JPH06157281A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic useful as a lotion promoting skin function, having excellent safety and inhibitory effect on aging of skin, comprising an extract of tuber of Aconitum carmishaeli. CONSTITUTION:The skin cosmetic is blended with preferably 0.0001-30wt.% extract of tuber of Aconitum carmishaeli such as processed tuber of Aconitum carmishaeli obtained by disinfecting root tuber of a plant of the genus Aconitum of the family banunculaceae and preparing.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic composition containing an extract of Fuzi. More specifically, the present invention relates to a skin cosmetic which enhances skin function and is excellent in skin aging prevention effects (skin softening effect, skin acuity improving effect, skin wrinkle improving effect, etc.).

[0002]

BACKGROUND OF THE INVENTION Aged skin has a dry and rough skin-like state, which is thought to be due to a decrease in the water retention function of the stratum corneum, a decrease in the barrier function, and a decrease in the amount of sebum secretion. Has been. In addition, a decrease in the number of cells in both the epidermis and dermis causes a decrease in metabolic function, and further, the redox-related enzyme activity of the epidermis and the oxygen partial pressure of the skin decrease, and the turnover rate of the stratum corneum decreases. It has been known. In particular, collagen and elastin, which make up most of the skin, are said to control the elasticity and flexibility of the skin, and the metabolism of collagen decreases with age, the soluble fraction decreases, and a crosslinked structure is formed. It is believed that this reduces elasticity and flexibility.

As an agent for improving such aged skin,
Many cosmetics containing collagen or hyaluronic acid have been proposed, but these merely improve the moisturizing effect on the skin surface and do not essentially improve aged skin. In addition, vitamins and crude drugs are used as skin cell activating agents, but the current situation is that they have not been able to treat aging skin.

[0004] The adjunct used as the raw material of the skin cosmetic of the present invention is
It has been described in Shenno Honzo Sutra in China since ancient times and is known as an important crude drug widely used in various Kampo prescriptions in Kampo medicine. The source plant is the Ranunculaceae (Ranuaceae).
acacia (Aconi)
tum species), and its tuberous root is used as a crude drug. In the literature, the root part of the tuberous root is called a fusi,
In the present situation, the abundant adjunct in the crude drug market is generally regarded as a crude drug abduct without any distinction made by subjecting the whole tuberous root to some processing. There are many kinds of aconite plants, and it is also well known that they contain highly toxic aconitine alkaloids, so that there are considerable differences in the components and toxicity of herbal medicines. Therefore, it is necessary to exercise extreme caution when using it, and incorrect application may cause unexpected acute poisoning.

[0005] In China, various treatments and preparations were made along with the cultivation from the Song Dynasty, and nowadays, the kinds of the source plants are
Depending on the processing method, dried rice (Japanese name: river crow), Shio-shi, Japanese sardine gourd (Japanese name: Shizushi), white adjuncts, cram-shikki, cho-shi, Shizushi, etc. It is commercially available.

Even in Japan, during the Edo period, the octocratic beetle (Aconitum Japanicum Thun)
b. ), And there is a record of the use of aconidia under the name of Shirakawa-bushi.
As shown in Japanese Patent Publication No. 37-18498, a method of detoxification treatment such as pressure heating has been proposed.

On the other hand, Fuzi is a Chinese medicine that has analgesic,
Known for its pharmacological effects such as diuresis, excitement, and hyperactivity of metabolism, it is used as decoctions and pills in various prescriptions. However, the method of administration in these Kampo medicines is mainly oral administration, and it is not known that the extract of Fuzi exerts an effect of preventing skin aging by external application.

[0008]

DISCLOSURE OF INVENTION Problems to be Solved by the Invention In view of the above circumstances, the present inventor has conducted extensive studies, and as a result, a specific detoxification-processed extract of adzuki bean has high safety and enhances skin function, The present invention has been completed by finding that it has excellent antiaging effects (skin softening effect, skin amelioration improving effect, skin wrinkle improving effect, etc.). That is, the object of the present invention is to provide a skin cosmetic having an excellent anti-aging effect on the skin.

[0009]

The above-mentioned object is achieved by a skin cosmetic composition containing an extract of Fuzi. The skin cosmetic of the present invention can enhance skin function and exhibit an excellent anti-aging effect on skin (skin softening effect, skin amelioration improving effect, skin wrinkle improving effect, etc.).

The raw material crude drug used in the skin cosmetic composition of the present invention is Ranunculaceae.
Aconitum plant (Aconitum specie)
It is called a processed adjunct prepared by detoxifying from the root root of s). There is no limitation on the source plant and its origin as long as it is prepared for detoxification. For example, a cultivar, Aconitum carp, produced in Sichuan, China
michaeli Debx. ), Wild species (Aconitum kusnesoffii Reic) from all over China
hb. ) Etc. from Korea.
tum triphyllum Nakai), Aconitum coreanum R
ap. ), Japanese octopus beetle (Acnitum)
japonicum Thunb. ), Aconitum chinese Paxt.
And so on. In particular, the agar beetle produced in Sichuan Province of China is preferable in terms of quality stability and supply with a certain cultivation method.

As a detoxification processing method, Japanese Patent Publication No. 37-1
Proposed in Japanese Patent No. 8498, tuberous roots in an autoclave at 100 to 130 ° C and pressure of 1.0 to 1.5 kg / c.
The method of preparing by applying pressure and heat treatment for m2 for 20 to 40 minutes is a particularly preferable method because a crude drug can be stably produced in a simple, effective and safe manner. An example of the product prepared by this method is "Processed bush powder", which is a brand name product of the Japanese Pharmacopoeia. Also, as a method mainly used in China,
Dip the water-washed tuberous root in bitter juice for several days to dry it, or further steam or boil it to prepare it after repeated treatments, or wash the tuber with water and split it vertically into ash when fresh. There is a method of burying, heating, pressurizing, etc. and drying to prepare. As an example of the preparation prepared by this method, the one commercially available as Fuzi gourd produced in Sichuan, China (referred to as Fuzi Fuzi in Japan) is preferable because it is sufficiently detoxified with a certain quality.

[0012] The extract of the adzuki bean of the present invention refers to a component transferred from the adduct to the solvent when the adzuki bean is extracted with a solvent, and the extract can also be used in a dried state after removing the solvent. Also, it can be used in a state of being dissolved in a solvent. In the latter case, the extraction solvent forms part of the base in the skin cosmetics according to the invention.

Solvents include water, alcohols such as methanol, ethanol, butanol, ethers such as diethyl ether, dioxane, ketones such as acetone, aliphatic hydrocarbons such as pentane, hexane, cyclohexane, esters such as Ethyl acetate or the like can be used. When the extract is used as a dried product after removing the solvent, any of the above-mentioned solvents can be used alone or as a mixture. However, when the extract is used in a state of being dissolved in a solvent, it is preferable to use water, ethanol, or a mixture thereof, which has no harmful effect on the human body.

In the extraction, the adjunct may be used as it is, or may be crushed or crushed to improve the contact with the solvent. Although the ratio of the adjunct to the solvent is not particularly limited, the adjunct 1 is taken into consideration from the viewpoint of extraction efficiency and convenience.
Preference is given to using 100 to 5000 ml of solvent per 00 g. The extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent under normal pressure, and the extraction time is preferably in the range of 30 minutes to 2 weeks, although it varies depending on the extraction temperature, the presence or absence of stirring and the like.

Since the detoxified extract of aconidium of the present invention is not toxic to the human body, its content in skin cosmetics is not particularly limited and can be selected within a wide range, but at an effective concentration. In consideration of the existence and economy, it is preferable that the content of the extract of Fuzi (as dry matter) is 0.0001 to 30% by weight based on the total amount of the skin cosmetic.

The skin cosmetic of the present invention can be prepared according to a conventional method such as lotions, emulsions, creams, ointments, packs,
It is possible to make a dosage form such as powders.

The skin cosmetic of the present invention includes a surfactant, a moisturizer, a pH adjuster, a thickener, a pigment, a fragrance, a bactericide, an antiseptic, a keratolytic agent, an anti-inflammatory agent, an antioxidant, and an ultraviolet absorbing agent. Agents, pigments and the like can be appropriately blended within a range that achieves the object of the present invention.

[0018]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. Incidentally, the skin viscoelasticity test method described in Examples,
The skin beautifying effect test method is shown below.

(1) Skin Viscoelasticity Test Wistar hairless rats (6 weeks old, male, 1 group 5)
The back of each animal was shaved, and 0.1 g of the sample was applied daily to a 2 × 2 cm site on the right shoulder. 45 days after the start of the test, the skin viscoelasticity value was measured using the surface viscoelasticity measuring device described in Japanese Patent Application No. 2-278505, and the average value of the skin viscoelasticity value of each group was obtained. In addition, the skin viscoelasticity value (arbitrary unit) displayed by the measuring device shows a higher value as the skin is harder.

(2) Skin beauty test method Female subjects (35-5) who complain of rough skin, fine wrinkles, dry skin, etc.
After allowing 20 people (5 years old) to use the sample twice a day (morning / evening) continuously for 2 months, skin softness, amelioration and wrinkle improvement were evaluated. The results are shown by the number of respondents who answered "improved skin flexibility,""improved skin acuity" and "improved skin wrinkles" for each item.

Production Example 1 (Preparation of extract of Fuzi) (1) A crushed product of dried root of Fuzi (commercially available as river crows or dried Fuzi) produced in Sichuan Province of China at 100 to 130 ° C in an autoclave, The pressure is adjusted to 1 to 1.5 kg / cm2, and pressure and heat treatment are performed for 40 minutes. Azushi 1 processed
00 g to 1500 ml of 70 v / v% ethanol (hereinafter, v / v% is abbreviated to%) at room temperature (20 to 25%).
C.) for 16 hours, the supernatant was collected by filtration, concentrated under reduced pressure at 45.degree. C. for 3 hours, and the solvent was distilled off to obtain 11.7 g of a brown extract.

(2) 100 g of the rice bran produced in Sichuan Province, China, which was processed in the same manner as in Production Example (1), was immersed in 1500 ml of 40% ethanol for 16 hours at room temperature (20 to 25 ° C.), and the supernatant was filtered. It was collected and concentrated under reduced pressure at 45 ° C. for 4 hours, and the solvent was distilled off to obtain 13.4 g of a brown extract.

(3) 50 g of Zhifuzi (commercially available as Zhizi) produced in Sichuan Province of China was immersed in 500 ml of 70% ethanol for 16 hours at room temperature (20 to 25 ° C.), and the supernatant was filtered. After collecting and concentrating at 45 ° C. under reduced pressure for 2 hours and distilling off the solvent, 5.3 g of a brown extract was obtained.

(4) 50 g of processed bush powder (manufactured by Sanwa Pharmaceutical Co., Ltd.) was added to 500 ml of 40% ethanol at room temperature (20 to 25).
C.) for 10 hours, the supernatant was collected by filtration, concentrated under reduced pressure at 45.degree. C. for 3 hours, and the solvent was distilled off to obtain 6.1 g of a brown extract.

Examples 1 to 4 and Comparative Example 1 "skin cream"

Using the extract of Fusuki obtained as in the composition of Table 1, skin creams of the present invention and comparative skin creams were prepared and the above tests were carried out. The results are shown in Table 2.

[0027]

[Table 1]

The component (C) is uniformly mixed and dissolved at about 80 ° C., added to the component (A) that has been uniformly mixed and dissolved at about 80 ° C. and emulsified, and then uniformly mixed and dissolved at about 50 ° C. The prepared portion (B) was added and the mixture was cooled to about 30 ° C. to prepare.

[0029]

[Table 2] * The extract of Fuzi of the composition ingredient is the weight% by dry matter conversion.
And ** Indicated as a relative value using the skin viscoelasticity value of Comparative Example 1 as a reference (1.0).

As can be seen from Table 2, the skin creams of the present invention of Examples 1 to 4 showed good results in all tests as compared with the skin cream of Comparative Example 1.

[0031]

EFFECTS OF THE INVENTION As described above, the present invention enhances skin functions and is excellent in skin aging prevention effects (skin softening effect, skin acuity improving effect, skin wrinkle improving effect, etc.) It is clear to provide the fee.

Claims (1)

[Claims] 1. A skin cosmetic comprising the extract of Fuzi.