JPS6293239A - Base material for external use - Google Patents
Base material for external useInfo
- Publication number
- JPS6293239A JPS6293239A JP23477885A JP23477885A JPS6293239A JP S6293239 A JPS6293239 A JP S6293239A JP 23477885 A JP23477885 A JP 23477885A JP 23477885 A JP23477885 A JP 23477885A JP S6293239 A JPS6293239 A JP S6293239A
- Authority
- JP
- Japan
- Prior art keywords
- water
- acid
- external use
- hydrogenated phospholipid
- base material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、外用基剤に関するものであり、皮膚への親和
性のよい、使用感の優れた安全性の高い外用基剤を提供
することを目的とする。[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a base for external use, and an object of the present invention is to provide a base for external use that has good affinity for the skin, has an excellent feeling of use, and is highly safe. With the goal.
従来外用基剤としては、油性基剤、水溶性基剤、乳化性
基剤、懸濁性基剤が広く使われている。これ、らのうち
水溶性基剤は各種重合度のポリエチレングリコールを混
合したものあるいはカーボボールゲルなどでアリ、他の
基剤に比べ水洗性、吸水性、化学安定性、展延性、薬物
放出性などに優れているため、注目されている基剤であ
る。Conventionally, as bases for external use, oil bases, water-soluble bases, emulsifying bases, and suspending bases have been widely used. Among these, water-soluble bases are mixtures of polyethylene glycol with various degrees of polymerization or carboball gel, etc., and have better washability, water absorption, chemical stability, spreadability, and drug release than other bases. It is a base material that is attracting attention because of its excellent properties.
しかしながら、従来の水溶性基剤は、水に不溶性の薬剤
を溶解するのが困難でおった。そこで従来の水溶性基剤
のように水洗性、安定性、展延性、薬物放出性に優れ、
かつ水に不溶性の薬剤を容易に配合でき、しかも安定な
外用基剤の開発が強く望まれている。However, conventional water-soluble bases have difficulty dissolving water-insoluble drugs. Therefore, unlike conventional water-soluble bases, it has excellent water washability, stability, spreadability, and drug release properties.
There is a strong demand for the development of a stable external use base that can be easily incorporated with water-insoluble drugs.
本発明者らは、このような要望に応えるために、水素添
加リン脂質を使用して、薬剤溶解性の優れた、且つ皮膚
への親和性のよい外用基剤を得ようと検討を重ねた結果
、水素添加リン脂質により水を増粘・ゲル化することＫ
より優れた外用基剤が得られることを見出した。即ち本
発明は水素添加リン脂質により水を増粘ゲル化してなる
外用基剤に係るものである。本発明の実施に当っては、
単に水素添加リン脂質を水に分散し、増粘ゲル化しただ
けで本発明の基剤が得られるが、更にこれに対して炭素
数８以上の飽和、不飽和または側鎖脂肪酸あるいは、無
機塩あるいは水溶性有機酸塩のどれか一つ、あるいはそ
れらを組み合わせたものを添加することによシ、外観、
使用感等を改良することができる。更に、動植物油、脂
肪酸エステル、炭化水素などの油相成分、或いはグリセ
リン、゛プロピレングリコール等の多価アルコール、糖
類などの保湿剤等、通常外用基剤に配合される成分を配
合することもできる。In order to meet these demands, the present inventors have conducted repeated studies to obtain a topical base that has excellent drug solubility and good affinity for the skin by using hydrogenated phospholipids. As a result, hydrogenated phospholipids thicken and gel water.
It has been found that a superior external base can be obtained. That is, the present invention relates to an external base prepared by thickening and gelling water with a hydrogenated phospholipid. In implementing the present invention,
The base of the present invention can be obtained by simply dispersing hydrogenated phospholipid in water and thickening it into a gel, but in addition to this, saturated, unsaturated or side chain fatty acids having 8 or more carbon atoms or inorganic salts can be obtained. Alternatively, by adding one or a combination of water-soluble organic acid salts, the appearance and
Usability etc. can be improved. Furthermore, ingredients that are usually included in external use bases, such as oil phase components such as animal and vegetable oils, fatty acid esters, and hydrocarbons, or moisturizing agents such as polyhydric alcohols such as glycerin and propylene glycol, and sugars, can also be blended. .
本発明に用いられる水素添加リン脂質は、卵黄、大豆な
どより抽出したリン脂質、又は中性脂質を含むリン脂質
を原料として使用し、これに常法により水素添加したも
のである。水素添加リン脂質のヨウ素価は０〜６０のも
のが好ましく１ １？ｉ１又は２種以上組み合わせて使
用する。The hydrogenated phospholipid used in the present invention is obtained by hydrogenating a phospholipid extracted from egg yolk, soybean, etc., or a phospholipid containing a neutral lipid as a raw material by a conventional method. The hydrogenated phospholipid preferably has an iodine value of 0 to 60.11? Use i1 or a combination of two or more.
本発明の外用基剤に使用され得る炭素数８以上の飽和、
不飽和又は側鎖脂肪酸としては、カブロン酸、カグリル
酸、ラウリル醒、ミリスチン酸、ステアリン酸、バルミ
チン酸、オレイン酸、ベヘニン酸、イソステアリン酸、
インパルミチン酸などがあり、通常化粧品、医薬品の外
用剤に使用される脂肪酸はなんでも使用できる。A saturated carbon number of 8 or more that can be used in the external base of the present invention,
Examples of unsaturated or side chain fatty acids include cabroic acid, cabrylic acid, lauryl acid, myristic acid, stearic acid, valmitic acid, oleic acid, behenic acid, isostearic acid,
Examples include impalmitic acid, and any fatty acid commonly used in external preparations for cosmetics and pharmaceuticals can be used.
本発明の外用基剤に使用され得る無機塩は、塩化ナトリ
ウム、塩化カリウム、硫酸マグネシウム、ポリリン酸ナ
トリクム、メタリン酸ナトリウム、塩化マグネシウム、
塩化カルシウムなど通常の水溶性の無機塩である。Inorganic salts that can be used in the external base of the present invention include sodium chloride, potassium chloride, magnesium sulfate, sodium polyphosphate, sodium metaphosphate, magnesium chloride,
It is a common water-soluble inorganic salt such as calcium chloride.
又本発明の外用基剤に使用され得る水溶性有機酸塩とし
ては、グリチルリチン酸塩、カーボボールやポリアクリ
ル酸塩、ヒアルロン酸などの水溶性高分子化合物、アス
コルビン酸エステル塩、乳酸塩、クエン酸塩、酪酸塩な
どが挙げられる。Water-soluble organic acid salts that can be used in the external base of the present invention include glycyrrhizinate, carbobol, polyacrylate, water-soluble polymer compounds such as hyaluronic acid, ascorbic acid ester salt, lactate, and citric acid. Examples include acid salts and butyrates.
本発明の外用基剤中に配合させる水素添加リン脂質の使
用斌の範囲は１％〜２０％が適当である。本発明の外用
基剤をつくるには、水に対し、上記量の水素添加リン脂
質と、必要に応じ上記の如き各種配合成分の適当量を加
え、加温、攪拌することにより増粘ゲル化させることに
より目的物が得られる。この際必要な薬剤成分も配合し
得ることは勿論である。The appropriate range of hydrogenated phospholipids used in the external base of the present invention is 1% to 20%. To prepare the external base of the present invention, the above amount of hydrogenated phospholipid and, if necessary, appropriate amounts of the various ingredients listed above are added to water, and the mixture is heated and stirred to thicken it into a gel. By doing so, the desired product can be obtained. Needless to say, necessary drug components can also be added at this time.
本発明の外用基剤は、生体成分の一種であるリン脂質を
使用しているため、皮膚への親和性に優れ、使用感が非
常に優れている。また安全性が高く、薬剤も親水性、親
油性を問わず自由に使用できる。Since the external use base of the present invention uses phospholipids, which are a type of biological component, it has excellent affinity for the skin and has an excellent feeling of use. It is also highly safe and can be used freely regardless of whether the drug is hydrophilic or lipophilic.
以下本発明の実施例を示すが、本発明はこれらの実施例
に限定されるものではない。Examples of the present invention will be shown below, but the present invention is not limited to these Examples.
実施例１
水素株加太豆レシチン ３ｖｔ、％中鎖トリ
グリセライド ３ステアリン酸
０．５グリセリン ３
ｗｔ％ピロリドンカルボン酸ナトリウム １
塩化ナトリウム ０．０５精製水で
１００上記各成分を７０〜８０℃に
加温し、ホモばキサ−にて２０分攪拌する。クリーム状
の外用基剤が得られる。Example 1 Hydrogen strain Kada bean lecithin 3vt, % medium chain triglyceride 3 stearic acid
0.5 glycerin 3
wt% Sodium pyrrolidone carboxylate 1 Sodium chloride 0.05 with purified water
100 The above ingredients were heated to 70 to 80°C and stirred for 20 minutes in a homovaxer. A creamy base for external use is obtained.
実施例２
水素添加大豆レシチン ５
植物油 ４
２．０
グリセリン ３
精製水で １００上記各成分を７
０〜８０℃に加温し、超音波を１０分かける。クリーム
状の外用基剤が得られる。Example 2 Hydrogenated soybean lecithin 5 Vegetable oil 4 2.0 Glycerin 3 100% of each of the above ingredients with purified water 7
Heat to 0-80°C and apply ultrasound for 10 minutes. A creamy base for external use is obtained.
Claims (1)
用基剤。 ２ 炭素数８以上の飽和、不飽和または側鎖脂肪酸の１
種または２種以上を配合してなる特許請求の範囲第１項
記載の外用基剤。 ３ 無機塩を含有する特許請求の範囲第１項または第２
項記載の外用基剤。 ４ 水溶性有機酸塩を含有する特許請求の範囲第１項、
第２項または第３項記載の外用基剤。[Claims] 1. A base for external use made by thickening and gelling water with hydrogenated phospholipid. 2 Saturated, unsaturated or side chain fatty acids with 8 or more carbon atoms
The external use base according to claim 1, which is a mixture of one or more types. 3 Claim 1 or 2 containing an inorganic salt
External base as described in section. 4 Claim 1 containing a water-soluble organic acid salt,
The external base according to item 2 or 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60234778A JPH0627075B2 (en) | 1985-10-21 | 1985-10-21 | External base |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60234778A JPH0627075B2 (en) | 1985-10-21 | 1985-10-21 | External base |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6293239A true JPS6293239A (en) | 1987-04-28 |
| JPH0627075B2 JPH0627075B2 (en) | 1994-04-13 |
Family
ID=16976222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60234778A Expired - Lifetime JPH0627075B2 (en) | 1985-10-21 | 1985-10-21 | External base |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0627075B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011081136A1 (en) | 2009-12-28 | 2011-07-07 | 株式会社資生堂 | Cosmetic preparation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201708A (en) * | 1982-05-18 | 1983-11-24 | Asahi Chem Ind Co Ltd | Cosmetic composition |
| JPS591404A (en) * | 1982-06-28 | 1984-01-06 | Shiseido Co Ltd | Emulsifiable composition |
| JPS6261915A (en) * | 1985-09-10 | 1987-03-18 | Taisho Pharmaceut Co Ltd | Antimycotic agent for external use |
-
1985
- 1985-10-21 JP JP60234778A patent/JPH0627075B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201708A (en) * | 1982-05-18 | 1983-11-24 | Asahi Chem Ind Co Ltd | Cosmetic composition |
| JPS591404A (en) * | 1982-06-28 | 1984-01-06 | Shiseido Co Ltd | Emulsifiable composition |
| JPS6261915A (en) * | 1985-09-10 | 1987-03-18 | Taisho Pharmaceut Co Ltd | Antimycotic agent for external use |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011081136A1 (en) | 2009-12-28 | 2011-07-07 | 株式会社資生堂 | Cosmetic preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0627075B2 (en) | 1994-04-13 |
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