JPH0525535B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention effectively utilizes phospholipids, which are known as naturally occurring and highly safe surfactants, as oil thickening/gelling agents and emulsifiers in cosmetics, pharmaceuticals, etc. For this purpose, the present invention provides a stable emulsified composition, and further provides an oil-in-water emulsified composition obtained by adding water to this emulsified composition. [Prior Art] Previously, attempts have been made to use phospholipids as oil thickeners, gelling agents, and emulsifiers. For example, phospholipids have been used as oil thickeners, gelling agents, and emulsifiers. An oil-in-polyhydric alcohol emulsion composition is known (Japanese Unexamined Patent Publication No. 70826/1982). [Problems to be Solved by the Invention] However, because the HLB value of lecithin is too low, the stability of the obtained emulsion composition is insufficient, and improvement in stability has been desired. [Means for Solving the Problems] In view of the above points, the present inventors conducted extensive research on emulsion compositions using phospholipids, particularly on stabilization methods, and as a result, they solved the problem by dissolving phospholipids in polyhydric alcohol. discovered that when adding an oil phase component to this to obtain an emulsified composition with a fine particle size, the stability was improved by using a specific soap and a higher alcohol in combination with the phospholipid, and the present invention completed. That is, the present invention comprises a phospholipid and/or a salt thereof, an N-long chain acylamino acid soap, a higher alcohol, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component. and an oil-in-water emulsion composition characterized in that the polyhydric alcohol-in-oil emulsion composition further contains water. The configuration of the present invention will be described below. The phospholipids used in the present invention are phospholipids extracted from plants such as soybeans, corn, peanuts, rapeseed, and wheat, animals such as egg yolks and cows, and microorganisms such as Escherichia coli. Phosphatidylinositol, phosphatidylethanolamine, phosphatidyl monomethylethanolamine, phosphatidylmethylethanolamine, phosphatidylcholine (lecithin), phosphatidylserine, bisphosphatidic acid, diphosphatidylglycerin ( Examples include glycerophospholipids such as cardiolipin, sphingophospholipids such as sphingomyelin, and hydrogenated products of these. These may be used alone or in combination. When using phospholipids as salts, salt-forming substances include inorganic bases such as lithium hydroxide, sodium hydroxide, potassium hydroxide, cesium hydroxide, and ammonium hydroxide, and arginine, lysine, histidine, ornithine, etc. Examples include basic amino acids, basic oligopeptides having basic amino acids as residues, and basic amines such as monoethanolamine, diethanolamine, and triethanolamine. Phospholipid salts may be used alone or in combination. The N-long chain acylamino acid soap used in the present invention is a reaction product obtained by reacting an N-long chain acylamino acid with a base. and,
The N-long chain acylamino acid used to synthesize this N-long chain acylamino acid soap has a fatty acid having 12 to 26 carbon atoms. Particularly preferred examples include N-stearoylglutamic acid, N-palmitoylglutamic acid, N-myristoylglutamic acid, N-stearoyl aspartic acid, N-palmitoyl aspartic acid, and N-myristoyl aspartic acid. In addition, these N-long chain acylamino acids are D-form, L-
Body/DL - Can be used regardless of body type. Moreover,
These may be used alone or in combination. Examples of the base used to synthesize the N-long chain acylamino acid soap include triethanolamine, sodium hydroxide, potassium hydroxide, arginine, lysine, histidine, ornithine, and oxylysine. Among these, basic amino acids include D-form, L-form, and DL-form.
- Can be used regardless of body type. Furthermore, these may be used alone or in combination. Further, higher alcohols include long chain saturated alcohols having 8 to 40 carbon atoms, saturated alcohols having side chains, straight chain unsaturated alcohols, and unsaturated alcohols having side chains. Particularly preferred examples include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, isostearyl alcohol, and behenyl alcohol. Further, these may be used alone or in combination. Water-soluble polyhydric alcohols having two or more hydroxyl groups in the molecule used in the present invention include, for example, propylene glycol, 1,3-butylene glycol,
Examples include glycols such as dipropylene glycol, glycerols such as glycerin and diglycerin, saccharides such as sorbitol and maltitol, and pentaerythritol. These may be used alone or in combination. Next, as the oil phase component, those that are normally used in the fields of cosmetics, medicine, food, etc. and are considered safe for the human body can be used. For example, vegetable oils such as olive oil and castor oil, waxes such as beeswax, lanolin, candelilla wax, and wood wax, hydrocarbons such as liquid paraffin, squalane, petrolatum, paraffin wax, and higher alcohols such as cetanol, stearyl alcohol, and behenyl alcohol. , other ester oils, silicone oils, etc. The blending amount of phospholipid and/or its salt and N-long chain acylamino acid soap is 1:9 to 1:9 by weight.
The range is 9:1, and if it is within this range, it is appropriate.
HLB and a good emulsified composition can be obtained. The blending amount of the N-long chain acylamino acid soap and the higher alcohol is in a weight ratio of 1:9 to 9:1, and within this range, good long-term stability is exhibited. The amount of water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule is 1 to 100 times the total weight of the phospholipid and/or its salt, N-long chain acylamino acid soap, and higher alcohol. and
Within this range, the solubility of phospholipids, soaps, higher alcohols, etc. is good, and the emulsion stability is also good. The blending amount of the oily component is within the range of 5 times the total weight of the phospholipid and/or its salt, N-long chain acylamino acid soap, and water-soluble polyhydric alcohol, and within this range, it is stable. An emulsified composition is obtained. The present invention is an oil-in-polyhydric alcohol emulsion composition characterized in that the above components are essentially blended, and another oil-in-water emulsion composition according to the present invention is an oil-in-polyhydric alcohol emulsion composition according to the present invention. It is characterized in that it essentially contains a type emulsion composition and water. In addition to the above essential ingredients, the emulsified composition of the present invention further contains drugs, powders, surfactants, pigments, fragrances, alcohol, humectants, preservatives, beauty agents, and oxidants commonly used in cosmetics and pharmaceuticals. Inhibitors, ultraviolet absorbers, water-soluble polymers, etc. can be added as appropriate. The oil-in-polyhydric alcohol emulsion composition obtained in the present invention is a homogeneous, translucent or white paste, so it can be used as it is, for example, in beauty serums, pine surge jelly, cleansing jelly, medicated jelly, etc.
Can be used as sun oil etc. Further, since the other oil-in-water emulsion composition obtained by the present invention has the same form as a general oil-in-water emulsion composition, it can be widely used as cosmetics and pharmaceuticals. [Example] Next, the present invention will be further explained by giving examples. These do not limit the present invention in any way. Examples 1 to 2, Comparative Examples 1 to 3 Lecithin, soap, higher alcohol, polyhydric alcohol, and oil phase components were treated in a homomixer at 70°C in the amounts shown in Tables 1 and 2. Oil-in-polyhydric alcohol emulsion compositions of Example 1 and Comparative Examples 1 and 2 were obtained. Furthermore, as shown in Tables 1 and 2, oil-in-water emulsion compositions of polyhydric alcohol were once prepared, and water at 70°C was added thereto to obtain oil-in-water emulsion compositions of Example 2 and Comparative Example 3. Ta.

[Table] Ingredients are shown in weight%

[Table] Ingredients are shown in weight%
In order to confirm the stability of the emulsified composition of the present invention, the conditions of Examples 1 and 2 and Comparative Examples 1 and 2 after one month at 40°C were observed.
Examples 1 and 2 were uniform and showed good stability, with no change from the time of manufacture. On the other hand, those of Comparative Examples 1 and 2 are separated,
Furthermore, in Comparative Example 3, precipitation of solids thought to be fatty acids was observed, and the stability was poor. Example 3 Cream (formulation) (wt%) (1) Soybean lecithin 2.0 (2) Monosodium N-myristoyl-L-glutamate 1.0 (3) Glycerin 10.0 (4) Methyl paraoxybenzoate 0.1 (5) Cetyl alcohol 1.0 ( 6) Squalane 50.0 (7) 1,3-butylene glycol 5.0 (8) Carboxyvinyl polymer 0.3 (9) Sodium hydroxide 0.04 (10) Purified water Remaining amount (manufacturing method) A Heat (1) to (4) to 70℃ Mix and dissolve. B Add (5) to (6) to A at 70°C and mix uniformly to obtain an oil-in-polyhydric alcohol emulsion composition. Mix and dissolve C (7) to (10) at 70°C. Add C to D B, emulsify it, and cool it to obtain cream. The cream of Example 3 obtained as described above was a fine-textured cream with high skin safety and excellent stability over time. Comparative Example 4 Cream (formulation) (wt%) (1) Soybean lecithin 2.0 (2) Monosodium N-myristoyl-L-glutamate 1.0 (3) Methyl paraoxybenzoate 0.1 (4) Cetyl alcohol 1.0 (5) Squalane 50.0 ( 6) 1,3-butylene glycol 5.0 (7) Glycerin 10.0 (8) Carboxyvinyl polymer 0.3 (9) Sodium hydroxide 0.04 (10) Purified water Remaining amount (manufacturing method) A Heat (1) to (3) to 70℃ Mix and dissolve. B Add (4) to (5) to A at 70°C and mix uniformly. Mix and dissolve C (6) to (10) at 70°C. D Add C to B, emulsify it, and cool it to obtain cream. The cream of Example 4 obtained as described above had a very poor texture and some solid precipitation was observed. Example 4 Emulsion (formulation) (wt%) (1) Egg yolk lecithin 1.0 (2) Sodium myristate 0.5 (3) Sorbitol 10.0 (4) Butyl paraoxybenzoate 0.1 (5) Monosodium N-stearoyl-L-glutamate 0.1 (6) Stearyl alcohol 0.5 (7) Liquid paraffin 5.0 (8) Hydrogenated oil 2.0 (9) Dipentaerythritol fatty acid ester 1.0 (10) Dipropylene glycol 10.0 (11) Methyl cellulose 0.1 (12) Purified water Remaining amount (manufacturing method) A Mix and dissolve (1) to (6) at 70°C. B Add (7) to (9) to A at 70°C and mix uniformly to obtain an oil-in-polyhydric alcohol emulsion composition. Mix and dissolve C (10) to (12) at 70°C. Add C to D B, emulsify it, and cool it to obtain a milky lotion. Example 5 Cloudy lotion (formulation) (wt%) (1) Soybean lecithin 0.5 (2) Monosodium N-cocoyl-L-glutamate 0.2 (3) Glycerin 5.0 (4) Methyl paraoxybenzoate 0.1 (5) Behenyl alcohol 0.2 ( 6) Liquid paraffin 1.0 (7) Polyoxyethylene (20) sorbitan monooleate 0.5 (8) Ethanol 10.0 (9) Purified water Remaining amount (manufacturing method) A Mix and dissolve (1) to (4) at 70℃. . B Add (5) to (6) to A at 70°C and mix uniformly to obtain an oil-in-polyhydric alcohol emulsion composition. Mix and dissolve C (7) to (9) at 60°C. D Cool B to 60°C, add C to emulsify, and cool to obtain a cloudy lotion. [Effects of the Invention] As detailed above, the present invention provides an emulsifying composition containing a phospholipid, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component. By using an N-long chain acylamino acid soap and a higher alcohol in combination with a lipid, an oil-in-water emulsion composition containing polyhydric alcohol and water, which has significantly improved stability, and an oil-in-water emulsion composition containing this and water are produced. This is what we were able to provide.

Claims (1)

[Claims] 1. A phospholipid and/or a salt thereof, an N-long chain acylamino acid soap, a higher alcohol, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component. An oil-in-polyhydric alcohol emulsion composition comprising: 2. A polyhydric alcohol containing a phospholipid and/or a salt thereof, an N-long chain acylamino acid soap, a higher alcohol, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component. An oil-in-water emulsion composition comprising a medium oil-in-water emulsion composition and water.