fatty acid fat and trimethanol propane fatty acid S can be used to improve the stability of serotonin A. According to the present invention, one or two types of polar oil components selected from the group consisting of pentaerythritol fatty acid and trimethanol propane fatty acid ester, and selected from butylhydroxytoluene, butylhydroxyanisole, α, / 9.7.3-At least one percent of oil-soluble antioxidants in the group of fertility, nordihydroguaiaretic acid, propyl gallate, vitamin C fatty acid vinegar and sorbic acid can significantly increase the stability of vitamin A Sex. Endeavor MU-1 ~ age example 14-1 ~ 14-2 install i silk (please read the notes on the back t-1 first, fill out this page) 1. The Ministry of Economic Affairs Central Standards Bureau employee consumer cooperative printed S9 This paper wave standard is applicable China National Standard (CNS) A4 specification (2 丨 0X297 g) 302284 A7 B7 V. Description of the invention (87) 実 1A-1: In the emulsion: > The results of the male half SA> g 梢 潮洲^ Example 14-1 Example 14-2 Comparative Example 14-1 Comparative Example 14-2 Purified water so that: the body is 100: the amount of glycerol 10 10 10 10 ethanol 5 5 5 5 methyl paraben 0.1 0.1 0.1 0.1 Glyceryl monostearate 1.5 1.5 1.5 1.5 POE (60) hardened ramie oil 2 2 2 2 Cetyl alcohol 2 2 2 2 Isopropyl myristate 4 4 4 4 Vaseline 3 3 3 3 Squalane 5 5 5 5 BHT-0.05-0.05 Triethylenediaminetetraacetic acid trisodium-0.03-0.03 Natural crystal removal kaolin group 2 2--Vitamin A 0.3 0.3 0.3 0.3 After modulation of vitamin A quantitative value (%) 100 100 100 100 40¾ 1 After (%) 90 95 53 68 * Natural microcrystalline kaolin group: trade name Kenny Bi G-4 printed by the Ministry of Economic Affairs, Central Bureau of Precinct Employee Consumer Cooperatives | (please read the back first 'Attention Flower' · Fill in this page) The method of the male cow S is based on the second method of the local administration (tenth-amendment) vitamin A quantification method, using isopropyl fermentation and quantification by absorbance measurement. Example 14- 1,14-2Compared with the comparative example, the paper standard of vitamin A can be improved. The Chinese national standard (CMS) A4 specification (210X297 mm) is applied. 90 A7 B7 Printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. (88) Stability, this is the effect of the present invention. 粜 U-2: Dairy and hemp formula field Wei Niu Mao Zhong Zhou Yuanli (weight bismuth) Examples Examples Comparative Examples Comparative Examples 14-3 14-4 14- 3 14-4 Natural soapstone 3 3--(必 搋 HV) Ascorbic acid 0.1-0.1 — ΒΗΤ 0.05 0.01 0.05 0.01 dl-α -fertility 0.01 0.01 0.02 0.01 0.02 Vitamin A 0.3 0.01 0.3 0.01 cetyl isooctanoate 10 7 10 7 Squalane 5 2 5 2 Cetyladol 2 2 2 2 Vaseline 1 1 1 1 Glyceryl monostearate 1.5 1.5 1.5 1.5 P0E (60) hardened kenaf oil 1.3 1.3 1.3 1.3 Glycerin 10 10 10 10 Propylene glycol Methyl paraben 3 0.2 3 0.2 0, 0, purified water so that: the body is 100: the amount of life After A quantitative value modulation (%) 100 100 100 100 4010 After 1 month (%) 95 92 63 51 g ^ Μ 1 A-.R: 31. m (£, ¾%) A. Cethenol monostearate Glycerol acid ester P〇E (25) hexadecyl ether stearate petrolatum (please read the notes on the back (.-Ϊ. Fill in this page), τ this paper standard uses the Chinese National Standard (CNS) Α4 specifications ( 210x297 mm) 91 302284 A7 B7 3 1 5 0.1 0.05 Appropriate amount 3 0.2 0. 1 0.001 The total amount is 100 V. Description of the invention (89 olive oil isopropyl myristate squalane vitamin A BHT fragrance B. Propylene glycol potassium hydroxide synthetic soapstone (trade name: Smithton SA) Citric acid purified water was heated at 70 to dissolve the oil phase part of A and the water phase part of B, and A was added to B to emulsify it. Then, cool Gong Li to get the cream. (Please read the note on the back r · and then fill out this page) Printed by the Ministry of Economic Affairs Central Standards Bureau employee consumer cooperative printed example 14-fi: _Hai Ningnuan synthetic hectorite (trade name: Le Bona XLG) glycerin propylene glycol earn Citric acid triethanolamine 2-hydroxy-4-methoxydibenzoyl-5-sulfonate sodium POE (60> hardened M sesame oil vitamin A octyl methoxy cinnamate methyl paraben (mm%) 10 15 5 0.5 1.8 1 9 0. 92 The standard of this paper is the General Chinese National Standard (CNS) A4 (210X 297 mm) 302284 A7 B7 Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Invention Instructions (90) Ethanol 3 Refined water makes the whole amount 100. Example 14-7: Kubu, make-up water (Heavy lye) Glycerin 2 Ethanol 7 P0E (50) Oil ether 0.5 Oil alcohol 0.002 Vitamin A 0.001 Synthetic soapstone (trade name: history Yukerton SA) 0.01 Lactate 0.01 Sodium lactate 0.09 Methyl paraben 0.1 Purified water to make the whole skull 100 in amount 14-14: Cream (® squalane 15 2-ethylhexanoic acid tri Glycerin 10 Olive oil 10 Butylparaben 0.2 Diisostearic acid diglyceride 2 Monooleic acid Oil ester 2 Natural soapstone (trade name: Glue HV) 3 Dimethyl ammonium distearate 1.0 Vitamin A 0.5 BHT 0.1 This paper scale is applicable to China National Standard (CNS) A4 specification (210X297 mm; -93 -302284 A7 B7 V. Description of the invention (91) Printing of Disodium Ethylenediaminetetraacetic Acid, Sodium Glycolate, Isoascorbic Acid, Sodium 2-Hydroxy-4-Methoxydibenzoate by the Employees ’Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Simplified glycerin phenoxyethanol purified water syrup Example 14-Q: Oil coagulation vitamin A 2-ethylhexanoic acid triglyceride α-tocopherol squalane natural crystalline kaolin group (trade name: Knibi G) Natural soapstone (trade name: Glue HV) ΒΗΤ p-dimethylamine benzoic acid 2-ethylhexyl ester ΡΟΕ (20) hardened sesame oil purified water Fenhuan Example 1 4-1 0: Different powder synthetic hectorite (Product name: Leboton XLG) D-Mannose Isopropyl Myristate Vitamin A Case Study 1 4-1 1: Xing Rong 'Oil Training 0.010.010.01 0.3 100.1 Make the whole skeleton 100 Bismuth) 1 40 9 10 10 10 1 10 6 4 (heavy medicine%) 50 48 1.9 0.1 (heavy a gutter (please read the note on the back first " Dan fill this page) This paper scale is applicable to the Chinese National Standard (CNS) Λ4 specification (2! Ο297297 mm) 94 302284 A7 B7 5. Description of the invention (92) Synthetic hectorite (trade name: Lebron XLG) Synthetic soapstone (trade name: Shi Yukun) glycerin propylene glycol citrate trisodium α-tocopherol 2-hydroxy-4-methoxybenzophenone-5-sulfonate 4-tributyl-4'-methoxy Dibenzoylmethane P0E (60> Hardened M Sesame oil Vitamin A Sodium phosphate sodium methyl p-hydroxybenzoic acid ethanol purified water 3 1 20 5 .03 .07 1 0.1 0.50.1 0.020.2 3 Set the whole to 100 (Please read the note on the back first, Dan fills in this page)

,ST 實施例14-5〜14-11之皮*外用組成物於日常生话使 用上爲具维生素A之安定性佳者。 本發明之皮虜外用組成物調配水膨潤性粘土礦物的一 種或二種以上，可明顯提高維生素A之安定性。 若依本發明*進而於皮虜外用組成物中調配水膨潤性 粘土礦物的一種或二種Μ上、與抗氧化劑、蝥合剤、紫外 線吸收劑的一種或二種以上*可更明顯提高維生素Α之安 定性。 本纸涑尺度逋用中國國家標準（CNS ) A4规格（210X 297公釐） 絲 經濟部中央標率局貝工消費合作社印製 95 ~ Q C： ·, ST Examples 14-5 ~ 14-11 The skin * external composition is used in daily life, and it has good stability of vitamin A. By mixing one or more types of water-swellable clay minerals with the skin composition for external use of the present invention, the stability of vitamin A can be significantly improved. According to the present invention *, if one or two types of water-swellable clay minerals are added to the external composition of Piru, one or two or more types of M, antioxidants, candidates, and ultraviolet absorbers can be used to increase vitamins more significantly The stability of Α. The size of this paper is printed in China National Standard (CNS) A4 (210X 297mm) silk. Printed by the Beigong Consumer Cooperative of the Central Standard Rating Bureau of the Ministry of Economic Affairs 95 ~ Q C: ·

Claims (1)

302284 公告減P π、申請專利範圍 第82105 57 2號專利再審査案申請專利範圍修正本 修正日期：85年12月 1.—種皮膚外用组成物，其包含有： (1)0.0001至1重量百分比之維生素Α、及 (H)—種選自下列（1)〜（8)中的安定劑； (1) 0)0.001至1重量百分比之螯合劑，其偽至少一 種選自乙二胺四醋酸之無機鏟鹽與有機齡鹽 以及檸檬酸之無機鹼鹽所組成之群；與 (ii ) 0.0 0 0 Q 1至5重量百分比之多糖類，其偽至少 一種選自缕維素、榲桴籽、硫酸軟骨素、德 麥塔硫酸（dermatansulfate)、阿拉伯膠、 透明質酸與蒼耳烷膠所組成之群； (2) Q.l至8Q重董百分比之至少一種選自聚乙二酵及 聚丙二醇所組成群的二醇類者； (3) 0.QQ1至1重量百分比之乳酸及其無機鹼鹽； (4) 0.0 01至10重置百分比之中性胺基酸，其偽至少 一種選自甘胺酸、丙胺酸、絲胺酸、苯基丙胺酸 與羥基脯胺酸所組成之群； (5) 0.001至5重量百分比之驗性胺基酸及其鹽，其偽 選自離氨酸及鳥胺酸及其等之鹽酸鹽與精胺酸所 組成之群； (6) 0.001至10重量百分比之酸性胺基酸或其鹽，其 偽至少一種遘自毅胺酸鹽、吡咯酮羧酸鹽與天冬 胺酸所組成之群； (7) Q . QQ2重量百分比以上之極性油成份，其偽至少 -1 - 本紙張尺度逋用中國國家梂準（CNS ) A4洗格（210X297公釐） — — — — — 114 _| 裝— — — I 訂— 111-·線 (請先Μ讀背面之注意事項再填寫本1) 經濟部中央橾準局負工消费合作社印製 A8 B8 C8 D8 3〇2284 '申請專利範圍 一種選自季戊四醇-四-(2-乙基己酸）酯、三羥甲 基丙院-三（2-乙基己酸）酯與季戊四醇-四癸酸酯 所組成之群；以及 (8) Q.01至5 0重量百分比之水膨潤性粘土礦物，其偽 至少一種選自天然微晶高嶺土群、天然皂石、合 成皂石與合成水輝石所組成之群3 2. 如申請專利範圍第1項之組成物，其中在組成物全重 置中，諏配有〇.〇〇 Q1至1重量百分比之維生素A , (i ) 0.005至0.5重量百分比之至少一種選自乙二胺 四醋酸之無機鹼鹽與有機鹼鹽與擰檬酸之無機鹼鹽所 組成之群的螯合劑，以及 (ii)Q.QQl至5重量百分比之至少一種為選自纖維素、 溫桴籽、硫酸軟骨素、德麥塔硫酸（dermatansia-fate)、阿拉伯膠、透明質酸與蒼耳烷膠所組成 之群的多糖類。 3. 如申請專利範圍第1項之組成物，其中在組成物全重 量中，調配有0.QQQ1至1重量百分比之維生素A及0.1 至30重量百分比之聚乙二醇及/或聚丙二醇。 4. 如申請專利範圍第1項之組成物，其中在組成物全重 量中，諏配有Q.OQQl至1重量百分比之維生素A,以 及0 . 05至1重量百分比之乳酸無機鹼鹽。 5. 如申請專利範圍第1項之組成物，其中在組成物全重 量中，調配有0.0 0 Q1至1重置百分比之維生素A及 0.01至5重量百分比之至少一種選自甘胺酸、丙胺酸 、絲胺酸、苯基丙胺酸與羥基晡胺酸所組成之群中的 本纸浪尺度逋用中困國家梂準（CNS ) A4規格（210x297公* ) -------1 I裝------訂----- (請先閲讀背面之注意事項再填寫本頁) 經濟部中央揉率局貝工消費合作社印装 302284 A8 B8 C8 D8 經濟部中央標準局貝工消費合作社印製 六、申請專利範圍 中性胺基酸。 S.如申請專利範圍第1項之組成物•其中在組成物金重 量中，調配有Q.0 〇〇1至1重量百分比之雒生素A及0.01 至5重置百分比之鹼性胺基酸及其鹽，其偽1自由精 胺酸、離氛酸與鳥胺酸及其等之鹽酸鹽所組成之群。 7. 如申請專利範圍第1項之組成物，其中在組成物全重 量中，諏配有Q.0⑽1至1重量百分比之雄生素A及！).01 至10重置百分比之至少一種酸性胺基酸或其鹽，該酸 性胺基酸或其鹽偽至少一種選自天冬胺酸、毅胺酸與 咯銅羧酸與其等鹽類者。 8. 如申請專利範圍策1項之組成物，其中在組成物全重 量中，調配有Q.QQQ1至1重量百分比之維生素A及 〇. 〇 Q 2重量百分比至9 9重量百分比以上的極性油分。 9. 如申請專利範圍第8項之組成物，其中組成物重量中 ,更進一步含有〇.〇1至重量百分比之油溶性抗氧化 劑.該抗氧化劑偽選自丁基羥基甲苯與ct, δ -生育酚所組成之群。 10.如申諳專利範圍第1項之組成物，其中在組成物全重 置中，調配有〇.〇〇〇 1至1重量百分比之維生素Α及0.1 至50重量百分比之至少一種選自嶺晶高嶺土群、路皂 石與水輝石所組成之群的水膨潤性粘土礦物。 vn^i I in It n^i mu i^i (請先Ht*背面之注意事項再填寫本s') 訂 線 本紙浪尺度適用中國國家梂準（CNS ) A4洗格（2丨0X297公釐）302284 Announcement minus P π, Patent Application No. 82105 57 Patent Reexamination Case No. 2 Application for amendment of the patent scope Amendment date: December 1985 1. A skin external composition, which includes: (1) 0.0001 to 1 weight Percentage of vitamin A, and (H)-a stabilizer selected from the following (1) to (8); (1) 0) 0.001 to 1 weight percent of a chelating agent, at least one of which is selected from ethylenediamine tetra A group consisting of inorganic shoveling salt of acetic acid and organic ageing salt and inorganic alkali salt of citric acid; and (ii) 0.0 0 0 Q 1 to 5 weight percent polysaccharides, at least one of which is selected from the group consisting of helix, quince Seeds, chondroitin sulfate, dermatansulfate (dermatansulfate), gum arabic, hyaluronic acid, and xanthane gum; (2) at least one of Ql to 8Q weight percent is selected from polyethylene glycol and polymer Glycols composed of propylene glycol; (3) 0. QQ1 to 1 weight percent of lactic acid and its inorganic alkali salts; (4) 0.0 01 to 10 percent replacement neutral amino acid, which is at least one pseudo-selective Composed of glycine, alanine, serine, phenylalanine and hydroxyproline Groups; (5) 0.001 to 5 weight percent of the test amino acids and their salts, which are pseudo-selected from the group consisting of lysine and ornithine and their hydrochlorides and arginine; (6 ) 0.001 to 10% by weight of acidic amino acid or its salt, its pseudo-at least one group consisting of amido acid salt, pyrrolidone carboxylate and aspartic acid; (7) Q. QQ2 more than 1% by weight The composition of the polar oil is at least -1. The paper size is based on the Chinese National Standard (CNS) A4 wash grid (210X297mm) — — — — — 114 _ | Packing — — I set — 111- · line (Please read the precautions on the back before filling in this 1) Printed A8 B8 C8 D8 3〇2284 by the Ministry of Economic Affairs, Central Bureau of Preservation and Consumer Cooperatives, the scope of patent application is selected from pentaerythritol-tetra- (2-ethylhexyl Acid) ester, trimethylolpropionate-tris (2-ethylhexanoic acid) ester and pentaerythritol-tetradecanoate; and (8) Q.01 to 50 weight percent water-swellable clay Minerals, at least one of which is selected from the group consisting of natural microcrystalline kaolin group, natural soapstone, synthetic soapstone and synthetic hectorite 32. The composition of claim 1 of the scope of patent application, wherein in the full replacement of the composition, it is equated with 〇.〇〇Q1 to 1 weight percent of vitamin A, (i) 0.005 to 0.5 weight percent of at least one selected from ethylene A chelating agent consisting of an inorganic base salt of amine tetraacetic acid and an organic base salt and an inorganic base salt of citric acid, and (ii) at least one of QQ.Ql to 5 weight percent is selected from cellulose and quince seeds , Chondroitin sulfate, dermatansia-fate, gum arabic, hyaluronic acid and xanthane gum group of polysaccharides. 3. The composition as claimed in item 1 of the patent application scope, in which the total weight of the composition is blended with 0. QQQ1 to 1 weight percent of vitamin A and 0.1 to 30 weight percent of polyethylene glycol and / or polypropylene glycol. 4. For a composition according to item 1 of the patent application scope, among the total weight of the composition, Q.OQQl to 1 weight percent vitamin A, and 0.05 to 1 weight percent lactic acid inorganic alkali salt are provided. 5. The composition as claimed in item 1 of the patent scope, in which the total weight of the composition is blended with 0.0 0 Q1 to 1 replacement percentage of vitamin A and 0.01 to 5 weight percent of at least one selected from glycine and propylamine In the group consisting of acid, serine, phenylalanine and hydroxymethionine, the original paper wave scale is used in the national standards (CNS) A4 standard (210x297 public *) ------- 1 I installed ------ ordered ----- (please read the notes on the back before filling in this page) Printed and printed by the Ministry of Economic Affairs, Central Bureau of Economic Cooperation, Beigong Consumer Cooperative 302284 A8 B8 C8 D8 Central Ministry of Economic Affairs Printed by industrial and consumer cooperatives. 6. Neutral amino acids for patent application. S. The composition as claimed in item 1 of the patent application scope • Among the weight of the composition gold, Q. 0.001 to 1% by weight of Luoshengsu A and 0.01 to 5% of replacement basic amine groups are blended Acids and their salts, its pseudo-1 free spermine acid, chlorinated acid and ornithine acid and its hydrochloride salt group. 7. As for the composition of claim 1 of the scope of patent application, among the total weight of the composition, Q.0⑽1 to 1 weight percent of androgen A and Q! ). 01 to 10 replacement percentages of at least one acidic amino acid or salt thereof, the acidic amino acid or salt thereof is at least one selected from aspartic acid, prednisic acid, and copper carboxylic acid and their salts . 8. The composition as claimed in item 1 of the patent application scope, in which the total weight of the composition is blended with Q.QQQ1 to 1% by weight of vitamin A and 〇Q 2% by weight to more than 99% by weight of polar oil . 9. The composition as claimed in item 8 of the patent scope, wherein the weight of the composition further contains 0.01 to weight percent of oil-soluble antioxidant. The antioxidant is pseudo-selected from butylhydroxytoluene and ct, δ- Group of tocopherols. 10. The composition as claimed in item 1 of the patent scope, wherein in the full replacement of the composition, 0.001 to 1 weight percent of vitamin A and 0.1 to 50 weight percent of at least one kind selected from Ling The water-swellable clay mineral of the group consisting of crystalline kaolin group, saponite and hectorite. vn ^ i I in It n ^ i mu i ^ i (please pay attention to the notes on the back of Ht * before filling in this s'). The line book size is applicable to the Chinese National Standard (CNS) A4 washing grid (2 丨 0X297mm )
TW82105572A 1992-07-13 1993-07-13 TW302284B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP22773092A JPH0632712A (en) 1992-07-13 1992-07-13 Skin external preparation
JP22772992A JP3455553B2 (en) 1992-07-13 1992-07-13 External preparation for skin
JP22772792A JPH0632729A (en) 1992-07-13 1992-07-13 External preparation for skin
JP22772892A JP3545429B2 (en) 1992-07-13 1992-07-13 Retinol stable combination skin external preparation
JP4227725A JP2794252B2 (en) 1992-07-13 1992-07-13 External preparation for skin

Publications (1)

Publication Number Publication Date
TW302284B true TW302284B (en) 1997-04-11

Family

ID=51565742

Family Applications (2)

Application Number Title Priority Date Filing Date
TW82105572A TW302284B (en) 1992-07-13 1993-07-13
TW85115876A TW317502B (en) 1992-07-13 1993-07-13

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW85115876A TW317502B (en) 1992-07-13 1993-07-13

Country Status (1)

Country Link
TW (2) TW302284B (en)

Also Published As

Publication number Publication date
TW317502B (en) 1997-10-11

Similar Documents

Publication Publication Date Title
DE69919287T2 (en) Ethyl acetate extract of indigo plant
JP5066342B2 (en) Novel hyaluronic acid and / or salt thereof, and cosmetics, pharmaceutical compositions, food compositions, and cosmetic kits using the same
TW307683B (en)
JP4091824B2 (en) Skin preparation
CN101588787A (en) Anti-wrinkle agent and ADAM inhibitor
EP2627414A2 (en) Microbiologically stable, easily applicable preparations comprising active substances susceptible to degradation
CN101594860A (en) The ADAM inhibitor
TW302284B (en)
CN106074225B (en) Edibility watch box cream and preparation method thereof
CN108652999B (en) A kind of children's toothpaste and preparation method thereof
JPS61130232A (en) Shikonin-containing composition
JP7321680B2 (en) external composition
CN108743502B (en) A kind of bamboo vinegar toothpaste and preparation method thereof
JP4392301B2 (en) Skin preparation for wrinkle improvement and prevention
CN109453084A (en) A kind of mildy wash and preparation method thereof
TW202239399A (en) Natural waterproof eye pencil cosmetic composition and method for manufacturing natural waterproof eye pencil cosmetic through the same
JPH09315987A (en) Utilization of awamori as antiallergic active ingredient
JP7321679B2 (en) external composition
CN109528611A (en) A kind of skin care item and preparation method thereof containing choline caffeiate
JP2001354545A (en) External skin preparation and external skin preparation composition
TW201600116A (en) Composition useful as external preparation for skin or cosmetic preparation
JP3747192B2 (en) Topical skin preparation
JP2003238381A (en) Cosmetic composition
JP3075438B2 (en) Novel acylated kefiran, its use and production method
JPH0632710A (en) Skin external preparation

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees