JPH0627075B2 - External base - Google Patents
External baseInfo
- Publication number
- JPH0627075B2 JPH0627075B2 JP60234778A JP23477885A JPH0627075B2 JP H0627075 B2 JPH0627075 B2 JP H0627075B2 JP 60234778 A JP60234778 A JP 60234778A JP 23477885 A JP23477885 A JP 23477885A JP H0627075 B2 JPH0627075 B2 JP H0627075B2
- Authority
- JP
- Japan
- Prior art keywords
- water
- base
- external use
- acid
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- Medicinal Preparation (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、外用基剤に関するものであり、皮膚への親和
性のよい、使用感の優れた安全性の高い外用基剤を提供
することを目的とする。TECHNICAL FIELD The present invention relates to a base for external use, and to provide a base for external use, which has a good affinity for skin, an excellent feeling in use, and high safety. With the goal.
従来外用基剤としては、油性基剤、水溶性基剤、乳化性
基剤、懸濁性基剤が広く使われている。これらのうち水
溶性基剤は各種重合度のポリエチレングリコールを混合
したものあるいはカーボポールゲルなどであり、他の基
剤に比べ水洗性、吸水性、化学安定性、展延性、薬物放
出性などに優れているため、注目されている基剤であ
る。Conventionally, oily bases, water-soluble bases, emulsifying bases and suspending bases have been widely used as external bases. Among these, the water-soluble base is a mixture of polyethylene glycol of various degrees of polymerization or carbopol gel, etc., and has better water washability, water absorption, chemical stability, spreadability, drug release, etc. than other bases. Since it is excellent, it is a base material that has been drawing attention.
しかしながら、従来の水溶性基剤は、水に不溶性の薬剤
を溶解するのが困難であつた。そこで従来の水溶性基剤
のように水洗性、安全性、展延性、薬物放出性に優れ、
かつ水に不溶性の薬剤を容易に配合でき、しかも安定な
外用基剤の開発が強く望まれている。However, conventional water-soluble bases have been difficult to dissolve insoluble drugs in water. Therefore, it has excellent water washability, safety, spreadability, and drug release like conventional water-soluble bases,
Further, it is strongly desired to develop a stable base for external use, which can easily mix a water-insoluble drug.
〔問題点を解決するための手段〕 本発明者らは、このような要望に応えるために、水素添
加リン脂質を使用して、薬剤溶解性の優れた、且つ皮膚
への親和性のよい外用基剤を得ようと検討を重ねた結
果、水素添加リン脂質により水を増粘・ゲル化すること
により優れた外用基剤が得られることを見出した。即ち
本発明は水素添加リン脂質により水を増粘ゲル化してな
る外用基剤に係るものである。本発明の実施に当つて
は、単に水素添加リン脂質を水に分散し、増粘ゲル化し
ただけで本発明の基剤が得られるが、更にこれに対して
炭素数８以上の飽和、不飽和または側鎖脂肪酸あるい
は、無機塩あるいは水溶性有機酸塩のどれか一つ、ある
いはそれらを組み合わせたものを添加することにより、
外観、使用感等を改良することができる。更に、動植物
油、脂肪酸エステル、炭化水素などの油相成分、或いは
グリセリン、プロピレングリコール等の多価アルコー
ル、糖類などの保湿剤等、通常外用基剤に配合される成
分を配合することもできる。[Means for Solving the Problems] In order to meet such a demand, the present inventors have used hydrogenated phospholipids and have excellent drug solubility and external application with good skin affinity. As a result of repeated studies to obtain a base, it was found that an excellent base for external use can be obtained by thickening and gelling water with hydrogenated phospholipid. That is, the present invention relates to a base for external use obtained by thickening and gelating water with hydrogenated phospholipids. In carrying out the present invention, the base of the present invention can be obtained by simply dispersing hydrogenated phospholipid in water and thickening and gelling it. By adding one of saturated or side chain fatty acids, or an inorganic salt or a water-soluble organic acid salt, or a combination thereof,
The appearance, the feeling of use, etc. can be improved. Further, oil phase components such as animal and vegetable oils, fatty acid esters, and hydrocarbons, polyhydric alcohols such as glycerin and propylene glycol, moisturizers such as sugars, and the like, and components that are usually blended with an external base can also be blended.
本発明に用いられる水素添加リン脂質は、卵黄、大豆な
どより抽出したリン脂質、又は中性脂質を含むリン脂質
を原料として使用し、これに常法により水素添加したも
のである。水素添加リン脂質のヨウ素価は０〜６０のも
のが好ましく、１種又は２種以上組み合わせて使用す
る。The hydrogenated phospholipid used in the present invention is obtained by using a phospholipid extracted from egg yolk, soybean or the like, or a phospholipid containing a neutral lipid as a raw material and hydrogenated by a conventional method. The hydrogenated phospholipid preferably has an iodine value of 0 to 60 and is used alone or in combination of two or more.
本発明の外用基剤に使用され得る炭素数８以上の飽和、
不飽和又は側鎖脂肪酸としては、カプロン酸、カプリル
酸、ラウリル酸、ミリスチン酸、ステアリン酸、バルミ
チン酸、オレイン酸、ベヘニン酸、イソステアリン酸、
イソパルミチン酸などがあり、通常化粧品、医薬品の外
用剤に使用される脂肪酸はなんでも使用できる。Saturation having 8 or more carbon atoms which can be used for the base material for external use of the present invention,
As the unsaturated or side chain fatty acid, caproic acid, caprylic acid, lauric acid, myristic acid, stearic acid, valmitic acid, oleic acid, behenic acid, isostearic acid,
There are isopalmitic acid and the like, and any fatty acid usually used for external preparations of cosmetics and pharmaceuticals can be used.
本発明の外用基剤に使用され得る無機塩は、塩化ナトリ
ウム、塩化カリウム、硫酸マグネシウム、ポリリン酸ナ
トリウム、メタリン酸ナトリウム、塩化マグネシウム、
塩化カルシウムなど通常の水溶性の無機塩である。Inorganic salts that can be used in the base for external use of the present invention include sodium chloride, potassium chloride, magnesium sulfate, sodium polyphosphate, sodium metaphosphate, magnesium chloride,
It is a normal water-soluble inorganic salt such as calcium chloride.
又本発明の外用基剤に使用され得る水溶性有機酸塩とし
ては、グリチルリチン酸塩、カーボポールやポリアクリ
ル酸塩、ヒアルロン酸などの水溶性高分子化合物、アス
コルビン酸エステル塩、乳酸塩、クエン酸塩、酪酸塩な
どが挙げられる。Examples of the water-soluble organic acid salt that can be used for the base for external use of the present invention include glycyrrhizin acid salt, carbopol and polyacrylic acid salts, water-soluble polymer compounds such as hyaluronic acid, ascorbic acid ester salts, lactate salts, and Examples thereof include acid salts and butyrate salts.
本発明の外用基剤中に配合させる水素添加リン脂質の使
用量の範囲は１％〜２０％が適当である。本発明の外用
基剤をつくるには、水に対し、上記量の水素添加リン脂
質と、必要に応じ上記の如き各種配合成分の適当量を加
え、加温、撹拌することにより増粘ゲル化させることに
より目的物が得られる。この際必要な薬剤成分も配合し
得ることは勿論である。The suitable range of the amount of hydrogenated phospholipid to be incorporated into the base for external use of the present invention is 1% to 20%. The base for external use of the present invention is prepared by adding to the water the above-mentioned amount of hydrogenated phospholipid and, if necessary, the appropriate amount of the various compounding ingredients as described above, and heating and stirring to thicken the gel. By doing so, the target product is obtained. In this case, needless to say, necessary drug components may be added.
本発明の外用基剤は、生体成分の一種であるリン脂質を
使用しているため、皮膚への親和性に優れ、使用感が非
常に優れている。また安全性が高く、薬剤も親水性、親
油性を問わず自由に使用できる。The base for external use of the present invention uses phospholipid, which is one of biological components, and therefore has excellent affinity to the skin and a very good feeling in use. It is also highly safe and can be used freely regardless of whether it is hydrophilic or lipophilic.
以下本発明の実施例を示すが、本発明はこれらの実施例
に限定されるものではない。Examples of the present invention will be shown below, but the present invention is not limited to these examples.
実施例１ 水素添加大豆レシチン ３wt％ 中鎖トリグリセライド ３ ステアリン酸 ０．５ グリセリン ３wt％ ピロリドンカルボン酸ナトリウム １ 塩化ナトリウム 0.05 精製水で 100 上記各成分を７０〜８０℃に加温し、ホモミキサーにて
２０分撹拌する。クリーム状の外用基剤が得られる。Example 1 Hydrogenated soybean lecithin 3 wt% Medium chain triglyceride 3 Stearic acid 0.5 Glycerin 3 wt% Sodium pyrrolidonecarboxylate 1 Sodium chloride 0.05 Purified water 100 The above components were heated to 70 to 80 ° C. and homogenized with a homomixer. Stir for 20 minutes. A creamy base for external use is obtained.
実施例２ 水素添加大豆レシチン ５ 植物油 ４ アスコルビン酸リン酸エステルマグネ シウム ２．０ グリセリン ３ 精製水で 100 上記各成分を７０〜８０℃に加温し、超音波を１０分か
ける。クリーム状の外用基剤が得られる。Example 2 Hydrogenated soybean lecithin 5 Vegetable oil 4 Ascorbyl phosphate Magnesium 2.0 Glycerin 3 Purified water 100 Each of the above components is heated to 70 to 80 ° C, and ultrasonic waves are applied for 10 minutes. A creamy base for external use is obtained.
Claims (4)
てなる外用基剤。1. A base for external use obtained by thickening and gelating water with hydrogenated phospholipids.
肪酸の１種または２種以上を配合してなる特許請求の範
囲第１項記載の外用基剤。2. The base material for external use according to claim 1, wherein one or more kinds of saturated, unsaturated or side chain fatty acids having 8 or more carbon atoms are blended.
たは第２項記載の外用基剤。3. The base material for external use according to claim 1 or 2, which contains an inorganic salt.
第１項、第２項または第３項記載の外用基剤。4. The base material for external use according to claim 1, 2, or 3 containing a water-soluble organic acid salt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60234778A JPH0627075B2 (en) | 1985-10-21 | 1985-10-21 | External base |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60234778A JPH0627075B2 (en) | 1985-10-21 | 1985-10-21 | External base |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6293239A JPS6293239A (en) | 1987-04-28 |
| JPH0627075B2 true JPH0627075B2 (en) | 1994-04-13 |
Family
ID=16976222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60234778A Expired - Lifetime JPH0627075B2 (en) | 1985-10-21 | 1985-10-21 | External base |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0627075B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5348784B2 (en) | 2009-12-28 | 2013-11-20 | 株式会社 資生堂 | Cosmetics |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201708A (en) * | 1982-05-18 | 1983-11-24 | Asahi Chem Ind Co Ltd | Cosmetic composition |
| JPS591404A (en) * | 1982-06-28 | 1984-01-06 | Shiseido Co Ltd | Emulsifiable composition |
| JPS6261915A (en) * | 1985-09-10 | 1987-03-18 | Taisho Pharmaceut Co Ltd | Antimycotic agent for external use |
-
1985
- 1985-10-21 JP JP60234778A patent/JPH0627075B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201708A (en) * | 1982-05-18 | 1983-11-24 | Asahi Chem Ind Co Ltd | Cosmetic composition |
| JPS591404A (en) * | 1982-06-28 | 1984-01-06 | Shiseido Co Ltd | Emulsifiable composition |
| JPS6261915A (en) * | 1985-09-10 | 1987-03-18 | Taisho Pharmaceut Co Ltd | Antimycotic agent for external use |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6293239A (en) | 1987-04-28 |
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