JPH0611225B2 - Method and apparatus for producing blood product from animal blood - Google Patents

Method and apparatus for producing blood product from animal blood

Info

Publication number
JPH0611225B2
JPH0611225B2 JP58249561A JP24956183A JPH0611225B2 JP H0611225 B2 JPH0611225 B2 JP H0611225B2 JP 58249561 A JP58249561 A JP 58249561A JP 24956183 A JP24956183 A JP 24956183A JP H0611225 B2 JPH0611225 B2 JP H0611225B2
Authority
JP
Japan
Prior art keywords
blood
pipe
storage tank
plasma
cleaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58249561A
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Japanese (ja)
Other versions
JPS60141241A (en
Inventor
旨孝 佐藤
晴彦 永澤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Niigata Engineering Co Ltd
Original Assignee
Niigata Engineering Co Ltd
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Publication date
Application filed by Niigata Engineering Co Ltd filed Critical Niigata Engineering Co Ltd
Priority to JP58249561A priority Critical patent/JPH0611225B2/en
Publication of JPS60141241A publication Critical patent/JPS60141241A/en
Publication of JPH0611225B2 publication Critical patent/JPH0611225B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Description

【発明の詳細な説明】 本発明は、屠畜動物から採取した血液を原料として、乾
燥血球粉、乾燥血漿粉等の有用な血液製品を製造する方
法およびその装置に関するものである。
The present invention relates to a method and an apparatus for producing useful blood products such as dried blood cell powder and dried plasma powder using blood collected from a slaughtered animal as a raw material.

牛、馬、豚等の屠畜動物の血液は、高蛋白質低脂肪であ
り、しかも蛋白質の中に含まれているアミノ酸構成もよ
く、栄養価の優れたものである。
Blood of slaughtered animals such as cows, horses and pigs has a high protein content and low fat content, the amino acid composition contained in the protein is good, and the nutritional value is excellent.

ところが、この屠畜の血液の利用状況を見ると、極く一
部が煮沸凝固等の簡単な処理で回収された低品質なもの
が肥料用として利用されている程度に過ぎず、大部分の
血液は、利用されることなく、単に排水処理装置に投棄
されている。また、この廃棄が処理設備に大きな負担を
与えている。
However, looking at the utilization situation of the blood of this slaughterhouse, only a very small part of the low quality recovered by simple treatment such as boiling coagulation is used for fertilizer, and most of it is used. The blood is simply dumped into the wastewater treatment device without being used. Moreover, this disposal puts a heavy burden on the treatment facility.

そこで、最近、別の血液処理方法として、血液を遠心分
離機にかけ、血液を血球と血漿に分離するか、あるいは
血液からフィブリンを取り除き、その血液を遠心分離機
にかけ血球と血清とに分離して、分離したそれぞれを乾
燥して乾燥製品を得る方法が提供されている。この方法
で得た血漿または血清は、本来淡黄色をしており、例え
ば血漿粉は代用卵白として有効利用できるものである。
しかし、従来、この方法を比較的大規模な血液処理装置
で行うと、血漿または血清の淡黄色がしばしば赤色を呈
し、用途上の制約を受けるといった問題が生じている。
Therefore, recently, as another blood treatment method, the blood is centrifuged to separate the blood into blood cells and plasma, or fibrin is removed from the blood, and the blood is centrifuged to separate blood cells and serum. , A method of drying each separated to obtain a dried product is provided. The plasma or serum obtained by this method originally has a pale yellow color, and, for example, plasma powder can be effectively used as a substitute egg white.
However, conventionally, when this method is performed in a relatively large-scale blood processing apparatus, the problem is that the pale yellow color of plasma or serum often exhibits a red color, which limits the application.

ところで、本発明に先立って、出願人は血液または血漿
等の血液成分からそれらの水溶性(易溶解性)と熱凝固
性の物性を低下せずに殺菌された乾燥製品を得る方法を
提案した(特開昭54−20875号)。
By the way, prior to the present invention, the applicant has proposed a method for obtaining a sterilized dry product from blood components such as blood or plasma without deteriorating the physical properties of their water solubility (easy solubility) and thermocoagulability. (JP-A-54-20875).

この方法は、血液または遠心分離機等によって分離され
た各血液成分を低温乾燥し、含水率30重量%以下の乾
燥品とし、それらの乾燥品をそれぞれの含水率に対応し
て80〜160℃の温度に加熱、殺菌するものである。
In this method, blood or each blood component separated by a centrifuge or the like is dried at a low temperature to obtain a dried product having a water content of 30% by weight or less, and the dried product is heated at 80 to 160 ° C. according to the water content. It is heated and sterilized at the temperature.

この方法による製造工程には製品化直前に殺菌工程を有
しているが、この殺菌工程前、すなわち乾燥品までの段
階で多量の微生物が含まれてしまうと、殺菌条件を苛酷
にせざるを得ず、水溶性や熱凝固性の優れた性質を損な
うことなく効果的に殺菌を行うことが困難となる。従っ
て、製品製造において、採血から乾燥に至る間での微生
物の増殖を抑えることが肝要である。そのためには微生
物増殖の最も大きな原因と考えられる血液処理装置の配
管、ポンプ、冷却用熱交換器、貯槽等の内部の作業終了
後の洗浄の不完全さをできるだけ避けなければならな
い。
The manufacturing process by this method has a sterilization process immediately before commercialization, but if a large amount of microorganisms are contained before this sterilization process, that is, until the dry product, the sterilization conditions must be severe. Therefore, it becomes difficult to effectively perform sterilization without impairing the properties of excellent water solubility and thermal coagulation. Therefore, in the production of products, it is important to suppress the growth of microorganisms during the period from blood collection to drying. For that purpose, it is necessary to avoid incomplete cleaning of the insides of the piping, pumps, cooling heat exchangers, storage tanks, etc. of the blood processing apparatus, which are considered to be the largest cause of microbial growth, after the work is completed.

ところが、屠畜場における作業は比較的に短時間で行わ
れる場合が多く、これに伴い採血装置から乾燥機前まで
の製造ラインの運転時間も短くなり、そのため血液処理
装置は、洗浄後から翌日の作業開始までの長い時間使用
されず放置されている状態である。従って、洗浄が不充
分で血液血漿あるいは血球等の残留があると、管路内等
に著しい微生物の増殖が起こり、ついには装置内に悪臭
が発生するようなことも起こり得る。
However, the work at the slaughterhouse is often performed in a relatively short time, and accordingly, the operation time of the production line from the blood collection device to the front of the dryer is shortened. It is in a state where it is not used for a long time before starting work and is left unattended. Therefore, if the cleaning is insufficient and blood plasma, blood cells, or the like remains, significant microbial growth may occur in the duct or the like, and finally, a bad odor may occur in the apparatus.

また、採血後の血液は短時間で凝固しやすく、これが血
糊となり貯槽、配管、ポンプ、冷却用熱交換器の内部に
付着するので、血液処理装置の洗浄を充分に行うことが
むずかしい。
Further, the blood after blood collection easily coagulates in a short time, and this becomes blood glue and adheres to the inside of the storage tank, piping, pump, and heat exchanger for cooling, so that it is difficult to sufficiently clean the blood processing apparatus.

なお、従来は通常採血(套管)ナイフから抗凝固剤とし
てクエン酸ナトリウム等の液を一定の比率で供給するこ
とにより血液の凝固を防止しているが、採血流量が一定
でないため、血液と抗凝固剤の比率のアンバランスを生
じ、採血後の血液凝固を完全に阻止することは困難であ
る。また、血液の凝固物は付着性が大であり、貯槽、配
管、ポンプ、熱交換器の内部に一旦付着すると、さらに
その上に凝固物や脂肪の固まり等が付着し、糊状とな
り、洗浄が困難になる。
Conventionally, the blood is prevented from coagulating by supplying a liquid such as sodium citrate as an anticoagulant at a constant ratio from a blood sampling (trocar) knife. It is difficult to completely prevent blood coagulation after blood collection, which causes imbalance in the ratio of anticoagulants. In addition, blood coagulation is highly adherent, and once it adheres to the inside of storage tanks, pipes, pumps, and heat exchangers, coagulation and fat clumps adhere to it, forming a paste, and cleaning. Becomes difficult.

そして、作業終了後の洗浄が不充分であったりすると、
糊状付着物に粘物質を作る微生物が発生して菌鞘を形成
し、付着物の付着が強固になり、一層洗浄による付着物
の除去が困難になる。
And if the cleaning after the work is insufficient,
Microorganisms that produce a mucous substance are generated in the pasty deposits to form fungal sheaths, and the deposits become stronger, making it more difficult to remove the deposits by washing.

上記状況に対し、洗浄水を装置内に流して洗浄する従来
の定置洗浄法では、貯槽内や配管内部の洗浄はある程度
行えるが、ポンプやプレート式熱交換器の内部の洗浄は
極めて困難である。従って、品質のよい製品を製造する
ために従来は、毎日の作業終了後、ポンプとプレート式
熱交換器の内部は、それらを分解して手作業で洗浄を行
わざるを得ず、この作業のため多大の労力を要してい
る。
In contrast to the above situation, in the conventional stationary cleaning method in which cleaning water is flowed into the apparatus for cleaning, the inside of the storage tank and the inside of the pipe can be cleaned to some extent, but the inside of the pump and the plate heat exchanger is extremely difficult to clean. . Therefore, in order to manufacture high quality products, conventionally, after the completion of daily work, the pump and the inside of the plate heat exchanger have to be disassembled and manually washed, and Therefore, a lot of labor is required.

上記のように屠畜動物から採血した血液から付加価値の
高い製品を得るいかなる製造方法および装置において
も、血液成分の色、溶解性等の本来の諸物性を損なうこ
となく、しかも有害な微生物やこれら微生物により起こ
される悪臭等が含まれないことが大切である。
As described above, in any manufacturing method and apparatus for obtaining a high-value-added product from blood collected from a slaughtered animal, color of blood components, without impairing the original physical properties such as solubility, and harmful microorganisms and It is important not to include the bad odor caused by these microorganisms.

本発明者らは、上記従来の欠点を改善すべく鋭意研究を
重ねたところ、下記のような知見を得るに至った。
The present inventors have earnestly studied to improve the above-mentioned conventional drawbacks, and as a result, have obtained the following findings.

すなわち、血液から分離した血漿や血清が本来の淡黄色
にならず、しばしば赤色を呈するのは、第1図に示すよ
うに、従来の血液処理装置において貯槽1に血液を槽頂
部から流入すると、流入配管2の開口部2aから槽底部
または液面までの落下距離(流入落差)が大きいため、
血液が槽内で底部または液面と衝突する際、血液中の血
球の細胞膜が破壊されるといういわゆる溶血を生じ、そ
の結果ヘモグロビンが流出して血漿や血清が赤色に着色
されてしまうことが判明した。
That is, plasma or serum separated from blood does not turn into an original pale yellow color but often exhibits a red color, as shown in FIG. 1, when blood flows into the storage tank 1 from the top of the tank as shown in FIG. Since the fall distance (inflow head) from the opening 2a of the inflow pipe 2 to the tank bottom or the liquid surface is large,
When blood collides with the bottom or the liquid surface in the tank, so-called hemolysis occurs, in which the cell membrane of blood cells in the blood is destroyed, and as a result, hemoglobin flows out and plasma and serum are colored red. did.

また、洗浄対象となる装置の内部に洗浄液とともに気体
を混入して流入させることにより装置を分解することな
く効果的な洗浄が行えることが判明し、さらに貯槽の血
液供給系を特殊な構成にすることにより、従来、血液処
理装置内の各貯槽間ごとに洗浄しなければならなかった
のを、血液輸送系全体を一度に洗浄可能となし得ること
も判明した。
It was also found that effective cleaning can be performed without disassembling the device by mixing and injecting a gas together with the cleaning liquid into the device to be cleaned, and further, the blood supply system of the storage tank has a special configuration. Thus, it has been found that the whole blood transport system can be cleaned at one time, which had to be conventionally cleaned for each storage tank in the blood processing apparatus.

本発明は上記知見に基づいてなされたものである。The present invention has been made based on the above findings.

すなわち、第1発明は、屠畜動物から採血ナイフで採ら
れた血液に採血直後に抗凝固剤を加えて該血液を採取す
る採血工程と、この採取血液を第1配管を通じて検査貯
槽内に落差零で流入させて貯留し、病畜血液の有無を検
査する検査工程と、検査貯槽内の血液を第2配管で受け
て微生物が増殖しない5℃以下に冷却して第3配管を通
じて血液保冷貯槽内に落差零で流入させて貯留する冷却
工程と、血液保冷貯槽内に貯留された血液を第4配管で
受けて血球と血漿とに分離する血液分離工程と、該血液
分離工程で分離された血球を乾燥し粉砕、殺菌して乾燥
血球を得る血球の製品化工程と、血液分離工程で分離さ
れた血漿を乾燥し粉砕、殺菌して乾燥血漿を得る血漿の
製品化工程と、血液を流す上記配管に洗浄液と圧縮気体
とを同時に流して上記配管の内壁面に付着した血液を除
去する洗浄工程とを具備した構成とした。
That is, the first invention is a blood collecting step of adding an anticoagulant to blood collected by a blood collecting knife from a slaughtered animal immediately after the blood collection, and dropping the collected blood into the test storage tank through the first pipe. An inspection process of inflowing and storing at zero, and inspecting the presence or absence of sick blood, and blood in the inspection storage tank that is received by the second pipe and cooled to 5 ° C or less at which microorganisms do not grow, and a blood cold storage tank through the third pipe A cooling step in which the blood is stored with a zero drop inside, and a blood separation step in which the blood stored in the blood cool storage tank is received by the fourth pipe and separated into blood cells and plasma; and the blood separation step Blood cells are dried, crushed and sterilized to obtain dried blood cells.Production process of blood cells, plasma separated in blood separation process is dried, crushed, and sterilized to obtain dried plasma. Apply the cleaning liquid and compressed gas to the above pipes at the same time. It has a structure that and a cleaning step of removing the serial adhered to the inner wall surface of the pipe blood.

また第2発明は、屠畜動物から採血ナイフで採られた血
液に採血直後に抗凝固剤を加える抗凝固剤注入設備と、
抗凝固剤を加えられた血液を第1配管を通じて落差零で
流入させて貯留する検査貯槽と、該検査貯槽で検査され
た血液を第2配管で受けて微生物が増殖しない5℃以下
に冷却する冷却器と、該冷却器で冷却された血液を第3
配管を通じて落差零で流入させて貯留する血液保冷貯槽
と、該血液保冷貯槽内に貯留された血液を第4配管で受
けて血球と血漿とに分離する分離装置と、該分離装置で
分離された血球を乾燥する血球乾燥機と、上記分離装置
で分離された血漿を乾燥する血漿乾燥機と、乾燥された
血球を粉砕する粉砕機と、乾燥された血漿を粉砕する粉
砕機と、乾燥された血球を殺菌する殺菌機と、乾燥され
た血漿を殺菌する殺菌機と、上記配管に洗浄液を流す洗
浄液流入口と、上記配管に圧縮気体を流す気体注入口と
を具備した構成とした。
The second invention is an anticoagulant injection facility for adding an anticoagulant to blood collected from a slaughtered animal by a blood sampling knife,
A test storage tank that stores blood to which an anticoagulant has been added by inflowing through the first pipe with a zero drop, and a blood stored in the test storage tank that is received by the second pipe and cooled to 5 ° C. or lower at which microorganisms do not grow. The cooler and the blood cooled by the cooler
A blood-cooling storage tank that is stored by inflowing at zero drop through a pipe, a separation device that receives blood stored in the blood-cooling storage tank by a fourth pipe and separates it into blood cells and plasma, and the separation device Blood cell dryer for drying blood cells, plasma dryer for drying plasma separated by the separating device, grinder for grinding dried blood cells, grinder for grinding dried plasma, and dried It was configured to include a sterilizer for sterilizing blood cells, a sterilizer for sterilizing dried plasma, a cleaning liquid inlet for flowing a cleaning liquid through the pipe, and a gas inlet for flowing a compressed gas through the pipe.

以下、本発明の一実施例を図面(第2図)を参照して説
明する。
An embodiment of the present invention will be described below with reference to the drawing (FIG. 2).

先ず、牛、豚等の屠畜動物3から套管ナイフ4によって
採られた血液は、套管ナイフ4で抗凝固剤タンク(抗凝
固剤注入設備)5から供給された抗凝固剤が混入され、
集血槽6中に導入される。そし、集血槽6に導かれた血
液は、所定流路で配管7中に送られるようになってい
る。この配管7の上流側には、開閉弁8aを有する洗浄
液流入口8と、空気調整バルブ9aを有する空気(気
体)注入口9とが設けられており、この配管7の中ほど
には濾過器10が介装されている。
First, blood collected from a slaughtered animal 3 such as a cow or a pig by a trocar knife 4 is mixed with an anticoagulant supplied from an anticoagulant tank (anticoagulant injection equipment) 5 by the trocar knife 4. ,
It is introduced into the blood collection tank 6. Then, the blood guided to the blood collecting tank 6 is sent into the pipe 7 through a predetermined flow path. A cleaning liquid inlet 8 having an opening / closing valve 8a and an air (gas) inlet 9 having an air adjusting valve 9a are provided on the upstream side of the pipe 7, and a filter is provided in the middle of the pipe 7. 10 is interposed.

上記配管7の下流端は、検査貯槽11の下部に接続され
ている。また配管7の下流端近くに配管12が接続され
ている。上記配管7,12の接続部13と検査貯槽11
との間の配管7には、空気調整バルブ14aを有する空
気注入口14が設けられており、配管12の接続部13
の下流側には開閉弁15が介装されている。
The downstream end of the pipe 7 is connected to the lower portion of the inspection storage tank 11. A pipe 12 is connected near the downstream end of the pipe 7. Connection part 13 of the pipes 7 and 12 and the inspection storage tank 11
An air inlet 14 having an air regulating valve 14a is provided in the pipe 7 between the pipe 7 and
An on-off valve 15 is provided on the downstream side of.

また、配管12の上記接続部13と開閉弁15との間に
は、開閉弁16aを有するドレーン管16が接続されて
いる。上記構成において配管7の下流側、配管12の上
流側、接続部13および開閉弁15は、血液供給系17
を構成している。
A drain pipe 16 having an on-off valve 16 a is connected between the connecting portion 13 of the pipe 12 and the on-off valve 15. In the above structure, the blood supply system 17 includes the downstream side of the pipe 7, the upstream side of the pipe 12, the connecting portion 13, and the on-off valve 15.
Are configured.

上記配管12の下流側には、調整バルブ18aを有する
空気注入口18が設けられ、つづいてロータリー型、チ
ューブ型等のポンプ19が介装され、さらに下流には順
次調整バルブ20aを有する空気注入口20および調整
バルブ21aを有する空気注入口21が設けられてい
る。この配管12の下流端は、プレート式等の熱交換器
(冷却器)22の一端に接続され、この熱交換器22の
他端には、配管23が接続されている。
An air inlet 18 having a regulating valve 18a is provided on the downstream side of the pipe 12, a pump 19 of a rotary type, a tube type, or the like is subsequently interposed, and an air injection having a regulating valve 20a is further provided downstream. An air inlet 21 having an inlet 20 and a regulating valve 21a is provided. The downstream end of the pipe 12 is connected to one end of a plate type heat exchanger (cooler) 22, and the other end of the heat exchanger 22 is connected to a pipe 23.

この配管23の開閉弁24を有する下流端は、血液保冷
貯槽25の下部に接続されている。また配管23の下流
端近くに配管26が接続されている。これら配管23,
26の接続部27近傍の下流側には、開閉弁28が介装
され、この開閉弁28と上記接続部27との間には開閉
弁29aを有するドレーン管29が接続されている。上
記構成において、配管23の下流側、配管26の上流
側、接続部27および開閉弁28は、血液供給系30を
構成している。
The downstream end of the pipe 23 having the opening / closing valve 24 is connected to the lower portion of the blood cold storage tank 25. A pipe 26 is connected near the downstream end of the pipe 23. These pipes 23,
An on-off valve 28 is provided on the downstream side in the vicinity of the connection portion 27 of 26, and a drain pipe 29 having an on-off valve 29 a is connected between the on-off valve 28 and the connection portion 27. In the above configuration, the downstream side of the pipe 23, the upstream side of the pipe 26, the connecting portion 27, and the opening / closing valve 28 form a blood supply system 30.

上記配管26のさらに下流側には、一軸スクリュー型、
ロータリー型等のポンプ31が介装され、このポンプ3
1のさらに下流側には開閉弁32aを有する洗浄液流出
口32が設けられている。この配管26の下流端は、遠
心分離機(分離装置)33に接続され、この遠心分離機
33中に保冷血液を供給するように構成されている。
On the further downstream side of the pipe 26, a uniaxial screw type,
A rotary type pump 31 is installed, and this pump 3
A cleaning liquid outlet 32 having an opening / closing valve 32a is provided further downstream of 1. The downstream end of the pipe 26 is connected to a centrifuge (separation device) 33, and is configured to supply cold blood to the centrifuge 33.

上記遠心分離機33で分離された血球は、一時血球貯槽
34に貯えられ、つづいてポンプ35を介して血球乾燥
機36に移送されてここで乾燥され、粉砕機37で粉末
化された後さらに殺菌機38に移送されてここで殺菌さ
れ、最後に袋詰機39で袋詰めされて製品となる。
The blood cells separated by the centrifuge 33 are temporarily stored in a blood cell storage tank 34, then transferred to a blood cell dryer 36 via a pump 35, dried there, and then powdered by a crusher 37, and then further. The product is transferred to the sterilizer 38 and sterilized there, and finally packed in the bagging machine 39 to obtain a product.

一方、上記遠心分離機33で分離された血漿は、一時血
漿貯槽40に貯えられ、つづいてポンプ41を介して血
漿乾燥機42に移送されてここで乾燥され、粉砕機43
で粉末化された後さらに殺菌機44で殺菌され、最後に
袋詰機45で袋詰されて製品となる。
On the other hand, the plasma separated by the centrifuge 33 is temporarily stored in the plasma storage tank 40, then transferred to the plasma dryer 42 via the pump 41 and dried there, and the crusher 43 is used.
The powder is pulverized, then further sterilized by the sterilizer 44, and finally packed by the bagging machine 45 to obtain a product.

なお、上記構成において、検査貯槽11および血液保冷
貯槽25の各々の上部には、それぞれ洗浄液供給手段4
6,47の先端に取り付けられているスプレーボール4
6a,47aが挿入されており、各槽内に洗浄液が散布
されるようになっている。
In the above configuration, the cleaning liquid supply means 4 is provided above the test storage tank 11 and the blood cold storage tank 25, respectively.
Spray ball 4 attached to the tip of 6,47
6a and 47a are inserted so that the cleaning liquid is sprayed in each tank.

次に上記構成とされた血液製品の製造装置における操作
を説明すると、まず採血を行う前に、洗浄液流入口8の
開閉弁8a、空気注入口9の空気調整バルブ9a、開閉
弁15、空気注入口14の空気調整バルブ14a、ドレ
ーン管16に設置されている開閉弁16aを閉じる。そ
して牛、豚等の屠畜動物3から套管ナイフ4によって採
血を開始するとともに、抗凝固剤タンク5が抗凝固剤を
混入し、集血槽6に血液を導入する。
Next, the operation of the blood product manufacturing apparatus configured as described above will be described. First, before performing blood collection, the opening / closing valve 8a of the washing liquid inlet 8, the air regulating valve 9a of the air inlet 9, the opening / closing valve 15, the air injection. The air regulating valve 14a at the inlet 14 and the opening / closing valve 16a installed in the drain pipe 16 are closed. Then, blood collection is started from the slaughtered animals 3 such as cows and pigs by the trocar knife 4, and the anticoagulant tank 5 is mixed with the anticoagulant and the blood is introduced into the blood collecting tank 6.

導入された血液は配管7の中ほどに介装された濾過器1
0によって動物の毛等の異物を取り除かれた後、落差零
で検査貯槽11内に流入される。従って配管7を流通し
てきた血液は、溶血を起こすことなく検査貯槽11内に
貯えることができる。検査貯槽11で病畜血液の混入が
ないことを確かめた上で前記開閉弁15を開ける。この
時には空気注入口18,20,21の調整バルブ18
a,20a,21a、開閉弁28、ドレーン管29の開
閉弁29aは閉じ、配管23の開閉弁24は開かれてい
る。検査貯槽11内の血液は配管12、ポンプ19を介
してプレート式熱交換器22に導かれ、微生物が増殖し
ない温度5℃以下まで冷却された後、配管23を通って
溶血を起こすことなく血液保冷貯槽25に貯えられる。
The introduced blood has a filter 1 interposed in the middle of the pipe 7.
After foreign matter such as animal hair is removed by 0, it is flown into the inspection storage tank 11 with a zero drop. Therefore, the blood flowing through the pipe 7 can be stored in the test storage tank 11 without causing hemolysis. The on-off valve 15 is opened after confirming that no blood of sick animal is mixed in the inspection storage tank 11. At this time, the adjustment valve 18 of the air inlet 18, 20, 21
a, 20a, 21a, the opening / closing valve 28, the opening / closing valve 29a of the drain pipe 29 is closed, and the opening / closing valve 24 of the pipe 23 is opened. The blood in the test storage tank 11 is guided to the plate heat exchanger 22 via the pipe 12 and the pump 19 and is cooled to a temperature of 5 ° C. or lower at which microorganisms do not grow, and then blood is passed through the pipe 23 without causing hemolysis. It is stored in the cold storage tank 25.

次いで前記配管23の開閉弁24を閉じ、開閉弁28を
開けて、血液保冷貯槽25内の血液を配管26、ポンプ
31を介して遠心分離機33に供給する。この時洗浄液
流出口32の開閉弁32aは閉じられている。
Next, the opening / closing valve 24 of the pipe 23 is closed and the opening / closing valve 28 is opened to supply the blood in the blood cold storage tank 25 to the centrifuge 33 via the pipe 26 and the pump 31. At this time, the opening / closing valve 32a of the cleaning liquid outlet 32 is closed.

血液は、遠心分離機33で血球と血漿とに分離されてそ
れぞれ血球貯槽34、血漿貯槽40に貯えられる。ここ
での水分量は血球液が約65%、血漿液が約92%であ
り、微生物が増殖し易い水分量であるため、保冷貯槽2
5と同様5℃以下の温度に保持される。
The blood is separated into blood cells and plasma by the centrifugal separator 33 and stored in the blood cell storage tank 34 and the plasma storage tank 40, respectively. The amount of water here is about 65% for blood cell fluid and about 92% for plasma fluid.
As in 5, the temperature is maintained at 5 ° C. or lower.

次いで血球液、血漿液はそれぞれ血球乾燥機36、血漿
乾燥機42で水分含量10%程度になるまで60℃以下
の真空低温乾燥を行い、さらに粉砕機37,43でそれ
ぞれ一定粒度以下に粉砕され、熱変性を起こさない温度
でそれぞれ殺菌機38,44で殺菌されて、袋詰機3
9,45で袋詰されて製品となる。従って、上記構造の
製造装置を用いて血液を製品化した場合、血漿の製品が
赤色を呈することもなく、商品価値を損ねることもな
い。
Next, the blood cell fluid and plasma fluid are dried at 60 ° C. or lower in a vacuum at a blood cell dryer 36 and a plasma dryer 42 to a water content of about 10%, respectively, and further pulverized to a certain particle size or less by pulverizers 37 and 43, respectively. The bagging machine 3 is sterilized by the sterilizers 38 and 44 at a temperature at which heat denaturation does not occur.
The product is packaged in bags at 9,45. Therefore, when blood is commercialized by using the manufacturing apparatus having the above structure, the plasma product does not show red color and the commercial value is not impaired.

次に上記構造の血液製品製造装置の洗浄方法を説明す
る。まず検査貯槽11、血液保冷貯槽25の上部に設置
されているスプレーボール46a,47aから水又は温
水を送入して、検査貯槽11、血液保冷貯槽25を簡単
に洗浄し、排水をドレーン管16,29より排出する。
Next, a method of cleaning the blood product manufacturing apparatus having the above structure will be described. First, water or hot water is fed from the spray balls 46a and 47a installed above the test storage tank 11 and the blood cool storage tank 25 to easily wash the test storage tank 11 and the blood cool storage tank 25, and drain the drain water 16 , 29.

次に開閉弁15,24,28,32aを開け、ドレーン
管16,29の開閉弁16a,29aを閉じ、検査貯槽
11のスプレーボール46aから洗浄水を出して検査貯
槽11に充たし、ポンプ19を起動し、同時に空気注入
口14,18,20,21から圧縮空気を送入する。な
お、配管7を洗浄する場合には洗浄水を洗浄液流入口8
から、圧縮空気を空気送入口9から同時に送入する。す
ると、圧縮空気は流路内の洗浄液を攪拌するとともに、
流路壁に作用して壁面に強く付着している血液を除去す
る。
Next, the on-off valves 15, 24, 28 and 32a are opened, the on-off valves 16a and 29a of the drain pipes 16 and 29 are closed, and washing water is discharged from the spray ball 46a of the inspection storage tank 11 to fill the inspection storage tank 11 and the pump 19 is turned on. At the same time, the compressed air is fed from the air inlets 14, 18, 20, 21 simultaneously. In addition, when cleaning the pipe 7, cleaning water is supplied to the cleaning liquid inlet 8
The compressed air is simultaneously fed from the air inlet 9. Then, the compressed air agitates the cleaning liquid in the flow path,
It acts on the wall of the flow path and removes blood strongly attached to the wall.

洗浄水としては、水又は45℃位の温水にPH10以上、
好ましくは0.05〜0.2%位の濃度になるように苛
性ソーダ、炭酸ソーダ等の洗浄剤を加えると若干洗浄時
間は短縮される。
As the washing water, PH or 10 or more in water or warm water of about 45 ° C,
If a cleaning agent such as caustic soda and sodium carbonate is added so that the concentration is preferably about 0.05 to 0.2%, the cleaning time is shortened slightly.

空気量は空気送入個所に関係なく送液量に対して0.3
のvol比以上、好ましくは2〜3倍あればよい。またポ
ンプ19が特殊なロータリー式のポンプの場合は送入圧
縮空気量は空気注入口14でポンプ19の送液量に対し
て0.3〜0.5のvol比で、他の空気注入口18,2
0,21ではポンプ19の送液量に対して2〜3倍のvo
l比で行う。
The amount of air is 0.3 with respect to the amount of liquid sent regardless of where the air is fed
Vol ratio or more, preferably 2 to 3 times. Further, when the pump 19 is a special rotary type pump, the amount of compressed air fed in is a volume ratio of 0.3 to 0.5 to the amount of liquid fed by the pump 19 in the air inlet 14, and the other air inlets 18, 2
At 0 and 21, the vo is 2 to 3 times as much as the pump 19
l ratio.

そして血液保冷貯槽25の底部に若干の洗浄水がたまる
程度になったら血液保冷貯槽25のスプレーボール47
aから若干の洗浄水の供給を開始するとともにポンプ3
1を起動し、洗浄液流出口32から洗浄水を排出させ
る。これにより、これら流路内の空気混入洗浄液は、ポ
ンプ19,31によって配管7の上流側から配管26の
下流側までの主要流路中をいきおいよく流れる。
Then, when a small amount of washing water is accumulated at the bottom of the blood cool storage tank 25, the spray ball 47 of the blood cool storage tank 25
Start supplying a small amount of washing water from a and pump 3
1 is started and the cleaning water is discharged from the cleaning liquid outlet 32. As a result, the air-mixed cleaning liquid in these flow paths flows vigorously in the main flow path from the upstream side of the pipe 7 to the downstream side of the pipe 26 by the pumps 19 and 31.

排水の色度合いから検査貯槽11から遠心分離機33の
直前に至る血液輸送系の内部の洗浄の状態を判断する。
洗浄効果を判断する手段としては、予め走査型分光光度
計等を用い血液の最大吸光波長及び吸光系数と残留血液
濃度の関係を調べておき比色計を用いると便利である。
通常20〜25分程度で洗浄困難な熱交換器22内部も
完全に洗浄できるが、洗浄排液の色との相関をみると洗
浄排水の吸光度が0になってから若干洗浄時間の余裕が
必要とみられる。洗浄時間の設定については、洗浄が困
難な熱交換器の内部やポンプ内部の洗浄状態との関連を
予め調べておき設定する必要がある。
The state of cleaning of the inside of the blood transport system from the test storage tank 11 to immediately before the centrifuge 33 is determined from the color degree of the waste water.
As a means for judging the washing effect, it is convenient to use a scanning spectrophotometer or the like in advance to examine the relationship between the maximum absorption wavelength and absorption coefficient of blood and the residual blood concentration, and to use a colorimeter.
Usually, it takes about 20 to 25 minutes to completely clean the inside of the heat exchanger 22, which is difficult to clean, but the correlation with the color of the cleaning drainage requires a slight cleaning time after the absorbance of the cleaning drainage becomes zero. Seen. Regarding the setting of the cleaning time, it is necessary to investigate beforehand and set the relationship with the cleaning state inside the heat exchanger or inside the pump, which is difficult to clean.

本発明で送入する空気の圧縮圧力は一応内部に空気が導
入できる程度の圧力(1〜5kg/cm2G)があれば十分
で、通常1〜2kg/cm2Gの圧力で行う。また洗浄水の流
速は配管内で1.5m/sec以上で行う。これにより、
内部形状が複雑な装置を含み、しかも距離の長い主要流
路を持つ本製造装置を充分に洗浄し、確実に血液を除去
でき、装置を長い間、不使用状態に放置しても腐敗等の
生じる心配がない。
In the present invention, it is sufficient that the compression pressure of the air to be fed is such that the air can be introduced into the interior (1 to 5 kg / cm 2 G), and it is usually 1 to 2 kg / cm 2 G. The flow rate of the washing water is 1.5 m / sec or more in the pipe. This allows
This manufacturing device, which includes a device with a complicated internal shape and has a main flow path with a long distance, can be thoroughly washed to reliably remove blood, and even if the device is left unused for a long time, it will not decompose. There is no worry about it occurring.

なお、前述した洗浄を行った後さらに100〜200pp
m程度の次亜塩素酸ソーダの水溶液で本製造装置を洗浄
し殺菌することは衛生上好ましいことである。さらに洗
浄開始時には熱交換器22内部からの脱着物とみられる
血糊状物質が多量に出てきて、ポンプ31のロータ部分
等にからみ付くと洗浄に支障が出る恐れがあるので洗浄
開始の際にはドレーン管29から一時的に洗浄水を排出
した方が好ましい。
In addition, after performing the above-mentioned washing, 100-200 pp
It is hygienically preferable to wash and sterilize the manufacturing apparatus with an aqueous solution of sodium hypochlorite of about m. Further, when the cleaning is started, a large amount of blood paste-like substance, which is considered to be desorbed substances, from the inside of the heat exchanger 22 comes out, and if it gets caught in the rotor portion of the pump 31 or the like, the cleaning may be disturbed. It is preferable to temporarily discharge the wash water from the drain pipe 29.

なお、上記実施例において、接続部13,27の下流側
に開閉弁15,28を設けるかわりに、上記接続部1
3,27に三方弁を取り付けるようにしてもよい。この
ようにすれば、上流側配管と下流側配管との接続を行う
とともに、血液処理時と洗浄時の流路の切替えを容易、
確実に行うことができる。
In the above-mentioned embodiment, instead of providing the on-off valves 15 and 28 on the downstream side of the connecting portions 13 and 27, the connecting portion 1
A three-way valve may be attached to 3,27. By doing this, while connecting the upstream side pipe and the downstream side pipe, it is easy to switch the flow paths during blood processing and washing,
It can be done reliably.

また、上記実施例においては、洗浄液流出口32を遠心
分離機の直前に設けたが、血球貯槽34および血漿貯槽
40の後に設けるようにしてもよい。
Further, in the above embodiment, the washing liquid outlet 32 is provided immediately before the centrifuge, but it may be provided after the blood cell storage tank 34 and the plasma storage tank 40.

以上、本発明の洗浄作業を手動で行う場合について説明
したが、空気洗浄水等のバルブ開閉及びポンプの起動停
止をタイマーを含めた順序運転のシーケンス操作回路を
組めば起動ボタン操作一つで自動運転可能となる。
The case where the cleaning work of the present invention is manually performed has been described above. However, if a sequence operation circuit for sequential operation including a timer for opening and closing valves for air cleaning water and starting / stopping the pump is assembled, it can be automatically performed by one start button operation. You can drive.

なお、上記説明では、空気注入口(気体注入口)を9,
14,18,20,21と5個所設けて洗浄時に各々か
ら空気を流路内に注入するようにしている。上記空気注
入口18,20,21を設けたのは、ポンプ19,3
1、特にポンプ19がチューブ型等の流路閉塞型のポン
プであった場合、この流路閉塞型のポンプにはこのポン
プの回転によって移動される量しか空気が通過できず、
このポンプの下流への空気の供給が少なくなってしまう
ためで、そのためにこのポンプの上流および下流側に、
特に下流側に空気を補ってやらなければならないからで
ある。従って、ポンプ19,20としてロータリー型、
一軸スクリュー型等の流路開放型のポンプを採用すれ
ば、空気注入口18,20,21は必要なく、最上流側
の空気注入口9および14で充分であり、この空気注入
口9,14からの空気の注入により形成された空気混入
洗浄液により装置の上流から下流に亘って一括して洗浄
を充分に行うことができる。
In the above description, the air inlet (gas inlet) is 9,
Fourteen, eighteen, twenty, and twenty-one are provided so that air can be injected into the flow channel from each of them during cleaning. The air inlets 18, 20, 21 are provided by the pumps 19, 3,
1. In particular, when the pump 19 is a flow passage block type pump such as a tube type, air can pass through the flow passage block type pump only by an amount moved by the rotation of the pump.
This is because the air supply to the downstream of this pump is reduced, and therefore, on the upstream and downstream sides of this pump,
This is because it is necessary to supplement the air especially on the downstream side. Therefore, the pumps 19 and 20 are rotary type,
If a flow passage open type pump such as a single screw type is adopted, the air inlets 18, 20, 21 are not necessary, and the air inlets 9 and 14 on the most upstream side are sufficient. With the air-containing cleaning liquid formed by injecting air from the device, cleaning can be sufficiently performed collectively from the upstream side to the downstream side of the apparatus.

また、空気注入口14は検査貯槽11内を通って幾分か
の空気が外部へ逃れでてしまうことを考慮し、その分を
補うために設けたものである。しかし検査貯槽11内に
は上方のスプレーボール46aから洗浄液が供給され、
検査貯槽11内に供給された洗浄液は、ポンプ19によ
って順々に流路内に吸い込まれるため、流路内の空気
は、この流れを逆流して検査貯槽11内にさかのぼるこ
とができず、ほとんど外部へ逃れでてくることはない。
従って、上記空気注入口14は強いて設ける必要のない
予備的なものである。
Further, the air inlet 14 is provided to compensate for the fact that some air escapes to the outside through the inspection storage tank 11. However, the cleaning liquid is supplied from the upper spray ball 46a into the inspection storage tank 11,
Since the cleaning liquid supplied into the inspection storage tank 11 is sequentially sucked into the flow path by the pump 19, the air in the flow path cannot flow back into the inspection storage tank 11 by backflowing this flow. There is no escape to the outside.
Therefore, the air inlet 14 is a preliminary one that does not need to be provided by force.

このように、上記製造装置では、ポンプとして流路開放
型のポンプを採用すれば、空気注入口は最上流の空気注
入口9のみで充分であり、この空気注入口9からの空気
の注入により形成された空気混入洗浄液により装置の最
上流から最下流にかけて一括して同時に充分に洗浄を行
うことが可能となる。従って、本発明の血液処理装置に
おいては、ポンプは一軸スクリュー型等の流路開放型ポ
ンプを使用することが望ましい。
As described above, in the above manufacturing apparatus, if the flow path open type pump is adopted as the pump, only the most upstream air inlet 9 is sufficient as the air inlet, and the air is injected from this air inlet 9 The air-containing cleaning liquid thus formed enables simultaneous and sufficient cleaning from the most upstream side to the most downstream side of the apparatus. Therefore, in the blood processing apparatus of the present invention, it is desirable to use a flow passage open type pump such as a single screw type.

以上説明したように、本発明によれば、屠畜動物の採取
血液から血球乾燥粉末や血漿乾燥粉末等の有用な製品を
得る場合において、下記のような優れた利点を得ること
ができる。
As described above, according to the present invention, the following excellent advantages can be obtained when a useful product such as a blood cell dry powder or a plasma dry powder is obtained from blood collected from a slaughtered animal.

貯槽に採血液を落差零にして流入させることによって
衝撃による血球の溶血現象を防止し、血漿製品の品質を
向上させることができる。
By allowing the collected blood to flow into the storage tank with a head of zero, the hemolysis phenomenon of blood cells due to impact can be prevented and the quality of plasma products can be improved.

採血液を5℃以下の低温に冷却し且つ保冷して貯蔵す
ることにより、貯蔵血液中の微生物の増殖を防止でき
る。
It is possible to prevent the growth of microorganisms in the stored blood by cooling the collected blood to a low temperature of 5 ° C. or lower and storing it by keeping it cool.

抗凝固剤を採血直後に添加するので、貯槽までの系路
での凝固が防止でき、汚染による微生物の増殖を抑える
ことができる。
Since the anticoagulant is added immediately after blood collection, coagulation in the system up to the storage tank can be prevented and the growth of microorganisms due to contamination can be suppressed.

空気と洗浄液を併用して設備停止直後に全系路を効率
よく洗浄するので、休止時系路を清浄に保持し微生物の
付着、増殖を防止できる。
Since air and a cleaning solution are used together to efficiently clean all system paths immediately after the facility is stopped, it is possible to keep the system paths at rest clean and prevent the attachment and growth of microorganisms.

上記〜の効果により、最終段階における殺菌工程
は製品の熱変性を起こさない温度で処理できる。
Due to the effects (1) to (3), the sterilization step in the final stage can be carried out at a temperature at which the product is not thermally denatured.

以上およびの効果によって、水溶性(易溶解性)
に優れ、熱凝固性を低下させずに、充分に殺菌され、血
漿製品における赤色呈色現象も発生しない高品質の乾燥
血漿製品を製造することができる。
Water solubility (easy solubility)
It is possible to manufacture a high-quality dry plasma product which is excellent in sterilization, is sufficiently sterilized, and does not cause a red coloring phenomenon in the plasma product, without lowering the heat coagulation property.

なお、以下に前述した気体混合洗浄効果について実験例
をあげて記述する。
The gas mixture cleaning effect described above will be described below with reference to experimental examples.

実験例1 上記実施例の装置の洗浄操作として、検査貯槽11及び
血液保冷貯槽25のスプレーボール46a,47aから
1分間位放水し、貯槽11,25内部の予備洗浄を行い
ドレーン管より洗浄水を排水した。次に開閉弁28を開
け検査貯槽11及び血液保冷貯槽25のスプレーボール
46a,47aから放水しながらポンプ19,31を起
動し、洗浄水を送り、空気注入口14から圧縮空気を
1.5kg/cm2Gの圧力で20Nl/min、空気注入口1
8,20,21から100Nl/minの割合で送入し、
水と空気の混合物で検査貯槽から遠心分離機迄の配管、
ポンプ、貯槽、熱交換器等一連の血液輸送装置の内部の
洗浄を行った。ポンプ19の送易量は50/minに調
整した。洗浄の終了は、排水の吸光度を測定し排水中の
血液濃度がなくなるまで行い終点とした。洗浄に要した
時間は30分であった。洗浄終了後系内の各部を分解点
検した結果、配管、貯槽、ポンプ、熱交換器の内部は完
全に洗浄されていた。
Experimental Example 1 As a cleaning operation of the apparatus of the above-mentioned example, water was sprayed from the spray balls 46a, 47a of the test storage tank 11 and the blood cool storage tank 25 for about 1 minute, the interior of the storage tanks 11, 25 was pre-cleaned, and the cleaning water was drained from the drain pipe. Drained. Next, the on-off valve 28 is opened and the pumps 19 and 31 are started while water is sprayed from the spray balls 46a and 47a of the test storage tank 11 and the blood cool storage tank 25. 20 Nl / min at a pressure of cm 2 G, 1 air inlet
Inject at a rate of 100 Nl / min from 8, 20, 21
Piping from test reservoir to centrifuge with a mixture of water and air,
The inside of a series of blood transport devices such as a pump, a storage tank, and a heat exchanger was cleaned. The easy delivery amount of the pump 19 was adjusted to 50 / min. The washing was terminated by measuring the absorbance of the wastewater and ending the concentration of blood in the wastewater until the end point. The time required for washing was 30 minutes. As a result of disassembling and inspecting each part in the system after the completion of cleaning, the insides of the pipe, the storage tank, the pump and the heat exchanger were completely cleaned.

比較例1 実験例1と同様に予備洗浄を行った後圧縮空気を送入し
ないで実験例1と同じ条件で洗浄を行った。洗浄に要し
た時間は80分であった。洗浄終了後系内の各部を分解
点検した結果、ポンプ内部には少量、熱交換器内部には
3〜5mm位の大きさの血糊状の物質が多量付着してお
り、洗浄が不完全であった。
Comparative Example 1 Preliminary cleaning was performed in the same manner as in Experimental Example 1, and then cleaning was performed under the same conditions as in Experimental Example 1 without feeding compressed air. The time required for washing was 80 minutes. After cleaning, each part of the system was disassembled and inspected, and as a result, a small amount of blood paste-like substance with a size of 3 to 5 mm adhered to the inside of the pump and a large amount of blood paste-like substance inside the heat exchanger. It was

以上の実験例1と比較例1の比較から、本発明の洗浄効
果が完全であり、且つ洗浄に要する時間を短縮できるこ
とが分かる。
From the above comparison between Experimental Example 1 and Comparative Example 1, it can be seen that the cleaning effect of the present invention is complete and the time required for cleaning can be shortened.

実験例2 洗浄水として45℃の温水を用いて実験例1、比較例1
と同じ条件で系内の洗浄を行った。洗浄に要した時間
は、圧縮空気を送入した場合は20分、送入しない場合
が50分であった。
Experimental Example 2 Experimental Example 1 and Comparative Example 1 using 45 ° C. warm water as washing water
The inside of the system was washed under the same conditions as above. The time required for cleaning was 20 minutes when the compressed air was fed and 50 minutes when the compressed air was not fed.

分解点検の結果、圧縮空気を送入した場合は洗浄が完全
であったのに対し送入しない場合は水を用いた場合より
も洗浄状態は良好であるが、ポンプ内部、熱交換器内部
に血糊状物質が多量に付着しており、洗浄は不完全であ
った。
As a result of the overhaul and inspection, when the compressed air was fed, the cleaning was complete, but when it was not fed, the cleaning condition was better than when water was used, but inside the pump and heat exchanger A large amount of blood pasty substance adhered and the washing was incomplete.

実験例3 洗浄水として0.2%苛性ソーダを用いて実験例1、比
較例1と同じ条件で系内の洗浄を行った。洗浄に要した
時間は、圧縮空気を送入した場合は20分、送入しない
場合は45分であった。
Experimental Example 3 The inside of the system was cleaned under the same conditions as in Experimental Example 1 and Comparative Example 1 using 0.2% caustic soda as cleaning water. The time required for cleaning was 20 minutes when the compressed air was fed and 45 minutes when the compressed air was not fed.

【図面の簡単な説明】[Brief description of drawings]

第1図は従来の血液処理装置の貯槽近傍の構成図、第2
図は本発明の実施例を示す血液製品の製造装置の構成図
である。 3……屠畜動物 4……採血ナイフ(套管ナイフ) 5……抗凝固剤タンク(抗凝固剤注入設備) 7,12,23,26……配管 8……洗浄液流入口 9,14,18,20,21……空気注入口(気体注入
口) 11……検査貯槽 13,27……接続部 15,28……開閉弁 19,31……ポンプ 22……熱交換器(冷却器) 25……血液保冷貯槽 33……遠心分離機(分離装置) 36……血球乾燥機 37,43……粉砕機 38,44……殺菌機 42……血漿乾燥機
FIG. 1 is a block diagram of the vicinity of a storage tank of a conventional blood processing apparatus, and FIG.
FIG. 1 is a block diagram of a blood product manufacturing apparatus showing an embodiment of the present invention. 3 …… Slaughtered animal 4 …… Blood sampling knife (trocar knife) 5 …… Anticoagulant tank (anticoagulant injection equipment) 7,12,23,26 …… Piping 8 …… Cleaning fluid inlet 9,14, 18, 20, 21 …… Air inlet (gas inlet) 11 …… Inspection storage tank 13,27 …… Connection part 15,28 …… Open / close valve 19,31 …… Pump 22 …… Heat exchanger (cooler) 25 ... Blood cold storage tank 33 ... Centrifuge (separation device) 36 ... Blood cell dryer 37, 43 ... Crusher 38, 44 ... Sterilizer 42 ... Plasma dryer

Claims (3)

【特許請求の範囲】[Claims] 【請求項1】屠畜動物(3)から採血ナイフ(4)で採られた
血液に採血直後に抗凝固剤を加えて該血液を採取する採
血工程と、この採取血液を第1配管(7)を通じて検査貯
槽(11)内に落差零で流入させて貯留し、病畜血液の有無
を検査する検査工程と、検査貯槽(11)内の血液を第2配
管(12)で受けて微生物が増殖しない5℃以下に冷却して
第3配管(23)を通じて血液保冷貯槽(25)内に落差零で流
入させて貯留する冷却工程と、血液保冷貯槽(25)内に貯
留された血液を第4配管(26)で受けて血球と血漿とに分
離する血液分離工程と、該血液分離工程で分離された血
球を乾燥し粉砕、殺菌して乾燥血球を得る血球の製品化
工程と、血液分離工程で分離された血漿を乾燥し粉砕、
殺菌して乾燥血漿を得る血漿の製品化工程と、血液を流
す上記配管(7,12,23,26)に洗浄液と圧縮気体とを同時に
流して上記配管(7,12,23,26)の内壁面に付着した血液を
除去する洗浄工程とを具備したことを特徴とする動物血
液を原料とする血液製品の製造方法。
1. A blood collection step of collecting blood by adding an anticoagulant to blood collected from a slaughtered animal (3) with a blood collection knife (4), and collecting the collected blood in a first pipe (7). ) Through the storage tank (11) with a zero drop to store it and test it for the presence or absence of sick blood, and the blood in the testing tank (11) is received by the second pipe (12) The cooling step of cooling to 5 ° C or less at which it does not grow and flowing into the blood cold storage tank (25) through the third pipe (23) with a zero drop and storing, and the blood stored in the blood cold storage tank (25) 4 blood separation step of receiving in 4 pipes (26) to separate blood cells and plasma; blood cell production step of drying, crushing and sterilizing the blood cells separated in the blood separation step to obtain dried blood cells; and blood separation The plasma separated in the process is dried and crushed,
Plasma production process to obtain dried plasma by sterilization, the pipe (7,12,23,26) flowing the blood at the same time by flowing the cleaning solution and compressed gas of the pipe (7,12,23,26) A method for producing a blood product using animal blood as a raw material, comprising a cleaning step for removing blood adhering to an inner wall surface.
【請求項2】屠畜動物(3)から採血ナイフ(4)で採られた
血液に採血直後に抗凝固剤を加える抗凝固剤注入設備
と、抗凝固剤を加えられた血液を第1配管(7)を通じて
落差零で流入させて貯留する検査貯槽(11)と、該検査貯
槽(11)で検査された血液を第2配管(12)で受けて微生物
が増殖しない5℃以下に冷却する冷却器(22)と、該冷却
器(22)で冷却された血液を第3配管(23)を通じて落差零
で流入させて貯留する血液保冷貯槽(25)と、該血液保冷
貯槽(25)内に貯留された血液を第4配管(26)で受けて血
球と血漿とに分離する分離装置(33)と、該分離装置(33)
で分離された血球を乾燥する血球乾燥機(36)と、上記分
離装置(33)で分離された血漿を乾燥する血漿乾燥機(42)
と、乾燥された血球を粉砕する粉砕機(37)と、乾燥され
た血漿を粉砕する粉砕機(43)と、乾燥された血球を殺菌
する殺菌機(38)と、乾燥された血漿を殺菌する殺菌機(4
4)と、上記配管(7,12,23,26)に洗浄液を流す洗浄液流入
口(8)と、上記配管(7,12,23,26)に圧縮気体を流す気体
注入口(9)とを具備したことを特徴とする動物血液を原
料とする血液製品の製造装置。
2. An anticoagulant injection facility for adding an anticoagulant to a blood sampled from a slaughtered animal (3) with a blood sampling knife (4), and blood to which the anticoagulant has been added is provided in a first pipe. The test storage tank (11) which is made to flow in and store at zero drop through (7) and the blood tested in the test storage tank (11) are received by the second pipe (12) and cooled to 5 ° C. or less at which microorganisms do not grow. Inside the blood cool storage tank (25), a cooler (22), a blood cold storage tank (25) for storing the blood cooled by the cooler (22) by flowing it through the third pipe (23) with a zero drop And a separating device (33) for receiving blood stored in the blood vessel in the fourth pipe (26) and separating it into blood cells and plasma.
Blood cell dryer for drying blood cells separated by (36), and plasma dryer for drying plasma separated by the separation device (33) (42)
And a crusher (37) for crushing dried blood cells, a crusher (43) for crushing dried plasma, a sterilizer (38) for sterilizing dried blood cells, and a sterilizer for dried plasma Sterilizer (4
4), a cleaning liquid inlet (8) for flowing a cleaning liquid through the pipes (7, 12, 23, 26), and a gas inlet (9) for flowing a compressed gas through the pipes (7, 12, 23, 26). An apparatus for producing a blood product using animal blood as a raw material, which comprises:
【請求項3】上流側配管(7,23)が貯槽(11,25)の底部に
開口され、下流側配管(12,26)が上記上流側配管(7,23)
の下流端近くに接続されたことを特徴とする特許請求の
範囲第2項記載の動物血液を原料とする血液製品の製造
装置。
3. The upstream pipe (7,23) is opened at the bottom of the storage tank (11,25), and the downstream pipe (12,26) is the upstream pipe (7,23).
An apparatus for producing a blood product using animal blood as a raw material according to claim 2, wherein the apparatus is connected near the downstream end of the.
JP58249561A 1983-12-29 1983-12-29 Method and apparatus for producing blood product from animal blood Expired - Lifetime JPH0611225B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP58249561A JPH0611225B2 (en) 1983-12-29 1983-12-29 Method and apparatus for producing blood product from animal blood

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58249561A JPH0611225B2 (en) 1983-12-29 1983-12-29 Method and apparatus for producing blood product from animal blood

Publications (2)

Publication Number Publication Date
JPS60141241A JPS60141241A (en) 1985-07-26
JPH0611225B2 true JPH0611225B2 (en) 1994-02-16

Family

ID=17194826

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58249561A Expired - Lifetime JPH0611225B2 (en) 1983-12-29 1983-12-29 Method and apparatus for producing blood product from animal blood

Country Status (1)

Country Link
JP (1) JPH0611225B2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2484639C2 (en) * 2011-03-16 2013-06-20 Государственное образовательное учреждение высшего профессионального образования Кемеровский технологический институт пищевой промышленности Device for farm animals blood processing and device application
CN103461642B (en) * 2013-09-18 2015-09-09 浙江索纳克生物科技有限公司 A kind of high performance Swine blood protein preparation facilities
CN112514955A (en) * 2020-10-22 2021-03-19 张效华 Pollution-free duck blood processing method
CN114982805A (en) * 2021-10-08 2022-09-02 东莞市踔厉智能科技有限公司 Vacuum blood drawing device for pig slaughtering

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5757259A (en) * 1980-09-25 1982-04-06 Terumo Corp Circuit device for filtering and separating blood

Also Published As

Publication number Publication date
JPS60141241A (en) 1985-07-26

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