JPH0611225B2 - Method and apparatus for producing blood product from animal blood - Google Patents

Description

The present invention relates to a method and an apparatus for producing useful blood products such as dried blood cell powder and dried plasma powder using blood collected from a slaughtered animal as a raw material.

Blood of slaughtered animals such as cows, horses and pigs has a high protein content and low fat content, the amino acid composition contained in the protein is good, and the nutritional value is excellent.

However, looking at the utilization situation of the blood of this slaughterhouse, only a very small part of the low quality recovered by simple treatment such as boiling coagulation is used for fertilizer, and most of it is used. The blood is simply dumped into the wastewater treatment device without being used. Moreover, this disposal puts a heavy burden on the treatment facility.

Therefore, recently, as another blood treatment method, the blood is centrifuged to separate the blood into blood cells and plasma, or fibrin is removed from the blood, and the blood is centrifuged to separate blood cells and serum. , A method of drying each separated to obtain a dried product is provided. The plasma or serum obtained by this method originally has a pale yellow color, and, for example, plasma powder can be effectively used as a substitute egg white.
However, conventionally, when this method is performed in a relatively large-scale blood processing apparatus, the problem is that the pale yellow color of plasma or serum often exhibits a red color, which limits the application.

By the way, prior to the present invention, the applicant has proposed a method for obtaining a sterilized dry product from blood components such as blood or plasma without deteriorating the physical properties of their water solubility (easy solubility) and thermocoagulability. (JP-A-54-20875).

In this method, blood or each blood component separated by a centrifuge or the like is dried at a low temperature to obtain a dried product having a water content of 30% by weight or less, and the dried product is heated at 80 to 160 ° C. according to the water content. It is heated and sterilized at the temperature.

The manufacturing process by this method has a sterilization process immediately before commercialization, but if a large amount of microorganisms are contained before this sterilization process, that is, until the dry product, the sterilization conditions must be severe. Therefore, it becomes difficult to effectively perform sterilization without impairing the properties of excellent water solubility and thermal coagulation. Therefore, in the production of products, it is important to suppress the growth of microorganisms during the period from blood collection to drying. For that purpose, it is necessary to avoid incomplete cleaning of the insides of the piping, pumps, cooling heat exchangers, storage tanks, etc. of the blood processing apparatus, which are considered to be the largest cause of microbial growth, after the work is completed.

However, the work at the slaughterhouse is often performed in a relatively short time, and accordingly, the operation time of the production line from the blood collection device to the front of the dryer is shortened. It is in a state where it is not used for a long time before starting work and is left unattended. Therefore, if the cleaning is insufficient and blood plasma, blood cells, or the like remains, significant microbial growth may occur in the duct or the like, and finally, a bad odor may occur in the apparatus.

Further, the blood after blood collection easily coagulates in a short time, and this becomes blood glue and adheres to the inside of the storage tank, piping, pump, and heat exchanger for cooling, so that it is difficult to sufficiently clean the blood processing apparatus.

Conventionally, the blood is prevented from coagulating by supplying a liquid such as sodium citrate as an anticoagulant at a constant ratio from a blood sampling (trocar) knife. It is difficult to completely prevent blood coagulation after blood collection, which causes imbalance in the ratio of anticoagulants. In addition, blood coagulation is highly adherent, and once it adheres to the inside of storage tanks, pipes, pumps, and heat exchangers, coagulation and fat clumps adhere to it, forming a paste, and cleaning. Becomes difficult.

And if the cleaning after the work is insufficient,
Microorganisms that produce a mucous substance are generated in the pasty deposits to form fungal sheaths, and the deposits become stronger, making it more difficult to remove the deposits by washing.

In contrast to the above situation, in the conventional stationary cleaning method in which cleaning water is flowed into the apparatus for cleaning, the inside of the storage tank and the inside of the pipe can be cleaned to some extent, but the inside of the pump and the plate heat exchanger is extremely difficult to clean. . Therefore, in order to manufacture high quality products, conventionally, after the completion of daily work, the pump and the inside of the plate heat exchanger have to be disassembled and manually washed, and Therefore, a lot of labor is required.

As described above, in any manufacturing method and apparatus for obtaining a high-value-added product from blood collected from a slaughtered animal, color of blood components, without impairing the original physical properties such as solubility, and harmful microorganisms and It is important not to include the bad odor caused by these microorganisms.

The present inventors have earnestly studied to improve the above-mentioned conventional drawbacks, and as a result, have obtained the following findings.

That is, plasma or serum separated from blood does not turn into an original pale yellow color but often exhibits a red color, as shown in FIG. 1, when blood flows into the storage tank 1 from the top of the tank as shown in FIG. Since the fall distance (inflow head) from the opening 2a of the inflow pipe 2 to the tank bottom or the liquid surface is large,
When blood collides with the bottom or the liquid surface in the tank, so-called hemolysis occurs, in which the cell membrane of blood cells in the blood is destroyed, and as a result, hemoglobin flows out and plasma and serum are colored red. did.

It was also found that effective cleaning can be performed without disassembling the device by mixing and injecting a gas together with the cleaning liquid into the device to be cleaned, and further, the blood supply system of the storage tank has a special configuration. Thus, it has been found that the whole blood transport system can be cleaned at one time, which had to be conventionally cleaned for each storage tank in the blood processing apparatus.

The present invention has been made based on the above findings.

That is, the first invention is a blood collecting step of adding an anticoagulant to blood collected by a blood collecting knife from a slaughtered animal immediately after the blood collection, and dropping the collected blood into the test storage tank through the first pipe. An inspection process of inflowing and storing at zero, and inspecting the presence or absence of sick blood, and blood in the inspection storage tank that is received by the second pipe and cooled to 5 ° C or less at which microorganisms do not grow, and a blood cold storage tank through the third pipe A cooling step in which the blood is stored with a zero drop inside, and a blood separation step in which the blood stored in the blood cool storage tank is received by the fourth pipe and separated into blood cells and plasma; and the blood separation step Blood cells are dried, crushed and sterilized to obtain dried blood cells.Production process of blood cells, plasma separated in blood separation process is dried, crushed, and sterilized to obtain dried plasma. Apply the cleaning liquid and compressed gas to the above pipes at the same time. It has a structure that and a cleaning step of removing the serial adhered to the inner wall surface of the pipe blood.

The second invention is an anticoagulant injection facility for adding an anticoagulant to blood collected from a slaughtered animal by a blood sampling knife,
A test storage tank that stores blood to which an anticoagulant has been added by inflowing through the first pipe with a zero drop, and a blood stored in the test storage tank that is received by the second pipe and cooled to 5 ° C. or lower at which microorganisms do not grow. The cooler and the blood cooled by the cooler
A blood-cooling storage tank that is stored by inflowing at zero drop through a pipe, a separation device that receives blood stored in the blood-cooling storage tank by a fourth pipe and separates it into blood cells and plasma, and the separation device Blood cell dryer for drying blood cells, plasma dryer for drying plasma separated by the separating device, grinder for grinding dried blood cells, grinder for grinding dried plasma, and dried It was configured to include a sterilizer for sterilizing blood cells, a sterilizer for sterilizing dried plasma, a cleaning liquid inlet for flowing a cleaning liquid through the pipe, and a gas inlet for flowing a compressed gas through the pipe.

An embodiment of the present invention will be described below with reference to the drawing (FIG. 2).

First, blood collected from a slaughtered animal 3 such as a cow or a pig by a trocar knife 4 is mixed with an anticoagulant supplied from an anticoagulant tank (anticoagulant injection equipment) 5 by the trocar knife 4. ,
It is introduced into the blood collection tank 6. Then, the blood guided to the blood collecting tank 6 is sent into the pipe 7 through a predetermined flow path. A cleaning liquid inlet 8 having an opening / closing valve 8a and an air (gas) inlet 9 having an air adjusting valve 9a are provided on the upstream side of the pipe 7, and a filter is provided in the middle of the pipe 7. 10 is interposed.

The downstream end of the pipe 7 is connected to the lower portion of the inspection storage tank 11. A pipe 12 is connected near the downstream end of the pipe 7. Connection part 13 of the pipes 7 and 12 and the inspection storage tank 11
An air inlet 14 having an air regulating valve 14a is provided in the pipe 7 between the pipe 7 and
An on-off valve 15 is provided on the downstream side of.

A drain pipe 16 having an on-off valve 16 a is connected between the connecting portion 13 of the pipe 12 and the on-off valve 15. In the above structure, the blood supply system 17 includes the downstream side of the pipe 7, the upstream side of the pipe 12, the connecting portion 13, and the on-off valve 15.
Are configured.

An air inlet 18 having a regulating valve 18a is provided on the downstream side of the pipe 12, a pump 19 of a rotary type, a tube type, or the like is subsequently interposed, and an air injection having a regulating valve 20a is further provided downstream. An air inlet 21 having an inlet 20 and a regulating valve 21a is provided. The downstream end of the pipe 12 is connected to one end of a plate type heat exchanger (cooler) 22, and the other end of the heat exchanger 22 is connected to a pipe 23.

The downstream end of the pipe 23 having the opening / closing valve 24 is connected to the lower portion of the blood cold storage tank 25. A pipe 26 is connected near the downstream end of the pipe 23. These pipes 23,
An on-off valve 28 is provided on the downstream side in the vicinity of the connection portion 27 of 26, and a drain pipe 29 having an on-off valve 29 a is connected between the on-off valve 28 and the connection portion 27. In the above configuration, the downstream side of the pipe 23, the upstream side of the pipe 26, the connecting portion 27, and the opening / closing valve 28 form a blood supply system 30.

On the further downstream side of the pipe 26, a uniaxial screw type,
A rotary type pump 31 is installed, and this pump 3
A cleaning liquid outlet 32 having an opening / closing valve 32a is provided further downstream of 1. The downstream end of the pipe 26 is connected to a centrifuge (separation device) 33, and is configured to supply cold blood to the centrifuge 33.

The blood cells separated by the centrifuge 33 are temporarily stored in a blood cell storage tank 34, then transferred to a blood cell dryer 36 via a pump 35, dried there, and then powdered by a crusher 37, and then further. The product is transferred to the sterilizer 38 and sterilized there, and finally packed in the bagging machine 39 to obtain a product.

On the other hand, the plasma separated by the centrifuge 33 is temporarily stored in the plasma storage tank 40, then transferred to the plasma dryer 42 via the pump 41 and dried there, and the crusher 43 is used.
The powder is pulverized, then further sterilized by the sterilizer 44, and finally packed by the bagging machine 45 to obtain a product.

In the above configuration, the cleaning liquid supply means 4 is provided above the test storage tank 11 and the blood cold storage tank 25, respectively.
Spray ball 4 attached to the tip of 6,47
6a and 47a are inserted so that the cleaning liquid is sprayed in each tank.

Next, the operation of the blood product manufacturing apparatus configured as described above will be described. First, before performing blood collection, the opening / closing valve 8a of the washing liquid inlet 8, the air regulating valve 9a of the air inlet 9, the opening / closing valve 15, the air injection. The air regulating valve 14a at the inlet 14 and the opening / closing valve 16a installed in the drain pipe 16 are closed. Then, blood collection is started from the slaughtered animals 3 such as cows and pigs by the trocar knife 4, and the anticoagulant tank 5 is mixed with the anticoagulant and the blood is introduced into the blood collecting tank 6.

The introduced blood has a filter 1 interposed in the middle of the pipe 7.
After foreign matter such as animal hair is removed by 0, it is flown into the inspection storage tank 11 with a zero drop. Therefore, the blood flowing through the pipe 7 can be stored in the test storage tank 11 without causing hemolysis. The on-off valve 15 is opened after confirming that no blood of sick animal is mixed in the inspection storage tank 11. At this time, the adjustment valve 18 of the air inlet 18, 20, 21
a, 20a, 21a, the opening / closing valve 28, the opening / closing valve 29a of the drain pipe 29 is closed, and the opening / closing valve 24 of the pipe 23 is opened. The blood in the test storage tank 11 is guided to the plate heat exchanger 22 via the pipe 12 and the pump 19 and is cooled to a temperature of 5 ° C. or lower at which microorganisms do not grow, and then blood is passed through the pipe 23 without causing hemolysis. It is stored in the cold storage tank 25.

Next, the opening / closing valve 24 of the pipe 23 is closed and the opening / closing valve 28 is opened to supply the blood in the blood cold storage tank 25 to the centrifuge 33 via the pipe 26 and the pump 31. At this time, the opening / closing valve 32a of the cleaning liquid outlet 32 is closed.

The blood is separated into blood cells and plasma by the centrifugal separator 33 and stored in the blood cell storage tank 34 and the plasma storage tank 40, respectively. The amount of water here is about 65% for blood cell fluid and about 92% for plasma fluid.
As in 5, the temperature is maintained at 5 ° C. or lower.

Next, the blood cell fluid and plasma fluid are dried at 60 ° C. or lower in a vacuum at a blood cell dryer 36 and a plasma dryer 42 to a water content of about 10%, respectively, and further pulverized to a certain particle size or less by pulverizers 37 and 43, respectively. The bagging machine 3 is sterilized by the sterilizers 38 and 44 at a temperature at which heat denaturation does not occur.
The product is packaged in bags at 9,45. Therefore, when blood is commercialized by using the manufacturing apparatus having the above structure, the plasma product does not show red color and the commercial value is not impaired.

Next, a method of cleaning the blood product manufacturing apparatus having the above structure will be described. First, water or hot water is fed from the spray balls 46a and 47a installed above the test storage tank 11 and the blood cool storage tank 25 to easily wash the test storage tank 11 and the blood cool storage tank 25, and drain the drain water 16 , 29.

Next, the on-off valves 15, 24, 28 and 32a are opened, the on-off valves 16a and 29a of the drain pipes 16 and 29 are closed, and washing water is discharged from the spray ball 46a of the inspection storage tank 11 to fill the inspection storage tank 11 and the pump 19 is turned on. At the same time, the compressed air is fed from the air inlets 14, 18, 20, 21 simultaneously. In addition, when cleaning the pipe 7, cleaning water is supplied to the cleaning liquid inlet 8
The compressed air is simultaneously fed from the air inlet 9. Then, the compressed air agitates the cleaning liquid in the flow path,
It acts on the wall of the flow path and removes blood strongly attached to the wall.

As the washing water, PH or 10 or more in water or warm water of about 45 ° C,
If a cleaning agent such as caustic soda and sodium carbonate is added so that the concentration is preferably about 0.05 to 0.2%, the cleaning time is shortened slightly.

The amount of air is 0.3 with respect to the amount of liquid sent regardless of where the air is fed
Vol ratio or more, preferably 2 to 3 times. Further, when the pump 19 is a special rotary type pump, the amount of compressed air fed in is a volume ratio of 0.3 to 0.5 to the amount of liquid fed by the pump 19 in the air inlet 14, and the other air inlets 18, 2
At 0 and 21, the vo is 2 to 3 times as much as the pump 19
l ratio.

Then, when a small amount of washing water is accumulated at the bottom of the blood cool storage tank 25, the spray ball 47 of the blood cool storage tank 25
Start supplying a small amount of washing water from a and pump 3
1 is started and the cleaning water is discharged from the cleaning liquid outlet 32. As a result, the air-mixed cleaning liquid in these flow paths flows vigorously in the main flow path from the upstream side of the pipe 7 to the downstream side of the pipe 26 by the pumps 19 and 31.

The state of cleaning of the inside of the blood transport system from the test storage tank 11 to immediately before the centrifuge 33 is determined from the color degree of the waste water.
As a means for judging the washing effect, it is convenient to use a scanning spectrophotometer or the like in advance to examine the relationship between the maximum absorption wavelength and absorption coefficient of blood and the residual blood concentration, and to use a colorimeter.
Usually, it takes about 20 to 25 minutes to completely clean the inside of the heat exchanger 22, which is difficult to clean, but the correlation with the color of the cleaning drainage requires a slight cleaning time after the absorbance of the cleaning drainage becomes zero. Seen. Regarding the setting of the cleaning time, it is necessary to investigate beforehand and set the relationship with the cleaning state inside the heat exchanger or inside the pump, which is difficult to clean.

In the present invention, it is sufficient that the compression pressure of the air to be fed is such that the air can be introduced into the interior (1 to 5 kg / cm ² G), and it is usually 1 to ² kg / cm ² G. The flow rate of the washing water is 1.5 m / sec or more in the pipe. This allows
This manufacturing device, which includes a device with a complicated internal shape and has a main flow path with a long distance, can be thoroughly washed to reliably remove blood, and even if the device is left unused for a long time, it will not decompose. There is no worry about it occurring.

In addition, after performing the above-mentioned washing, 100-200 pp
It is hygienically preferable to wash and sterilize the manufacturing apparatus with an aqueous solution of sodium hypochlorite of about m. Further, when the cleaning is started, a large amount of blood paste-like substance, which is considered to be desorbed substances, from the inside of the heat exchanger 22 comes out, and if it gets caught in the rotor portion of the pump 31 or the like, the cleaning may be disturbed. It is preferable to temporarily discharge the wash water from the drain pipe 29.

In the above-mentioned embodiment, instead of providing the on-off valves 15 and 28 on the downstream side of the connecting portions 13 and 27, the connecting portion 1
A three-way valve may be attached to 3,27. By doing this, while connecting the upstream side pipe and the downstream side pipe, it is easy to switch the flow paths during blood processing and washing,
It can be done reliably.

Further, in the above embodiment, the washing liquid outlet 32 is provided immediately before the centrifuge, but it may be provided after the blood cell storage tank 34 and the plasma storage tank 40.

The case where the cleaning work of the present invention is manually performed has been described above. However, if a sequence operation circuit for sequential operation including a timer for opening and closing valves for air cleaning water and starting / stopping the pump is assembled, it can be automatically performed by one start button operation. You can drive.

In the above description, the air inlet (gas inlet) is 9,
Fourteen, eighteen, twenty, and twenty-one are provided so that air can be injected into the flow channel from each of them during cleaning. The air inlets 18, 20, 21 are provided by the pumps 19, 3,
1. In particular, when the pump 19 is a flow passage block type pump such as a tube type, air can pass through the flow passage block type pump only by an amount moved by the rotation of the pump.
This is because the air supply to the downstream of this pump is reduced, and therefore, on the upstream and downstream sides of this pump,
This is because it is necessary to supplement the air especially on the downstream side. Therefore, the pumps 19 and 20 are rotary type,
If a flow passage open type pump such as a single screw type is adopted, the air inlets 18, 20, 21 are not necessary, and the air inlets 9 and 14 on the most upstream side are sufficient. With the air-containing cleaning liquid formed by injecting air from the device, cleaning can be sufficiently performed collectively from the upstream side to the downstream side of the apparatus.

Further, the air inlet 14 is provided to compensate for the fact that some air escapes to the outside through the inspection storage tank 11. However, the cleaning liquid is supplied from the upper spray ball 46a into the inspection storage tank 11,
Since the cleaning liquid supplied into the inspection storage tank 11 is sequentially sucked into the flow path by the pump 19, the air in the flow path cannot flow back into the inspection storage tank 11 by backflowing this flow. There is no escape to the outside.
Therefore, the air inlet 14 is a preliminary one that does not need to be provided by force.

As described above, in the above manufacturing apparatus, if the flow path open type pump is adopted as the pump, only the most upstream air inlet 9 is sufficient as the air inlet, and the air is injected from this air inlet 9 The air-containing cleaning liquid thus formed enables simultaneous and sufficient cleaning from the most upstream side to the most downstream side of the apparatus. Therefore, in the blood processing apparatus of the present invention, it is desirable to use a flow passage open type pump such as a single screw type.

As described above, according to the present invention, the following excellent advantages can be obtained when a useful product such as a blood cell dry powder or a plasma dry powder is obtained from blood collected from a slaughtered animal.

By allowing the collected blood to flow into the storage tank with a head of zero, the hemolysis phenomenon of blood cells due to impact can be prevented and the quality of plasma products can be improved.

It is possible to prevent the growth of microorganisms in the stored blood by cooling the collected blood to a low temperature of 5 ° C. or lower and storing it by keeping it cool.

Since the anticoagulant is added immediately after blood collection, coagulation in the system up to the storage tank can be prevented and the growth of microorganisms due to contamination can be suppressed.

Since air and a cleaning solution are used together to efficiently clean all system paths immediately after the facility is stopped, it is possible to keep the system paths at rest clean and prevent the attachment and growth of microorganisms.

Due to the effects (1) to (3), the sterilization step in the final stage can be carried out at a temperature at which the product is not thermally denatured.

Water solubility (easy solubility)
It is possible to manufacture a high-quality dry plasma product which is excellent in sterilization, is sufficiently sterilized, and does not cause a red coloring phenomenon in the plasma product, without lowering the heat coagulation property.

The gas mixture cleaning effect described above will be described below with reference to experimental examples.

Experimental Example 1 As a cleaning operation of the apparatus of the above-mentioned example, water was sprayed from the spray balls 46a, 47a of the test storage tank 11 and the blood cool storage tank 25 for about 1 minute, the interior of the storage tanks 11, 25 was pre-cleaned, and the cleaning water was drained from the drain pipe. Drained. Next, the on-off valve 28 is opened and the pumps 19 and 31 are started while water is sprayed from the spray balls 46a and 47a of the test storage tank 11 and the blood cool storage tank 25. ²⁰ Nl / min at a pressure of cm ² G, 1 air inlet
Inject at a rate of 100 Nl / min from 8, 20, 21
Piping from test reservoir to centrifuge with a mixture of water and air,
The inside of a series of blood transport devices such as a pump, a storage tank, and a heat exchanger was cleaned. The easy delivery amount of the pump 19 was adjusted to 50 / min. The washing was terminated by measuring the absorbance of the wastewater and ending the concentration of blood in the wastewater until the end point. The time required for washing was 30 minutes. As a result of disassembling and inspecting each part in the system after the completion of cleaning, the insides of the pipe, the storage tank, the pump and the heat exchanger were completely cleaned.

Comparative Example 1 Preliminary cleaning was performed in the same manner as in Experimental Example 1, and then cleaning was performed under the same conditions as in Experimental Example 1 without feeding compressed air. The time required for washing was 80 minutes. After cleaning, each part of the system was disassembled and inspected, and as a result, a small amount of blood paste-like substance with a size of 3 to 5 mm adhered to the inside of the pump and a large amount of blood paste-like substance inside the heat exchanger. It was

From the above comparison between Experimental Example 1 and Comparative Example 1, it can be seen that the cleaning effect of the present invention is complete and the time required for cleaning can be shortened.

Experimental Example 2 Experimental Example 1 and Comparative Example 1 using 45 ° C. warm water as washing water
The inside of the system was washed under the same conditions as above. The time required for cleaning was 20 minutes when the compressed air was fed and 50 minutes when the compressed air was not fed.

As a result of the overhaul and inspection, when the compressed air was fed, the cleaning was complete, but when it was not fed, the cleaning condition was better than when water was used, but inside the pump and heat exchanger A large amount of blood pasty substance adhered and the washing was incomplete.

Experimental Example 3 The inside of the system was cleaned under the same conditions as in Experimental Example 1 and Comparative Example 1 using 0.2% caustic soda as cleaning water. The time required for cleaning was 20 minutes when the compressed air was fed and 45 minutes when the compressed air was not fed.

[Brief description of drawings]

FIG. 1 is a block diagram of the vicinity of a storage tank of a conventional blood processing apparatus, and FIG.
FIG. 1 is a block diagram of a blood product manufacturing apparatus showing an embodiment of the present invention. 3 …… Slaughtered animal 4 …… Blood sampling knife (trocar knife) 5 …… Anticoagulant tank (anticoagulant injection equipment) 7,12,23,26 …… Piping 8 …… Cleaning fluid inlet 9,14, 18, 20, 21 …… Air inlet (gas inlet) 11 …… Inspection storage tank 13,27 …… Connection part 15,28 …… Open / close valve 19,31 …… Pump 22 …… Heat exchanger (cooler) 25 ... Blood cold storage tank 33 ... Centrifuge (separation device) 36 ... Blood cell dryer 37, 43 ... Crusher 38, 44 ... Sterilizer 42 ... Plasma dryer

Claims (3)

[Claims] 1. A blood collection step of collecting blood by adding an anticoagulant to blood collected from a slaughtered animal (3) with a blood collection knife (4), and collecting the collected blood in a first pipe (7). ) Through the storage tank (11) with a zero drop to store it and test it for the presence or absence of sick blood, and the blood in the testing tank (11) is received by the second pipe (12) The cooling step of cooling to 5 ° C or less at which it does not grow and flowing into the blood cold storage tank (25) through the third pipe (23) with a zero drop and storing, and the blood stored in the blood cold storage tank (25) 4 blood separation step of receiving in 4 pipes (26) to separate blood cells and plasma; blood cell production step of drying, crushing and sterilizing the blood cells separated in the blood separation step to obtain dried blood cells; and blood separation The plasma separated in the process is dried and crushed,
Plasma production process to obtain dried plasma by sterilization, the pipe (7,12,23,26) flowing the blood at the same time by flowing the cleaning solution and compressed gas of the pipe (7,12,23,26) A method for producing a blood product using animal blood as a raw material, comprising a cleaning step for removing blood adhering to an inner wall surface. 2. An anticoagulant injection facility for adding an anticoagulant to a blood sampled from a slaughtered animal (3) with a blood sampling knife (4), and blood to which the anticoagulant has been added is provided in a first pipe. The test storage tank (11) which is made to flow in and store at zero drop through (7) and the blood tested in the test storage tank (11) are received by the second pipe (12) and cooled to 5 ° C. or less at which microorganisms do not grow. Inside the blood cool storage tank (25), a cooler (22), a blood cold storage tank (25) for storing the blood cooled by the cooler (22) by flowing it through the third pipe (23) with a zero drop And a separating device (33) for receiving blood stored in the blood vessel in the fourth pipe (26) and separating it into blood cells and plasma.
Blood cell dryer for drying blood cells separated by (36), and plasma dryer for drying plasma separated by the separation device (33) (42)
And a crusher (37) for crushing dried blood cells, a crusher (43) for crushing dried plasma, a sterilizer (38) for sterilizing dried blood cells, and a sterilizer for dried plasma Sterilizer (4
4), a cleaning liquid inlet (8) for flowing a cleaning liquid through the pipes (7, 12, 23, 26), and a gas inlet (9) for flowing a compressed gas through the pipes (7, 12, 23, 26). An apparatus for producing a blood product using animal blood as a raw material, which comprises: 3. The upstream pipe (7,23) is opened at the bottom of the storage tank (11,25), and the downstream pipe (12,26) is the upstream pipe (7,23).
An apparatus for producing a blood product using animal blood as a raw material according to claim 2, wherein the apparatus is connected near the downstream end of the.