JPH05509292A - 組織インプランテーション法 - Google Patents
組織インプランテーション法Info
- Publication number
- JPH05509292A JPH05509292A JP3508056A JP50805691A JPH05509292A JP H05509292 A JPH05509292 A JP H05509292A JP 3508056 A JP3508056 A JP 3508056A JP 50805691 A JP50805691 A JP 50805691A JP H05509292 A JPH05509292 A JP H05509292A
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- cam
- mammalian
- implanted
- implantation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 78
- 238000002513 implantation Methods 0.000 title claims description 43
- 210000001519 tissue Anatomy 0.000 claims description 108
- 210000003711 chorioallantoic membrane Anatomy 0.000 claims description 68
- 235000013601 eggs Nutrition 0.000 claims description 50
- 210000000981 epithelium Anatomy 0.000 claims description 25
- 210000004027 cell Anatomy 0.000 claims description 23
- 210000001161 mammalian embryo Anatomy 0.000 claims description 21
- 239000007943 implant Substances 0.000 claims description 16
- 210000000287 oocyte Anatomy 0.000 claims description 14
- 230000001143 conditioned effect Effects 0.000 claims description 13
- 230000004720 fertilization Effects 0.000 claims description 13
- 201000004384 Alopecia Diseases 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 241000271566 Aves Species 0.000 claims description 8
- 241000272534 Struthio camelus Species 0.000 claims description 8
- 210000002459 blastocyst Anatomy 0.000 claims description 7
- 210000004556 brain Anatomy 0.000 claims description 7
- 238000000338 in vitro Methods 0.000 claims description 7
- 231100000360 alopecia Toxicity 0.000 claims description 6
- 230000006870 function Effects 0.000 claims description 6
- 210000003780 hair follicle Anatomy 0.000 claims description 6
- 208000014674 injury Diseases 0.000 claims description 6
- 210000000130 stem cell Anatomy 0.000 claims description 6
- 230000002500 effect on skin Effects 0.000 claims description 5
- 230000003779 hair growth Effects 0.000 claims description 5
- 210000001577 neostriatum Anatomy 0.000 claims description 5
- 210000001943 adrenal medulla Anatomy 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 210000003754 fetus Anatomy 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 210000003491 skin Anatomy 0.000 claims description 4
- 208000018737 Parkinson disease Diseases 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 108010003272 Hyaluronate lyase Proteins 0.000 claims description 2
- 102000001974 Hyaluronidases Human genes 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- 229960002773 hyaluronidase Drugs 0.000 claims description 2
- 230000000926 neurological effect Effects 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 230000004077 genetic alteration Effects 0.000 claims 1
- 231100000118 genetic alteration Toxicity 0.000 claims 1
- 230000009395 genetic defect Effects 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 25
- 108090000623 proteins and genes Proteins 0.000 description 12
- 241000287828 Gallus gallus Species 0.000 description 10
- 235000013330 chicken meat Nutrition 0.000 description 10
- 230000004083 survival effect Effects 0.000 description 9
- 210000004204 blood vessel Anatomy 0.000 description 8
- 230000004927 fusion Effects 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 238000002054 transplantation Methods 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 6
- 230000002792 vascular Effects 0.000 description 6
- 230000002068 genetic effect Effects 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 230000003676 hair loss Effects 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000035755 proliferation Effects 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 230000008733 trauma Effects 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 230000007547 defect Effects 0.000 description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
- 210000004209 hair Anatomy 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000001919 adrenal effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000004720 cerebrum Anatomy 0.000 description 3
- 210000003161 choroid Anatomy 0.000 description 3
- 208000024963 hair loss Diseases 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010034010 Parkinsonism Diseases 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 230000000394 mitotic effect Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241001455272 Amniota Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000003939 Membrane transport proteins Human genes 0.000 description 1
- 108090000301 Membrane transport proteins Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010040925 Skin striae Diseases 0.000 description 1
- 241000271567 Struthioniformes Species 0.000 description 1
- 241000375392 Tana Species 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000001643 allantois Anatomy 0.000 description 1
- 239000002870 angiogenesis inducing agent Substances 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
- 229960002170 azathioprine Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000029803 blastocyst development Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000002219 extraembryonic membrane Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000009061 membrane transport Effects 0.000 description 1
- 210000001259 mesencephalon Anatomy 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 230000005868 ontogenesis Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000033885 plasminogen activation Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0604—Whole embryos; Culture medium therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
- C12N2533/92—Amnion; Decellularised dermis or mucosa
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Environmental Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Virology (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51329090A | 1990-04-17 | 1990-04-17 | |
US513.290 | 1990-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH05509292A true JPH05509292A (ja) | 1993-12-22 |
Family
ID=24042643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3508056A Pending JPH05509292A (ja) | 1990-04-17 | 1991-04-17 | 組織インプランテーション法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0528842A4 (fr) |
JP (1) | JPH05509292A (fr) |
AU (1) | AU7746091A (fr) |
CA (1) | CA2080464A1 (fr) |
WO (1) | WO1991016419A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10005329A1 (de) * | 2000-02-08 | 2001-09-20 | Albert Scheller | Humanisiertes, vitalisiertes Haarbewachsen und Haarwiederbewachsen mit subkutanen Kanüleneinstich-Haut-Färbungs-Zeichnungsverfahren |
AU2001247732A1 (en) * | 2000-03-24 | 2001-10-08 | Geron Corporation | A strategy for maintaining pregnancy |
CN100362972C (zh) * | 2004-12-24 | 2008-01-23 | 李宇 | 人工毛乳头替代结构及其制作方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE68013T1 (de) * | 1985-07-05 | 1991-10-15 | Whitehead Biomedical Inst | Expression von fremdem genetischem material in epithelzellen. |
US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
GB8604360D0 (en) * | 1986-02-21 | 1986-03-26 | Univ Dundee | Stimulation of hair growth |
-
1991
- 1991-04-17 CA CA002080464A patent/CA2080464A1/fr not_active Abandoned
- 1991-04-17 WO PCT/US1991/002629 patent/WO1991016419A1/fr not_active Application Discontinuation
- 1991-04-17 AU AU77460/91A patent/AU7746091A/en not_active Abandoned
- 1991-04-17 EP EP19910908414 patent/EP0528842A4/en not_active Withdrawn
- 1991-04-17 JP JP3508056A patent/JPH05509292A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2080464A1 (fr) | 1991-10-18 |
AU7746091A (en) | 1991-11-11 |
WO1991016419A1 (fr) | 1991-10-31 |
EP0528842A1 (fr) | 1993-03-03 |
EP0528842A4 (en) | 1993-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MORIYAMA et al. | Progesterone facilitates implantation of xenogenic cultured cells in hamster uterus | |
CN100503814C (zh) | 一种用于治疗皮肤缺损的可移植性产品的制备方法 | |
US20100166719A1 (en) | Hair growth method | |
CN101102800A (zh) | 使用羊膜的片状组合物及其制作方法 | |
EP0574527A1 (fr) | Tissu d'implantation et procedes de traitement et d'utilisation | |
CN104087551B (zh) | 一种体外分离培养人的表皮细胞的方法 | |
Rygaard | Skin grafts in nude mice: 3. Fate of grafts from man and donors of other taxonomic classes | |
Gullino | Angiogenesis factor (s) | |
BR102019014873A2 (pt) | Processo de obtenção de um substituto dérmico funcional a partir de membrana amniótica descelularizada proveniente de placenta em combinação com queratinócitos e seu uso como agente de regeneração tissular de pele | |
CN106635967A (zh) | 一种毛囊干细胞的移植方法 | |
JP2009544362A (ja) | 損傷を受けた組織の修復のための有糸分裂的に不活性化された幹細胞の使用方法 | |
TW506827B (en) | Method for expansion of epithelial stem cells on an amniotic membrane and resulting graft | |
JPH05509292A (ja) | 組織インプランテーション法 | |
JP4324988B2 (ja) | 発毛誘導剤および発毛方法 | |
TWI389696B (zh) | 人工腎臟前驅物及其製造方法 | |
CN110090228A (zh) | 人羊膜上皮细胞在自身免疫性疾病中的治疗用途 | |
CN112522180B (zh) | 一种人头皮毛囊单细胞悬液及其制备方法和用途 | |
JP5164439B2 (ja) | 毛乳頭細胞培養方法 | |
JP4373652B2 (ja) | 毛包再構成系およびその担持動物 | |
Olszewska-Słonina2EF et al. | Establishing melanocyte cultures in a serum-free system for transplantation in vitiligo patients | |
CN109321513B (zh) | 一种具有生理功能的组织工程皮肤构建方法 | |
JP4212280B2 (ja) | ヒト毛のinvivo発毛誘導方法と、ヒト毛を有する非ヒト動物 | |
WO2023164799A1 (fr) | Produit de gelée de wharton capable de favoriser l'ostéogenèse | |
Bommert | Therapeutic Approach of the Anterior Ocular Surface. Evaluation with in Vivo Confocal Microscopy | |
RU2268062C1 (ru) | Биотрансплантат, способ его получения (варианты) и способ лечения дилятационной кардиомиопатии |